Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  The Lancet

• Publication date

  2010-02-06

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0140-6736(09)61879-1PMID 20097417
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial

  2009cited by this paper
• Procalcitonin for Reduced Antibiotic Exposure in Ventilator Associated Pneumonia-A Randomized Study

  2009cited by this paper
• Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study

  2009cited by this paper
• Antibiotic resistance in the intensive care unit

  2009cited by this paper
• Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial.

  2009cited by this paper
• Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial.

  2008cited by this paper
• Procalcitonin assay in systemic inflammation, infection, and sepsis: Clinical utility and limitations

  2008cited by this paper
• Issues in noninferiority trials: the evidence in community-acquired pneumonia.

  2008cited by this paper
• Daily cost of antimicrobial therapy in patients with Intensive Care Unit-acquired, laboratory-confirmed bloodstream infection.

  2008cited by this paper
• Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia.

  2008cited by this paper
• Guidelines for the management of hospital-acquired pneumonia in the UK: Report of the Working Party on Hospital-Acquired Pneumonia of the British Society for Antimicrobial Chemotherapy

  2008cited by this paper
• Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care.

  2008cited by this paper
• Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia

  2008cited by this paper
• Position paper: recommended design features of future clinical trials of antibacterial agents for community-acquired pneumonia.

  2008cited by this paper
• Acinetobacter infection.

  2008cited by this paper
• Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: diagnosis and treatment.

  2008cited by this paper
• Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis.

  2007cited by this paper
• Inadequate treatment of ventilator-associated pneumonia: risk factors and impact on outcomes.

  2007cited by this paper
• Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy.

  2007cited by this paper
• Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults

  2007cited by this paper
• Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship.

  2007cited by this paper
• Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement.

  2006cited by this paper
• Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial.

  2006cited by this paper
• Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

  2006cited by this paper
• Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement.

  2006cited by this paper
• Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study

  2006cited by this paper
• Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis

  2006cited by this paper
• Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia.

  2005cited by this paper
• Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial.

  2004cited by this paper
• A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia.

  2004cited by this paper
• Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults. A randomized trial. Chastre J, Wolff M, Fagon JY, Chevret S et al. JAMA 2003; 290: 2588-98

  2004cited by this paper
• Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.

  2003cited by this paper
• Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use.

  2003cited by this paper
• Emergence of Resistance in Normal Human Aerobic Commensal Flora during Telithromycin and Amoxicillin-Clavulanic Acid Treatments

  2003cited by this paper
• Current epidemiology of septic shock: the CUB-Réa Network.

  2003cited by this paper
• Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia.

  2002cited by this paper
• Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis.

  2001cited by this paper
• Guidance for Industry E 10 Choice of Control Group and Related Issues in Clinical Trials

  2001cited by this paper
• Antibiotic Resistance in the Intensive Care Unit

  2001cited by this paper
• Invasive and Noninvasive Strategies for Management of Suspected Ventilator-Associated Pneumonia

  2000cited by this paper
• Antibiotic susceptibility among aerobic gram-negative bacilli in intensive care units in 5 European countries. French and Portuguese ICU Study Groups.

  1999cited by this paper
• Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients.

  1999cited by this paper
• Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine.

  1998cited by this paper
• Strategies to Prevent and Control the Emergence and Spread of Antimicrobial-Resistant Microorganisms in Hospitals. A challenge to hospital leadership.

  1996cited by this paper
• The ACCP-SCCM consensus conference on sepsis and organ failure.

  1992cited by this paper
• Longitudinal data analysis for discrete and continuous outcomes.

  1986cited by this paper
• PNEUMOCOCCAL BACTEREMIA WITH ESPECIAL REFERENCE TO BACTEREMIC PNEUMOCOCCAL PNEUMONIA.

  1964cited by this paper

• Duration Matters: Tailoring Antibiotic Therapy for Ventilator-Associated Pneumonia

  2026influential citation
• Postoperative Antibiotic Escalation After Major Free-Flap Reconstruction Requiring ICU Admission: Associations with Day-1 Procalcitonin, Shock, and Microbiological Positivity.

