Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal Kv7 Channels

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2005-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1124/JPET.105.083923PMID 15814569
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002influential reference
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  2001influential reference
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  2001influential reference
• Differential Expression of Genes Encoding Subthreshold-Operating Voltage-Gated K+ Channels in Brain

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• KCNQ potassium channels: physiology, pathophysiology, and pharmacology.

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  1998cited by this paper
• Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy*

  1998cited by this paper
• From normal fear to pathological anxiety.

  1998cited by this paper
• A potassium channel mutation in neonatal human epilepsy.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Stable expression of the human large-conductance Ca2+-activated K+ channel alpha- and beta-subunits in HEK293 cells.

  1997cited by this paper
• Preparation of 3-fluoro oxindole derivatives

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

  1996cited by this paper
• Effects of 5-HT1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat

  1996cited by this paper
• Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

  1994cited by this paper
• Muscarinic inhibition of M‐current and a potassium leak conductance in neurones of the rat basolateral amygdala.

  1992cited by this paper
• The role of the amygdala in fear and anxiety.

  1992cited by this paper
• Benzodiazepines, putative anxiolytics and animal models of anxiety.

  1991cited by this paper
• Scheduling positive reinforcers

  1991cited by this paper
• Brainstem Control of Wakefulness and Sleep

  1990cited by this paper
• Effects of Nucleus Basalis Magnocellularis Lesions in Rats on Delayed Matching and Non-Matching to Position Tasks.

  1989cited by this paper
• Effects of Nucleus Basalis Magnocellularis Lesions in Rats on Delayed Matching and Non‐Matching to Position Tasks

  1989cited by this paper
• Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice.

  1986influential reference
• Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

  1980cited by this paper
• Modification of seizure activity by electrical stimulation. I. After-discharge threshold.

  1972cited by this paper
• Modification of seizure activity by electrical stimulation. 3. Mechanisms.

  1972cited by this paper
• Modification of seizure activity by electrical stimulation. II. Motor seizure.

  1972cited by this paper
• Pre-clinical drug evaluation and method development.

  1969cited by this paper

• Coordinated excitatory and inhibitory circuits governing unpredictable threat-induced anxiety.

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• Structure basis for the activation of KCNQ2 by endogenous and exogenous ligands.

  2025cites this paper
• A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors

  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023influential citation
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  2023influential citation
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• Pharmacological Evaluation of Drugs in Animal Models of Tinnitus.

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  2013cites this paper
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  2013cites this paper
• [Retigabine - a new antiepileptic drug with a different mechanism of action].

  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012influential citation
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  2012cites this paper
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  2012cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper