Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Clinical Oncology

• Publication date

  2012-07-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1200/JCO.2011.37.8539PMID 22711850
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Progressive upregulation of PD-1 in primary and metastatic melanomas associated with blunted TCR signaling in infiltrating T lymphocytes.

  2011influential reference
• Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database.

  2011cited by this paper
• Prognostic Significance of Tumor Infiltrating Lymphocytes in Melanoma

  2011cited by this paper
• White Paper on Adoptive Cell Therapy for Cancer with Tumor-Infiltrating Lymphocytes: A Report of the CTEP Subcommittee on Adoptive Cell Therapy

  2011cited by this paper
• Establishment and Large-scale Expansion of Minimally cultured “Young” Tumor Infiltrating Lymphocytes for Adoptive Transfer Therapy

  2011cited by this paper
• Expansion and Characterization of Human Melanoma Tumor-Infiltrating Lymphocytes (TILs)

  2010cited by this paper
• Cancer Statistics, 2009

  2010cited by this paper
• Quality of histopathological reporting on melanoma and influence of use of a synoptic template

  2010cited by this paper
• CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma

  2010cited by this paper
• MART-1–Specific Melanoma Tumor-Infiltrating Lymphocytes Maintaining CD28 Expression Have Improved Survival and Expansion Capability Following Antigenic Restimulation In Vitro

  2009cited by this paper
• Cancer Statistics, 2009

  2009cited by this paper
• Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

  2009cited by this paper
• Clinical and histopathological risk factors to predict sentinel lymph node positivity, disease-free and overall survival in clinical stages I-II AJCC skin melanoma: outcome analysis from a single-institution prospectively collected database.

  2009cited by this paper
• Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma.

  2009influential reference
• Cutaneous melanoma in the era of molecular profiling.

  2009cited by this paper
• Final version of 2009 AJCC melanoma staging and classification.

  2009cited by this paper
• Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T‐lymphocytes and preserved MHC class I antigen expression

  2008cited by this paper
• The advantage of using a synoptic pathology report format for cutaneous melanoma

  2007cited by this paper
• Sentinel node biopsy in cutaneous melanoma: correlations between melanoma prognostic factors and sentinel node status.

  2007cited by this paper
• Leukocyte infiltration and tumor cell plasticity are parameters of aggressiveness in primary cutaneous melanoma

  2007cited by this paper
• Tumor-infiltrating lymphocytes predict sentinel lymph node positivity in patients with cutaneous melanoma.

  2007cited by this paper
• Inflammatory chemokines in cancer growth and progression.

  2006cited by this paper
• Regulation of the T cell response

  2006cited by this paper
• Results of Sentinel Lymph Node Biopsy in Patients With Thin Melanoma

  2006cited by this paper
• Sentinel-node biopsy or nodal observation in melanoma.

  2006cited by this paper
• Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma

  2006cited by this paper
• Human T cell responses against melanoma.

  2006cited by this paper
• The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors1

  2006cited by this paper
• Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma.

  2005cited by this paper
• Fatal attraction: tumors beckon regulatory T cells

  2004cited by this paper
• The Prognostic Importance of Tumor Mitotic Rate Confirmed in 1317 Patients With Primary Cutaneous Melanoma and Long Follow-Up

  2004cited by this paper
• Interobserver Reproducibility of Histopathologic Prognostic Variables in Primary Cutaneous Melanomas

  2003cited by this paper
• Tumor mitotic rate is a more powerful prognostic indicator than ulceration in patients with primary cutaneous melanoma

  2003cited by this paper
• Pathologic Review of Negative Sentinel Lymph Nodes in Melanoma Patients With Regional Recurrence: A Clinicopathologic Study of 1152 Patients Undergoing Sentinel Lymph Node Biopsy

  2003cited by this paper
• Risk assessment in localized primary cutaneous melanoma: a Southwest Oncology Group study evaluating nine factors and a test of the Clark logistic regression prediction model.

  2002cited by this paper
• Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system.

  2001cited by this paper
• Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma.

  2001cited by this paper
• New cancer therapy by immunomanipulation: development of immunotherapy for human melanoma as a model system.

  2000cited by this paper
• Prediction of sentinel lymph node micrometastasis by histological features in primary cutaneous malignant melanoma.

  1998cited by this paper
• Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma

  1996cited by this paper
• Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response.

