Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils

The amyloid-β1–42 (Aβ42) peptide rapidly aggregates to form oligomers, protofibils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. We show that low-temperature and low-salt conditions can stabilize disc-shaped oligomers (pentamers) that are substantially more toxic to mouse cortical neurons than protofibrils and fibrils. We find that these neurotoxic oligomers do not have the β-sheet structure characteristic of fibrils. Rather, the oligomers are composed of loosely aggregated strands whose C termini are protected from solvent exchange and which have a turn conformation, placing Phe19 in contact with Leu34. On the basis of NMR spectroscopy, we show that the structural conversion of Aβ42 oligomers to fibrils involves the association of these loosely aggregated strands into β-sheets whose individual β-strands polymerize in a parallel, in-register orientation and are staggered at an intermonomer contact between Gln15 and Gly37.

• Publication year

  2010

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2010-04-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nsmb.1799PMID 20383142PMCID 2922021
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures.

  2009cited by this paper
• Interprotofilament interactions between Alzheimer's Aβ1–42 peptides in amyloid fibrils revealed by cryoEM

  2009cited by this paper
• Small molecule blockers of the Alzheimer Aβ calcium channel potently protect neurons from Aβ cytotoxicity

  2009cited by this paper
• Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies.

  2009cited by this paper
• Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance.

  2009cited by this paper
• Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.

  2009cited by this paper
• Antiparallel β -sheet: a signature structure of the oligomeric amyloid β -peptide

  2009cited by this paper
• Structural characterization of a soluble amyloid beta-peptide oligomer.

  2009cited by this paper
• Seeded growth of β-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

  2009cited by this paper
• Collagen VI protects neurons against Aβ toxicity

  2009cited by this paper
• Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils.

  2009cited by this paper
• Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals.

  2008cited by this paper
• Role of electrostatic interactions in amyloid β -protein (A β ) oligomer formation: A discrete molecular dynamics study

  2008cited by this paper
• Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's beta-amyloid peptide.

  2008cited by this paper
• Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

  2008cited by this paper
• Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity

  2008cited by this paper
• Amyloid Precursor Protein Trafficking, Processing, and Function*

  2008cited by this paper
• Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils

  2008cited by this paper
• Paired β-sheet structure of an Aβ(1-40) amyloid fibril revealed by electron microscopy

  2008cited by this paper
• Abeta-globulomers are formed independently of the fibril pathway.

  2008cited by this paper
• Calpastatin overexpression attenuates amyloid-beta-peptide toxicity in differentiated PC12 cells.

  2008cited by this paper
• Monomer adds to preformed structured oligomers of Aβ-peptides by a two-stage dock–lock mechanism

  2007cited by this paper
• Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid

  2007cited by this paper
• Cytotoxicity of Aβ 1-42, RAGE23-54, and An Aβ -RAGE Complex in PC-12 Cells

  2007cited by this paper
• Effects of Alzheimer's Disease on Different Cortical Layers: The Role of Intrinsic Differences in Aβ Susceptibility

  2007cited by this paper
• Amide solvent protection analysis demonstrates that amyloid-β(1–40) and amyloid-β(1–42) form different fibrillar structures under identical conditions

  2007cited by this paper
• The Solvent Protection of Alzheimer Amyloid-β-(1–42) Fibrils as Determined by Solution NMR Spectroscopy*

  2006cited by this paper
• Molecular structure of amyloid fibrils: insights from solid-state NMR

  2006cited by this paper
• A specific amyloid-β protein assembly in the brain impairs memory

  2006cited by this paper
• The structural biology of protein aggregation diseases: Fundamental questions and some answers.

  2006cited by this paper
• Dynamics of Asp23-Lys28 salt-bridge formation in Abeta10-35 monomers.

  2006cited by this paper
• A specific amyloid-beta protein assembly in the brain impairs memory.

  2006cited by this paper
• Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

  2006cited by this paper
• DISTINCT EARLY FOLDING AND AGGREGATION PROPERTIES OF ALZHEIMER AMYLOID-ß PEPTIDE Aß40 AND Aß42: STABLE TRIMER OR TETRAMER FORMATION BY Aß42.

  2006cited by this paper
• Common mechanisms of amyloid oligomer pathogenesis in degenerative disease.

  2006cited by this paper
• Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

  2006cited by this paper
• High-resolution Atomic Force Microscopy of Soluble Aβ42 Oligomers

  2006cited by this paper
• The α‐to‐β Conformational Transition of Alzheimer's Aβ‐(1–42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of β Conformation Seeding

  2006cited by this paper
• Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

  2006cited by this paper
• High-resolution atomic force microscopy of soluble Abeta42 oligomers.

  2006cited by this paper
• Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid.

  2005cited by this paper
• Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.

  2005cited by this paper
• Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

  2005cited by this paper
• 3D structure of Alzheimer's amyloid-beta(1-42) fibrils.

  2005cited by this paper
• 3D structure of Alzheimer's amyloid-β(1–42) fibrils

  2005cited by this paper
• Globular amyloid β‐peptide1−42 oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease

  2005cited by this paper
• Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.

  2005cited by this paper
• Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays.

  2005cited by this paper
• Single chain variable fragments against β-amyloid (Aβ) can inhibit Aβ aggregation and prevent Aβ-induced neurotoxicity

  2004cited by this paper
• Direct Observation of Aβ Amyloid Fibril Growth and Inhibition

  2004cited by this paper
• Direct observation of Abeta amyloid fibril growth and inhibition.

  2004cited by this paper
• In silico study of amyloid β-protein folding and oligomerization

  2004cited by this paper
• Analysis of the Secondary Structure of β-Amyloid (Aβ42) Fibrils by Systematic Proline Replacement*

  2004cited by this paper
• Aβ1-28 Fragment of the Amyloid Peptide Predominantly Adopts a Polyproline II Conformation in an Acidic Solution†

  2004cited by this paper
• Dipolar assisted rotational resonance NMR of tryptophan and tyrosine in rhodopsin

  2004cited by this paper
• Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders.

  2003cited by this paper
• Elucidation of Primary Structure Elements Controlling Early Amyloid β-Protein Oligomerization*

  2003cited by this paper
• Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling*

  2002cited by this paper
• Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

  2002cited by this paper
• Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance.

  2002cited by this paper
• Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance.

  2002cited by this paper
• Supramolecular Structure in Full-Length Alzheimer's β-Amyloid Fibrils: Evidence for a Parallel β-Sheet Organization from Solid-State Nuclear Magnetic Resonance

  2002cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• 13C–1H dipolar-assisted rotational resonance in magic-angle spinning NMR

  2001cited by this paper
• Fourier transform infrared spectroscopy in analysis of protein deposits.

  1999cited by this paper
• Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.

  1999cited by this paper
• Quantification of beta-sheet amyloid fibril structures with thioflavin T.

  1999cited by this paper
• Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

  1999cited by this paper
• Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer’s Disease

  1999cited by this paper
• Plasma amyloid β‐peptide 1–42 and incipient Alzheimer's disease

  1999cited by this paper
• Toxicity of protein aggregates in PC12 cells: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

  1999cited by this paper
• Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

  1999cited by this paper
• Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.

  1999cited by this paper
• Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

  1998cited by this paper
• Infrared spectroscopy of proteins and peptides in lipid bilayers

  1997cited by this paper
• Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

  1997cited by this paper
• A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).

  1997cited by this paper
• Nucleation and Growth of Amyloid β-Protein Fibrils: Detection of Nuclei and Quantitation of Rate Constants

  1996cited by this paper
• Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.

  1996cited by this paper
• Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.

  1996cited by this paper
• Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

  1996cited by this paper
• On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.

  1996cited by this paper
• beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

  1993cited by this paper
• The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.

  1993cited by this paper
• Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

  1992cited by this paper
• Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition.

  1991cited by this paper
• The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

  1987cited by this paper
• X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

  1986cited by this paper
• Amyloid plaque core protein in Alzheimer disease and Down syndrome.

  1985cited by this paper

• Amphiphilic Tetraphenylethylene Derivative with Hydrophobic-Hydrophilic Complementarity to Amyloid Oligomers for in Situ Imaging and Modulation of Membrane-Disruptive Neurotoxicity.