  2026cites this paper
• Guidelines for the Initial Assessment of Respiratory Distress in the Emergency Department.

  2026cites this paper
• A case of necrotizing pneumonia leading to respiratory failure and tracheostomy

  2026cites this paper
• Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis

  2025cites this paper
• Severe Pneumonia.

  2025cites this paper
• Ventilator-Associated Pneumonia (VAP) in Neurocritical Patients: The Hidden Dialog of Brain and Infection

  2025cites this paper
• Reassessing Procalcitonin-Guided Antibiotic Therapy in Critically Ill Patients with Sepsis: Lessons from the ADAPT-Sepsis Trial.

  2025cites this paper
• A short-term cross-sectional retrospective study on procalcitonin as a diagnostic aid for various infectious diseases

  2025cites this paper
• Mid‐regional pro‐adrenomedullin: A rapid sepsis biomarker for diagnosing spontaneous bacterial peritonitis in cirrhosis

  2025cites this paper
• An update on antimicrobial selection and duration for intra-abdominal infections

  2025cites this paper
• Real-word utility of procalcitonin in patients hospitalized with community-acquired pneumonia: A matched cohort study

  2025influential citation
• Clinical features, procalcitonin concentration, and bacterial infection in febrile hospitalized cancer patients: a descriptive study and association analysis

  2025cites this paper
• Transforming Microbiological Diagnostics in Nosocomial Lower Respiratory Tract Infections: Innovations Shaping the Future

  2025cites this paper
• ICU ‘Magic Numbers’: The Role of Biomarkers in Supporting Clinical Decision-Making

  2025cites this paper
• S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge – Update 2025

  2025cites this paper
• Short-course antibiotic strategies for ventilator-associated pneumonia

  2025cites this paper
• Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial

  2025cites this paper
• Role of Procalcitonin as a Prognostic Biomarker in Hospitalized COVID-19 Patients: A Comparative Analysis

  2025cites this paper
• The Use of Biomarkers to Track and Treat Critical Illness.

  2025cites this paper
• Procalcitonin-Guided Early Stop of Antibiotics Prevents Gut Inflammation and Preserves Gut Microbiome: Data from the PROGRESS Controlled Trial.

  2025cites this paper
• Towards a holistic approach to pulmonary infections. Insights from the Sixth Annual Meeting of Spanish Experts 2024

  2025cites this paper
• Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial.

  2025cites this paper
• Comparison of Procalcitonin, C-reactive Protein, and Interleukin-6 in the Postoperative Course After Lung Decortication Surgery: A Prospective Observational Study

  2025cites this paper
• Diagnostic Accuracy of Procalcitonin in the Diagnosis of Sepsis in Cancer Patients Hospitalized for Infection

  2025influential citation
• Synergistic dual-strategy immunoassays using carbon dots@MOF enable ultrasensitive procalcitonin stratification.

  2025cites this paper
• Procalcitonin in the management of lower respiratory tract infection and sepsis.

  2025cites this paper
• Ultrasensitive detection of six sepsis-associated proteins in neonatal saliva

  2025cites this paper
• Dauer der Antibiotikatherapie – wie kurz ist kurz genug?

  2025cites this paper
• Efficacy and safety of an algorithm using C-reactive protein to guide antibiotic therapy applied through a digital clinical decision support system: a study protocol for a randomised controlled clinical trial

  2025cites this paper
• Determining the optimal antibiotic duration for skin and soft tissue infections

  2025cites this paper
• Procalcitonin levels in septic and nonseptic subjects with AKI and ESKD prior to and during continuous kidney replacement therapy (CKRT)

  2025cites this paper
• Combined use of respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in sickle-cell adult patients with acute chest syndrome (The ANTIBIO-STA study): a randomised, controlled, open-label trial

  2025influential citation
• Quantifying the Relationship Between Renal Function and Procalcitonin: A Study of 14 431 Blood Cultures

  2025cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

  2025cites this paper
• Procalcitonin: Infection or Maybe Something More? Noninfectious Causes of Increased Serum Procalcitonin Concentration: Updated Knowledge

  2025cites this paper
• Are Procalcitonin Measures a Reliable Predictor of Stopping Antibiotics Among Patients With Sepsis?

