Abstract Interest about interactions between microplastics and organisms is on the rise. Accessing organisms' responses to these chemically “inert” compounds plays an important role in determining their potential toxicity. Microplastics from the environment tend to accumulate and move through living organisms, inducing a variety of biological effects, such as disturbances in energy metabolism, oxidative balance, antioxidative capacity, DNA, immunological, neurological and histological damage. In the present review, we summarized the adverse effects of different size, concentrations and types of microplastics on animals' antioxidative system, energy metabolism and nervous system. Results showed that microplastics can: induce oxidative damage (increased lipid peroxidation and DNA strand breaks); alter antioxidative system (superoxide dismutase, catalase and glutathione peroxidase were parameters with the highest and significant changes in activities) and metabolism (isocitrate dehydrogenase and lactate dehydrogenase activity); and have neurotoxic effects (inhibition of acetylcholinesterase activity). The effects were depending on size and dose of used microplastics, and/or their interaction with other xenobiotics. We examined also potential strategies and offer research priorities for current and future studies.
Ecotoxicological effects of microplastics: Examination of biomarkers, current state and future perspectives
Marko D. Prokić,Tijana B. Radovanović,Jelena Gavric,C. Faggio
Published 2019 in Trends in Analytical Chemistry (TrAC)
ABSTRACT
PUBLICATION RECORD
- Publication year
2019
- Venue
Trends in Analytical Chemistry (TrAC)
- Publication date
2019-02-01
- Fields of study
Chemistry, Environmental Science
- Identifiers
- External record
- Source metadata
Semantic Scholar
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- acetylcholinesterase activity
The enzymatic activity of acetylcholinesterase used here as a neurotoxicity marker.
Aliases: AChE activity
- antioxidative system
The collection of antioxidant defenses that protect organisms from oxidative stress.
Aliases: antioxidant system
- dna strand breaks
Breaks in DNA strands used as a marker of genotoxic damage in the reviewed studies.
Aliases: DNA breaks
- energy metabolism
The cellular processes that produce and use energy, summarized in the review through metabolic enzyme markers.
- lipid peroxidation
Oxidative degradation of lipids used as a marker of cellular damage in exposed animals.
- microplastics
Small plastic particles from the environment that are the exposure material discussed in the review.
Aliases: MPs
- size and dose dependence
The relationship between microplastic particle size, exposure concentration, and effect magnitude.
Aliases: size dependence, dose dependence
- xenobiotics
Foreign chemical substances that can interact with microplastics in exposed organisms.
Aliases: other xenobiotics
REFERENCES
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