  2026cites this paper
• Small molecule ensembles reshape amyloid aggregation landscapes

  2026cites this paper
• Surface-Enhanced Raman Spectroscopy for Alzheimer’s Disease Biomarkers Detection: Advances, Challenges, and Future Perspectives

  2026cites this paper
• Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression

  2026cites this paper
• Triterpenoid saponin-containing Holothuria leucospilota extract mitigates amyloid-β proteotoxicity in transgenic C. elegans through activations of protein clearance and stress resistance pathways

  2026cites this paper
• Label-free plasmonic biosensors for neurodegenerative disease diagnosis: Progress and perspectives

  2026cites this paper
• Protein disulfide isomerase dissolves and detoxifies oligomeric assemblies of amyloid beta peptide.

  2026cites this paper
• A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

  2026cites this paper
• Effects of ultrasound treatment on the formation of food-derived amyloid fibrils: A review.

  2026cites this paper
• Mechanistic insights into amyloid β fibril disruption by ginsenosides through molecular dynamics simulations

  2026cites this paper
• Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles

  2025cites this paper
• Current understanding of the microscopic effects of intrinsically disordered protein aggregates on the interfacial solvent properties

  2025cites this paper
• Nucleation dynamics in amyloid-beta dimerization revealed by single-molecule fingerprinting.

  2025cites this paper
• Herpes Simplex Virus Glycoprotein D Associated with Aβ1-42 Tetramers Mediates Neurotoxicity by Perturbing Neuronal Membrane Integrity: A Molecular Dynamics Simulation.

  2025cites this paper
• Mangiferin and norathyriol acting on Alzheimer's disease biomarkers: acetylcholinesterase, β-secretase (BACE-1), and amyloid β-peptide.

  2025cites this paper
• Biophysical insights into the molecular mechanisms of beta amyloid aggregation and its toxic effects in Alzheimer’s disease

  2025cites this paper
• Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers

  2025cites this paper
• Deciphering the full-length PrPC(23-231) receptor and characterizing the size/subphase-dependent impact of Aβ oligomers on the PrPC(23-231) receptor: insights from molecular dynamics simulations.

  2025cites this paper
• Design Guidelines to Control Rippled β-Sheets versus Pleated β-Sheets in Mixed-Chirality Peptides.

  2025cites this paper
• Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

  2025cites this paper
• In Vivo Seeding of Amyloid-β Protein and Implications in Modeling Alzheimer’s Disease Pathology

  2025cites this paper
• Kaempferia parviflora extract and its methoxyflavones as potential anti-Alzheimer assessing in vitro, integrated computational approach, and in vivo impact on behaviour in scopolamine-induced amnesic mice

  2025cites this paper
• Atractylenolide III alleviates amyloid-β-induced cognitive impairments in mice

  2025cites this paper
• Bay leaves: the neuroprotective dietary spice via inhibition of amyloid-like aggregation

  2025influential citation
• Insights into the coaggregation mechanisms of amyloid-α and amyloid-β.

  2025cites this paper
• Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril.

  2025cites this paper
• Residue-Specific Modulation of Aggregation-Associated Interactions by Spermine in Tau, α-Synuclein, and Aβ40

  2025cites this paper
• Mass-Spectrometry-Based GEE Footprinting Characterizes Kinetic Mechanisms and Sites of Conformational Change in Amyloid β 1-42 Aggregation.

  2025cites this paper
• Sampling Conformational Ensembles of Highly Dynamic Proteins via Generative Deep Learning

  2025cites this paper
• Conformational constraints and ligand interactions are key determinants of the distinct aggregation pathways observed in human serum albumin.

  2025cites this paper
• Assessing amyloid fibrils and amorphous aggregates: A review.

  2025cites this paper
• Kinetics of Amyloid Oligomer Formation.

  2025cites this paper
• Delineating the tryptophan-galactosylamine conjugate mediated structural distortions in Aβ42 protofibrils.

  2025cites this paper
• Oligomerization Propensity Governs Self-Assembly Morphology: Insights from Steady-State Oligomer Analysis.

  2025cites this paper
• Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non‐human primate models

  2025cites this paper
• Small-Molecule Inhibitors of Amyloid Beta: Insights from Molecular Dynamics—Part A: Endogenous Compounds and Repurposed Drugs

  2025cites this paper
• Preparation and NMR Characterization of Aβ Peptides at Pathological pH.

