Pioglitazone ameliorates intracerebral insulin resistance and tau-protein hyperphosphorylation in rats with type 2 diabetes.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Experimental and clinical endocrinology & diabetes

• Publication date

  2013-03-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1055/s-0032-1333277PMID 23512416
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimer's Disease

  2012cited by this paper
• Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimer’s Disease

  2012cited by this paper
• Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.

  2012cited by this paper
• Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease.

  2012cited by this paper
• Insulin resistance in the brain: an old-age or new-age problem?

  2012cited by this paper
• Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus.

  2011cited by this paper
• Insulin signaling to hepatic lipid metabolism in health and disease

  2011cited by this paper
• Proteome Analysis of Differential Protein Expression in Brain of Rats with Type 1 Diabetes Mellitus

  2011cited by this paper
• Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

  2010cited by this paper
• Insulin-Resistant Brain State after Intracerebroventricular Streptozotocin Injection Exacerbates Alzheimer-like Changes in Tg2576 AβPP-Overexpressing Mice

  2010cited by this paper
• Common pathogenesis of type 2 diabetes and Alzheimer's disease:a potential mechanism

  2010cited by this paper
• Prevalence of diabetes among men and women in China.

  2010cited by this paper
• PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

  2010cited by this paper
• Pioglitazone improves superoxide dismutase mediated vascular reactivity in the obese Zucker rat

  2010cited by this paper
• Prevalence of diabetes among men and women in China.

  2010cited by this paper
• CNS leptin and insulin action in the control of energy homeostasis

  2010cited by this paper
• Prevalence of diabetes among men and women in China.

  2010cited by this paper
• 2010 Alzheimer's disease facts and figures

  2010cited by this paper
• Insulin and the brain

  2009cited by this paper
• Effects of pioglitazone hydrochloride on Japanese patients with type 2 diabetes mellitus.

  2007cited by this paper
• Tau protein phosphorylation levels and glycogen synthase kinase-3βactivities were increased in hippocampus of rats with type 1 or type 2 diabetes

  2007cited by this paper
• Effects of PPAR gamma agonists on cardiovascular function in obese, non-diabetic patients.

  2006cited by this paper
• Detection of β-endorphin in the cerebrospinal fluid after intrastriatal microinjection into the rat brain

  2005cited by this paper
• Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats.

  2004cited by this paper
• Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function.

  2004cited by this paper
• Diabetes mellitus and risk of dementia in the Kungsholmen project

  2004cited by this paper
• Effect of pioglitazone compared with metformin on glycemic control and indicators of insulin sensitivity in recently diagnosed patients with type 2 diabetes.

  2003cited by this paper
• Effect of pioglitazone on blood proinsulin levels in patients with type 2 diabetes mellitus.

  2002cited by this paper
• Intracerebroventricular insulin enhances memory in a passive-avoidance task.

  2000cited by this paper
• Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease

  1998cited by this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cited by this paper
• Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor

  1969cited by this paper

• Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes

  2025cites this paper
• Regulation of Apoptotic and Autophagic Pathways by Propionic Acid in the Ventromedial Hypothalamus of Type 2 Diabetic Rats

  2025cites this paper
• Pharmacological modulation of the PI3K/AKT/GSK3β axis: a new frontier in Alzheimer’s disease treatment

  2025cites this paper
• Vitamin D potentiation of metformin hepatoprotective activities: Concurrent targeting of carbohydrate enzymatic pathways and PCSK9/AGEs-regulated oxidative stress mechanisms in type 2 diabetic male Wistar rats.

  2025cites this paper
• The dynamic psychoendocrine relation between diabetes mellitus and mental health disorders: A review of the literature

  2025cites this paper
• Targeting of the PI3 K/AKT/GSK3β Pathway in Parkinson's Disease: A Therapeutic Blueprint

  2025cites this paper
• The possible role of neurogenesis activators in temporal lobe epilepsy: State of art and future perspective.

  2025cites this paper
• Progressive impairment in gastric and duodenal slow waves and autonomic function during progression of type 2 diabetes in rats.

  2025cites this paper
• Synergistic Effects of Vitamin D and Exercise on Diabetes-induced Gonadotoxicity in Male Wistar Rats: Role of Xanthine Oxidase/Uric Acid and Nrf2/NfkB Signaling

  2024cites this paper
• The Promising Potency of Sodium–Glucose Cotransporter 2 Inhibitors in the Prevention of and as Treatment for Cognitive Impairment Among Type 2 Diabetes Patients

  2024cites this paper
• Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)

  2024cites this paper
• Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies

  2024cites this paper
• Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer’s disease

  2024cites this paper
• Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats.