  2025cites this paper
• Beyond Lactate: The Evolving Landscape of Biomarkers for Sepsis in Critical Care – A Systematic Review and Critical Analysis

  2025cites this paper
• Reduced antimicrobial consumption through enhanced pneumonia management in critically ill patients: outcomes of an antibiotic stewardship program in the intensive care unit

  2025cites this paper
• Real-world interpretation of procalcitonin to guide antibiotic prescribing: a retrospective cohort study with regression discontinuity analysis

  2025cites this paper
• Plasma procalcitonin and C-reactive protein concentrations in dogs with bacterial sepsis and non-infectious systemic inflammatory response syndrome

  2025cites this paper
• Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT.

  2025cites this paper
• Antibiotic De-Escalation in the Intensive Care Unit: Rationale and Potential Strategies

  2025influential citation
• Update der S3-Leitlinie: Epidemiologie, Diagnostik und Therapie erwachsener Patienten mit nosokomialer Pneumonie

  2025cites this paper
• Mortality time frame variability in septic shock clinical trials: A systematic review.

  2025cites this paper
• Serum Procalcitonin as a Diagnostic and Prognostic Marker in Children With Severe Bacterial Infection: A Prospective Observational Study

  2025cites this paper
• Ventilator-associated pneumonia: how long is long enough?

  2025cites this paper
• Emerging Paradigms in Sepsis Management: Critical Insights from Contemporary Clinical Trials

  2025cites this paper
• Impact of Complying with a Procalcitonin-Guided Stopping Rule on the Duration of Antibiotic Therapy in Critically Ill Patients: A Real-Life Study

  2025influential citation
• Optimal antibiotic use in the intensive care unit

  2025cites this paper
• Glucocorticoid Treatment for Hospital-Acquired and Ventilator-Associated Pneumonia

  2025cites this paper
• Predictive enrichment using biomarkers in studies of critically-ill patients with sepsis: a systematic review

  2025cites this paper
• Recent advances in biomarkers for detection and diagnosis of sepsis and organ dysfunction: a comprehensive review

  2025cites this paper
• Role of procalcitonin in identifying systemic inflammatory response syndrome and sepsis in acute-on-chronic liver failure and its impact on survival

  2025cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

  2025cites this paper
• Procalcitonin-guided antibiotic treatment in patients with cancer: a patient-level meta-analysis from randomized controlled trials

  2024cites this paper
• Therapy of Aspiration: Out-of-Hospital and In-Hospital-Acquired

  2024cites this paper
• Biomarkers in sepsis.

  2024cites this paper
• Duration of Antimicrobial Treatment in Adult Patients with Pneumonia: A Narrative Review

  2024cites this paper
• Procalcitonin Level Monitoring in Antibiotic De-Escalation and Stewardship Program for Patients with Cancer and Febrile Neutropenia

  2024influential citation
• Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.

  2024cites this paper
• Procalcitonin Guided Antibiotic Stewardship

  2024cites this paper
• The utility of an algorithm based on procalcitonin monitoring in patients with sepsis.

  2024cites this paper
• The Role of Procalcitonin to Determine Infection in Diabetic Foot Ulcer

  2024influential citation
• Point-of-care procalcitonin trends in suspected neonatal late-onset infection: a prospective observational study

  2024cites this paper
• Korean Guidelines for the Management and Antibiotic Therapy in Adult Patients with Hospital-Acquired Pneumonia

  2024cites this paper
• Point-of-care tests, diagnostic uncertainty and antimicrobial stewardship in the ICU: procalcitonin or PCR to aid antibiotic-stop decisions – an observational cohort study

  2024cites this paper
• Nosokomiale Pneumonie

  2024cites this paper
• Das aktute Abdomen auf der Intensivstation

  2024cites this paper
• Re: 'ESR and CRP: It's Time to Stop the Zombie Tests' by Spellberg et al.

  2024cites this paper
• Physiologic changes of pregnancy and considerations for screening and diagnosis of sepsis.

