Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecules and Cells

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S1097-2765(00)80363-9PMID 10488331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Backbone side chain interactions in peptides. II. Solution study of serine-containing model dipeptides.

  2009cited by this paper
• Maintenance of G2 arrest in the Xenopus oocyte: a role for 14‐3‐3‐mediated inhibition of Cdc25 nuclear import

  1999cited by this paper
• Cytoplasmic Localization of Human cdc25C during Interphase Requires an Intact 14-3-3 Binding Site

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

  1999cited by this paper
• Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

  1999cited by this paper
• Mutations in the Hydrophobic Surface of an Amphipathic Groove of 14-3-3ζ Disrupt Its Interaction with Raf-1 Kinase*

  1998cited by this paper
• Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

  1998cited by this paper
• Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

  1998cited by this paper
• Developmental regulation of 14‐3‐3 ϵ isoform in rat heart

  1998cited by this paper
• The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

  1998cited by this paper
• Structure of an IkappaBalpha/NF-kappaB complex.

  1998cited by this paper
• Structure of an IκBα/NF-κB Complex

  1998cited by this paper
• The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.

  1998cited by this paper
• 14-3-3ζ Binds a Phosphorylated Raf Peptide and an Unphosphorylated Peptide via Its Conserved Amphipathic Groove*

  1998cited by this paper
• 14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity

  1998cited by this paper
• Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template.

  1998cited by this paper
• A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

  1998cited by this paper
• Candida pathogenesis: unravelling the threads of infection.

  1997cited by this paper
• Beta-hairpins in proteins revisited: lessons for de novo design.

  1997cited by this paper
• The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase--structural consequences and functional implications.

  1997cited by this paper
• Nucleocytoplasmic transport: signals, mechanisms and regulation

  1997cited by this paper
• CRM1 is responsible for intracellular transport mediated by the nuclear export signal

  1997cited by this paper
• Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.

  1997cited by this paper
• The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export.

  1997cited by this paper
• Interaction of the Ligand-activated Glucocorticoid Receptor with the 14-3-3η Protein*

  1997cited by this paper
• 14-3-3 (ε) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner*

  1997cited by this paper
• Exportin 1 (Crm1p) is an essential nuclear export factor.

  1997cited by this paper
• The structural basis for 14-3-3:phosphopeptide binding specificity.

  1997cited by this paper
• CRM1 is an export receptor for leucine-rich nuclear export signals.

  1997cited by this paper
• 14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain*

  1997cited by this paper
• 14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase.

  1997cited by this paper
• Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.

  1997cited by this paper
• Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3 Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif*

  1997cited by this paper
• Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.

  1997cited by this paper
• 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila.

  1997cited by this paper
• Evidence for a role of CRM1 in signal-mediated nuclear protein export.

  1997cited by this paper
• An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

  1997cited by this paper
• Dissection of protein kinase and phosphatase targeting interactions.

  1997cited by this paper
• Using CLUSTAL for multiple sequence alignments.

  1996cited by this paper
• GOR method for predicting protein secondary structure from amino acid sequence.

  1996cited by this paper
• Conformational analysis and clustering of short and medium size loops connecting regular secondary structures: A database for modeling and prediction

  1996cited by this paper
• Molecular evolution of the 14-3-3 protein family

  1996cited by this paper
• Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.

  1996cited by this paper
• Activation-modulated Association of 14–3–3 Proteins with Cbl in T Cells*

  1996cited by this paper
• 14-3-3 and its possible role in co-ordinating multiple signalling pathways.

  1996cited by this paper
• Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal*

  1996cited by this paper
• Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

  1996cited by this paper
• 14-3-3 Proteins Associate with A20 in an Isoform-specific Manner and Function Both as Chaperone and Adapter Molecules*

  1996cited by this paper
• Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

  1996cited by this paper
• Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function

  1996cited by this paper
• Conformational effects of serine phosphorylation in phospholamban peptides.

  1996cited by this paper
• The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation.

