The Surface pH of the Intestinal Mucosa and its Significance in the Permeability of Organic Anions

No abstract is available for this paper.

• Publication year

  1984

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-3-642-69508-7_3
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Drug absorption from the small intestine of the triparanol-treated rat in situ.

  2009cited by this paper
• Altered jejunal surface pH in coeliac disease: its effect on propranolol and folic acid absorption.

  1982cited by this paper
• [Acid-base changes across the rat jejunum, in vitro (author's transl)].

  1979cited by this paper
• DRUG BINDING TO α1-GLYCOPROTEIN

  1979cited by this paper
• Influence of intraluminal pH on folate absorption: studies in control subjects and in patients with pancreatic insufficiency.

  1979cited by this paper
• Intestinal absorption of carbohydrate and protein in man.

  1979cited by this paper
• Epithelial transport of weak electrolytes.

  1979cited by this paper
• The intestinal absorption of folates.

  1979cited by this paper
• Scientific basis of gastroenterology

  1979cited by this paper
• Fitting nonlinear models to data.

  1979cited by this paper
• Studies on digestion and absorption in the intestines of growing pigs

  1979cited by this paper
• Effect of pH on salicylic acid permeation through ethyl cellulose‐PEG 4000 films

  1979cited by this paper
• Effect of ethanol, diphenylhydantoin, methotrexate and low sodium ion concentration on jejunal surface pH and folic acid transfer in the rat [proceedings].

  1978cited by this paper
• Structure of gastrointestinal mucus glycoproteins and the viscous and gel-forming properties of mucus.

  1978cited by this paper
• The magnitude and distribution of the acid microclimate in proximal jejunum and its relation to luminal acidification

  1978cited by this paper
• Acid microclimate in coeliac and Crohn's disease: a model for folate malabsorption.

  1978cited by this paper
• An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption

  1978cited by this paper
• A membrane model of the human oral mucosa as derived from buccal absorption performance and physicochemical properties of the β‐blocking drugs atenolol and propranolol

  1978cited by this paper
• Role of intestinal mucus in the absorption of quinine and water-soluble dyes from the rat small intestine.

  1978cited by this paper
• Effects of free fatty acids as membrane components on permeability of drugs across bilayer lipid membranes: a mechanism for intestinal absorption of acidic drugs.

  1978cited by this paper
• Effects of theophylline on salicylate transport in isolated rat jejunum

  1978cited by this paper
• Volatile fatty acids and pH in the gastrointestinal contents of normal and Shigella-infected monkeys.

  1978cited by this paper
• Perspectives in Coeliac Disease

  1978cited by this paper
• Intestinal transport of weak electrolytes: Determinants of influx at the luminal surface

  1978cited by this paper
• Electrostatic interactions at charged lipid membranes. Measurement of surface pH with fluorescent lipoid pH indicators.

  1978cited by this paper
• Intestinal transport of salt and water.

  1978cited by this paper
• Absorption of 14C-bumadizone-Ca and 14C-phenylbutazone in isolated intestinal segments in vitro and tied-off gastrointestinal sections in vivo of rats and guinea pigs.

  1977cited by this paper
• Mechanical properties of taenia coli smooth muscle in spontaneous contraction.

  1977cited by this paper
• Changes in the Jejunal Glycocalyx and their Relationship to Intestinal Malabsorption

  1977cited by this paper
• The influence of pH, low sodium ion concentration and methotrexate on the jejunal-surface pH: a model for folic acid transfer.

  1977cited by this paper
• Acidic dissociation constants of folic acid, dihydrofolic acid, and methotrexate.

  1977cited by this paper
• The reactivity of α-chymotrypsin immobilized on radiation-grafted hydrogel surfaces

  1977cited by this paper
• Epithelial transport of weak electrolytes. Properties of a model of the three compartment system.

  1977cited by this paper
• THE GASTROINTESTINAL ABSORPTION OF PENICILLIN V IN CHILDREN WITH SUSPECTED COELIAC DISEASE

  1977cited by this paper
• Derivation of the equations that describe the effects of unstirred water layers on the kinetic parameters of active transport processes in the intestine.

  1977cited by this paper
• Unstirred layer and kinetics of electrogenic glucose absorption in the human jejunum in situ

  1977cited by this paper
• Lung pH and pulmonary absorption of nonvolatile drugs in the rat.

  1977cited by this paper
• HCO3 transport in rat jejunum: relationship to NaCl and H2O transport in vivo.