  1996cited by this paper
• Predicting five‐year outcome for patients with cutaneous melanoma in a population‐based study

  1996cited by this paper
• Model predicting survival in stage I melanoma based on tumor progression.

  1989cited by this paper
• Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report.

  1988cited by this paper
• The immunopathology of sequential tumor biopsies in patients treated with interleukin-2. Correlation of response with T-cell infiltration and HLA-DR expression.

  1987cited by this paper
• The role of lymph node dissection for clinical stage I malignant melanoma of intermediate thickness (1.51—3.99 mm)

  1985cited by this paper
• Prognosis in patients with thin malignant melanoma: influence of regression

  1983cited by this paper
• A prognostic model for clinical stage I melanoma of the trunk. Location near the midline is not an independent risk factor for recurrent disease.

  1981cited by this paper
• A Retrospective Histological Study of 669 Cases of Primary Cutaneous Malignant Melanoma in Clinical Stage I

  1978cited by this paper
• The relatively favorable prognosis of medullary carcinoma of the breast

  1949cited by this paper

• Predicting skin melanoma progression via LAG-3, TIGIT and HAVCR2

  2026cites this paper
• From Immunobiology to Clinical Application: Tumor-Infiltrating Lymphocytes in Melanoma

  2026cites this paper
• Expression of HMMR in Hepatocellular Carcinoma and Its Clinical Significance

  2026cites this paper
• Enrichment of CD103⁺CD4⁺ T Cells in Bone Metastases Compared to Non-Malignant Controls.

  2026cites this paper
• GLUT1 expression, lymphocyte distribution and CD3+ T-cell metabolic subsets as predictive markers of response to immunotherapy in advanced melanoma

  2026cites this paper
• Non-Genetically Modified Adoptive Cell Therapies for Solid Tumors: Current Landscape and Future Challenges

  2026cites this paper
• Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma.

  2025cites this paper
• ADC histogram analysis of tumor-infiltrating CD8+ T cell levels in meningioma

  2025influential citation
• Prognostic Enhancement in Gastric Cancer Through the Integration of Inflammatory Indices into the pTNM-Inflammation Staging System (pTNM-I)

  2025cites this paper
• A new marker for predicting sentinel lymph node metastasis in early (cT1-2N0) breast cancer: Tumor-infiltrating lymphocytes (TILs)

  2025cites this paper
• Tumor infiltrating lymphocytes in primary melanoma are associated with a better prognosis.

  2025cites this paper
• Ferroptosis: A Targetable Vulnerability for Melanoma Treatment.

  2025cites this paper
• Immune checkpoint inhibitor outcomes and prognostic factors in gynecologic tract melanoma: a single-center analysis

  2025cites this paper
• The Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study

  2025cites this paper
• Prognostic value of PD-L1, tumor-infiltrating lymphocytes, and CD117 in vulvovaginal melanoma.

  2025cites this paper
• Opportunities for Discovery Using Neoadjuvant Immune Checkpoint Blockade in Melanoma

  2025cites this paper
• T lymphocyte heterogeneity in NSCLC: implications for biomarker development and therapeutic innovation

  2025cites this paper
• SB 11285, a Novel Canonical Purine-Pyrimidine Cyclic Dinucleotide, is a Systemically Bioavailable STING Agonist for Cancer Immunotherapy

  2025cites this paper
• Antigen-specific profiling identifies T-bet+ melanoma-specific CD8+ T cells associated with response to neoadjuvant PD-1 blockade.

  2025cites this paper
• Cuproptosis-related gene DLD expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma

  2025cites this paper
• Comprehensive analysis of the LINC01122/TPD52 axis as a predictive biomarker in prostate adenocarcinoma

  2025cites this paper
• Longitudinal analysis reveals dynamic changes in histopathologic features in responders to neoadjuvant treatment in a stage III BRAF-mutant melanoma cohort.

  2025cites this paper
• LAG-3 and TIM-3 expression in melanoma and histopathological correlation: a single-center study

  2025cites this paper
• Lymphangiogenesis driven by VEGF-C reshapes tumor immune landscape and enables tumor eradication by viral immunotherapy

  2025cites this paper
• Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization

  2025cites this paper
• MYO1G promoter hypomethylation correlates with its mRNA expression, lymphocyte infiltration, and immunotherapy response in melanoma

  2025cites this paper
• Tumor-infiltrating lymphocytes in melanoma: diagnostic and prognostic implications from biopsy to circulation

  2025cites this paper
• A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features

  2025cites this paper
• Pathomic immune biomarkers define recurrence risk in early-stage melanoma

  2025cites this paper
• Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma

  2025cites this paper
• Tumor-Infiltrating Lymphocyte Therapy for the Treatment of Metastatic Melanoma

  2025cites this paper
• E2F transcription factor 1 as a potential prognostic biomarker and promotes tumor proliferation in skin cutaneous melanoma.

