Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections.
Nanoparticle-based drug delivery systems: promising approaches against infections
Shweta Ranghar,P. Sirohi,P. Verma,V. Agarwal
Published 2013 in Brazilian Archives of Biology and Technology
ABSTRACT
PUBLICATION RECORD
- Publication year
2013
- Venue
Brazilian Archives of Biology and Technology
- Publication date
2013-11-19
- Fields of study
Medicine, Materials Science
- Identifiers
- External record
- Source metadata
Semantic Scholar
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- antimicrobial agents
Drugs or compounds used to inhibit or kill infectious microorganisms and delivered by nanoparticle carriers in the review.
Aliases: antimicrobial drugs, antimicrobial compounds
- antimicrobial nanoparticles
Nanoparticles with antimicrobial activity that are discussed as a class of infection-fighting materials.
Aliases: antimicrobial nanparticles, antimicrobial nano-particles
- infections
Infectious diseases targeted by the antimicrobial nanoparticle approaches discussed in the review.
Aliases: infectious diseases
- mechanism of action
The way antimicrobial nanoparticles exert effects on microbes, as discussed in the review.
Aliases: mode of action
- metal nanoparticles
Antimicrobial nanoparticles composed of metallic materials and included as one reviewed class.
Aliases: metal NPs
- metal oxide nanoparticles
Antimicrobial nanoparticles made from metal oxides and included as one reviewed class.
Aliases: metal oxide NPs
- nanoparticle-based drug delivery systems
Nanoscale carrier systems used to transport antimicrobial drugs to infection sites.
Aliases: nanoparticle drug delivery systems, nanosized drug delivery carriers, nanocarriers
REFERENCES
Showing 1-85 of 85 references · Page 1 of 1