From current immunosuppressive strategies to clinical tolerance of allografts

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Transplant International

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1432-2277.2006.00401.xPMID 17181648
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Retraction: Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control.

  2008cited by this paper
• Regulatory T cells in transplantation tolerance.

  2005cited by this paper
• Phenotypically and functionally distinct CD8+ lymphocyte populations in long-term drug-free tolerance and chronic rejection in human kidney graft recipients.

  2005cited by this paper
• Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

  2005cited by this paper
• Costimulation blockade with belatacept in renal transplantation.

  2005cited by this paper
• Operationally Tolerant and Minimally Immunosuppressed Kidney Recipients Display Strongly Altered Blood T‐Cell Clonal Regulation

  2005cited by this paper
• Rational Development of LEA29Y (belatacept), a High‐Affinity Variant of CTLA4‐Ig with Potent Immunosuppressive Properties

  2005influential reference
• Development of a Chimeric Anti-CD40 Monoclonal Antibody That Synergizes with LEA29Y to Prolong Islet Allograft Survival1

  2005cited by this paper
• Dendritic Cells: Tools and Targets for Transplant Tolerance

  2005cited by this paper
• Results from a Human Renal Allograft Tolerance Trial Evaluating T-Cell Depletion with Alemtuzumab Combined with Deoxyspergualin

  2005cited by this paper
• Chapter Title: Chronic graft loss. Immunological and non-immunological factors.

  2005cited by this paper
• Costimulation blockade with belatacept in renal transplantation.

  2005cited by this paper
• 2005 Immunosuppressive Strategies in Kidney Transplantation: Which Role for the Calcineurin Inhibitors?

  2005cited by this paper
• New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance.

  2004cited by this paper
• Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery1

  2004cited by this paper
• Analyses of Peripheral Blood Mononuclear Cells in Operational Tolerance After Pediatric Living Donor Liver Transplantation

  2004cited by this paper
• The role of b7 ligands (cd80 and cd86) in cd152-mediated allograft tolerance: a crosscheck hypothesis

  2004cited by this paper
• Commentary: Priming of alloreactive T cells – where does it happen?

  2004cited by this paper
• CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates

  2004cited by this paper
• Update in renal transplantation.

  2004cited by this paper
• The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials.

  2004cited by this paper
• Mixed chimerism and transplantation tolerance.

  2004cited by this paper
• Transplantation 50 years later--progress, challenges, and promises.

  2004cited by this paper
• Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.

  2004cited by this paper
• Homeostatic proliferation is a barrier to transplantation tolerance

  2004cited by this paper
• A Novel Pathway of Alloantigen Presentation by Dendritic Cells1

  2004cited by this paper
• Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation1

  2004cited by this paper
• RABBIT ANTITHYMOCYTE GLOBULIN INDUCTION AND SIROLIMUS MONOTHERAPY SUPPORTS PROLONGED ISLET ALLOGRAFT FUNCTION IN A NONHUMAN PRIMATE ISLET TRANSPLANTATION MODEL

  2003cited by this paper
• Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys1

  2003cited by this paper
• Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade

  2003cited by this paper
• Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection1

  2003cited by this paper
• The complementary roles of deletion and regulation in transplantation tolerance

  2003cited by this paper
• Kidney Transplantation Under a Tolerogenic Regimen of Recipient Pretreatment and Low-Dose Postoperative Immunosuppression With Subsequent Weaning

  2003cited by this paper
• Memory T cells: a hurdle to immunologic tolerance.

  2003cited by this paper
• Heterologous immunity: an overlooked barrier to tolerance

  2003cited by this paper
• Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.

  2003cited by this paper
• Immunologic monitoring

  2003cited by this paper
• Heterologous immunity provides a potent barrier to transplantation tolerance.

  2003cited by this paper
• Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1

  2002cited by this paper
• Strategies to improve long-term outcomes after renal transplantation.

  2002cited by this paper
• Innate immune recognition.