  2023cites this paper
• Orange Peel Extract and Physical Exercise Synergistically Ameliorate Type 2 Diabetes Mellitus-Induced Dysmetabolism by Upregulating GLUT4 Concentration in Male Wistar Rats

  2023cites this paper
• Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study

  2023cites this paper
• New insights toward molecular and nanotechnological approaches to antidiabetic agents for Alzheimer’s disease

  2023cites this paper
• Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation

  2022cites this paper
• Experimental Approaches to Diabetes Mellitus

  2022cites this paper
• [Influence of intranasally administered insulin on metabolic and hormonal parameters in adult male rats, impaired due to three-day fasting in the early postnatal period].

  2022cites this paper
• Therapeutic Strategies for Tauopathies and Drug Repurposing as a Potential Approach.

  2022cites this paper
• Insulin and Leptin Levels in Blood and Brain Structures of Rats with Diet-Induced Obesity and the Effect of Various Drugs on Them

  2022cites this paper
• Regulation of the apoptosis/autophagy switch by propionic acid in ventromedial hypothalamus of rats with type 2 diabetes mellitus

  2022cites this paper
• Streptozotocin-Induced Diabetes in a Mouse Model (BALB/c) Is Not an Effective Model for Research on Transplantation Procedures in the Treatment of Type 1 Diabetes

  2021cites this paper
• Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier

  2021cites this paper
• Brain insulin signalling in metabolic homeostasis and disease

  2021cites this paper
• Protective Effects of Bariatric Surgery on Kidney Functions by Inhibiting Oxidative Stress Responses Through Activating PPARα in Rats With Diabetes

  2021cites this paper
• The Link Between Diabetes Mellitus and Tau Hyperphosphorylation: Implications for Risk of Alzheimer's Disease

  2021influential citation
• Development and characterization of a high fat diet-streptozotocin induced type 2 diabetes model in nude athymic rats

  2021cites this paper
• Effects of Chronic Administration of Pioglitazone on Learning and Memory in Rat Model of Streptozotocin-induced Alzheimer’s Disease

  2020cites this paper
• IRISIN: A POTENTIAL PROMISING AGENT AGAINST NON-ALCOHOLIC FATTY LIVER DISEASE IN TYPE 2 DIABETIC RATS

  2019cites this paper
• Scope of new formulation approaches in the repurposing of pioglitazone for the management of Alzheimer’s disease

  2019cites this paper
• The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect

  2019cites this paper
• Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer’s disease using Box-Behnken design

  2019cites this paper
• Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats

  2019cites this paper
• Exaggerated pressor and sympathetic responses to stimulation of the mesencephalic locomotor region and exercise pressor reflex in type II diabetic rats.

  2019cites this paper
• Prospective of managing impaired brain insulin signalling in late onset Alzheimers disease with excisting diabetic drugs

  2019cites this paper
• Inhibition of Hypothalamic Inhibitor κB Kinase β/Nuclear Transcription Factor κB Pathway Attenuates Metabolism and Cardiac Dysfunction in Type 2 Diabetic Rats

  2019cites this paper
• Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: A retrospective cohort study

  2019cites this paper
• Type 2 Diabetes Mellitus in Rats on a High-Fat Diet with Streptozotocin Induction: Evaluation of the Model

  2018cites this paper
• Pioglitazone/microRNA‑141/FOXA2: A novel axis in pancreatic β‑cells proliferation and insulin secretion.

  2018cites this paper
• Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes.

  2018cites this paper
• The Effect of Abelmoscus Esculentus Powder on Histological Changes of the Ovary in Diabetic Rats

  2018cites this paper
• High Fat Diet-Fed , Streptozotocin-Induced Diabetic Rat Model : Is It an Ideal Type 2 Diabetic Model ?

  2017influential citation
• Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

  2017cites this paper
• A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin.

  2017cites this paper
• A New Method for Targeted and Sustained Induction of Type 2 Diabetes in Rodents

  2017cites this paper
• Peripheral iInsulin rResistance iInduced by sStreptozotocin and mModified Ddiets: iImplications for hHippocampal sStructural and fFunctional Iintegrity

  2017cites this paper
• Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies

  2017cites this paper
• Curcumin ameliorates insulin signalling pathway in brain of Alzheimer’s disease transgenic mice

  2016cites this paper
• A Review of High Fat Diet-Streptozotocin Model for Induction of Type 2 Diabetes in Rat

  2016cites this paper
• Pioglitazone prevents tau oligomerization.

  2016cites this paper
• The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

  2016cites this paper
• Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain

  2016cites this paper
• The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect.

  2016cites this paper
• Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis.

  2016cites this paper
• Role of insulin resistance in Alzheimer’s disease

  2015cites this paper
• Pioglitazone treatment enhances the sympathetic nervous system response to oral carbohydrate load in obese individuals with metabolic syndrome.

  2015cites this paper
• A Quantitative Analysis of Insulin Signaling in Neurodegeneration

  2015cites this paper
• A mathematical model of insulin resistance in Parkinson's disease

  2015cites this paper
• Modeling type 2 diabetes in rats using high fat diet and streptozotocin

  2014cites this paper
• Insulin dysfunction and Tau pathology

  2013cites this paper