Plasma Free Fatty Acids and Risk of Heart Failure: The Cardiovascular Health Study

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Circulation: Heart Failure

• Publication date

  2013-08-07

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/CIRCHEARTFAILURE.113.000521PMID 23926204PMCID PMC3884584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma Fatty Acid–Binding Protein 4, Nonesterified Fatty Acids, and Incident Diabetes in Older Adults

  2012cited by this paper
• High free fatty acids level related with cardiac dysfunction in obese rats.

  2012cited by this paper
• Plasma free fatty acids and risk of atrial fibrillation (from the Cardiovascular Health Study).

  2012cited by this paper
• Lipotoxicity in type 2 diabetic cardiomyopathy.

  2011cited by this paper
• Heart failure

  2011cited by this paper
• Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality

  2011cited by this paper
• Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects

  2010cited by this paper
• Influence of various fatty acids on the activity of protein phosphatase type 2C and apoptosis of endothelial cells and macrophages.

  2008cited by this paper
• Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD.

  2008cited by this paper
• Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance?

  2007cited by this paper
• Free fatty acids and insulin resistance

  2007cited by this paper
• Fatty acid signaling in the beta-cell and insulin secretion.

  2006cited by this paper
• Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction.

  2006cited by this paper
• Thematic review series: Patient-Oriented Research. Free fatty acid metabolism in human obesity Published, JLR Papers in Press, May 10, 2006.

  2006cited by this paper
• The Atherosclerosis Risk in Communities Study

  2006cited by this paper
• Fatty Acid Signaling in the β-Cell and Insulin Secretion

  2006cited by this paper
• Sudden cardiac death: the lost fatty acid hypothesis.

  2006cited by this paper
• Trends in mortality attributed to heart failure in Worcester, Massachusetts, 1992 to 2001.

  2005cited by this paper
• Incidence and hospital death rates associated with heart failure: a community-wide perspective.

  2005cited by this paper
• Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2Cbeta and induce apoptosis in endothelial cells.

  2005cited by this paper
• Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2Cβ and induce apoptosis in endothelial cells

  2005cited by this paper
• The expanding national burden of heart failure in the United States: the influence of heart failure in women.

  2004cited by this paper
• Hospitalized heart failure: rates and long-term mortality.

  2004cited by this paper
• Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy.

  2004cited by this paper
• Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study.

  2004cited by this paper
• Free fatty acid metabolism during myocardial ischemia and reperfusion

  2004cited by this paper
• Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects.

  2003cited by this paper
• Heart failure.

  2003cited by this paper
• A free fatty acid tolerance test identifies patients with coronary artery disease among individuals with a low conventional coronary risk profile

  2002cited by this paper
• Metabolic causes and prevention of ventricular fibrillation during acute coronary syndromes.

  2002cited by this paper
• Lifetime Risk for Developing Congestive Heart Failure: The Framingham Heart Study

  2002cited by this paper
• High plasma nonesterified fatty acids are predictive of cancer mortality but not of coronary heart disease mortality: results from the Paris Prospective Study.

  2001cited by this paper
• Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study.

  2000cited by this paper
• Free fatty acids and pathogenesis of type 2 diabetes mellitus.

  2000cited by this paper
• Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.

  2000cited by this paper
• High levels of nonesterified fatty acids are associated with increased familial risk of cardiovascular disease.

  2000influential reference
• Cross‐sectional but not longitudinal associations between non‐esterified fatty acid levels and glucose intolerance and other features of the metabolic syndrome

  1999cited by this paper
• High free fatty acid concentration: an independent risk factor for hypertension in the Paris Prospective Study.

  1998cited by this paper
• The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study

  1997cited by this paper
• Evolving trends in the epidemiologic factors of heart failure: rationale for preventive strategies and comprehensive disease management.

  1997cited by this paper
• Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation.

  1997cited by this paper
• Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women.

  1996cited by this paper
• Flexible smoothing with B-splines and penalties

  1996cited by this paper
• A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM

  1995cited by this paper
• Applying Cox regression to competing risks.

