Regulation of Ca2+ and Na+ in Normal and Failing Cardiac Myocytes

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Annals of the New York Academy of Sciences

• Publication date

  2006-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1196/annals.1380.015PMID 17132783
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

  2006cited by this paper
• Phospholemman overexpression inhibits Na+-K+-ATPase in adult rat cardiac myocytes: relevance to decreased Na+ pump activity in postinfarction myocytes.

  2006cited by this paper
• Expression and Phosphorylation of the Na-Pump Regulatory Subunit Phospholemman in Heart Failure

  2005cited by this paper
• Chronic inhibition of Na+/H+-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure.

  2005cited by this paper
• Ca2+/Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca2+ Leak in Heart Failure

  2005cited by this paper
• Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

  2005cited by this paper
• Phospholemman-Phosphorylation Mediates the β-Adrenergic Effects on Na/K Pump Function in Cardiac Myocytes

  2005cited by this paper
• Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase.

  2005cited by this paper
• Characterization of a Novel PKA Phosphorylation Site, Serine-2030, Reveals No PKA Hyperphosphorylation of the Cardiac Ryanodine Receptor in Canine Heart Failure

  2005cited by this paper
• Interaction with the Na,K-ATPase and Tissue Distribution of FXYD5 (Related to Ion Channel)*

  2005cited by this paper
• Intracellular calcium release and cardiac disease.

  2005cited by this paper
• FXYD3 (Mat-8), a new regulator of Na,K-ATPase.

  2005cited by this paper
• Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels.

  2005cited by this paper
• Increased late sodium current in myocytes from a canine heart failure model and from failing human heart.

  2005cited by this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor

  2004cited by this paper
• Ischemia‐induced phosphorylation of phospholemman directly activates rat cardiac Na/K ATPase

  2004cited by this paper
• Protection from Cardiac Arrhythmia Through Ryanodine Receptor-Stabilizing Protein Calstabin2

  2004cited by this paper
• Stereoselective electrophysiological effects of propafenone in Langendorff perfused guinea pig hearts

  2004cited by this paper
• FXYD7, Mapping of Functional Sites Involved in Endoplasmic Reticulum Export, Association With and Regulation of Na,K-ATPase*

  2004cited by this paper
• Cellular Basis of Abnormal Calcium Transients of Failing Human Ventricular Myocytes

  2003cited by this paper
• Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure.

  2003cited by this paper
• Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells.

  2003cited by this paper
• Increased Na+/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model.

  2003cited by this paper
• The &dgr;C Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure

  2003cited by this paper
• Elevated Sarcoplasmic Reticulum Ca2+ Leak in Intact Ventricular Myocytes From Rabbits in Heart Failure

  2003cited by this paper
• Transgenic CaMKII&dgr;C Overexpression Uniquely Alters Cardiac Myocyte Ca2+ Handling: Reduced SR Ca2+ Load and Activated SR Ca2+ Release

  2003cited by this paper
• Characterization of Recombinant Skeletal Muscle (Ser-2843) and Cardiac Muscle (Ser-2809) Ryanodine Receptor Phosphorylation Mutants*

  2003cited by this paper
• Intracellular Na+ regulation in cardiac myocytes.

  2003cited by this paper
• Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties

  2002cited by this paper
• Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure

  2002cited by this paper
• Abnormal Ca2+ Release, but Normal Ryanodine Receptors, in Canine and Human Heart Failure

  2002cited by this paper
• Dual regulation of cardiac Na+-K+ pumps and CFTR Cl– channels by protein kinases A and C

  2002cited by this paper
• Rate Dependence of [Na+]i and Contractility in Nonfailing and Failing Human Myocardium

  2002cited by this paper
• A functional interaction between CHIF and Na-K-ATPase: implication for regulation by FXYD proteins.

  2002cited by this paper
• Differential Regulation of Renal Na,K-ATPase by Splice Variants of the γ Subunit*

  2002cited by this paper
• Protein Kinase A Phosphorylation of the Ryanodine Receptor Does Not Affect Calcium Sparks in Mouse Ventricular Myocytes

  2002cited by this paper
• Electrophysiology of the sodium-potassium-ATPase in cardiac cells.

