Products of activated lymphocytes: leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF).

The mechanism of inhibition in the leukocyte migration system was investigated. The migration of human buffy coat cells was inhibited by a soluble product of activated lymphocytes. This factor was found to have an elution pattern in Sephadex G-100 gels similar to that of albumin (69,000 daltons), thus differentiating it from human migratory inhibitory factor (MIF) (23,000 daltons). Leukocyte inhibitory factor (LIF), like MIF, was shown to be elaborated by sensitized lymphocytes following stimulation by specific antigen. LIF selectively inhibited the migration of polymorphonuclear (PMN) leukocytes but did not affect the migration of guinea pig macrophages or human monocytes. Thus, the leukocyte migration system has been shown to be mediated by a separate factor (LIF) and different indicator cells (PMN leukocytes) than the MIF-mediated system of migration inhibition which utilizes guinea pig macrophages or human monocytes as indicator cells.

• Publication year

  1974

• Venue

  Journal of Immunology

• Publication date

  1974-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.112.4.1461PMID 4592603
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• In Vitro Correlates of Delayed Hypersensitivity in Man: Ambiguity of Polymorphonuclear Neutrophils as Indicator Cells in Leukocyte Migration Test

  1973cited by this paper
• Migration inhibitory effect of cell-free supernatants from tuberculin-stimulated cultures of human mononuclear leukocytes demonstrated by two-step MIF agarose assay.

  1973cited by this paper
• Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis.

  1972cited by this paper
• Cellular interactions in the leukocyte migration inhibition system.

  1972cited by this paper
• Characterization of human migration inhibitory factor (MIF) from antigen-stimulated lymphocytes.

  1972cited by this paper
• TUBERCULIN‐INDUCED MIGRATION INHIBITION OF HUMAN PERIPHERAL LEUCOCYTES IN AGAROSE MEDIUM

  1971cited by this paper
• Studies on lymphocyte and monocyte function in chronic mucocutaneous candidiasis.

  1971cited by this paper
• An in vitro assay for cellular hypersensitivity in man.

  1970cited by this paper
• Inhibition of leukocyte migration: an evaluation of this in vitro assay of delayed hypersensitivity in man to a soluble antigen.

  1970cited by this paper
• Cell Migration Inhibition Factor released by Antigen from Human Peripheral Lymphocytes

  1968cited by this paper
• Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity

  1966cited by this paper

• Immunologic Aspects of Myasthenia Gravis 0

  2015cites this paper
• Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors.

  2013cites this paper
• Cell mediated immunity of calves to bovine parainfluenza-3 virus; leukocyte migration inhibition and leukocyte aggregation response.

  2010cites this paper
• Identification of a chemokinetic inhibitor in serum from patients with chronic lymphocytic leukaemia.

  2009cites this paper
• Effect of human leucocyte migration inhibitory factor (LIF) on 3', 5'-cyclic AMP levels of peripheral blood leucocytes.

  2009cites this paper
• DRUG EFFECTS ON HUMAN LEUCOCYTE MIGRATION AND MIGRATION INHIBITORY ACTIVITY FROM LYMPHOCYTES STIMULATED WITH CONCANAVALIN A

  2009cites this paper
• Allergy diagnostic testing: an updated practice parameter.

  2008cites this paper
• Leukocyte migration inhibition induced by the combination of drug and a liver constituent in patients with drug-induced hepatitis

  2007cites this paper
• Inhibition of leukocyte migration by the agarose plate technique. Application to antigen from Candida albicans and Fusobacterium nucleatum.

  2007cites this paper
• Cell mediated immunity to bovine rhinovirus type 1 in calves

  2005cites this paper
• The diagnostic role of the in vitro drug‐induced interferon‐γ release test in Stevens–Johnson syndrome

  1999cites this paper
• Practice parameters for allergy diagnostic testing. Joint Task Force on Practice Parameters for the Diagnosis and Treatment of Asthma. The American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology.

  1995cites this paper
• Textbook of Contact Dermatitis

  1995influential citation
• 3H-NECA binding to polymorphonuclear membrane: effect of sera from patients with Hodgkin's disease.

  1994cites this paper
• In Vitro Testing in Contact Hypersensitivity

  1992cites this paper
• The role of neutrophil-activating mediators in canine health and disease (with special reference to the role of leukotrienes in inflammatory dermatoses)

  1991cites this paper
• The role of neutrophil-activating mediators in canine health and disease (with special reference to the role of leukotrienes in inflammatory dermatoses).

  1991cites this paper
• Differential expression of migration inhibitory and migration stimulatory factors in two lines of mice genetically selected for high or low responsiveness to phytohemagglutinin. 1. Migration stimulatory factor(s) from T and B cells of immune spleen.

  1991cites this paper
• Multiple sclerosis: cell-mediated immunity to human brain gangliosides.

  1990cites this paper
• Partial characterization of a C5a-inhibitor in peritoneal fluid.

