Inhibition of Xenogeneic Response in Porcine Endothelium Using RNA Interference

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Transplantation

• Publication date

  2005-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/01.TP.0000148733.57977.FDPMID 15699758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modification of xenoantigens on porcine erythrocytes for xenotransfusion.

  2004cited by this paper
• Improved suppression of circulating complement does not block acute vascular rejection of pig‐to‐rhesus monkey cardiac transplants

  2004cited by this paper
• Aberrant expression of alpha-Gal on primary human endothelium does not confer susceptibility to NK cell cytotoxicity or increased NK cell adhesion.

  2004influential reference
• Lack of Galactose-α-1,3-Galactose Expression on Porcine Endothelial Cells Prevents Complement-Induced Lysis but Not Direct Xenogeneic NK Cytotoxicity1

  2004cited by this paper
• Production of α1,3-Galactosyltransferase-Knockout Cloned Pigs Expressing Human α1,2-Fucosylosyltransferase1

  2003cited by this paper
• Production of alpha 1,3-galactosyltransferase-knockout cloned pigs expressing human alpha 1,2-fucosylosyltransferase.

  2003influential reference
• Porcine endothelium activated by anti-&agr;-GAL antibody binding mediates increased human neutrophil adhesion under flow

  2003cited by this paper
• Caspase 8 small interfering RNA prevents acute liver failure in mice

  2003cited by this paper
• Small RNA: can RNA interference be exploited for therapy?

  2003cited by this paper
• U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells

  2002cited by this paper
• Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs.

  2002cited by this paper
• Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning

  2002cited by this paper
• Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs

  2002cited by this paper
• Human NK Cell-Mediated Cytotoxicity Triggered by CD86 and Galα1,3-Gal Is Inhibited in Genetically Modified Porcine Cells1

  2002cited by this paper
• Stable suppression of tumorigenicity by virus-mediated RNA interference.

  2002cited by this paper
• Remodeling of the Major Pig Xenoantigen by N-Acetylglucosaminyltransferase III in Transgenic Pig*

  2001cited by this paper
• Frameshift and Nonsense Mutations in a Human Genomic Sequence Homologous to a Murine UDP-Gal:&D-Gal( 1,4)-D-GlcNAc CY( 1,3)-Galactosyltransferase cDNA*

  2001cited by this paper
• The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts.

  2000cited by this paper
• SPECIFIC DEPLETION OF PREFORMED IgM NATURAL ANTIBODIES BY ADMINISTRATION OF ANTI-&mgr; MONOCLONAL ANTIBODY SUPPRESSES HYPERACUTE REJECTION OF PIG TO BABOON RENAL XENOGRAFTS1

  2000cited by this paper
• Molecular Cloning of Endo-β-galactosidase C and Its Application in Removing α-Galactosyl Xenoantigen from Blood Vessels in the Pig Kidney*

  2000cited by this paper
• Masking and reduction of the Galactose-alpha1,3-Galactose (alpha-Gal) epitope, the major xenoantigen in swine, by the glycosyltransferase gene transfection.

  1999cited by this paper
• Masking and Reduction of the Galactose-α1,3-Galactose (α-Gal) Epitope, the Major Xenoantigen in Swine, by the Glycosyltransferase Gene Transfection

  1999cited by this paper
• Complement inhibition by FUT‐175 and K76‐COOH in a pig‐to‐human lung xenotransplant model

  1998cited by this paper
• Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

  1998cited by this paper
• Porcine alpha1,3-galactosyltransferase: tissue-specific and regulated expression of splicing isoforms.

  1997cited by this paper
• Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues.

  1997cited by this paper
• Selective IgM depletion prolongs organ survival in an ex vivo model of pig-to-human xenotransplantation.

  1996cited by this paper
• Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury

  1995influential reference
• Complement in organ transplantation. Contributions to inflammation, injury, and rejection.

  1995cited by this paper
• Cytolytic effect of human anti‐Gal IgM and complement on porcine endothelial cells: A kinetic analysis

  1994cited by this paper
• The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts.

  1994cited by this paper
• EFFECTS OF TRANSFECTED COMPLEMENT REGULATORY PROTEINS, MCP, DAF, AND MCP/DAF HYBRID, ON COMPLEMENT‐MEDIATED SWINE ENDOTHELIAL CELL LYSIS

  1994cited by this paper
• Characterization of porcine endothelial cell determinants recognized by human natural antibodies

  1994cited by this paper
• Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA.

  1990cited by this paper
• Endothelial cell antigens recognized by xenoreactive human natural antibodies.

  1990cited by this paper
• Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1----3Gal epitope in primates.

  1987cited by this paper

• Shiqian Shen, M.D., Recipient of the 2024 James E. Cottrell, M.D., Presidential Scholar Award

  2024cites this paper
• Genetically engineered pigs for xenotransplantation: Hopes and challenges

  2023cites this paper
• Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation

  2018cites this paper
• The Role of NK Cells in Pig-to-Human Xenotransplantation

  2017cites this paper
• Effects of interfering RNA of α-1,3-galactosyltransferase and nuclear factor-kappa B on cardiac xenotransplantation.

  2014cites this paper
• Successful suppression of endogenous α-1,3-galactosyltransferase expression by RNA interference in pig embryos generated in vitro.

  2012cites this paper
• Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement‐mediated lysis is associated with low expression of α‐Gal and high production of clusterin and CD59

  2010cites this paper
• Resistance to anti-xenogeneic response by combining alpha-Gal silencing with HO-1 upregulation.

  2008cites this paper
• Mechanism of Humoral and Cellular Immune Modulation Provided by Porcine Sertoli Cells

  2008cites this paper
• Somatic cell nuclear transfer in pigs: recent achievements and future possibilities.

  2007cites this paper
• Immunological research using RNA interference technology

  2007cites this paper
• Endothelial cell protection in xenotransplantation: looking after a key player in rejection

  2006cites this paper
• Induction of accommodation model by combined RNA interference targeting 1,3-galactosyltransferase gene and low-dose GS-IB4 lectin in vitro.

  2006cites this paper
• Human NK cells can lyse porcine endothelial cells independent of their expression of Galα(1,3)‐Gal and killing is enhanced by activation of either effector or target cells

  2006cites this paper
• Glycobiology relating to xenotransplantation

  2006cites this paper
• Modifying xenogeneic immune recognition and engraftment by genetic engineering

  2005cites this paper
• Reducing Gal expression on the pig organ – a retrospective review

  2005cites this paper
• Xenotransplantation Literature Update January–February, 2005

  2005cites this paper
• Developments in transgenic technology: applications for medicine.

  2005cites this paper
• Progress of xenotransplantation

  year unknowncites this paper