  2001cited by this paper
• Arrhythmogenesis and Contractile Dysfunction in Heart Failure: Roles of Sodium-Calcium Exchange, Inward Rectifier Potassium Current, and Residual &bgr;-Adrenergic Responsiveness

  2001cited by this paper
• Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure

  2001cited by this paper
• Predicted location and limited accessibility of protein kinase A phosphorylation site on Na-K-ATPase.

  2001cited by this paper
• PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

  2000cited by this paper
• Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na(+)-H(+)Exchange blockers.

  2000cited by this paper
• Activation of the cAMP–protein kinase A pathway facilitates Na+ translocation by the Na+–K+ pump in guinea‐pig ventricular myocytes

  2000cited by this paper
• Physical Interactions between Phospholamban and Sarco(endo)plasmic Reticulum Ca2+-ATPases Are Dissociated by Elevated Ca2+, but Not by Phospholamban Phosphorylation, Vanadate, or Thapsigargin, and Are Enhanced by ATP*

  2000cited by this paper
• Mechanisms of sodium pump regulation.

  2000cited by this paper
• The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.

  2000cited by this paper
• Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current

  1999cited by this paper
• Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium.

  1999cited by this paper
• Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure.

  1999cited by this paper
• Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure.

  1999cited by this paper
• Reduced Sodium Pump α1, α3, and β1-Isoform Protein Levels and Na+,K+-ATPase Activity but Unchanged Na+-Ca2+ Exchanger Protein Levels in Human Heart Failure

  1999cited by this paper
• Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.

  1999cited by this paper
• Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium.

  1999cited by this paper
• alpha-Adrenergic effects on Na+-K+ pump current in guinea-pig ventricular myocytes.

  1998cited by this paper
• Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects.

  1998cited by this paper
• Reduced myocardial Na+, K(+)-pump capacity in congestive heart failure following myocardial infarction in rats.

  1998cited by this paper
• The inhibitory effect of β-stimulation on the Na/K pump current in guinea pig ventricular myocytes is mediated by a cAMP-dependent PKA pathway

  1998cited by this paper
• Na+‐K+ pump cycle during β‐adrenergic stimulation of adult rat cardiac myocytes

  1998cited by this paper
• Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure.

  1998cited by this paper
• Na(+)-K+ pump cycle during beta-adrenergic stimulation of adult rat cardiac myocytes.

  1998cited by this paper
• Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects.

  1998cited by this paper
• α‐Adrenergic effects on Na+‐K+ pump current in guinea‐pig ventricular myocytes

  1998cited by this paper
• Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.

  1997cited by this paper
• Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits.

  1995cited by this paper
• Alpha 1b-adrenoceptor-mediated stimulation of Na-K pump current in adult rat ventricular myocytes.

  1993cited by this paper
• β-Adrenergic stimulation does not regulate Na pump function in voltage-clamped ventricular myocytes of the rat heart

  1993cited by this paper
• Ca(2+)-currents and intracellular [Ca2+]i-transients in single ventricular myocytes isolated from terminally failing human myocardium.

  1992cited by this paper
• Na,K-ATPase expression in normal and failing human left ventricle.

  1992cited by this paper
• Isoprenaline, Ca2+ and the Na(+)‐K+ pump in guinea‐pig ventricular myocytes.

  1992cited by this paper
• Excitation-Contraction Coupling and Cardiac Contractile Force

  1991cited by this paper
• Alpha-adrenergic stimulation of sarcolemmal protein phosphorylation and slow responses in intact myocardium.

  1986cited by this paper
• Isoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardium.

  1985cited by this paper
• Effect of strophanthidin on intracellular Na ion activity and twitch tension of constantly driven canine cardiac Purkinje fibers.

  1982cited by this paper
• Intracellular Na (cid:1) Concentration Is Elevated in Heart Failure But Na/K Pump Function Is Unchanged

  year unknowncited by this paper
• Intracellular Na (cid:1) Concentration Is Elevated in Heart Failure But Na/K Pump Function Is Unchanged

  year unknowncited by this paper

• Potential Antiarrhythmic Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)

  2026cites this paper
• The role of physical exercise in modulating microRNAs expression in acute myocardial infarction: a review

  2025cites this paper
• Interplay between variability in intrinsic cellular properties and heart failure-associated remodeling in a simulated population with human heart failure.