  2025cites this paper
• Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration

  2025cites this paper
• Immune Biomarkers for Checkpoint Blockade in Solid Tumors: Transitioning from Tissue to Peripheral Blood Monitoring and Future Integrated Strategies

  2025influential citation
• [Uveal melanoma and its local inflammation - good or bad for the patient?]

  2025cites this paper
• Prediction and analysis of tumor infiltrating lymphocytes across 28 cancers by TILScout using deep learning

  2025cites this paper
• Prognostic significance and multivariate modeling of COL4A family genes and HMGA2 in glioma

  2025cites this paper
• Aberrant expression of PYGB as a potential therapeutic target and its associations with immune cell infiltration in lung cancer

  2025cites this paper
• Spatial features of tumor-infiltrating lymphocytes in primary lesions of lung adenocarcinoma predict lymph node metastasis

  2025cites this paper
• Treatment of non-small cell lung cancer using chem-bioinformatics-driven engineering of exosomal cargo-vehicle for telmisartan and pioglitazone targeted-delivery

  2025cites this paper
• Prognostic Significance of T Lymphocytes in Immunotherapy for Non-Small Cell Lung Cancer

  2024cites this paper
• MRI features and tumor-infiltrating CD8 + T cells-based nomogram for predicting meningioma recurrence risk

  2024cites this paper
• Lymphocyte T Subsets and Outcome of Immune Checkpoint Inhibitors in Melanoma Patients: An Oncologist’s Perspective on Current Knowledge

  2024cites this paper
• Review of the comparative pathological and immunohistochemical features of human and canine cutaneous melanocytic neoplasms.

  2024cites this paper
• Tissue adaptation of CD4 T lymphocytes in homeostasis and cancer.

  2024cites this paper
• SLAMF8 can predict prognosis of pan-cancer and the immunotherapy response effectivity of gastric cancer

  2024cites this paper
• Pan-cancer analysis and experimental validation of FPR3 as a prognostic and immune infiltration-related biomarker for glioma

  2024cites this paper
• A novel disulfidptosis-related prognostic gene signature and experimental validation identify ACTN4 as a novel therapeutic target in lung adenocarcinoma.

  2024cites this paper
• Comprehensive analysis indicated that NDE1 is a potential biomarker for pan‐cancer and promotes bladder cancer progression

  2024cites this paper
• Sentinel lymph node risk prognostication in primary cutaneous melanoma through tissue-based profiling, potentially redefining the need for sentinel lymph node biopsy.

  2024cites this paper
• Intraepithelial tumor-infiltrating lymphocytes shape loco-regional PET/CT spread of locally advanced cervical cancer

  2024cites this paper
• Characterizing and forecasting neoantigens-resulting from MUC mutations in COAD

  2024cites this paper
• Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial

  2024cites this paper
• Density of high endothelial venules and PDL-1 expression: relationship with tumor-infiltrating lymphocytes in primary cutaneous melanomas.

  2024cites this paper
• miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2

  2024cites this paper
• H-VISTA Immunohistochemistry Score Is Associated with Advanced Stages in Cutaneous and Ocular Melanoma

  2024cites this paper
• Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

  2024cites this paper
• Absence of Tils in Biopsy is Associated with Worse Progression Free Survival in Early Stage Melanoma

  2024cites this paper
• Role of tumor-infiltrating lymphocytes in melanoma prognosis and treatment strategies: A systematic review and meta-analysis

  2024cites this paper
• The Expression of Forkhead Box P3 T Regulatory Lymphocytes as a Prognostic Factor in Malignant Melanomas

  2024cites this paper
• Exploring the potential biological significance of KDELR family genes in lung adenocarcinoma

  2024cites this paper
• Clinical protocol phase II study of tumor infiltrating lymphocytes in advanced tumors with alterations in the SWI/SNF complex: the TILTS study.

  2024cites this paper
• High‐risk histopathologic features in local advanced conjunctival melanoma

  2024cites this paper
• SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression.