  2025cites this paper
• Novel Hyperbranched Rolling Circle Amplification-Driven Aptasensor for Ultrasensitive and Multiplex Biomarkers Detection of Alzheimer's Disease

  2025cites this paper
• An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates

  2025cites this paper
• Targeting amyloid β42 aggregation using a structurally defined graphene quantum dot model: A combined molecular and biological investigation.

  2025cites this paper
• A Solvatochromic Near Infrared Fluorophore Sensitive to the Full Amyloid Beta Aggregation Pathway.

  2025cites this paper
• Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion

  2025cites this paper
• Targeting multiple pathways with virtual screening to identify the multi-target agent for Alzheimer’s disease treatment

  2025cites this paper
• Sizes of amyloid-β oligomers predicted using atomic force microscopy and two-point crosslinked dimers as standards.

  2025cites this paper
• Residue-level structural information from isotope-edited FTIR spectroscopy reveals distinct molecular structures of different amyloid-β42 oligomers

  2025influential citation
• Impacts of D-aspartate on the aggregation kinetics and structural polymorphism of amyloid β peptide 1-42.

  2025cites this paper
• Mechanism of interaction between TTR tetramer and Aβ42 oligomers: Dependence on the Aβ42 oligomeric size and morphology

  2025cites this paper
• Is The Renin-Angiotensin System A Friend or Foe in Neurological Diseases? Unveiling Its Role and Therapeutic Potential.

  2025cites this paper
• Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM

  2025cites this paper
• Targeting phagocytosis for amyloid-β clearance: implications of morphology remodeling and microglia activation probed by bifunctional chimaeras

  2025influential citation
• Small-Molecule Inhibitors of Amyloid Beta: Insights from Molecular Dynamics—Part B: Natural Compounds

  2025cites this paper
• Rosavin and salidroside attenuate microglia injury via nuclear factor κ-B signaling pathway.

  2025cites this paper
• Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function

  2025cites this paper
• Neuroprotective functions of the APPI domain of amyloid precursor protein (APP): Reducing KLK6-mediated APP cleavage and Aβ42 formation and aggregation.

  2025cites this paper
• Protein aggregation in health and disease: A looking glass of two faces.

  2025cites this paper
• Decoding the Relationship between Alzheimer's Disease and Type-2 Diabetes via the Protein Aggregation Prism.

  2025cites this paper
• Surface-enhanced Raman scattering for the detection of biomarkers of neurodegenerative diseases: A review

  2025cites this paper
• How Salt and Temperature Drive Reentrant Condensation of Aβ40.

  2024cites this paper
• Discovering Effective Chiral Dipeptides against Aβ(1-42) Aggregation by the Computational Screening Strategy.

  2024cites this paper
• A Spectroscopic Study on the Amyloid‐β Interaction with Clicked Peptide‐Porphyrin Conjugates: a Vision Toward the Detection of Aβ Peptides in Aqueous Solution

  2024cites this paper
• Protective effect of water-soluble nervonic acid micro-powder coated with chitosan oligosaccharide and silk fibroin on hippocampal neuronal HT22 cells.

  2024cites this paper
• Novel Prospects in Targeting Neurodegenerative Disorders via Autophagy.

  2024cites this paper
• Islet amyloid polypeptide fibril catalyzes amyloid-β aggregation by promoting fibril nucleation rather than direct axial growth.

  2024cites this paper
• Anti-aggregation potential of polyphenols from Ajwa date palm (Phoenix dactylifera): An in-silico analysis

  2024cites this paper
• Fluorescence Detection and Inhibition Mechanisms of DNTPH on Aβ42 Oligomers Characterized as Products in the Four Stages of Aggregation.

  2024cites this paper
• Neuroprotective effects and possible mechanisms of berberine in animal models of Alzheimer’s disease: a systematic review and meta-analysis

  2024cites this paper
• Magnetic stirring with iron oxide nanospinners accretes neurotoxic Aβ42 oligomers into phagocytic clearable plaques for Alzheimer's disease treatment

  2024cites this paper
• Alzheimer's Disease and Effects of ABCA7 Polymorphisms: A Review.