  2025cites this paper
• Piscidin-1 regulates lipopolysaccharide-induced intracellular calcium, sodium dysregulation, and oxidative stress in atrial cardiomyocytes.

  2024cites this paper
• Ion channel trafficking implications in heart failure

  2024cites this paper
• N-terminal truncated cardiac troponin I enhances Frank-Starling response by increasing myofilament sensitivity to resting tension

  2023cites this paper
• Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction

  2023cites this paper
• A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+ leak but activates SERCA2a Ca2+ uptake

  2023cites this paper
• Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure

  2022cites this paper
• Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure

  2022cites this paper
• SAR340835, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Cardiac Function and Restores Sympathovagal Balance in Heart Failure

  2021cites this paper
• Ontogenetic Features of Changes in the Calcium-Accumulating Ability of the Sarcoplasmic Reticulum of the Myocardium in Rats with Postinfarction Cardiosclerosis

  2021cites this paper
• SAR340835, a novel selective NCX inhibitor, improves cardiac function and restores sympathovagal balance in Heart Failure

  2021cites this paper
• Metabolic Remodeling and Implicated Calcium and Signal Transduction Pathways in the Pathogenesis of Heart Failure

  2021cites this paper
• MitoQ regulates redox-related non-coding RNAs to preserve mitochondrial network integrity in pressure overload heart failure.

  2020cites this paper
• Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

  2020cites this paper
• Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

  2020influential citation
• The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes

  2020cites this paper
• Heart Rate–Induced Myocardial Ca2+ Retention and Left Ventricular Volume Loss in Patients With Heart Failure With Preserved Ejection Fraction

  2020cites this paper
• MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.

  2019cites this paper
• Kdm6A Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis via H3K27me3 Demethylation of Ncx Gene

  2019cites this paper
• Cardiovascular Physiology

  2019cites this paper
• Calcium-handling abnormalities underlying atrial arrhythmogenesis in a Fontan operation canine model

  2018cites this paper
• A privileged role for neuronal Na+ channels in regulating ventricular [Ca2+] and arrhythmias

  2018cites this paper
• Structural heterogeneity of the rat pulmonary vein myocardium: consequences on intracellular calcium dynamics and arrhythmogenic potential

  2018cites this paper
• Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents

  2018influential citation
• Etude cellulaire et moléculaire de l'insuffisance cardiaque à fonction systolique préservée

  2018influential citation
• Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

  2018cites this paper
• Exercise-induced right ventricular impairment and arrhythmia susceptibility in mice

  2018cites this paper
• The inotropic consequences of selective Na+/Ca2+ exchanger inhibition is controlled by the actual transport balance

  2018cites this paper
• The Sodium-Calcium Exchanger 1: Novel Regulatory Mechanisms and Interacting Partners

  2017cites this paper
• Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy

  2017cites this paper
• Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

  2017cites this paper
• A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart

  2017cites this paper
• The effects of KB-R7943, an inhibitor of reverse Na+/Ca2+ exchange, on the force of contraction of papillary muscles in the heart of the ground squirrel Spermophilus undulatus

  2017cites this paper
• The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments

  2016cites this paper
• the Normal and Failing Myocardium No Rest for the Weary: Diastolic Calcium Homeostasis in

  2016cites this paper
• Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes.

  2016cites this paper
• Høydal, M. A. et al. (2016) Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+-

  2016influential citation
• Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure.

  2016cites this paper
• Beta-adrenergic receptor signalling and excitation-contraction coupling in the heart: impact of circadian rhythms and beta-3 receptors

  2016cites this paper
• Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+ homeostasis.

  2016influential citation
• Lessons learned from multi-scale modeling of the failing heart.

  2015cites this paper
• Investigation of the cardioprotective effect of selective NCX inhibition in cellular models

  2015cites this paper
• heartsand hyperthermic heat-acclimated rat in desensitization underlie cardiomyocyte performance handling and myofilament

  2015cites this paper
• Intracellular Calcium Attenuates Late Current Conducted by Mutant Human Cardiac Sodium Channels

  2015cites this paper
• Ca2+ cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells

  2015cites this paper
• Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat

  2015cites this paper
• Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts

  2015cites this paper
• Enzyme localization, crowding, and buffers collectively modulate diffusion-influenced signal transduction: Insights from continuum diffusion modeling.