  2002cited by this paper
• Anti-CD154 monoclonal antibody and thromboembolism revisted.

  2002cited by this paper
• Mixed chimerism and immunosuppressive drug withdrawal after hla-mismatched kidney and hematopoietic progenitor transplantation1

  2002cited by this paper
• Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates.

  2002cited by this paper
• Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy.

  2002cited by this paper
• T Cells Primed by Leishmania major Infection Cross-React with Alloantigens and Alter the Course of Allograft Rejection1

  2002cited by this paper
• Induction Of Kidney Allograft Tolerance After Transient Lymphohematopoietic Chimerism In Patients With Multiple Myeloma And End-Stage Renal Disease1

  2002cited by this paper
• Allorecognition

  2001cited by this paper
• The contributions of T‐cell anergy to peripheral T‐cell tolerance

  2001cited by this paper
• Regulation of T cell immunity by dendritic cells.

  2001cited by this paper
• Mixed chimerism and transplant tolerance.

  2001cited by this paper
• Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models1

  2001cited by this paper
• Anti-CD154 monoclonal antibody and thromboembolism.

  2001cited by this paper
• Costimulation Blockade, Busulfan, and Bone Marrow Promote Titratable Macrochimerism, Induce Transplantation Tolerance, and Correct Genetic Hemoglobinopathies with Minimal Myelosuppression1

  2001cited by this paper
• Indirect Allorecognition of Mismatched Donor HLA Class II Peptides in Lung Transplant Recipients with Bronchiolitis Obliterans Syndrome

  2001cited by this paper
• Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy1

  2001cited by this paper
• THE ROLE OF THE ALLOGRAFT IN THE INDUCTION OF DONOR-SPECIFIC T CELL HYPORESPONSIVENESS

  2001cited by this paper
• INDUCTION THERAPY WITH MONOCLONAL ANTIBODIES SPECIFIC FOR CD80 AND CD86 DELAYS THE ONSET OF ACUTE RENAL ALLOGRAFT REJECTION IN NON-HUMAN PRIMATES1

  2001cited by this paper
• Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation.

  2001cited by this paper
• Phenotypic and functional analysis of T-cell recovery after anti-CD3 immunotoxin treatment for tolerance induction in rhesus macaques.

  2001cited by this paper
• Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy

  2001cited by this paper
• General health management and long-term care of the renal transplant recipient.

  2001cited by this paper
• Costimulatory blockade for induction of mixed chimerism and renal allograft tolerance in nonhuman primates.

  2001cited by this paper
• Dendritic cells in transplantation--friend or foe?

  2001cited by this paper
• Monotherapy with anti-CD40 ligand antibody (IDEC 131) for non-human primate allograft heart transplantation.

  2001cited by this paper
• Allorecognition. [Review] [29 refs]

  2001cited by this paper
• Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

  2000cited by this paper
• Reply to Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

  2000cited by this paper
• Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance1

  2000cited by this paper
• CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection1

  2000cited by this paper
• Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: absence of chronic allograft nephropathy.

  2000cited by this paper
• Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

  2000cited by this paper
• Evidence for thymic function in the elderly.

  2000cited by this paper
• Long-term complications in renal transplantation.

  2000cited by this paper
• Clinical transplantation tolerance twelve years after prospective withdrawal of immunosuppressive drugs: studies of chimerism and anti-donor reactivity.

  2000cited by this paper
• Recipients With Chronic Rejection Significant Frequencies of T Cells With Indirect Anti-Donor Specificity in Heart Graft

  2000cited by this paper
• Prevention of renal allograft rejection in primates by blocking the B7/CD28 pathway.

  1999cited by this paper
• Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

  1999cited by this paper
• Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice.

  1999cited by this paper
• Immunosuppressive strategies in transplantation.

  1999cited by this paper
• Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.

  1999cited by this paper
• T cell co-stimulatory molecules other than CD28.

  1999cited by this paper
• Direct and indirect recognition: the role of MHC antigens in graft rejection.