  2024cites this paper
• Identification of a CpG-based signature coupled with gene expression as prognostic indicators for melanoma: a preliminary study

  2024cites this paper
• Hypoxic transcriptomes predict survival and tumor-infiltrating immune cell composition in cutaneous melanoma

  2024cites this paper
• Tumor-infiltrating lymphocytes as a prognostic and predictive factor for Melanoma

  2024cites this paper
• Immune checkpoint ligands expressed on mature high endothelial venules predict poor prognosis of NSCLC: have a relationship with CD8+ T lymphocytes infiltration

  2024cites this paper
• Multiomics data identifies RSPO2 as a prognostic biomarker in human tumors associated with pan-cancer.

  2024cites this paper
• Methods behind oncolytic virus-based DC vaccines in cancer: Toward a multiphase combined treatment strategy for Glioblastoma (GBM) patients.

  2024cites this paper
• Tumour-infiltrating lymphocyte therapy for patients with advanced-stage melanoma

  2024cites this paper
• Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity

  2024cites this paper
• Comprehensive analysis of prognostic and immune infiltrates for E2Fs in human head and neck squamous cell carcinoma.

  2024cites this paper
• Macroscopic tumor dimension, sentinel lymph node outcome, and survival analysis among cutaneous melanoma

  2024cites this paper
• The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma

  2024cites this paper
• Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of GNAL in glioma

  2024cites this paper
• Low-dose radiotherapy promotes the formation of tertiary lymphoid structures in lung adenocarcinoma

  2024cites this paper
• Programmed Cell Death Ligand 1 Immunohistochemical Expression and Cutaneous Melanoma: A Controversial Relationship

  2024cites this paper
• Entering a new era of tumor-infiltrating lymphocyte cell therapy innovation.

  2024cites this paper
• The prognostic value of tumor-infiltrating lymphocytes in vulvovaginal melanoma

  2024cites this paper
• Roles of cathepsin S expression levels on the prognosis and tumour microenvironment in clear cell renal cell carcinoma

  2024cites this paper
• Tumor-infiltrating lymphocytes in melanoma: from prognostic assessment to therapeutic applications

  2024cites this paper
• Stromal Expression Profiling Reveals Immune‐Driven Adaption to Malignancy in Canine Melanoma Subtypes

  2024cites this paper
• Unlocking the potential of immunotherapy in platinum-resistant ovarian cancer: rationale, challenges, and novel strategies

  2024cites this paper
• Exploring resistance to immune checkpoint inhibitors and targeted therapies in melanoma

  2024cites this paper
• The relationships between dietary inflammatory and antioxidant index with inflammatory markers in children with acute lymphocytic leukemia

  2024cites this paper
• Mapping the single cell spatial immune landscapes of the melanoma microenvironment

  2024cites this paper
• The Utility of PRAME and Ki-67 as Prognostic Markers for Cutaneous Melanoma

  2024cites this paper
• Genomic landscape of superficial malignant peripheral nerve sheath tumor.

  2024cites this paper
• Depletion of PHLDB2 Suppresses Epithelial–Mesenchymal Transition and Enhances Anti-Tumor Immunity in Head and Neck Squamous Cell Carcinoma

  2024cites this paper
• IL-1 receptor-associated kinase 3 (IRAK3) in lung adenocarcinoma predicts prognosis and immunotherapy resistance: involvement of multiple inflammation-related pathways

  2023cites this paper
• The differential effect of the immune system in breast cancer

  2023cites this paper
• The Role of Inflammatory Biomarkers in Predicting the Prognosis of Gastric Cancer

  2023cites this paper
• Prognostic and predictive biomarkers in melanoma.

  2023cites this paper
• Therapeutic effect and transcriptome-methylome characteristics of METTL3 inhibition in liver hepatocellular carcinoma

  2023cites this paper
• Characteristics of long-survivor metastatic melanoma after polychemotherapy and interferon: a retrospective study.

  2023cites this paper
• Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments

  2023cites this paper
• KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN UNG THƯ HẮC TỐ DA GIAI ĐOẠN CHƯA DI CĂN XA TẠI BỆNH VIỆN K

  2023cites this paper
• FKBP5 associated CD8 T cell infiltration is a novel prognostic biomarker in luminal B breast cancer

  2023cites this paper
• Systematic analysis reveals distinct roles of USF family proteins in various cancer types

  2023cites this paper