  1995cited by this paper
• Surveillance and ascertainment of cardiovascular events. The Cardiovascular Health Study.

  1995cited by this paper
• Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin

  1995cited by this paper
• Economic impact of heart failure in the United States: time for a different approach.

  1994cited by this paper
• The Cardiovascular Health Study: design and rationale.

  1991cited by this paper
• The free fatty acid pattern in blood serum in young spontaneously hypertensive rats.

  1979cited by this paper
• The free fatty acid pattern in blood serum in young spontaneously hypertensive rats.

  1979cited by this paper
• A questionnaire for the assessment of leisure time physical activities.

  1978cited by this paper
• Heart Failure

  1937cited by this paper

• Albumin-Bound Fatty Acids Modulate Endogenous Angiotensin-Converting Enzyme (ACE) Inhibition

  2026cites this paper
• Inflammatory cardiomyopathy: a comprehensive review of biomarkers and future therapeutic perspectives

  2025cites this paper
• Association Between Blood Free Fatty Acid Concentrations in Midlife and Cerebral Small Vessel Disease

  2025cites this paper
• Sleep disordered breathing and circulating non-esterified fatty acids: the cardiovascular health study

  2025cites this paper
• The regulatory role of exercise in heart failure and myocardial energy metabolism: A review

  2025cites this paper
• Non-Esterified Fatty Acid Profiles and Cause-Specific Mortality: The Cardiovascular Health Study.

  2025cites this paper
• GLP-1 receptor agonists synergistic effects of metabolic reprogramming and cardioprotection

  2025cites this paper
• PDE5 inhibition mitigates heart failure in hyperlipidemia.

  2024cites this paper
• The potential of circulating nonesterified fatty acids and sphingolipids in the biological understanding of cognitive decline and dementia.

  2024cites this paper
• Plasma metabolome mediates the causal relationship between immune cells and heart failure: a two-step bidirectional Mendelian randomization study

  2024cites this paper
• Metabolic dysfunction and incidence of heart failure subtypes among Black individuals: The Jackson Heart Study

  2024cites this paper
• Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries

  2024cites this paper
• Circulating beta‐hydroxybutyrate levels in advanced heart failure with reduced ejection fraction: Determinants and prognostic impact

  2024influential citation
• Energy metabolism and redox balance: How phytochemicals influence heart failure treatment.

  2024cites this paper
• Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury

  2023cites this paper
• Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients

  2023cites this paper
• Impact of Free Fatty Acids on Vascular Insulin Responses Across the Arterial Tree: a Randomized Crossover Study.

  2023cites this paper
• Relationship of Acylcarnitines to Myocardial Ischemic Remodeling and Clinical Manifestations in Chronic Heart Failure

  2023cites this paper
• Higher circulating levels of non-esterified fatty acids are associated with faster kidney function decline in post-menopausal women with type 2 diabetes: a pilot prospective study

  2023cites this paper
• Energy metabolism: A critical target of cardiovascular injury.

  2023cites this paper
• Association Between Free Fatty Acids and Cardiometabolic Risk in Coronary Artery Disease: Results From the PROMISE Study.

  2023cites this paper
• The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart

  2023cites this paper
• Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges

  2023cites this paper
• Microbial metabolites in chronic heart failure and its common comorbidities

  2023cites this paper
• Circulating metabolic signatures of heart failure in precision cardiology

  2023cites this paper
• Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism

  2023cites this paper
• Non-esterified fatty acids and risk of peripheral artery disease in older adults: The cardiovascular health study.

  2023cites this paper
• Fasting Substrate Concentrations Predict Cardiovascular Outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS).

  2022cites this paper
• Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling

  2022cites this paper
• Fasting and Post-Load Non-Esterified Fatty Acids and Glucose Dysregulation in Older Adults: The Cardiovascular Health Study.

  2022cites this paper
• Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)

  2022cites this paper
• A scoping review of intermittent fasting, chronobiology, and metabolism.

