Human prolidase and prolidase deficiency: an overview on the characterization of the enzyme involved in proline recycling and on the effects of its mutations

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Amino Acids

• Publication date

  2008-03-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00726-008-0055-4PMID 18340504
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Molecular characterisation of six patients with prolidase deficiency: identification of the first small duplication in the prolidase gene and of a mutation generating symptomatic and asymptomatic outcomes within the same family

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• The role of emerging techniques in the investigation of prolidase deficiency: from diagnosis to the development of a possible therapeutical approach.

  2006cited by this paper
• A homozygous missense mutation in PEPD encoding peptidase D causes prolidase deficiency associated with hyper‐IgE syndrome

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• Intracellular delivery of liposome-encapsulated prolidase in cultured fibroblasts from prolidase-deficient patients.

  2005cited by this paper
• Characterization of the dinuclear metal center of Pyrococcus furiosus prolidase by analysis of targeted mutants

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• Characterization of prolidase activity in erythrocytes from a patient with prolidase deficiency: comparison with prolidase I and II purified from normal human erythrocytes.

  2005cited by this paper
• Purification and characterization of recombinant human liver prolidase expressed in Saccharomyces cerevisiae

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
• Structure of the prolidase from Pyrococcus furiosus.

  2004cited by this paper
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  2001cited by this paper
• Crystallization and characterization of the prolidase from Pyrococcus furiosus.

  2001cited by this paper
• Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8.

  2000cited by this paper
• A novel nonsense mutation of the PEPD gene in a Japanese patient with prolidase deficiency

  2000cited by this paper
• Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme.

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  2000cited by this paper
• Transient Beneficial Effect of GH Replacement Therapy and Topical GH Application on Skin Ulcers in a Boy with Prolidase Deficiency

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• Orlistat

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  1999cited by this paper
• Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.

  1998cited by this paper
• Characterization of Native and Recombinant Forms of an Unusual Cobalt-Dependent Proline Dipeptidase (Prolidase) from the Hyperthermophilic Archaeon Pyrococcus furiosus

  1998cited by this paper
• Handbook of proteolytic enzymes

  1998cited by this paper
• Prolyl Oligopeptidase: An Unusual β-Propeller Domain Regulates Proteolysis

  1998cited by this paper
• Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli.

  1998influential reference
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  1998cited by this paper
• Regulation of cytokine production by eicosanoids and nitric oxide.

  1997cited by this paper
• Prolidase deficiency and systemic lupus erythematosus

  1997cited by this paper
• Nitric oxide, an autocrine regulator of wound fibroblast synthetic function.

  1997cited by this paper
• Cloning and expression of a gene encoding a bacterial enzyme for decontamination of organophosphorus nerve agents and nucleotide sequence of the enzyme

  1996cited by this paper
• Is there a role for nitric oxide in regulation of T cell secretion of IL-2?

  1996cited by this paper
• Topical Treatment of Skin Ulcers in Prolidase Deficiency

  1996cited by this paper
• A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1

  1996influential reference
• Recombinant proteins for therapy.

  1996cited by this paper
• Expression and molecular analysis of mutations in prolidase deficiency.

  1996cited by this paper
• The proteolytic system of starter and non-starter bacteria: Components and their importance for cheese ripening

  1995cited by this paper
• Proline motifs in peptides and their biological processing

  1995cited by this paper
• Four novel PEPD alleles causing prolidase deficiency.

  1994cited by this paper
• Human kidney prolidase--purification, preincubation properties and immunological reactivity.

  1994cited by this paper
• Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families.

  1993cited by this paper
• Prolidase deficiency: a multisystemic hereditary disorder.

  1993cited by this paper
• Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme.

  1993cited by this paper
• Hydrolysis of proline dipeptides completely fulfills the proline requirement in a proline-auxotrophic Chinese hamster ovary cell line.

  1993cited by this paper
• Differential regulation of cytokine production by nitric oxide.

  1993cited by this paper
• Proline-dependent structural and biological properties of peptides and proteins.

  1993influential reference
• Molecule of the year.

  1993cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Primary structure and gene localization of human prolidase.

  1989cited by this paper
• Prolidase deficiency: biochemical classification of alleles.

  1989cited by this paper
• Characterization of fibroblast-derived prolidase. The presence of two forms of prolidase.

  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
• In Situ Activation of Human Erythrocyte Prolidase: Potential for Enzyme Replacement Therapy in Prolidase Deficiency

  1988cited by this paper
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  1988cited by this paper
• Immunochemical Studies of Human Prolidase with Monoclonal and Polyclonal Antibodies:Absence of the Subunit of Prolidase in Erythrocytes from a Patient with Prolidase Deficiency

  1987cited by this paper
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  1986cited by this paper
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  1985influential reference
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  1985cited by this paper
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  1984influential reference
• Prolidase deficiency: characteristics of human skin fibroblast prolidase using colorimetric and fluorimetric assays.

  1984cited by this paper
• Human Erythrocyte Prolidase and Prolidase Deficiency

  1982cited by this paper
• Autosomal recessive prolidase deficiency. Three patients with recalcitrant ulcers.

  1981cited by this paper
• Activation and Inhibition of Cerebral Prolidase

  1980cited by this paper
• Proteins of the kidney microvillar membrane. The amphipathic form of dipeptidyl peptidase IV.

  1979cited by this paper
• Iminopeptiduria, skin ulcerations, and edema in a boy with prolidase deficiency.

  1977cited by this paper
• Clinical applications of urinary hydroxyproline determination.

  1975cited by this paper

• Isolating the prolidase enzyme and studying some pharmaceutical compounds for people with thyroid

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• Targeting pivotal amino acids metabolism for treatment of leukemia

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• Further Clinical Delineation of Prolidase Deficiency Associated with c.1103T>G Variant

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• A Facile Method to Determine Prolidase Activity Using a Peptide-Specific Fluorometric Reaction.

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• Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD

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• Recombinant Prolidase Activates EGFR-Dependent Cell Growth in an Experimental Model of Inflammation in HaCaT Keratinocytes. Implication for Wound Healing

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• M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome

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• Proline Metabolism in Malignant Gliomas: A Systematic Literature Review

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• Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase

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• Structural analysis of new compound heterozygous variants in PEPD gene identified in a patient with Prolidase Deficiency diagnosed by exome sequencing

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• The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps

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• Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants

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• PROLIDASE: A Review from Discovery to its Role in Health and Disease

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• Differential protein abundance associated with delayed regeneration of the scleractinian coral Montastraea cavernosa

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