  1990cites this paper
• Silibinin (Legalon-70®) enhances the motility of human neutrophils immobilized by formyl-tripeptide, calcium ionophore, lymphokine and by normal human serum

  1990cites this paper
• Macrophages and polymorphonuclear neutrophils in lung defense and injury.

  1990cites this paper
• Leukotriene release enhancing factor. Purification, specific allergen induction, and further biologic properties.

  1989cites this paper
• Regulation of lymphokine response during reinfection by influenza virus. Production of a factor that inhibits lymphokine activity.

  1989cites this paper
• Influence of technical parameters on the in vitro motility of equine neutrophils in the presence of streptococcal culture supernatant.

  1989cites this paper
• Application of leucocyte migration tests to detection of allergenic drugs in patients with hypersensitivity to beta-lactam antibiotics.

  1989cites this paper
• Thrombocytopenia associated with hypersensitivity to ranitidine: possible cross-reactivity with cimetidine.

  1989cites this paper
• Proceedings of the Task Force on Guidelines for Standardizing Old and New Technologies Used for the Diagnosis and Treatment of Allergic Diseases. Washington, DC. June 18-19, 1987.

  1988cites this paper
• Potentiation of neutrophil aggregation by human leukocyte inhibitory factor

  1988cites this paper
• Studies on leukocyte migration inhibitory factor (LIF) produced by activated T and B cells.

  1988cites this paper
• Enhancement of the function of neutrophil type-1 and type-3 complement receptors by human leukocyte inhibitory factor (LIF).

  1988cites this paper
• [Pathophysiology of fibroses. Progressive systemic scleroderma as a model disease].

  1988cites this paper
• The chemotactic peptide receptor. A model for future understanding of chemotactic disorders.

  1988cites this paper
• Possible mechanisms to explain dust overloading of the lungs.

  1988cites this paper
• Cell-mediated immune response of goats to leptospirosis.

  1988cites this paper
• Inhibition of human neutrophil migration by supernatants from Hodgkin's disease‐derived cell lines

  1988cites this paper
• A T-lymphocyte-derived factor that enhances IgG-dependent release of leukotriene B4 (LTB4) from human neutrophils.

  1988cites this paper
• Influence of administration of ovarian steroids on the function of neutrophils isolated from the blood and uterus of ovariectomized mares.

  1987cites this paper
• Current trends in research on the etiology and pathogenesis of byssinosis.

  1987cites this paper
• Effects of leukocyte inhibitory factor (LIF) on neutrophil phagocytosis and bactericidal activity.

  1987cites this paper
• Effects of leukocyte inhibitory factor (LIF) on neutrophil mediated antibody-dependent cellular cytotoxicity.

  1987cites this paper
• Cell-mediated immune functions in multiple sclerosis.

  1987cites this paper
• A rapid photoelectric method for reading human leukocyte migration

  1987cites this paper
• Inhibition of Neutrophil Shape Change by an Inhibitor of Chemotaxis

  1987cites this paper
• Inflammatory Lymphokines in Hypersensitivity Reactions

  1986cites this paper
• Leukocyte migration inhibition detects cross-reacting antigens between cells transformed by Epstein-Barr virus (EBV) and EBV-like simian viruses.

  1986cites this paper
• Leukocyte migration inhibition in bacillus Calmette-Guérin vaccinated healthy adults and in tuberculosis assayed by a rapid photoelectric procedure.

  1986cites this paper
• Radiation leukemia virus-transformed immunocompetent T cells. II. Antigen-induced macrophage migration inhibition factor and leukocyte migration inhibition factor production.

  1986cites this paper
• Leukocyte migration inhibitory factor (LIF) to sperm from autoimmune men in infertile couples.

  1986cites this paper
• Cell‐mediated immune responses to artificial food additives in chronic urticaria

  1986cites this paper
• The Chemokinetic Inhibitory Factor Derived from Chronic Lymphocytic Leukaemia Cells

  1986cites this paper
• A T cell leukemia line produces factor(s) that render rat neutrophils cytotoxic.

  1986cites this paper
• The regulation of tissue eosinophilia. IV. Purification and properties of eosinophil-directed chemotactic inhibitory factors from complete Freund's adjuvant-treated guinea pigs.

  1986cites this paper
• Early cellular events in pulmonary fibrosis.

  1986cites this paper
• Cellular immunity in congestive cardiomyopathy. The normal cellular immune response.

  1985cites this paper
• Antigen nonspecific lymphokines: an overview.

  1985cites this paper
• Leukocyte migration inhibition in recurrent aphthous ulceration.

  1985cites this paper
• Demonstration of leukocyte inhibitory factor in human Schistosomiasis mansoni and its evaluation from patients in an endemic setting.

  1985cites this paper
• Studies on the vertical transmission of suid herpesvirus-1 in pigs.