  2022cites this paper
• The Associations of Individual and Subclasses of Non-Esterified Fatty Acids with Disability, and Mobility Limitation in Older Adults: the Cardiovascular Health Study.

  2022cites this paper
• Disturbed Cardiac Metabolism Triggers Atrial Arrhythmogenesis in Diabetes Mellitus: Energy Substrate Alternate as a Potential Therapeutic Intervention

  2022cites this paper
• Fasting and Post-Load Glucose and Non-Esterified Fatty Acids and Risk of Heart Failure and its Subtypes in Older Adults.

  2022cites this paper
• Immunometabolic Reprogramming in Response to HIV Infection Is Not Fully Normalized by Suppressive Antiretroviral Therapy

  2022cites this paper
• Cardiac Energy Metabolism in Heart Failure

  2021cites this paper
• Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort

  2021cites this paper
• Free Fatty Acids Signature in Human Intestinal Disorders: Significant Association between Butyric Acid and Celiac Disease

  2021cites this paper
• Serum Individual Nonesterified Fatty Acids and Risk of Heart Failure in Older Adults

  2021cites this paper
• Nonesterified Fatty Acids and Kidney Function Decline in Older Adults: Findings From the Cardiovascular Health Study.

  2021cites this paper
• Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity.

  2021cites this paper
• Cellular and molecular pathobiology of heart failure with preserved ejection fraction

  2021cites this paper
• Nonesterified Fatty Acids and Hospitalizations Among Older Adults: The Cardiovascular Health Study

  2021cites this paper
• Serum Free Fatty Acids Independently Predict Adverse Outcomes in Acute Heart Failure Patients

  2021cites this paper
• Lauric Acid, a Dietary Saturated Medium-Chain Fatty Acid, Elicits Calcium-Dependent Eryptosis

  2021cites this paper
• Macrophage-Dependent Interleukin-6-Production and Inhibition of IK Contributes to Acquired QT Prolongation in Lipotoxic Guinea Pig Heart

  2021cites this paper
• Serum free fatty acids are associated with severe coronary artery calcification, especially in diabetes: a retrospective study

  2021cites this paper
• Free fatty acids and heart failure in the Multi-Ethnic Study of Atherosclerosis (MESA).

  2021cites this paper
• Long-Chain Acylcarnitines and Monounsaturated Fatty Acids Discriminate Heart Failure Patients According to Pulmonary Hypertension Status

  2021cites this paper
• Mitochondrial function, dynamics and quality control in the pathophysiology of HFpEF.

  2021cites this paper
• Non-Esterified Fatty Acids and Hospitalizations among Older Adults: The Cardiovascular Health Study.

  2020cites this paper
• Cardiorenal protection with SGLT2: Lessons from the cardiovascular outcome trials

  2020cites this paper
• Gas chromatography-mass spectrometry-based analytical strategies for fatty acid analysis in biological samples.

  2020cites this paper
• High-density lipoprotein-mediated cardioprotection in heart failure

  2020cites this paper
• An overview of rosuvastatin/ezetimibe association for the treatment of hypercholesterolemia and mixed dyslipidemia

  2020cites this paper
• Dexamethasone causes defective glucose-6-phosphate dehydrogenase-dependent antioxidant barrier through endoglin in pregnant and non-pregnant rats.

  2020cites this paper
• Metabolic syndrome, nutritional deficits and heart failure

  2020cites this paper
• Caloric restriction in heart failure: A systematic review.

  2020cites this paper
• Reduced nNOS activity is responsible for impaired fatty acid–dependent mitochondrial oxygen consumption in atrial myocardium from hypertensive rat

  2020cites this paper
• Free fatty acids, cardiovascular disease, and mortality in the Multi-Ethnic Study of Atherosclerosis.

  2020cites this paper
• Non‐Esterified Fatty Acids and Risks of Frailty, Disability, and Mobility Limitation in Older Adults: The Cardiovascular Health Study

  2020cites this paper
• Non-esterified fatty acids and telomere length in older adults: The Cardiovascular Health Study

  2020cites this paper
• Myocardial Cell Aging in the Elderly

  2020cites this paper
• Impact of short-acting loop diuretic doses and cardiac sympathetic nerve abnormalities on outcomes of patients with reduced left ventricular function

  2019cites this paper
• PBI-4050 Reduces Pulmonary Hypertension, Lung fibrosis and Right Ventricular Dysfunction in Heart Failure.

