Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Genes & Development

• Publication date

  2008-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.1643908PMID 18347089PMCID PMC2394721
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.

  2008cited by this paper
• Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

  2007cited by this paper
• Aberrant cytokine signaling in leukemia.

  2007cited by this paper
• STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.

  2007cited by this paper
• The JAK-STAT Signaling Pathway: Input and Output Integration1

  2007cited by this paper
• Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration

  2007influential reference
• Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey.

  2007cited by this paper
• Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

  2007cited by this paper
• Defects in growth hormone receptor signaling.

  2007cited by this paper
• STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression

  2007cited by this paper
• Aberrant cytokine signaling in leukemia

  2007cited by this paper
• Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression.

  2007cited by this paper
• Postnatal body growth is dependent on the transcription factors signal transducers and activators of transcription 5a/b in muscle: a role for autocrine/paracrine insulin-like growth factor I.

  2007influential reference
• STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells.

  2007cited by this paper
• Nonredundant roles for Stat5a/b in directly regulating Foxp3.

  2007cited by this paper
• IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1

  2007cited by this paper
• The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.

  2007cited by this paper
• Cutting Edge: Decreased Accumulation and Regulatory Function of CD4+CD25high T Cells in Human STAT5b Deficiency1

  2006cited by this paper
• Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model.

  2006cited by this paper
• Socs2 and elf5 mediate prolactin-induced mammary gland development.

  2006influential reference
• Caveolin-1-Deficient Mice Show Defects in Innate Immunity and Inflammatory Immune Response during Salmonella enterica Serovar Typhimurium Infection

  2006cited by this paper
• Conditional Deletion of Shp2 in the Mammary Gland Leads to Impaired Lobulo-alveolar Outgrowth and Attenuated Stat5 Activation*

  2006cited by this paper
• Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

  2006cited by this paper
• STAT5 signaling is required for the efficient induction and maintenance of CML in mice.

  2006cited by this paper
• Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.

  2006cited by this paper
• IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.

  2006cited by this paper
• Stat5a/b are essential for normal lymphoid development and differentiation.

  2006cited by this paper
• Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation

  2006cited by this paper
• Clinical and biochemical characteristics of a male patient with a novel homozygous STAT5b mutation.

  2006cited by this paper
• The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production.

  2005cited by this paper
• SOCS2 negatively regulates growth hormone action in vitro and in vivo.

  2005cited by this paper
• ERBB4/HER4 Potentiates STAT5A Transcriptional Activity by Regulating Novel STAT5A Serine Phosphorylation Events*[boxs]

  2005cited by this paper
• In Vivo Analysis of Growth Hormone Receptor Signaling Domains and Their Associated Transcripts

  2005cited by this paper
• Structure of the Unphosphorylated STAT5a Dimer*

  2005cited by this paper
• Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

  2005cited by this paper
• Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b.

  2005cited by this paper
• Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

  2005cited by this paper
• A function for interleukin 2 in Foxp3-expressing regulatory T cells

  2005cited by this paper
• Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth.

  2004cited by this paper
• Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation

  2004influential reference
• Impaired Alveologenesis and Maintenance of Secretory Mammary Epithelial Cells in Jak2 Conditional Knockout Mice

  2004cited by this paper
• Identification of Shp-2 as a Stat5A Phosphatase*

  2003cited by this paper
• Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

  2003cited by this paper
• Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5

  2003cited by this paper
• Acute Control of Insulin-like Growth Factor-I Gene Transcription by Growth Hormone through Stat5b*

  2003cited by this paper
• SOCS3 regulates the plasticity of gp130 signaling

  2003cited by this paper
• SOCS3 negatively regulates IL-6 signaling in vivo

  2003cited by this paper
• Growth hormone insensitivity associated with a STAT5b mutation.

  2003influential reference
• Loss of Stat5a delays mammary cancer progression in a mouse model

  2002cited by this paper
• Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium.

  2002cited by this paper
• Supporting Online Material

  2002cited by this paper
• Mutational switch of an IL-6 response to an interferon-gamma-like response.

  2002cited by this paper
• Mutational switch of an IL-6 response to an interferon-γ-like response

  2002cited by this paper
• Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

  2002cited by this paper
• Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

  2001cited by this paper
• Stat1-independent regulation of gene expression in response to IFN-γ

  2001cited by this paper
• Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

  2001cited by this paper
• Biologic consequences of Stat1-independent IFN signaling

  2001cited by this paper
• SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.

  2001cited by this paper
• The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation.

  2001cited by this paper
• Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

  2000cited by this paper
• Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors1

  2000cited by this paper
• Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5.

  2000cited by this paper
• Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.

  1999cited by this paper
• Normal growth and development in the absence of hepatic insulin-like growth factor I.

  1999cited by this paper
• Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.

  1999cited by this paper
• Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.

  1998cited by this paper
• Jak2 is essential for signaling through a variety of cytokine receptors.

  1998cited by this paper
• Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

  1998cited by this paper
• DNA binding of the glucocorticoid receptor is not essential for survival.

  1998cited by this paper
• Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

  1998influential reference
• Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

  1997cited by this paper
• A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).