  2024cites this paper
• Structural Reorganization Mechanism of the Aβ42 Fibril Mediated by N-Substituted Oligopyrrolamide ADH-353.

  2024cites this paper
• Amyloid-α Peptide Formed through Alternative Processing of the Amyloid Precursor Protein Attenuates Alzheimer's Amyloid-β Toxicity via Cross-Chaperoning.

  2024cites this paper
• Adverse Effects of Aβ1-42 Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons

  2024cites this paper
• Exploring the Impact of C‐Terminal Based Pentapeptides on the Disassembly of Aβ42 Fibrils

  2024cites this paper
• DNA Nanocage-Assisted Size-Selective Recognition and Quantification toward Low-Mass Soluble β-Amyloid Oligomers.

  2024cites this paper
• Exploring pathological link between antimicrobial and amyloid peptides.

  2024cites this paper
• Aggregation mechanisms and molecular structures of amyloid-β in Alzheimer's disease.

  2024cites this paper
• Computational modelling of supramolecular metallopeptide assemblies.

  2024cites this paper
• Synthesis and bio-activities of bifunctional tetrahydrosalen Cu (II) chelators with potential efficacy in Alzheimer's disease therapy.

  2024cites this paper
• Aggregation Dynamics of a 150 kDa Aβ42 Oligomer: Insights from Cryo Electron Microscopy and Multimodal Analysis

  2024cites this paper
• Probing the anti-Aβ42 aggregation and protective effects of prenylated xanthone against Aβ42-induced toxicity in transgenic Caenorhabditis elegans model.

  2024cites this paper
• Aβ-binding with alcohol dehydrogenase drives Alzheimer's disease pathogenesis: A review.

  2024cites this paper
• Heterotypic Seeding Generates Mixed Amyloid Polymorphs

  2024cites this paper
• A turn for the worse: Aβ β-hairpins in Alzheimer's disease.

  2024cites this paper
• Beta-Amyloid and Its Asp7 Isoform: Morphological and Aggregation Properties and Effects of Intracerebroventricular Administration

  2024cites this paper
• Incubation of Amyloidogenic Peptides in Reverse Micelles Allow Active Control of Oligomer Size and Study of Protein–Protein Interactions

  2024cites this paper
• Rationally Designed Peptoid Inhibitors of Amyloid‐β Oligomerization

  2024cites this paper
• Lipid metabolism in Alzheimer’s disease

  2024cites this paper
• Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases

  2024cites this paper
• Structural characterization of amyloid aggregates with spatially resolved infrared spectroscopy.

  2024cites this paper
• Recent Advancements in Biosensors for the Detection and Characterization of Amyloids: A Review

  2024cites this paper
• APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

  2024cites this paper
• Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives targeting amyloid beta aggregation-mediated oxidative stress and neuroinflammation for enhanced neuroprotection.

  2024cites this paper
• Bifunctional halloysite nanotube-based Ripk1 siRNA delivery system rescues cognitive impairment by targeting amyloid β plaques for clearance and reducing necrotic neurons in Alzheimer’s disease mice

  2024cites this paper
• Sampling Conformational Ensembles of Highly Dynamic Proteins via Generative Deep Learning

  2024cites this paper
• Molecular docking and proteomics approaches for the identification of neuroprotective effects of IL15.5 peptide against oxidative stress-induced apoptosis in SH-SY5Y neurons

  2024cites this paper
• De novo design of a mechano-pharmaceutical screening platform against formation of individual beta-amyloid oligomers

  2024cites this paper
• Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis

  2024cites this paper
• Polyphenols and Their Biogenic Nano-Formulations Targeting BACE1 as Anti-Amyloid Therapies; Meeting the Challenges of Bioavailability, Safety, and Specificity for the Treatment of Alzheimer's Disease.

  2024cites this paper
• Early events during the aggregation of Aβ16-22-derived switch-peptides tracked using Protein Charge Transfer Spectra.

  2024cites this paper
• Multiscale modeling of protofilament structures: A case study on insulin amyloid aggregates.

  2024cites this paper
• Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer’s Disease

  2024cites this paper