  1995cited by this paper
• Sequential phosphorylation of adjacent serine residues on the N‐terminal region of cardiac troponin‐I: structure‐activity implications of ordered phosphorylation

  1995cited by this paper
• Expression and structural analysis of 14-3-3 proteins.

  1995cited by this paper
• Crystal structure of the zeta isoform of the 14-3-3 protein

  1995cited by this paper
• Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

  1995cited by this paper
• Regulation of Raf‐1 kinase activity by the 14‐3‐3 family of proteins.

  1995cited by this paper
• The Mouse 14-3-3 ϵ Isoform, a Kinase Regulator Whose Expression Pattern Is Modulated in Mesenchyme and Neuronal Differentiation

  1995cited by this paper
• Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

  1995cited by this paper
• 14-3-3 proteins: biological function and domain structure.

  1995cited by this paper
• Identification of a signal for rapid export of proteins from the nucleus.

  1995cited by this paper
• The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.

  1995cited by this paper
• Nuclear export signals and the fast track to the cytoplasm.

  1995cited by this paper
• 14-3-3 proteins associate with cdc25 phosphatases.

  1995cited by this paper
• 14-3-3 Proteins: Hot numbers in signal transduction

  1995cited by this paper
• Cloning and Characterization of the ∈ and ζ Isoforms of the 14-3-3 Proteins

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins.

  1994cited by this paper
• Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation.

  1994cited by this paper
• Phosphorylation effects on flanking charged residues. Structural implications for signal transduction in protein kinases.

  1994cited by this paper
• Characterization of 14-3-3 proteins in adrenal chromaffin cells and demonstration of isoform-specific phospholipid binding.

  1994cited by this paper
• ALSCRIPT: a tool to format multiple sequence alignments.

  1993cited by this paper
• Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system.

  1993cited by this paper
• Developmental regulation of neuronal expression for the eta subtype of the 14-3-3 protein, a putative regulatory protein for protein kinase C.

  1993cited by this paper
• Molecular cloning of rat cDNAs for β and γ subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system

  1993cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif

  1991cited by this paper
• The regulation by insulin of glucose transporter gene expression in 3T3 adipocytes.

  1989cited by this paper
• Analysis and prediction of the different types of beta-turn in proteins.

  1988cited by this paper
• Analysis and prediction of the different types of β-turn in proteins

  1988cited by this paper
• Turn prediction in proteins using a pattern-matching approach.

  1986cited by this paper
• Secondary structure assignment for alpha/beta proteins by a combinatorial approach.

  1983cited by this paper
• Prediction of chain turns in globular proteins on a hydrophobic basis

  1978cited by this paper
• Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.

  1978cited by this paper

• Analytical applications of gas-phase ion chemistry enabled by mass spectrometry

  2026cites this paper
• Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

  2025cites this paper
• Discovery of an allosteric 14-3-3 inhibitor for suppressing NRF2-driven cancer via phenotypic screening and chemoproteomic-based target deconvolution

  2025cites this paper
• 14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

  2025cites this paper
• ATP‐Driven Allosteric Regulation of 14‐3‐3: Positive Modulation of ATP Hydrolysis and Negative Regulation of Peptide Binding

  2025cites this paper
• Analysis of the 14-3-3/GRF gene family reveals the role of PagGRF12a in leaf development in poplar.

  2025cites this paper
• Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif

  2025cites this paper
• Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins.

  2025cites this paper
• The Big, Mysterious World of Plant 14-3-3 Proteins

  2025cites this paper
• Recent Developments in 14-3-3 Stabilizers for Regulating Protein-Protein Interactions: An Update.

  2025cites this paper
• 14-3-3ε inhibits premature centriole disengagement by inhibiting the activity of Plk1 and separase

  2024cites this paper
• 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

  2024cites this paper
• The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways

  2024cites this paper
• Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins.

  2024cites this paper
• Development of a novel representation of drug 3D structures and enhancement of the TSR-based method for probing drug and target interactions

  2024cites this paper
• 14-3-3 protein and its isoforms: A common diagnostic marker for Alzheimer's disease, Parkinson's disease and glaucomatous neurodegeneration.

  2024cites this paper
• Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice.