  1985cites this paper
• Mechanism of priming of human neutrophils by a soluble lymphoblastoid cell factor.

  1985cites this paper
• Activation of Neutrophils by Antigen‐Induced Lymphokine, With Emphasis on Antibody‐Independent Cytotoxicity

  1985cites this paper
• Human mononuclear cells exposed to staphylococci rapidly produce an inhibitor of neutrophil chemotaxis.

  1985cites this paper
• Physiological studies with human leukocyte inhibitory factor.

  1985cites this paper
• Migration inhibition and stimulation factors produced from peripheral blood lymphocyte cultures of sensitised guinea pigs.

  1985cites this paper
• Cytomegalovirus (CMV): specific lymphokine production in congenital CMV infection.

  1985cites this paper
• Application of migration inhibition techniques in tumor immunology.

  1985cites this paper
• Physiological studies with human leukocyte inhibitory factor

  1985cites this paper
• [26] Antigen nonspecific lymphokines: An overview

  1985cites this paper
• The effect of selenium deficiency in goats on lymphocyte production of leukocyte migration inhibitory factor.

  1985cites this paper
• Leukocyte migration inhibitory factor production by activated lymphocytes representing immunological memory or virus-receptor interaction: response of T cell subsets to Epstein-Barr virus nuclear antigen, response of B cells to UV inactivated Epstein-Barr virus.

  1985cites this paper
• Evaluation of blocking mechanisms against immunological responses in patients with laryngeal carcinoma

  1984cites this paper
• Anergy. The mysterious loss of immunological energy.

  1984cites this paper
• Spontaneous release of leukocyte migration inhibition factor (LMIF) by lymphocytes in chronic lymphatic leukemia patients.

  1984cites this paper
• Further purification of neutrophil migration inhibition factor from T lymphocytes (NIF-T): evidence that NIF-T and leukocyte inhibitory factor (LIF) are immunologically distinct.

  1984cites this paper
• Nonspecific Immune Response: The Role of Accessory Systems in the Expression and Regulation of Specific Immunity

  1984cites this paper
• Species-restriction of rat lymphoid cell migration inhibitory factor.

  1984cites this paper
• The regulation of tissue eosinophil chemotactic factor and inhibitor in allergic skin lesions of Freund's complete adjuvant-treated guinea-pigs.

  1984cites this paper
• A C5a inhibitor in peritoneal fluid.

  1984cites this paper
• The appearance of eosinophil-directed chemotactic inhibitory factor in the serum of complete Freund's adjuvant-treated guinea pigs.

  1984cites this paper
• Chemotactic factors associated with leukocyte emigration in immune tissue injury: their separation, characterization, and functional specificity.

  1984cites this paper
• Effects of leukocyte inhibitory factor (LIF) on human neutrophil function

  1983cites this paper
• Neutrophil response to LIF: lack of glucocorticoid effect despite enhanced chemokinesis.

  1983cites this paper
• A chemotactic inhibitor in synovial fluid.

  1983cites this paper
• In vitro induction of cytotoxic polymorphonuclear leukocytes by supernatant from a concanavalin A-stimulated spleen cell culture.

  1983cites this paper
• Effect of prostaglandins on polymorphonuclear leukocyte motility.

  1983cites this paper
• Studies on the mechanism of PMN activation III. by lymphokines

  1983cites this paper
• [In vitro tuberculin reaction and cellular and humoral immune response in patients with pulmonary tuberculosis].

  1983cites this paper
• Immunopathology of Delayed Hypersensitivity

  1983cites this paper
• THE IMMUNOLOGICAL ENIGMA OF TRANSFER FACTOR

  1983cites this paper
• Utilization of purified human monocytes in the agarose droplet assay for measuring migration inhibitory factors.

  1983cites this paper
• Two inhibitors of neutrophil chemotaxis are produced by hyperimmunoglobulin E recurrent infection syndrome mononuclear cells exposed to heat-killed staphylococci

  1983cites this paper
• [Crohn disease. Physiopathologic concept, typical radiologic markers as well as remarks on therapy].

  1983cites this paper
• Cell-mediated immunity to myoglobin in polymyositis.

  1983cites this paper
• Physiochemical characterization of human histamine-induced suppressor factor.

  1983cites this paper
• Neutrophil response to LIF

  1983cites this paper
• Delayed-type skin reaction to tuberculin and the cellular and humoral immune response "in vitro" in patients with pulmonary tuberculosis

  1983cites this paper
• Inhibition of chicken leukocyte migration in vitro: a direct agarose plate assay.

  1982cites this paper
• Mitogenic responses of peripheral blood lymphocytes from pregnant and ovariectomized heifers and their modulation by serum.

  1982cites this paper
• Humoral and cell-mediated immune response to influenza virus. II. Experiments in ferrets.

  1982cites this paper
• In vitro production of leucocyte migration inhibitory factor by lymphocytes in exudative pleural effusions.

  1982cites this paper