Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling

Increased transcriptional complex activity, or pharmacological mimics of increased complex activity, predict lifespan in mice and mediate the protective effects of dietary restriction during aging.

• Publication year

  2009

• Venue

  PLoS Biology

• Publication date

  2009-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pbio.1000245PMID 19924292PMCID 2774267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

  2009influential reference
• Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

  2009cited by this paper
• Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

  2009influential reference
• SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.

  2009cited by this paper
• Chemosensory and caloric mechanisms influence distinct components of mortality rate.

  2008cited by this paper
• Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf‐1‐dependent mechanism in Caenorhabditis elegans

  2008influential reference
• Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan.

  2008cited by this paper
• Two neurons mediate diet-restriction-induced longevity in C. elegans

  2007influential reference
• PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

  2007influential reference
• An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.

  2007cited by this paper
• Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease.

  2007cited by this paper
• Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.

  2007influential reference
• Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

  2006cited by this paper
• Opposing Activities Protect Against Age-Onset Proteotoxicity

  2006cited by this paper
• SMK-1, an essential regulator of DAF-16-mediated longevity.

  2006cited by this paper
• Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression.

  2006cited by this paper
• Mechanisms of dietary restriction in aging and disease.

  2006cited by this paper
• Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats.

  2006cited by this paper
• Dietary deprivation extends lifespan in Caenorhabditis elegans

  2006cited by this paper
• RNA interference in Caenorhabditis elegans.

  2005cited by this paper
• SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression.

  2005influential reference
• Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia.

  2005cited by this paper
• Mining Microarrays for Metabolic Meaning: Nutritional Regulation of Hypothalamic Gene Expression

  2004cited by this paper
• Coactivator ASC‐2 mediates heat shock factor 1‐mediated transactivation dependent on heat shock

  2004influential reference
• Association between Hepatocyte Nuclear Factor 6 (HNF-6) and FoxA2 DNA Binding Domains Stimulates FoxA2 Transcriptional Activity but Inhibits HNF-6 DNA Binding

  2003cited by this paper
• Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

  2003influential reference
• Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans.

  2003influential reference
• Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans.

  2002cited by this paper
• Interaction of intracellular β amyloid peptide with chaperone proteins

  2002cited by this paper
• Interaction of intracellular beta amyloid peptide with chaperone proteins.

  2002cited by this paper
• Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.

  2002cited by this paper
• Stimulation of NF-E2 DNA Binding by CREB-binding Protein (CBP)-mediated Acetylation*

  2001cited by this paper
• Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span.

  2001cited by this paper
• Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

  2001cited by this paper
• CBP, a transcriptional coactivator and acetyltransferase.

  2001cited by this paper
• DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.

  2000influential reference
• Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.

  2000cited by this paper
• The genetics of caloric restriction in Caenorhabditis elegans.

  1998cited by this paper
• A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans.

  1998cited by this paper
• The CBP co-activator is a histone acetyltransferase

  1996cited by this paper
• Oxidative Stress, Caloric Restriction, and Aging

  1996cited by this paper
• Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

  1995cited by this paper
• A C. elegans mutant that lives twice as long as wild type

  1993cited by this paper
• Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging.

  1990cited by this paper
• The relationship of genotype, sex, body weight, and growth parameters to lifespan in inbred and hybrid mice.

  1982cited by this paper
• Life-span and the inheritance of longevity of inbred mice.

  1975cited by this paper

• The interplay of epigenetic remodelling and transposon-mediated genomic instability in ageing and longevity.

  2026cites this paper
• How to measure, analyze, and interpret age-related changes in Caenorhabditis elegans: lessons for mechanistic and evolutionary theories of aging.

  2025cites this paper
• Large extension of C. elegans lifespan in diluted axenic medium: a balancing act between different survival responses.

  2025cites this paper
• Chromatin and epigenetics in aging biology.

  2025cites this paper
• The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

  2025cites this paper
• Transgenerational response of germline histone acetyltransferases and deacetylases to nanoplastics at predicted environmental doses in Caenorhabditis elegans.

  2024cites this paper
• Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR

  2024cites this paper
• SATB1, senescence and senescence‐related diseases

  2024cites this paper
• Mitochondrial clearance and increased HSF-1 activity are coupled to promote longevity in fasted Caenorhabditis elegans

  2024cites this paper
• Epigenetics as a link between environmental factors and dementia risk

  2024cites this paper
• An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

  2024cites this paper
• Nonlinear DNA methylation trajectories in aging male mice

  2024cites this paper
• Neuronal CBP-1 is required for enhanced body muscle proteostasis in response to reduced translation downstream of mTOR

  2024influential citation
• Mitophagy-promoting agents and their ability to promote healthy-aging

  2023cites this paper
• Role of primary aging hallmarks in Alzheimer´s disease

  2023cites this paper
• Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin

  2023cites this paper
• Structure, Function, and Molecular Landscapes of the Aging Retina.

  2023cites this paper
• Novel compound inhibits glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheimer’s, Huntington’s, and stroke: Aging as a consequence of glycolysis

  2023influential citation
• Chromatin: the old and young of it

  2023cites this paper
• Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysis

  2023influential citation
• Genomic Instability and Epigenetic Changes during Aging

  2023cites this paper
• Endocytic coelomocytes are required for lifespan extension by axenic dietary restriction

  2023cites this paper
• The role of nutrition and oxidative stress as aging factors in Caenorhabditis elegans

  2023cites this paper
• CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain

  2022cites this paper
• Biological age and environmental risk factors for dementia and stroke: Molecular mechanisms

  2022cites this paper
• Axenic Culture of Caenorhabditis elegans Alters Lysosomal/Proteasomal Balance and Increases Neuropeptide Expression

  2022cites this paper
• Hsp90: From Cellular to Organismal Proteostasis

  2022cites this paper
• Diets, genes, and drugs that increase lifespan and delay age-related diseases: Role of nutrient-sensing neurons and Creb-binding protein.