  1999cited by this paper
• The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.

  1999influential reference
• Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.

  1999cited by this paper
• Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance.

  1999cited by this paper
• Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

  1999cited by this paper
• Natural adjuvants: Endogenous activators of dendritic cells

  1999cited by this paper
• Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients.

  1999cited by this paper
• A very high level of crossreactivity is an essential feature of the T-cell receptor.

  1998cited by this paper
• Inhaled nitric oxide and heparin for infantile primary pulmonary hypertension.

  1998cited by this paper
• Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts.

  1998cited by this paper
• Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans.

  1998cited by this paper
• Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control.

  1998cited by this paper
• The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells

  1998cited by this paper
• Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance

  1998cited by this paper
• The role of T-cell costimulatory activation pathways in transplant rejection.

  1998cited by this paper
• Tolerance induction with CD4 monoclonal antibodies.

  1998cited by this paper
• Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen.

  1998cited by this paper
• Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine.

  1998cited by this paper

• Novel cell-based strategies for immunomodulation in vascularized composite allotransplantation

  2023cites this paper
• Immunosuppression Monitoring-What Clinician Needs to Know?

  2023cites this paper
• Kidney Transplant-Immunosuppression and Rejection

  2018cites this paper
• Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective

  2017cites this paper
• Immunosuppressive Effects of Bryoria sp. (Lichen-Forming Fungus) Extracts via Inhibition of CD8+ T-Cell Proliferation and IL-2 Production in CD4+ T Cells.

  2017cites this paper
• What Is Direct Allorecognition?

  2016cites this paper
• Analysis and monitoring of anti-HLA antibodies in solid-organ and stem cell transplantation : What to do? When should they be tested?

  2015cites this paper
• Synthesis and biological evaluation of pseudolaric acid B derivatives as potential immunosuppressive agents

  2015cites this paper
• Immune tolerance and immunosuppression in solid organ transplantation.

  2014cites this paper
• Lung transplantation: chronic allograft dysfunction and establishing immune tolerance.

  2014cites this paper
• Decellularisation and characterisation of porcine bone-medial meniscus-bone

  2014influential citation
• Engineering Immune Responses to Allografts

  2014cites this paper
• Mixed chimerism induction influences cytokine release from chimeric mice cells.

  2013cites this paper
• Amnion‐Derived Multipotent Progenitor Cells Support Allograft Tolerance Induction

  2013cites this paper
• Bone Marrow Lin-/Sca-1+/C-Kit+ and Lin-/Sca-1-/C-Kit+ cells Induce Stable Mixed Chimerism and Permanent Skin Graft Acceptance in a Mouse Model

  2013cites this paper
• The role of genetics in drug dosing

  2012cites this paper
• Immunosuppressive effects of ginsenoside-Rd on skin allograft rejection in rats.

  2012cites this paper
• Emerging Role of Pharmacogenetic in Organ Transplantation

  2012cites this paper
• Tolerance-Inducing Immunosuppressive Strategies in Clinical Transplantation

  2012cites this paper
• Vitamin D3 modulates T lymphocyte responses in hepatitis C virus-infected liver transplant recipients.

  2012cites this paper
• Metabolic Pathways as Possible Targets for a Pharmacogenetic Strategy

  2012cites this paper
• In vitro and in vivo proof of tolerance after two-step haploidentical bone marrow and kidney transplantation of the same donor.

  2012cites this paper
• Different strategies of mixed chimerism induction may determine stem/progenitor cell populations in recipient mice.

  2012cites this paper
• Potential of T-regulatory cells to protect xenografts

  2012cites this paper
• Effects of chimerism on the mice heart transplanted survival with the bone marrow infusion.

  2011cites this paper
• Enantioselective Total Synthesis of (–)‐Subglutinols A and B: Potential Immunosuppressive Agents Isolated from a Microorganism

  2011cites this paper
• Transplant long-surviving induced by CD40-CD40 ligand costimulation blockade is dependent on IFN-γ through its effect on CD4(+)CD25(+) regulatory T cells.