  2024cites this paper
• Guidelines for Antibiotics Prescription in Critically Ill Patients

  2024cites this paper
• Key summary of German national guideline for adult patients with nosocomial pneumonia- Update 2024 Funding number at the Federal Joint Committee (G-BA): 01VSF22007

  2024cites this paper
• Comparative Analysis of C-reactive Protein and Procalcitonin as Biomarkers for Prognostic Assessment in Pediatric Sepsis

  2024cites this paper
• Serum C-reactive protein and haptoglobin decrease in the first three months of treatment and relative change in haptoglobin predict remission in dogs with pulmonary coccidioidomycosis.

  2024cites this paper
• Interpretation of results of PCR and B-D-glucan for the diagnosis of Pneumocystis Jirovecii Pneumonia in immunocompromised adults with acute respiratory failure

  2024cites this paper
• Sepsis in 2024: A Review

  2024cites this paper
• Analytical Evaluation of Point-of-Care Finecare™ Procalcitonin Rapid Quantitative Test in Sepsis Population as Compared with Elecsys® BRAHMS Procalcitonin Immunoassay

  2024cites this paper
• Validation of a Machine Learning Diagnostic Tool for the Prediction of Sepsis and Critical Illness

  2024cites this paper
• Can Procalcitonin and Other Biomarkers Help Rapidly Identify Sepsis Among Undifferentiated High-Risk Patients in the Emergency Department?

  2024cites this paper
• Association of antibiotics with the outcomes in COVID-19 pneumonia patients with elevated PCT levels.

  2024cites this paper
• Serum procalcitonin and C-reactive protein as indices of early sepsis and mortality in North Indian pediatric burn injuries: a prospective evaluation and literature review

  2024cites this paper
• Procalcitonin and qSOFA as a Marker of Mortality in Sepsis.

  2024cites this paper
• The Clinical Pulmonary Infection Score Combined with Procalcitonin and Lung Ultrasound (CPIS-PLUS), a Good Tool for Ventilator Associated Pneumonia Early Diagnosis in Pediatrics

  2024cites this paper
• Evaluation of Serial Procalcitonin Levels for the Optimization of Antibiotic Use in Non-Critically Ill COVID-19 Patients

  2024influential citation
• Therapeutic Drug Monitoring and Biomarkers; towards Better Dosing of Antimicrobial Therapy

  2024influential citation
• Role of biomarkers in antimicrobial stewardship: physicians’ perspectives

  2024influential citation
• Aspiration Pneumonia

  2024cites this paper
• Utilidad de la procalcitonina como biomarcador en cirugía cardiaca

  2024cites this paper
• Benefits and Harms of Procalcitonin- or C-Reactive Protein-Guided Antimicrobial Discontinuation in Critically Ill Adults With Sepsis: A Systematic Review and Network Meta-Analysis*

  2024cites this paper
• Antibiotic Stewardship in Surgical Departments

  2024cites this paper
• Compliance with antibiotic therapy guidelines in french paediatric intensive care units: a multicentre observational study

  2024cites this paper
• Das aktute Abdomen auf der Intensivstation

  2024cites this paper
• Procalcitonin-guided antimicrobial stewardship in critically ill patients with sepsis: A pre– post interventional study

  2024cites this paper
• The Diagnostic and Therapeutic Challenges of Culture Negative Sepsis

  2024cites this paper
• Comparative Impact of an Optimized PK/PD Target Attainment of Piperacillin-Tazobactam vs. Meropenem on the Trend over Time of SOFA Score and Inflammatory Biomarkers in Critically Ill Patients Receiving Continuous Infusion Monotherapy for Treating Documented Gram-Negative BSIs and/or VAP

  2024cites this paper
• Management of Ventilator-Associated Pneumonia: Guidelines.

  2024cites this paper
• Sepsis Stewardship: The Puzzle of Antibiotic Therapy in the Context of Individualization of Decision Making

  2024influential citation
• Antibiotic Strategies for Severe Community-Acquired Pneumonia

  2024cites this paper
• Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients

  2024cites this paper