Immunometabolism governs dendritic cell and macrophage function

In this review, O’Neill and Pearce discuss recent intriguing findings on metabolic changes regulating the function of macrophages and dendritic cells.

• Publication year

  2016

• Venue

  Journal of Experimental Medicine

• Publication date

  2016-01-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20151570PMID 26694970PMCID 4710204
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Abolition of mitochondrial substrate‐level phosphorylation by itaconic acid produced by LPS‐induced Irg1 expression in cells of murine macrophage lineage

  2016cited by this paper
• mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.

  2015cited by this paper
• Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

  2015cited by this paper
• High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells

  2015cited by this paper
• Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.

  2015cited by this paper
• Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.

  2015cited by this paper
• T cell metabolism drives immunity

  2015cited by this paper
• ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

  2015cited by this paper
• Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.

  2015cited by this paper
• Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.

  2015cited by this paper
• Glycolysis and the significance of lactate in traumatic brain injury

  2015cited by this paper
• Metabolic reprogramming in macrophages and dendritic cells in innate immunity

  2015cited by this paper
• Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

  2015cited by this paper
• The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

  2014cited by this paper
• Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

  2014cited by this paper
• TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

  2014cited by this paper
• Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

  2014cited by this paper
• Adiponectin receptor signaling on dendritic cells blunts antitumor immunity.

  2014cited by this paper
• Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

  2014cited by this paper
• Dendritic cell metabolism

  2014cited by this paper
• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  2014cited by this paper
• Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

  2014cited by this paper
• Metabolic Reprograming in Macrophage Polarization

  2014cited by this paper
• Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation

  2014cited by this paper
• Metabolic pathways in immune cell activation and quiescence.

  2013cited by this paper
• Succinate is an inflammatory signal that induces IL-1β through HIF-1α

  2013cited by this paper
• Metabolism of inflammation limited by AMPK and pseudo-starvation

  2013cited by this paper
• Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid

  2013cited by this paper
• Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells

  2013cited by this paper
• Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

  2013cited by this paper
• Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions

  2013cited by this paper
• Rapamycin and omega‐1: mTOR‐dependent and ‐independent Th2 skewing by human dendritic cells

  2013cited by this paper
• AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

  2013cited by this paper
• TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.

  2013cited by this paper
• The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

  2012cited by this paper
• Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice

  2012cited by this paper
• Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury.

  2012cited by this paper
• mTOR, metabolism, and the regulation of T‐cell differentiation and function

  2012cited by this paper
• A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

  2012cited by this paper
• Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

  2012cited by this paper
• Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

  2012cited by this paper
• Alternative macrophage activation and metabolism.

  2011cited by this paper
• The mitochondrial citrate carrier: a new player in inflammation.

  2011cited by this paper
• Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.

  2010cited by this paper
• TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

  2010cited by this paper
• Dendritic cells treated with resveratrol during differentiation from monocytes gain substantial tolerogenic properties upon activation

  2010cited by this paper
• A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation

  2010cited by this paper
• Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

  2010cited by this paper
• Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

  2008cited by this paper
• Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

  2008influential reference
• Hypoxia and Hypoxia-Inducible Factor-1α Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function1

  2008cited by this paper
• ERRalpha: a metabolic function for the oldest orphan.

  2008cited by this paper
• Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.

  2006cited by this paper
• Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1

  1996cited by this paper
• Dexamethasone enhances expression of mitochondrial oxidative phosphorylation genes in rat distal colon.

  1995cited by this paper
• Endotoxin-Induced Enhancement of Glucose Influx into Murine Peritoneal Macrophages via GLUT1

  1995cited by this paper
• Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages.

  1986cited by this paper
• CHANGES IN THE METABOLIC PATTERN OF POLYMORPHO-NUCLEAR LEUCOCYTES DURING PHAGOCYTOSIS.

  1964cited by this paper
• METABOLIC PATTERNS IN THREE TYPES OF PHAGOCYTIZING CELLS

  1963cited by this paper
• [Metabolism of leukocytes].

  1958cited by this paper
• Stoffwechsel der weißen Blutzellen

  1958cited by this paper
• Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI ( 3 ) K-mTOR-p 70 S 6 K pathway

  year unknowncited by this paper

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  2026cites this paper
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  2026cites this paper
• ¹H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis

  2026cites this paper
• Emerging frontiers in the mitochondrial regulation of dendritic cell biology

  2026cites this paper
• Post-Transplant Sepsis After Liver Transplantation: Clinical Characteristics and Therapeutic Challenges

  2026cites this paper
• MitoTex (Mitochondria Texture Analysis User Interface): Open-Source Framework for Textural Characterization and Classification of Mitochondrial Structures

  2026cites this paper
• Beyond inflammation: metabolic implications of biological and TsDMARD therapies in dermatologic and rheumatologic diseases.

  2026cites this paper
• Advances in artificial metabzymes for macrophage polarization in tumor metabolic immunotherapy.

  2026cites this paper
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• Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer

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• Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty

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• Macrophage reprogramming and functional plasticity in sepsis

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• Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

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  2026cites this paper
• Monocyte/macrophage-mediated trained immunity in disease prevention and immunotherapy

  2026cites this paper
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  2026cites this paper
• Assessing Intracellular Metabolism of Immune Cells In Situ in Live Zebrafish Larvae by Autofluorescence Lifetime Imaging Microscopy of NAD(P)H and FAD.

  2026cites this paper
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  2026cites this paper
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  2026cites this paper
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  2026cites this paper
• Suppression of electron transport chain Complex III assembly is an adaptive mechanism to reduce host inflammation during viral infection

  2026influential citation
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• Illustrating the functional heterogeneity of M-MDSCs to predict sepsis outcomes.

  2026cites this paper
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  2025cites this paper
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  2025cites this paper
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