  2015cites this paper
• Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart.

  2015cites this paper
• Modulation of the QT interval duration in hypertension with antihypertensive treatment

  2015cites this paper
• Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy.

  2015cites this paper
• Multiscale Modeling and Simulation of Human Heart Failure

  2015influential citation
• Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner.

  2014cites this paper
• Gene- and Cell-Based Therapy for Cardiovascular Disease

  2014cites this paper
• Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman

  2014cites this paper
• Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700

  2014cites this paper
• Calcium Handling Abnormality in Ventricular Tachyarrhythmias

  2014cites this paper
• Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure

  2014cites this paper
• Tight Coupling of Na+/K+-ATPase with Glycolysis Demonstrated in Permeabilized Rat Cardiomyocytes

  2014cites this paper
• Electrophysiological and Structural Remodeling in Heart Failure Modulate Arrhythmogenesis. 1D Simulation Study

  2014cites this paper
• Genetic ablation of ryanodine receptor 2 phosphorylation at Ser‐2808 aggravates Ca2+‐dependent cardiomyopathy by exacerbating diastolic Ca2+ release

  2014cites this paper
• Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells

  2014cites this paper
• Future perspectives in the pharmacological treatment of atrial fibrillation and ventricular arrhythmias in heart failure.

  2014cites this paper
• University of Birmingham Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman

  2014cites this paper
• Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes

  2014cites this paper
• Depolarization of cardiac membrane potential synchronizes calcium sparks and waves in tissue.

  2014cites this paper
• αB‐Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca2+‐handling proteins and endoplasmic reticulum stress in mice

  2014cites this paper
• The late sodium current in heart failure: pathophysiology and clinical relevance

  2014influential citation
• This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon.

  2014cites this paper
• Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity

  2014cites this paper
• The late sodium current in heart failure: pathophysiology and clinical relevance: Late sodium current in heart failure

  2014cites this paper
• Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation.

  2014cites this paper
• Biophysics of Normal and Abnormal Cardiac Sodium Channel Function

  2014cites this paper
• Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

  2014cites this paper
• Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes.

  2013cites this paper
• [Ca2+]i-induced augmentation of the inward rectifier potassium current (IK1) in canine and human ventricular myocardium

  2013cites this paper
• Development of heart failure is independent of K+ channel‐interacting protein 2 expression

  2013influential citation
• The effect of SN-6, a novel sodium-calcium exchange inhibitor, on contractility and calcium handling in isolated failing rat ventricular myocytes.

  2013cites this paper
• Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity.

  2013cites this paper
• T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.

  2013cites this paper
• Redox Regulation of Sodium and Calcium Handling

  2013cites this paper
• High inborn aerobic capacity does not protect the heart following myocardial infarction.

  2013cites this paper
• The effect of biomimetic tissue engineering constructs on the phenotype of immature cardiomyocytes

  2013cites this paper
• New Insights into Mechanisms of Cardioprotection Mediated by Thyroid Hormones

  2013cites this paper
• Increased sarcolemmal Na+/H+ exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block

  2013cites this paper
• Nuclear Reprogramming and Stem Cells

  2012cites this paper
• Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy.

  2012cites this paper
• The Late Na+ Current - Origin and Pathophysiological Relevance

  2012cites this paper
• Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension.

  2012cites this paper
• Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

  2012cites this paper
• Dantrolene prevents arrhythmogenic Ca2+ release in heart failure.

  2012cites this paper
• No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium.

  2012cites this paper
• Na / Ca 2 exchanger-1 protects against systolic failure in the Akitains 2 model of diabetic cardiomyopathy via a CXCR 4 / NF-B pathway

  2012cites this paper
• Disease-Related Cardiac Troponins Alter Thin Filament Ca2+ Association and Dissociation Rates

  2012cites this paper
• Chapter 10 – Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network

  2012influential citation
• Role of the Na(+)/Ca(2+) exchanger on the development of diabetes mellitus and its chronic complications.

  2012cites this paper
• Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes.

  2012cites this paper
• Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway.

  2012cites this paper