Structure and Function of the mTOR Activator Rheb

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-3-7091-1806-1_13
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Discovery and saturation analysis of cancer genes across 21 tumor types

  2014cited by this paper
• Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.

  2014cited by this paper
• Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)*

  2014cited by this paper
• Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

  2014cited by this paper
• Rheb (Ras Homologue Enriched in Brain)-dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period*

  2013cited by this paper
• Ras and Rheb Signaling in Survival and Cell Death

  2013cited by this paper
• A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues.

  2013cited by this paper
• Deacetylated αβ-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading.

  2013cited by this paper
• In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

  2013cited by this paper
• mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

  2013cited by this paper
• Rheb regulates mitophagy induced by mitochondrial energetic status.

  2013cited by this paper
• NMR-based functional profiling of RASopathies and oncogenic RAS mutations

  2013cited by this paper
• Genetic and pharmacological inhibition of Rheb1-mTORC1 signaling exerts cardioprotection against adverse cardiac remodeling in mice.

  2013cited by this paper
• MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

  2013cited by this paper
• Functional Assessment of TSC2 Variants Identified in Individuals with Tuberous Sclerosis Complex

  2013cited by this paper
• Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

  2013cited by this paper
• Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc.

  2013influential reference
• Upregulation of Ras homolog enriched in the brain (Rheb) in lipopolysaccharide-induced neuroinflammation.

  2013cited by this paper
• Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.

  2012cited by this paper
• AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth.

  2012cited by this paper
• Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.

  2012cited by this paper
• mTOR inhibitors in cancer therapy.

  2012cited by this paper
• An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis.

  2012cited by this paper
• Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

  2012cited by this paper
• mTOR signaling in growth control and disease.

  2012cited by this paper
• TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

  2012cited by this paper
• A comprehensive survey of Ras mutations in cancer.

  2012cited by this paper
• The Small GTPase Rheb Affects Central Brain Neuronal Morphology and Memory Formation in Drosophila

  2012cited by this paper
• Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia: Pathophysiological Implications in Obesity and Metabolic Syndrome

  2012cited by this paper
• Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

  2012cited by this paper
• Raptor and Rheb Negatively Regulate Skeletal Myogenesis through Suppression of Insulin Receptor Substrate 1 (IRS1)*

  2011cited by this paper
• Dopaminergic pathway reconstruction by Akt/Rheb‐induced axon regeneration

  2011cited by this paper
• Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

  2011cited by this paper
• Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

  2011cited by this paper
• The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

  2011cited by this paper
• Rheb Is Essential for Murine Development

  2011cited by this paper
• cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

  2011cited by this paper
• Structure-function relationships of the G domain, a canonical switch motif.

  2011cited by this paper
• mTOR signaling in disease.

  2011cited by this paper
• GLUT1 enhances mTOR activity independently of TSC2 and AMPK.

  2011cited by this paper
• Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6

  2011cited by this paper
• Rheb1 is required for mTORC1 and myelination in postnatal brain development.

  2011cited by this paper
• Functional assessment of variants in the TSC1 and TSC2 genes identified in individuals with Tuberous Sclerosis Complex

  2011cited by this paper
• Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy.

  2011cited by this paper
• Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer

  2011cited by this paper
• Nanoscale mapping and affinity constant measurement of signal-transducing proteins by atomic force microscopy.

  2011cited by this paper
• Targeting protein prenylation for cancer therapy

  2011cited by this paper
• Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells

  2011cited by this paper
• The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling

  2011cited by this paper
• Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

  2010cited by this paper
• Association of the Small GTPase Rheb with the NMDA Receptor Subunit NR3A

  2010cited by this paper
• Rheb GTPase Controls Apoptosis by Regulating Interaction of FKBP38 with Bcl-2 and Bcl-XL*

  2010cited by this paper
• Conformational States of Human Rat Sarcoma (Ras) Protein Complexed with Its Natural Ligand GTP and Their Role for Effector Interaction and GTP Hydrolysis*

  2010cited by this paper
• Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

  2010cited by this paper
• Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling

  2010cited by this paper
• Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy depletion-induced suppression of mTORC1

  2010cited by this paper
• Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis

  2010cited by this paper
• cAMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D

  2010cited by this paper
• Regulation of androgen receptor transactivity and mTOR–S6 kinase pathway by Rheb in prostate cancer cell proliferation

  2010cited by this paper
• Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.

  2010cited by this paper
• Synthesis of the Rheb and K-Ras4B GTPases.

  2010cited by this paper
• Fundamental link between folding states and functional states of proteins.

  2009cited by this paper
• An emerging role of mTOR in lipid biosynthesis.

  2009cited by this paper
• Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

  2009cited by this paper
• Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

  2009cited by this paper
• Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

  2009cited by this paper
• Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

  2009cited by this paper
• Characterization of the Intrinsic and TSC2-GAP–Regulated GTPase Activity of Rheb by Real-Time NMR

  2009influential reference
• Distinctive Responses to Nitrogen Starvation in the Dominant Active Mutants of the Fission Yeast Rheb GTPase

  2009cited by this paper
• Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein*

  2009cited by this paper
• Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM.

  2009cited by this paper
• Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

  2009cited by this paper
• Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF*

  2009cited by this paper
• Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation.

  2009cited by this paper
• Molecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor Protein*

  2009cited by this paper
• Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics*

  2009cited by this paper
• Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia

  2009cited by this paper
• Tumorigenic activity and therapeutic inhibition of Rheb GTPase.

  2008cited by this paper
• Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP interaction

  2008cited by this paper
• Constitutively active Rheb induces oncogenic transformation

  2008cited by this paper
• Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb

  2008cited by this paper
• The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid.

  2008cited by this paper
• Membrane-dependent signal integration by the Ras activator Son of sevenless

  2008cited by this paper
• Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.

  2008cited by this paper
• RHEB expression in fibroadenomas of the breast

  2008cited by this paper
• Phospholipase D1 is an effector of Rheb in the mTOR pathway

  2008cited by this paper
• The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

  2008cited by this paper
• Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling*

  2008cited by this paper
• Interactions of Ras proteins with the plasma membrane and their roles in signaling.

  2008cited by this paper
• Mechanisms of Ras membrane organization and signaling: Ras on a rocker

  2008cited by this paper
• Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes.

  2008cited by this paper
• mTOR is activated in the majority of malignant melanomas.

  2008cited by this paper
• The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

  2008cited by this paper
• The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners.

  2008cited by this paper
• Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.

  2008cited by this paper
• A novel switch region regulates H‐ras membrane orientation and signal output

  2008cited by this paper
• Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach.

  2007influential reference
• Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila

  2007cited by this paper
• The TSC/Rheb/TOR Signaling Pathway in Fission Yeast and Mammalian Cells: Temperature Sensitive and Constitutive Active Mutants of TOR

  2007cited by this paper
• Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb*

  2007cited by this paper

• Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase

  2018cites this paper
• The characterization of RHEB gene and its responses to hypoxia and thermal stresses in the small abalone Haliotis diversicolor.

  2017cites this paper