  1997cited by this paper
• Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression.

  1997influential reference
• Stat5a is mandatory for adult mammary gland development and lactogenesis.

  1997influential reference
• P210 and P190BCR/ABL Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members*

  1996cited by this paper
• Functional interactions between Stat5 and the glucocorticoid receptor

  1996cited by this paper
• Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.

  1995cited by this paper
• Interleukin‐3, granulocyte‐macrophage colony stimulating factor and interleukin‐5 transduce signals through two STAT5 homologs.

  1995cited by this paper
• Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

  1995cited by this paper
• Interleukin‐3 signals through multiple isoforms of Stat5.

  1995cited by this paper
• Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

  1994cited by this paper
• Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism?

  1966cited by this paper

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  2026cites this paper
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• Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development

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• Prolactin Mediates Distinct Time Course Regulation of Tyrosine Hydroxylase Phosphorylation and Gene Expression in Tuberoinfundibular Dopaminergic Neurons of Female Rats

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• Effects of STAT5B and BMPR-1B genes on growth and production traits in Red Jungle Fowl, Fayoumi, Hilly chickens, and their crossbreeds

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• EM Dipeptide Enhances Milk Protein Secretion: Evidence from Integrated Metabolomic and Transcriptomic Analysis

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• Stafib-2-CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib-2.

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• Roles of dendritic epidermal T cells in steady and different pathological states

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• Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism

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• Broflanilide impairs cell viability and milk protein secretion in mammary epithelial cells by regulating Akt/mTOR and STAT5 signaling.

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• The Role of the JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia

  2024cites this paper
• A genome-wide association study to identify the genes associated with growth-related traits in Tegillarca granosa

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• JAK-STAT signaling maintains homeostasis in T cells and macrophages

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• Interaction of the intestinal cytokines-JAKs-STAT3 and 5 axes with RNA N6-methyladenosine to promote chronic inflammation-induced colorectal cancer

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• Prolactin Modulates the Proliferation and Secretion of Goat Mammary Epithelial Cells via Regulating Sodium-Coupled Neutral Amino Acid Transporter 1 and 2

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• STAT5 is essential for inducing the suppressive subset and attenuate cytotoxicity of Vδ2+ T cells in acute myeloid leukemia.

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• Strand-Specific RNA Sequencing Reveals Gene Expression Patterns in F1 Chick Breast Muscle and Liver after Hatching

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• The Association between the JAK-STAT Pathway and Hypertension among Kenyan Women Diagnosed with Breast Cancer

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• Syncytia: Origin, Structure, and Functions

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• PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling

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• STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia

  2023cites this paper
• Stat5a promotes Col10a1 gene expression during chondrocyte hypertrophic differentiation.

  2023cites this paper
• Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways

  2023cites this paper
• Synthesis of 1,2,4‐triazole and 1,3,4‐oxadiazole derivatives as inhibitors for STAT3 enzymes of breast cancer

  2023cites this paper
• STAT5b is a key effector of NRG‐1/ERBB4‐mediated myocardial growth

  2023cites this paper
• Dissecting Selectivity Determinants of Small-Molecule Inhibitors of SH2 Domains Via Fluorescence Polarization Assays.

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• Engineering T Cell Development for the Next Generation of Stem Cell-Derived Immunotherapies

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• The Regulation of Insulin-like Growth Factor 1 by The Regulation of Insulin-like Growth Factor 1 by Growth Hormone via Stat5b Growth Hormone via Stat5b

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• Genetic variants affecting chemical mediated skin immunotoxicity

  2022cites this paper
• STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential

  2022cites this paper
• Growth hormone and insulin-like growth factor I regulation of nonalcoholic fatty liver disease.

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• Genomic Mutations of the STAT5 Transcription Factor Are Associated with Human Cancer and Immune Diseases

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• Long Non-Coding RNA LINC01410 Promoted Tumor Progression via the ErbB Signaling Pathway by Targeting STAT5 in Gallbladder Cancer

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• STAT5a Confers Doxorubicin Resistance to Breast Cancer by Regulating ABCB1

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• STAT3 but Not STAT5 Contributes to the Protective Effect of Electroacupuncture Against Myocardial Ischemia/Reperfusion Injury in Mice

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• The Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia

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• Serum Cytokine Analysis in Patients with Hepatocellular Carcinoma

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• Phosphatases are predicted to govern prolactin-mediated JAK-STAT signaling in pancreatic beta cells

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• Asymmetrically Substituted m‐Terphenyl Phosphates Inhibit the Transcription Factor STAT5a

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• A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation

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• Structural and mutational analysis of member-specific STAT functions.

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• Molecular Signaling and Transcriptional Regulation of Histamine H1 Receptor Gene.

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• The Prolactin Family of Hormones as Regulators of Maternal Mood and Behavior

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• The potential and controversy of targeting STAT family members in cancer.

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• The role of cyadox and recombinant growth hormone (rGH) on the promotion of growth through epigenetics

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• Anti-hyperglycemic effect of Aloe vera peel extract on blood sugar level of alloxan-induced Wistar rats

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