An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cell

• Publication date

  2007-09-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CELL.2007.07.013PMID 17889653PMCID PMC2128786
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vesicle disruption, plasma membrane bleb formation, and acute cell death caused by illumination with blue light in acridine orange-loaded malignant melanoma cells.

  2007cited by this paper
• Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity

  2007cited by this paper
• Cell death by necrosis: towards a molecular definition.

  2007cited by this paper
• Regulation of hemostasis by heparin-binding serpins

  2007cited by this paper
• Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination.

  2007cited by this paper
• Coping with stress: cellular relaxation techniques.

  2006cited by this paper
• Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species.

  2006cited by this paper
• Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules.

  2006cited by this paper
• Necrotic death as a cell fate.

  2006cited by this paper
• Association of Calpastatin with Inactive Calpain

  2006cited by this paper
• An overview of the serpin superfamily

  2006cited by this paper
• Developmental cell biology: Developmental apoptosis in C. elegans: a complex CEDnario

  2006cited by this paper
• Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.

  2005cited by this paper
• Calpains and disease.

  2005cited by this paper
• Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress.

  2005cited by this paper
• Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis

  2004influential reference
• Targeted Disruption of SPI3/Serpinb6 Does Not Result in Developmental or Growth Defects, Leukocyte Dysfunction, or Susceptibility to Stroke

  2004cited by this paper
• Interaction of calpastatin with calpain: a review

  2004cited by this paper
• Developmental cell death: morphological diversity and multiple mechanisms

  2004cited by this paper
• A Reduction in Intestinal Cell pHi Due to Loss of the Caenorhabditis elegans Na+/H+ Exchanger NHX-2 Increases Life Span*

  2003cited by this paper
• Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates

  2003cited by this paper
• Dying for a cause: invertebrate genetics takes on human neurodegeneration

  2003cited by this paper
• The calpain system.

  2003cited by this paper
• Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

  2003cited by this paper
• Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

  2002cited by this paper
• Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2

  2002influential reference
• Mechanisms Sensing and Modulating Signals Arising From Cell Swelling

  2002influential reference
• Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum.

  2001cited by this paper
• The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

  2001cited by this paper
• Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration.

  2001cited by this paper
• Aspartic Proteases from the Nematode Caenorhabditis elegans

  2000cited by this paper
• The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival.

  1999cited by this paper
• The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.

  1998cited by this paper
• Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display.

  1998influential reference
• clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.

  1998cited by this paper
• Gαs-Induced Neurodegeneration inCaenorhabditis elegans

  1998cited by this paper
• G alphas-induced neurodegeneration in Caenorhabditis elegans.

  1998cited by this paper
• Genetically targeted cell disruption in Caenorhabditis elegans.

  1997cited by this paper
• Prognostic value of preoperative squamous cell carcinoma antigen level in patients surgically treated for cervical carcinoma.

  1997cited by this paper
• Transient Brain Ischaemia Provokes Ca2+, PIP2 and Calpain Responses Prior to Delayed Neuronal Death in Monkeys

  1996cited by this paper
• Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

  1995cited by this paper
• The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans

  1990influential reference
• [Genetics of Caenorhabditis elegans].

  1989cited by this paper
• Plasminogen activator

  1988cited by this paper
• The lysosome membrane

  1986cited by this paper
• Functional study of the Caenorhabditis elegans secretory-excretory system using laser microsurgery.

  1984cited by this paper
• Lysosomes revisited.

  1983cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper
• Specific aspartyl and calpain proteases are required for neurodegeneration in C . elegans

  year unknowncited by this paper

• Proteomic Analysis of Urinary Extracellular Vesicles from Patients with ADTKD-HNF1β identifies roles for Cilia-related Proteins and Serpins.

  2025cites this paper
• A one-two punch against cancer: combining CDK4 inhibitors with lysosomotropic agents

  2025cites this paper
• Different concentrations of 2-Undecanone triggers repellent and nematicidal responses in Caenorhabditis elegans

  2025cites this paper
• The molecular signature of heat stress in sweat reveals non-invasive biomarker candidates for health monitoring

  2025cites this paper
• SERPINB6 Promotes Epithelial‐Mesenchymal Transition via PI3K/AKT/mTOR Signalling Pathway in Glioma

  2025cites this paper
• Phenotypic expansion of CALM1/2-associated disorders to include neurologic phenotypes without arrhythmia.