  2024cites this paper
• YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway

  2024cites this paper
• On the use of dioxane as reference for determination of the hydrodynamic radius by NMR spectroscopy.

  2024cites this paper
• The Development of CDC25A-Derived Phosphoseryl Peptides That Bind 14-3-3ε with High Affinities

  2024cites this paper
• Exploring the Oligomerization of Nav1.5 and Its Implication for the Dominant-Negative Effect

  2023cites this paper
• Mechanistic Insights into the Function of 14-3-3 Proteins as Negative Regulators of Brassinosteroid Signaling in Arabidopsis

  2023cites this paper
• MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach

  2023influential citation
• Characterization of 14-3-3 gene family and their expression patterns under abiotic and biotic stresses in melon (Cucumis melo L.)

  2023cites this paper
• Revisiting the use of dioxane as a reference compound for determination of the hydrodynamic radius of proteins by pulsed field gradient NMR spectroscopy

  2023cites this paper
• Ser149 is another potential 14-3-3 ε binding site of Cdc25B in the G2/M transition of mouse fertilized eggs

  2023cites this paper
• Small-molecule inhibitors targeting apoptosis signal-regulated kinase 1.

  2023cites this paper
• Enhancement of Drought Tolerance in Transgenic Arabidopsis thaliana Plants Overexpressing Chickpea Ca14-3-3 Gene

  2022cites this paper
• Clearance of an amyloid-like translational repressor is governed by 14–3–3 proteins

  2022cites this paper
• HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

  2022cites this paper
• The 14-3-3γ isoform binds to and regulates the localization of endoplasmic reticulum (ER) membrane protein TMCC3 for the reticular network of the ER

  2022cites this paper
• Molecular Evolution of Plant 14-3-3 Proteins and Function of Hv14-3-3A in Stomatal Regulation and Drought Tolerance.

  2022cites this paper
• Structural insights into the functional roles of 14-3-3 proteins

  2022influential citation
• Structure of a 14-3-3ε:FOXO3apS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins

  2022cites this paper
• 14-3-3 Proteins are Potential Regulators of Liquid–Liquid Phase Separation

  2022cites this paper
• Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome

  2022cites this paper
• The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3

  2021cites this paper
• Structural insights into the interaction between CRTCs and 14-3-3.

  2021cites this paper
• Evaluation of the relationship between the 14-3-3ε protein and LvRab11 in the shrimp Litopenaeus vannamei during WSSV infection

  2021cites this paper
• Chemical Approach Toward Controlling of Transient Protein Interactions

  2021cites this paper
• 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

  2021cites this paper
• How phosphorylation of peptides affects their interaction with 14‐3‐3η domains

  2021cites this paper
• Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3 ζ Protein

  2021cites this paper
• Pathways to Parkinson’s disease: a spotlight on 14-3-3 proteins

  2021cites this paper
• Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling

  2021cites this paper
• Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

  2021cites this paper
• 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

  2021cites this paper
• Validamycin A enhances the interaction between neutral trehalase and 14‑3‑3 protein Bmh1 in Fusarium graminearum.

  2021cites this paper
• Unified synthesis and assessment of tumor cell migration inhibitory activity of optically active UTKO1, originally designed moverastin analog.

  2021cites this paper
• 14-3-3σ and Its Modulators in Cancer

  2020cites this paper
• Splicing factors: Insights into their regulatory network in alternative splicing in cancer.

  2020cites this paper
• Missense substitutions at a conserved 14-3-3 binding site in HDAC4 cause a novel intellectual disability syndrome

  2020cites this paper
• Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.

  2020cites this paper
• The Multifarious Role of 14-3-3 Family of Proteins in Viral Replication

  2020cites this paper
• The 14-3-3 (YWHA) Proteins in Mammalian Reproduction

  2020cites this paper
• Emerging roles of 14-3-3γ in the brain disorder

  2020cites this paper
• CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

  2020cites this paper
• Molecular dynamics simulations and biochemical characterization of Pf14-3-3 and PfCDPK1 interaction towards its role in growth of human malaria parasite.