  2011cites this paper
• Regulation of HLA class II expression prevents allogeneic T-cell responses.

  2011cites this paper
• Anti-CD154 mAb and Rapamycin Induce T Regulatory Cell Mediated Tolerance in Rat-to-Mouse Islet Transplantation

  2010cites this paper
• Donor-Reactive T-cell Responses after HLA-Identical Living-Related Kidney Transplantation

  2010cites this paper
• The new immunosuppressant PLNPK prolongs allograft survival in mice.

  2010cites this paper
• An optimization of protocol for mixed chimerism induction in mice model.

  2010cites this paper
• Investigation of the Regenerative Capacity of an Acellular Porcine Medial Meniscus for Tissue Engineering Applications

  2010cites this paper
• Current progress in pharmacogenetics and individualized immunosuppressive drug dosing in organ transplantation.

  2010cites this paper
• Effect of lentivirus expressing TLR4 shRNA on function of rat alveolar macrophage: Effect of lentivirus expressing TLR4 shRNA on function of rat alveolar macrophage

  2010cites this paper
• Synthesis, immunosuppressive activity and structure-activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues.

  2010cites this paper
• Experimental uterus transplantation.

  2010cites this paper
• Pathogen-induced immune regulation in transplantation

  2010cites this paper
• Minimization of steroids in liver transplantation

  2009cites this paper
• Transplantation tolerance induced by regulatory T cells: in vivo mechanisms and sites of action.

  2009cites this paper
• The immunological monitoring of kidney and liver transplants in adult and pediatric recipients.

  2009cites this paper
• Hurdles to the Induction of Tolerogenic Mixed Chimerism

  2009cites this paper
• Mitomycin C-treated antigen-presenting cells as a tool for control of allograft rejection and autoimmunity: from bench to bedside.

  2009cites this paper
• Deficient TNF-α and IFN-γ Production Correlates With Nondetectable Donor-Specific Cytotoxicity After Clinical Kidney Transplantation

  2009cites this paper
• Cold Ischemia Does Not Interfere With Tolerance Induction

  2009cites this paper
• Induction of mixed chimerism in mice by employing different conditioning protocols and bone marrow cell transplantation.

  2009cites this paper
• Immune profiling of operational tolerance in liver transplantation

  2009cites this paper
• A Prospective, Randomized Study to Compare the Effect of Combination Therapy With Campath-1H on Peripheral Blood Mononuclear Cells in Kidney Transplant Recipients

  2009cites this paper
• Monotherapy rapamycin allows an increase of CD4+ CD25bright+ FoxP3+ T cells in renal recipients

  2009cites this paper
• A cell‐based approach to the minimization of immunosuppression in renal transplantation

  2008cites this paper
• Role of resident macrophages in the immunologic response and smooth muscle dysfunction during acute allograft rejection after intestinal transplantation

  2008cites this paper
• Influència del microquimerisme hematopoètic en l'establiment del rebuig en transplantaments d'òrgans sòlids

  2008influential citation
• Functional analysis of CD4+ CD25bright T cells in kidney transplant patients: improving suppression of donor‐directed responses after transplantation

  2008cites this paper
• Tacrolimus Monotherapy in Liver Transplantation: One-Year Results of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study

  2008cites this paper
• Immunomodulation and Allogeneic Blood Transfusion

  2008cites this paper
• Tolerance-inducing immunosuppressive strategies in clinical transplantation: an overview.

  2008cites this paper
• CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.

  2007cites this paper
• Uterus transplantation - substantial progress in research but not yet ready for the clinic

  2007cites this paper
• Células T reguladoras y tolerancia en trasplante: Efecto de la inmunosupresión farmacológica

  2007cites this paper
• Recent advances in immune modulation.

  2007cites this paper
• Host T cells affect donor T cell engraftment and graft-versus-host disease after reduced-intensity hematopoietic stem cell transplantation.

  2007cites this paper