  1977cited by this paper
• Transport of purine nucleotides and nucleosides by in vitro rabbit ileum.

  1977cited by this paper
• Activity of chloride in absorptive cells of Amphiuma small intestine.

  1977cited by this paper
• Human ascaris--purification of chymotrypsin inhibitor and properties of partially purified chymotrypsin and trypsin inhibitors.

  1977cited by this paper
• Drug Absorption in Gastrointestinal Disease With Particular Reference to Malabsorption Syndromes

  1977cited by this paper
• NMR studies of pH-induced transport of carboxylic acids across phospholipid vesicle membranes.

  1977cited by this paper
• Everted rat intestinal sacs as an in vitro model for assessing absorptivity of new drugs.

  1977cited by this paper
• Effects of Bethanechol on Intestinal Ion Transport in the Rat

  1977cited by this paper
• The Syrian hamster: a reproducible model for studying changes in intestinal fluid secretion in response to enterotoxin challenge

  1976cited by this paper
• Electrostatic interactions at charged lipid membranes. I. Effects of pH and univalent cations on membrane structure.

  1976cited by this paper
• Plasma levels of propranolol in treated patients with coeliac disease and patients with Crohn's disease.

  1976cited by this paper
• Pharmacokinetics of antibiotic absorption in coeliac disease.

  1976cited by this paper
• The effect of pH on folic acid absorption in man.

  1976cited by this paper
• Gastrointestinal absorption of carbenoxolone in the rat determined in vitro and in situ: deviations from the pH‐partition hypothesis

  1976cited by this paper
• Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney.

  1976cited by this paper
• Aspects of intestinal folate transport in the rat.

  1976cited by this paper
• Intestinal ion transport: effect of norepinephrine, pilocarpine, and atropine.

  1976cited by this paper
• Studies on digestion and absorption in the intestines of growing pigs. Measurements of the flow of digesta and pH

  1976cited by this paper
• Intracellular potassium activities in Amphiuma small intestine.

  1976cited by this paper
• Thiamine transport in thiamine-deficient rats. Role of the unstirred water layer.

  1976cited by this paper
• Absorption of propranolol and practolol in Coeliac disease.

  1976cited by this paper
• A physical model for the simultaneous membrane transport and metabolism of drugs.

  1976cited by this paper
• The association between acidification and electrogenic events in the rat proximal jejunum

  1976cited by this paper
• Relationship of the acid micro-climate in rat and human intestine to malabsorption.

  1976cited by this paper
• Inhibition of pyruvate transport by fatty acids in isolated cells from rat small intestine.

  1975cited by this paper
• Absorption of Short and Medium Chain Fatty Acids in the Jejunum of the Rat

  1975cited by this paper
• Thyroid control of small intestinal oxygen consumption and the influence of sodium ions, oxyhen tension, glucose and anaesthesia.

  1975cited by this paper
• Some characteristics of monocarboxylic acid transfer across the cell membrane of epithelial cells from rat small intestine.

  1975cited by this paper
• Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum

  1975cited by this paper
• Intestinal absorption and malabsorption

  1975cited by this paper
• Acidification in the rat proximal jejunum.

  1975cited by this paper
• Relations of weak-electrolyte transport and acid-base metabolism in rat small intestine in vitro.

  1975cited by this paper
• Intra- and extracellular gradients of electrical potential and ion activities of the epithelial cells of the rabbit ileum in vivo recorded by microelectrodes.

  1975cited by this paper
• Radiothelemetric monitoring of hydrogen ion levels of the small intestine.

  1975cited by this paper
• An analysis of the D-glucose influx kinetics of in vitro hamster jejunum, based on considerations of the mass-transfer coefficient.

  1975cited by this paper
• Transport of short chain fatty acids.

  1974cited by this paper
• Intestinal Transport of Weak Electrolytes

  1974cited by this paper
• Folic acid: a new approach to the mechanism of its intestinal absorption.

  1974cited by this paper
• Validation of a chamber that allows measurement of both tissue uptake rates and unstirred layer thicknesses in the intestine under conditions of controlled stirring.

  1974cited by this paper
• The effect of mucin on the bioavailability of tetracycline from the gastrointestinal tract; in vivo, in vitro correlations

  1974cited by this paper
• Acid microclimate in intestinal absorption.

  1974cited by this paper
• Drug permeation through membranes. 3. Effect of pH and various substances on permeation of phenylbutazone through everted rat intestine and polydimethylsiloxane.