  2019cites this paper
• Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus

  2019cites this paper
• Impact of free fatty acids on prognosis in coronary artery disease patients under different glucose metabolism status

  2019cites this paper
• Dietary Patterns Are Associated with Serum Metabolite Patterns and Their Association Is Influenced by Gut Bacteria among Older German Adults

  2019cites this paper
• Intermittent fasting improves metabolic flexibility in short-term high-fat diet-fed mice.

  2019cites this paper
• Differential effects of saturated and unsaturated fatty acids on vascular reactivity in isolated mesenteric and femoral arteries of rats

  2019cites this paper
• Differential Modulation of IK and ICa,L Channels in High-Fat Diet-Induced Obese Guinea Pig Atria

  2019cites this paper
• Comparison of Fatty Acid Profiles in a Group of Female Patients with Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS)–Similar Trends of Changes, Different Pathophysiology

  2019cites this paper
• A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution.

  2019cites this paper
• Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.

  2018cites this paper
• Plasma levels of free fatty acid differ in patients with left ventricular preserved, mid-range, and reduced ejection fraction

  2018cites this paper
• Impact of Nutrition on Cardiovascular Function

  2018influential citation
• Downregulation of growth arrest‑specific transcript 5 alleviates palmitic acid‑induced myocardial inflammatory injury through the miR‑26a/HMGB1/NF‑κB axis.

  2018cites this paper
• Sex-Dimorphic Association of Plasma Fatty Acids with Cardiovascular Fitness in Young and Middle-Aged General Adults: Subsamples from NHANES 2003–2004

  2018cites this paper
• Impact of Nutrition on CardiovascularFunction.

  2018cites this paper
• REGULATION OF FREE FATTY ACID BY SITAGLIPTIN MONOTHERAPY IN DRUG-NAÏVE SUBJECTS WITH TYPE 2 DIABETES.

  2018cites this paper
• Dietary patterns and components to prevent and treat heart failure: a comprehensive review of human studies

  2018cites this paper
• Epicardial Fat Thickness and Free Fatty Acid Level are Predictors of Acute Ischemic Stroke with Atrial Fibrillation

  2018cites this paper
• Adiponectin, Free Fatty Acids, and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Acute Coronary Syndrome

  2018cites this paper
• Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

  2017cites this paper
• Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics.

  2017cites this paper
• Complex Energy Metabolic Changes in Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction.

  2017cites this paper
• Conjugated fatty acid-rich oil from Gynostrmma pentaphyllum seed can ameliorate lipid and glucose metabolism in type 2 diabetes mellitus mice.

  2017cites this paper
• Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

  2017cites this paper
• Review of a causal role of fructose-containing sugars in myocardial susceptibility to ischemia/reperfusion injury.

  2017influential citation
• Fatty Acid Transport Proteins: Targeting FATP2 as a Gatekeeper Involved in the Transport of Exogenous Fatty Acids.

  2016cites this paper
• Effect of intravenous l-carnitine in Chinese patients with chronic heart failure

  2016cites this paper
• Partial Adenosine A1 Agonist in Heart Failure.

  2016cites this paper
• Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart

  2016cites this paper
• Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis

  2016cites this paper
• Free fatty acid availability is closely related to myocardial lipid storage and cardiac function in hypoglycemia counterregulation.

  2015cites this paper
• The role of metabolic syndrome in heart failure.

  2015cites this paper
• Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Stroke Subtypes and Severity in Chinese Patients with Acute Ischemic Stroke.

  2015cites this paper
• Free Fatty Acid Effects on the Atrial Myocardium: Membrane Ionic Currents Are Remodeled by the Disruption of T-Tubular Architecture

  2015cites this paper
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  2015cites this paper