  2025cites this paper
• Underlying Mechanism of Lysosomal Membrane Permeabilization in CNS Injury: A Literature Review

  2024cites this paper
• Nematodes exposed to furfural acetone exhibit a species-specific vacuolar H+-ATPase response.

  2024cites this paper
• Improving Diagnostic Precision: Urine Proteomics Identifies Promising Biomarkers for Necrotizing Enterocolitis

  2024cites this paper
• Intestinal Development and Gut Disease: Contributions From the Caenorhabditis elegans Model.

  2024cites this paper
• Photochemical and biological dual-effects enhance the inhibition of photosensitizers for tumour growth

  2024cites this paper
• SERPINB3, Adult-Onset Immunodeficiency, and Generalized Pustular Psoriasis

  2023cites this paper
• Blue light stimulated-autofluorescence green flash of lysosome-related organelles in the intestinal cells of nematodes

  2023cites this paper
• Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse

  2023cites this paper
• Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse

  2023cites this paper
• Serum squamous cell carcinoma antigen is a predictive factor of outcomes in patients with locally advanced unresectable esophageal squamous cell carcinoma treated by definitive chemoradiotherapy

  2022cites this paper
• Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

  2022cites this paper
• SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

  2022cites this paper
• GPCR signaling regulates severe stress‐induced organismic death in Caenorhabditis elegans

  2022cites this paper
• C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens

  2022cites this paper
• Recent advances in identification of potential drug targets and development of novel drugs in parasitic diseases. Part II. Parasite targets

  2022cites this paper
• Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases

  2021cites this paper
• FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

  2021cites this paper
• Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6.

  2021cites this paper
• The squamous cell carcinoma antigen/SERPINB3 protects cervical cancer cells from chemoradiation by preventing lysoptosis

  2021cites this paper
• SerpinB13 antibodies promote β cell development and resistance to type 1 diabetes

  2021cites this paper
• A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency

  2021cites this paper
• Real-time Simultaneous Imaging of Acidification and Proteolysis in Single Phagosomes Using Bifunctional Janus Particle Probes.

  2021cites this paper
• C. elegans monitor energy status to trigger innate immune responses via AMPK pathway against bacterial pathogens

  2021cites this paper
• The Role of Cysteine Peptidases in Hematopoietic Stem Cell Differentiation and Modulation of Immune System Function

  2021cites this paper
• Clinical Significance of Pretherapeutic Serum Squamous Cell Carcinoma Antigen Level in Patients with Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma

  2020cites this paper
• Serpin-type serine protease inhibitor mediates coelomocyte apoptosis in Apostichopus japonicus.

  2020cites this paper
• Expression interference of a number of Heterodera avenae conserved genes perturbs nematode parasitic success in Triticum aestivum.

  2020cites this paper
• Lysyl oxidase promotes neuronal ferroptosis exacerbating seizure-induced hippocampal damage

  2019cites this paper
• Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.

  2019cites this paper
• Radioresistance of Serpinb3a-/- Mice and Derived Hematopoietic and Marrow Stromal Cell Lines.

  2019influential citation
• CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans

  2019cites this paper
• Myocardial Preservation

  2019influential citation
• Cell Death: Many Causes and Many Effects

  2019cites this paper
• Activation of Viruses by Host Proteases

  2019cites this paper
• Azo‐based small molecular hypoxia responsive theranostic for tumor‐specific imaging and therapy

  2018cites this paper
• Lysosome targeted drugs: rhodamine B modified N^N-chelating ligands for half-sandwich iridium(III) anticancer complexes

  2018cites this paper
• Stat3-mediated alterations in lysosomal membrane protein composition

  2018cites this paper
• Host Cell Proteases: Cathepsins

  2018cites this paper
• Elucidating the Mechanism by which KRI-1/CCM1 Regulates Apoptosis Cell Non-Autonomously in Caenorhabditis elegans

  2018cites this paper
• Lysosome-dependent necrosis specifically evoked in cancer cells by gold nanorods.

  2017cites this paper
• Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans

  2017cites this paper
• SERPINB3 and B4: From biochemistry to biology.

  2017cites this paper
• Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

  2017cites this paper
• Arabidopsis thaliana serpins AtSRP4 and AtSRP5 negatively regulate stress-induced cell death and effector-triggered immunity induced by bacterial effector AvrRpt2.

  2017cites this paper
• Niemann-Pick Type C Disease: Protective Mechanisms from Neurodegeneration and Targets for Therapeutic Intervention.