  1974cited by this paper
• Absorption of folic acid by everted segments of rat jejunum

  1974cited by this paper
• The effect of bicarbonate and acidification on water and electrolyte absorption by the intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats

  1974cited by this paper
• Cellular mechanisms of urinary acidification.

  1974cited by this paper
• Misconceptions and thermodynamic untenability of deviations from pH-partition hypothesis.

  1973cited by this paper
• Effect of luminal sodium concentration on bicarbonate absorption in rat jejunum.

  1973cited by this paper
• Relationships between ion and water movement in the human jejunum, ileum and colon during perfusion with bile acids.

  1973cited by this paper
• The influence of secretin on ion transport in the human jejunum

  1973cited by this paper
• Uptake and reduction of radioactive folate by everted sacs of rat small intestine.

  1973cited by this paper
• Intestinal folate absorption. II. Conversion and retention of pteroylmonoglutamate by jejunum.

  1973cited by this paper
• Unstirred layer, source of biased Michaelis constant in membrane transport.

  1973cited by this paper
• Drug absorption in patients with intestinal villous atrophy.

  1973cited by this paper
• Determinants of intestinal mucosal uptake of short- and medium-chain fatty acids and alcohols.

  1973cited by this paper
• The uptake of pteroylglutamic acid by the rat jejunum.

  1973cited by this paper
• Membrane digestion. A concept of enzyme hydrolysis on cell membranes.

  1973cited by this paper
• Determination of unidirectional uptake rates for lipids across the intestinal brush border.

  1972cited by this paper
• The Production of Intestinal Fluid by Cholera Toxin in the Rat 1

  1972cited by this paper
• Gastric juice neutralization in the duodenum.

  1972cited by this paper
• Effects of Secretin and Glucagon on Intestinal Transport of Ions and Water in the Rat 1

  1972cited by this paper
• In vitro andin vivo studies on transport kinetics of medium chain fatty acids in the small intestine of rats: In vitro- undin vivo-Versuche an Ratten

  1972cited by this paper
• In vitro model for transport of solutes in three-phase system. I. Theoretical principles.

  1972cited by this paper
• pH profile of gut as measured by radiotelemetry capsule.

  1972cited by this paper

• Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption

  2011cites this paper
• Drug dissolution under physiologically relevant conditions in vitro and in vivo.

  2006cites this paper
• Relationship between antipyrine absorption and blood flow rate in rat jejunum, ileum, and colon

  2004cites this paper
• Phosphatase activities of rat intestinal enterocytes and their relation to diverse luminal pH, with special references to the possible localization of phytase along the brush border membrane.

  2001cites this paper
• Cimetidine Transport in Brush-Border Membrane Vesicles from Rat Small Intestine 1

  1999cites this paper
• Cimetidine transport in brush-border membrane vesicles from rat small intestine.

  1999cites this paper
• Adhesive mucous gel layer and mucus release as intestinal barrier in rats.

  1996cites this paper
• Influence of organic acid excretion on cuticle pH and drug absorption by Haemonchus contortus.

  1996cites this paper
• Effect of perfusate pH on the influx of 5-5'-dimethyl-oxazolidine-2,4-dione and dissociation of epidermal growth factor from the cell-surface receptor: the existence of the proton diffusion barrier in the Disse space.

  1994cites this paper
• Effect of Theophylline on the Intestinal Clearance of Drugs in Rats

  1992cites this paper
• The effect of sodium deoxycholate and other surfactants on the mucosal surface pH in proximal jejunum or rat

  1991cites this paper
• Transport of Weak Electrolytes

  1991cites this paper
• Absorption and metabolism of procaine by the rat small intestine

  1990cites this paper
• Role of unstirred water layer in the exsorption of quinidine

  1990cites this paper
• Characteristics of transmural potential changes associated with the proton‐peptide co‐transport in toad small intestine.

  1987cites this paper
• A revision of current data and views on membrane hydrolysis and transport in the mammalian small intestine based on a comparison of techniques of chronic and acute experiments: experimental re-investigation and critical review.

  1986cites this paper
• Sodium-independent, hydrogen ion-dependent changes in membrane potential and conductance induced by dipeptides in Triturus enterocytes.

  1986cites this paper
• Proton-coupled transport of organic solutes in animal cell membranes and its relation to Na+ transport.

  1985cites this paper
• Effect of hydrogen ion-gradient on carrier-mediated transport of glycylglycine across brush border membrane vesicles from rabbit small intestine.

  1985cites this paper