A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

• Publication date

  2017-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.biopha.2017.08.098PMID 28881291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Experimental Models of Diabetes

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  2017cited by this paper
• A murine model of type 2 diabetes mellitus developed using a combination of high fat diet and multiple low doses of streptozotocin treatment mimics the metabolic characteristics of type 2 diabetes mellitus in humans.

  2017influential reference
• Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling.

  2017influential reference
• Nitrite increases glucose-stimulated insulin secretion and islet insulin content in obese type 2 diabetic male rats.

  2017influential reference
• Chronic treatment of (R)‐α‐lipoic acid reduces blood glucose and lipid levels in high‐fat diet and low‐dose streptozotocin‐induced metabolic syndrome and type 2 diabetes in Sprague‐Dawley rats

  2017cited by this paper
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  2017cited by this paper
• Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes.

  2017cited by this paper
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  2017cited by this paper
• Cortex Mori Radicis extract attenuates myocardial damages in diabetic rats by regulating ERS.

  2017cited by this paper
• Anti-obesity and anti-diabetic effects of nitrate and nitrite.

  2017cited by this paper
• Synergistic effects of acarbose and an Oroxylum indicum seed extract in streptozotocin and high-fat-diet induced prediabetic mice.

  2017cited by this paper
• Modulatory effect of berberine on adipose tissue PPAR γ , adipocytokines and oxidative stress in high fat diet / streptozotocin-induced diabetic rats

  2017cited by this paper
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  2017cited by this paper
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  2016cited by this paper
• Effect of dietary supplementation of Padauk (Pterocarpus soyauxii) leaf on high fat diet/streptozotocin induced diabetes in rats' brain and platelets.

  2016cited by this paper
• Bauhinia variegata (Caesalpiniaceae) leaf extract: An effective treatment option in type I and type II diabetes.

  2016cited by this paper
• A Review of High Fat Diet-Streptozotocin Model for Induction of Type 2 Diabetes in Rat

  2016influential reference
• Metabolomic Analysis of Biochemical Changes in the Plasma of High-Fat Diet and Streptozotocin-Induced Diabetic Rats after Treatment with Isoflavones Extract of Radix Puerariae

  2016cited by this paper
• Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in Type-2 diabetes.

  2016cited by this paper
• Dietary nitrate improves glucose tolerance and lipid profile in an animal model of hyperglycemia.

  2015cited by this paper
• Cut-off points of homeostasis model assessment of insulin resistance, beta-cell function, and fasting serum insulin to identify future type 2 diabetes: Tehran Lipid and Glucose Study

  2015cited by this paper
• Streptozotocin‐Induced Diabetic Models in Mice and Rats

  2015influential reference
• High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

  2015cited by this paper
• Age- and sex-specific reference values for fasting serum insulin levels and insulin resistance/sensitivity indices in healthy Iranian adults: Tehran Lipid and Glucose Study.

  2014cited by this paper
• Modeling type 2 diabetes in rats using high fat diet and streptozotocin

  2014influential reference
• Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review).

  2014cited by this paper
• Six week follow-up of metabolic effects induced by a high-fat diet and streptozotocin in a rodent model of type 2 diabetes mellitus.

  2014influential reference
• Impact of dietary oils and fats on lipid peroxidation in liver and blood of albino rats.

  2014cited by this paper
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  2013cited by this paper
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• Embelia ribes extract reduces high fat diet and low dose streptozotocin-induced diabetic nephrotoxicity in rats

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin

  2013influential reference
• Positioning of HIV-protease inhibitors in clinical practice.

  2012cited by this paper
• The impact of 1,25-dihydroxy vitamin D3 on the expressions of vascular endothelial growth factor and transforming growth factor-β₁ in the retinas of rats with diabetes.

  2012cited by this paper
• Streptozotocin–nicotinamide-induced diabetes in the rat. Characteristics of the experimental model

  2012cited by this paper
• The use of animal models in diabetes research

  2012cited by this paper
• Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats.

  2012cited by this paper
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  2012cited by this paper
• Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes.

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes

  2012cited by this paper
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  2011cited by this paper
• Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models

  2011influential reference
• Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats.

  2010cited by this paper
• Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats.

  2010cited by this paper
• The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

  2009influential reference
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  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
• High-fat diets promote insulin resistance through cytokine gene expression in growing female rats.

  2008cited by this paper
• Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic.

  2008cited by this paper
• Effects of Dietary Onion (Allium cepa L.) in a High-Fat Diet Streptozotocin-Induced Diabetes Rodent Model

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• Brain-derived neurotrophic factor (BDNF) and type 2 diabetes

  2007cited by this paper
• Diet-induced models for obesity and type 2 diabetes

  2007cited by this paper
• Animal models in type 2 diabetes research: an overview.

  2007cited by this paper
• High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents

  2007influential reference
• Low dose streptozotocin (STZ) combined with high energy intake can effectively induce type 2 diabetes through altering the related gene expression.

  2007cited by this paper
• [Oxidative stress].

  2007cited by this paper
• The potential role of olive oil-derived MUFA in insulin sensitivity.

  2007cited by this paper
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  2005influential reference
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  2005cited by this paper
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  2005cited by this paper
• Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.

  2005cited by this paper
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  2005cited by this paper
• Mouse models of diabetic nephropathy.

  2005cited by this paper
• Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.

  2005cited by this paper
• Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.

  2005cited by this paper
• The pathobiology of diabetic complications: a unifying mechanism.

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Report on carcinogens.

  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• The rat model of type 2 diabetic mellitus and its glycometabolism characters.

  2003cited by this paper
• Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity.

  2003cited by this paper
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  2003cited by this paper
• Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats

  2003cited by this paper
• Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses.

  2003cited by this paper
• Dietary polyunsaturated fatty acids and regulation of gene transcription

  2002cited by this paper
• Fat intake affects adiposity, comorbidity factors, and energy metabolism of sprague-dawley rats.

  2002cited by this paper
• Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats.

  2001cited by this paper
• Insulin signalling.

  2001influential reference
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  2001influential reference
• A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.

  2000cited by this paper
• Lipid oxidation is reduced in obese human skeletal muscle.

  2000cited by this paper
• Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.

  1999cited by this paper

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