  2016cites this paper
• The Effect of In Vitro Cultivation on the Transcriptome of Adult Brugia malayi

  2016cites this paper
• Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1)

  2016influential citation
• Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells.

  2016cites this paper
• Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1

  2016cites this paper
• Lysosomal cell death mechanisms in aging.

  2016cites this paper
• Protease signaling in animal and plant‐regulated cell death

  2016cites this paper
• Reverse genetics in the tide pool: knock‐down of target gene expression via RNA interference in the copepod Tigriopus californicus

  2015cites this paper
• Serpins in Plants

  2015cites this paper
• Serpins in Caenorhabditis elegans

  2015cites this paper
• SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.

  2015cites this paper
• University of São Paulo “Luiz de Queiroz” College of Agriculture Differential expression of genes related with meat tenderness in Nellore cattle

  2015cites this paper
• Selective cancer-killing ability of metal-based nanoparticles: implications for cancer therapy

  2015cites this paper
• Proteolysis mediated by cysteine cathepsins and legumain—recent advances and cell biological challenges

  2015cites this paper
• The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in C. elegans

  2015cites this paper
• Quantitative proteome analysis of Caenorhabditis elegans upon exposure to nematicidal Bacillus thuringiensis.

  2015cites this paper
• Gene expression profile of necrotizing enterocolitis model in neonatal mice.

  2015cites this paper
• A pan caspase inhibitor decreases caspase-1, IL-1α and IL-1β, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules

  2015cites this paper
• Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

  2015influential citation
• A two-domain protein triggers heat shock pathway and necrosis pathway both in model plant and nematode.

  2015cites this paper
• Antibody Response to Serpin B13 Induces Adaptive Changes in Mouse Pancreatic Islets and Slows Down the Decline in the Residual Beta Cell Function in Children with Recent Onset of Type 1 Diabetes Mellitus*

  2015cites this paper
• Microscopic Investigation of Protein Function in C. elegans Using Fluorescent Imaging

  2015cites this paper
• Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia

  2015cites this paper
• The Mechanisms and Modalities of Cell Death

  2015cites this paper
• Establishing the Drosophila Larval Neuroblast as a System to Study Regulated Cell Death in vivo.

  2015cites this paper
• The Aggregation-Prone Intracellular Serpin SRP-2 Fails to Transit the ER in Caenorhabditis elegans

  2015cites this paper
• Genetic and environmental modulation of necrosis and health span in Caenorhabditis elegans

  2014cites this paper
• Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection

  2014cites this paper
• the RNAi pathway to misfolded protein turnover

  2014cites this paper
• Arthritic Cell-Based Assay Model For Measuring Inflammatory Response To Therapeutic Biological Agents

  2014cites this paper
• Necrotic cell death in Caenorhabditis elegans.

  2014cites this paper
• NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic C. elegans DEG/ENaCs

  2014cites this paper
• Calcium phosphate nanoparticles primarily induce cell necrosis through lysosomal rupture: the origination of material cytotoxicity.

  2014cites this paper
• Organelle-specific initiation of cell death

  2014cites this paper
• Oncogenic Ras induces inflammatory cytokine production by up-regulating the squamous cell carcinoma antigens SerpinB3/B4

  2014cites this paper
• A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging.

  2014cites this paper
• NOX1, Reactive Oxygen Species, JNK, and Necrotic Cell Death

  2014cites this paper
• Isolation of serpin-interacting proteins in C. elegans using protein affinity purification.

  2014cites this paper
• Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges.

  2014cites this paper
• A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.

  2014cites this paper
• NRA-2, a Nicalin Homolog, Regulates Neuronal Death by Controlling Surface Localization of Toxic Caenorhabditis elegans DEG/ENaC Channels*

  2014cites this paper
• Necrotizing Enterocolitis: Predictive Markers and

  2013cites this paper
• Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans

  2013cites this paper
• Cross-Presentation Pathway Cooperate in a MHC-I Antigen HLA-F and MHC-I Open Conformers

  2013cites this paper
• Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression.

  2013cites this paper
• HLA-F and MHC-I Open Conformers Cooperate in a MHC-I Antigen Cross-Presentation Pathway

  2013cites this paper
• Combating apoptosis and multidrug resistant cancers by targeting lysosomes.

  2013cites this paper
• Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis.

  2013cites this paper
• Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.

  2013cites this paper
• Programmed cell death with a necrotic-like phenotype

  2013cites this paper