Nutritional Immunology: A Multi-Dimensional Approach

Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare, and reproductive success of individual organisms [1], [2], and also has profound ecological and evolutionary implications [3]–[5]. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world [1]. Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease [6]. Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens, and commensals; (ii) host immunity is a complex, multi-dimensional trait; and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host's microbiota.

• Publication year

  2011

• Venue

  PLoS Pathogens

• Publication date

  2011-12-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.1371/journal.ppat.1002223PMID 22144886PMCID 3228798
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Understanding nutrition-immunity interactions requires a multi-dimensional framework that treats both nutrition and immunity as complex traits and accounts for direct and indirect pathways, including the microbiota.

  Confidence 0.97

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• Nutrition is presented as critical to immune defence, and both under-nutrition and over-nutrition are linked to impaired resistance to infection.

  Confidence 0.92

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review

• direct and indirect pathways

  interaction pathway, research theme

  The direct and indirect routes through which nutrition and immunity influence one another.

  Aliases: multiple pathways

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• host immunity

  biological system, research theme

  The host immune system treated as a complex trait with multiple dimensions relevant to nutrition.

  Aliases: immunity

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• immune defence

  biological process, research theme

  The host mechanisms discussed as protecting against pathogen infection.

  Aliases: immune defense

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• microbiota

  microbial community, research theme

  The host-associated microbial community considered as part of nutrition-immunity interactions.

  Aliases: commensal microbiota, symbiotic microbiota, host microbiota

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• multi-dimensional immunity

  conceptual framework, research theme

  Immunity viewed as a complex trait with multiple interacting components and scales.

  Aliases: complex multi-dimensional trait, multi-dimensional immune trait

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• multi-dimensional nutrition

  conceptual framework, research theme

  Nutrition viewed as a complex problem involving hosts, pathogens, and commensal organisms.

  Aliases: complex multi-dimensional nutrition, multi-dimensional problem

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• nutrition

  biological process, research theme

  Dietary intake and nutritional state considered as determinants of immune defence in the article.

  Aliases: diet

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• over-nutrition

  nutritional state, research theme

  A state of excessive nutrient intake, discussed here together with related metabolic disorders.

  Aliases: overnutrition, excess nutrition

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• under-nutrition

  nutritional state, research theme

  A state of insufficient nutrient intake, highlighted here for its importance in the context of infection.

  Aliases: undernutrition, protein deficiency

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewq (76h6bfydm6) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review

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