  2020cites this paper
• Identification of a HSP14‐3‐3 in Setaria cervi and its cross‐reactivity with W bancrofti‐infected human sera

  2020cites this paper
• Development of predictive QSAR models on the phosphopeptide binding affinity against 14-3-3 isoforms

  2020cites this paper
• Identification of phosphate-containing compounds as new inhibitors of 14-3-3/c-Abl protein-protein interaction.

  2020cites this paper
• Interaction of 14-3-3I and CDPK1 mediates the growth of human malaria parasite

  2020cites this paper
• Reading the phosphorylation code: binding of the 14-3-3 protein to multivalent client phosphoproteins.

  2020cites this paper
• Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle

  2020cites this paper
• 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban

  2020cites this paper
• 14‐3‐3 protein binding blocks the dimerization interface of caspase‐2

  2020cites this paper
• Molecular characterization and in vitro interaction analysis of Op14-3-3 μ protein from Opuntia ficus-indica: identification of a new client protein from shikimate pathway.

  2019cites this paper
• Protein-Peptide Interactions in Regulatory Events

  2019cites this paper
• The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution

  2019cites this paper
• 14-3-3 gene family in spotted sea bass (Lateolabrax maculatus): Genome-wide identification, phylogenetic analysis and expression profiles after salinity stress.

  2019cites this paper
• Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein.

  2019cites this paper
• YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization

  2019cites this paper
• The 14-3-3 (YWHA) Proteins in Signalling and Development of the Fruit Fly, Drosophila melanogaster

  2019cites this paper
• Two negatively charged invariant residues influence ligand binding and conformational dynamics of 14‐3‐3ζ

  2019cites this paper
• The protein 14-3-3: A functionally versatile molecule in Giardia duodenalis.

  2019cites this paper
• Allosteric Modulation of Intrinsically Disordered Proteins.

  2019cites this paper
• The activity of Saccharomyces cerevisiae Na+, K+/H+ antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481.

  2019cites this paper
• Activation of the Ca2+ sensing receptor and the PKC/WNK4 downstream signaling cascade induces incorporation of ZO-2 to tight junctions and its separation from 14-3-3

  2019cites this paper
• Rac1 S71 Mediates the Interaction between Rac1 and 14-3-3 Proteins

  2019cites this paper
• Association of Multiple Phosphorylated Proteins with the 14-3-3 Regulatory Hubs: Problems and Perspectives.

  2018cites this paper
• 14‐3‐3 protein masks the nuclear localization sequence of caspase‐2

  2018cites this paper
• 14‐3‐3 Protein: Effectors of Enzyme Function

  2018cites this paper
• 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).

  2018cites this paper
• Cotylenin A and tyrosine kinase inhibitors synergistically inhibit the growth of chronic myeloid leukemia cells.

  2018cites this paper
• GR-regulating Serine/Threonine Kinases: New Physiologic and Pathologic Implications.

  2018cites this paper
• CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein

  2018cites this paper
• Synthesis of α,α-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation of β-Difluorophosphonomethyl α-(Acylamino)acrylates.

  2018cites this paper
• Nuclear Export of the Thyroid Hormone Receptor [Alpha]

  2018cites this paper
• 14-3-3 Proteins in Glutamatergic Synapses

  2018cites this paper
• Facile synthesis of Fmoc-protected phosphonate pSer mimetic and its application in assembling a substrate peptide of 14-3-3 ζ

  2017cites this paper
• Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease

  2017cites this paper
• Structural aspects of protein kinase ASK1 regulation.

  2017cites this paper
• Interaction between Rho GTPases and 14-3-3 Proteins

  2017cites this paper
• Modulators of 14-3-3 Protein–Protein Interactions

  2017cites this paper
• Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

  2017cites this paper
• Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function.

  2017influential citation
• Structural changes of homodimers in the PDB.

  2017cites this paper
• Extracellular functions of 14-3-3 adaptor proteins.

  2017cites this paper
• Structure of the complex of phosphorylated liver kinase B1 and 14-3-3ζ.

  2017cites this paper
• Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1

  2017influential citation