  2022cites this paper
• The CBP-1/p300 Lysine Acetyltransferase Regulates the Heat Shock Response in C. elegans

  2022influential citation
• Pleiotropic effects of mitochondria in aging

  2022cites this paper
• Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis

  2021cites this paper
• Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

  2021influential citation
• Gene co-expression analyses of health(span) across multiple species

  2021cites this paper
• Acetylation regulation associated with the induction of protective response to polystyrene nanoparticles in Caenorhabditis elegans.

  2021cites this paper
• Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes

  2021influential citation
• The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress

  2021cites this paper
• A conserved role of CBP/p300 in mitochondrial stress response and longevity

  2020cites this paper
• Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension

  2020cites this paper
• New Insights into the Role of Histone Changes in Aging

  2020cites this paper
• Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.

  2020influential citation
• The flip side of sirtuins: the emerging roles of protein acetyltransferases in aging

  2020cites this paper
• Chromatin-associated effectors of energy-sensing pathways mediate intergenerational effects

  2020cites this paper
• Role of insulin/insulin-like growth factor-1 signaling pathway genes on the lifespan of Caenorhabditis elegans

  2020influential citation
• An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

  2020cites this paper
• Lysine Acetyltransferase p300/CBP Plays an Important Role in Reproduction, Embryogenesis and Longevity of the Pea Aphid Acyrthosiphon pisum

  2020cites this paper
• Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging

  2019cites this paper
• Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress

  2019cites this paper
• CBP-1/p300 acetyltransferase regulates SKN-1/Nrf cellular levels, nuclear localization, and activity in C. elegans.

  2019cites this paper
• Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole

  2018cites this paper
• Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer’s Disease

  2018cites this paper
• Glucose-Induced Transcriptional Hysteresis: Role in Obesity, Metabolic Memory, Diabetes, and Aging

  2018influential citation
• The Special AT-rich Sequence Binding Protein 1 (SATB1) and its role in solid tumors.

  2018cites this paper
• Extension of C. elegans lifespan using the ·NO-delivery dinitrosyl iron complexes

  2018cites this paper
• Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring

  2018cites this paper
• Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome

  2018cites this paper
• Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49.

  2018cites this paper
• Healthy Aging and Epigenetic Drugs for Diabetes and Obesity

  2018cites this paper
• Aging Epigenetics: Changes and Challenges

  2018cites this paper
• Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling

  2018cites this paper
• Histone Modification Changes During Aging: Cause or Consequence?—What We Have Learned About Epigenetic Regulation of Aging From Model Organisms

  2018cites this paper
• New molecular mechanisms of aging regulation

  2018cites this paper
• In silico prediction of regulators of neuronal identity through phylogenetic footprinting

  2018cites this paper
• Silencing of Repetitive DNA Is Controlled by a Member of an Unusual Caenorhabditis elegans Gene Family

  2017cites this paper
• Dietary Restriction in C. elegans

  2017cites this paper
• Longevity Regulation by Insulin/IGF-1 Signalling

  2017cites this paper
• CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans

  2017influential citation
• Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis

  2017cites this paper
• The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF‐16/FOXO transcription factors

  2017cites this paper
• pals-22, a member of an expanded C. elegans gene family, controls silencing of repetitive DNA

  2017cites this paper
• Mechanisms by Which the Ketogenic Diet Reverses Obesity and Diabetes

  2017cites this paper
• Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet.

  2017cites this paper
• HSF1 Regulation in Aging and Its Role in Longevity

  2016cites this paper
• The aryl hydrocarbon receptor promotes aging phenotypes across species

  2016cites this paper
• Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates

  2016cites this paper
• Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT.

  2016cites this paper
• Age-related epigenetic changes at base excision repair genes and their modulation by dietary restriction in mice

  2015cites this paper
• Advances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ Damage

  2015cites this paper
• A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans

  2015cites this paper
• Genes and Pathways That Influence Longevity in Caenorhabditis elegans

  2015cites this paper
• Regulation of the Cytosolic Stress Response: Identification of Positive and Negative Modulators by a Genome-Wide RNA Interference Screen

  2014cites this paper
• Epigenetic effect of testosterone in the behavior of C. elegans. A clue to explain androgen-dependent autistic traits?

  2014cites this paper
• D-beta-hydroxybutyrate extends lifespan in C. elegans

  2014cites this paper
• Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging

  2014cites this paper
• Lifespan regulation under axenic dietary restriction: a close look at the usual suspects.

  2014cites this paper
• Molecular Regulation of SATB1 in Regulatory T-cells

  2013cites this paper
• Genes that link the insulin/IGF-like signaling pathway to stress response

  2013cites this paper
• Role of the hypothalamus in mediating protective effects of dietary restriction during aging.

  2013cites this paper
• Deletion of microRNA-80 Activates Dietary Restriction to Extend C. elegans Healthspan and Lifespan

  2013influential citation
• Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

  2013cites this paper
• Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

  2013cites this paper
• CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging.

  2013cites this paper
• Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus.

  2013cites this paper
• Reduced neuronal expression of ribose‐5‐phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila

  2012cites this paper
• The great unravelling: chromatin as a modulator of the aging process.

  2012cites this paper
• The endocannabinoid system in normal and pathological brain ageing

  2012cites this paper
• C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

  2012cites this paper
• Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics

  2012cites this paper
• MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation

  2012cites this paper
• Neuroprotection by dietary restriction and the PPAR transcription complex

  2012cites this paper
• Regulators and Effectors of Acetyltransferase p300 During Oxidative Stress, Heart Disease and Aging

  2012cites this paper