Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Neuroscience

• Publication date

  1997-06-06

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0306-4522(97)00037-7PMID 9219966
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Local cerebral glucose utilisation following acute and chronic bilateral carotid artery ligation in Wistar rats: relation to changes in local cerebral blood flow

  2004cited by this paper
• Neuronal damage and decrease of central acetylcholine level following permanent occlusion of bilateral common carotid arteries in rat.

  1995cited by this paper
• Effect of white matter disease on functional connections in the aging brain.

  1994cited by this paper
• Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats.

  1994cited by this paper
• Differential effects of transient occlusion of common carotid arteries in normotensive rats on the somatosensory and visual system.

  1994cited by this paper
• Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study

  1994cited by this paper
• The interaction between central cholinergic and peripheral beta-adrenergic systems on radial maze performance in rats.

  1993cited by this paper
• Metabolic changes during and after transient clamping of carotid arteries in normotensive rats.

  1993cited by this paper
• Light and biological rhythms

  1992cited by this paper
• Cerebral blood flow and its relationship with severity of dementia in patients with multi-infarct dementia and in those with dementia of Alzheimer type.

  1992cited by this paper
• The Calcium Antagonist Nisoldipine Improves the Functional Recovery of Reperfused Myocardium Only When Given Before Ischemia

  1992cited by this paper
• Measurement of Regional Myocardial Blood Flow With Multiple Colored Microspheres*

  1991cited by this paper
• Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins.

  1990cited by this paper
• Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats.

  1989cited by this paper
• Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress.

  1989cited by this paper
• Brain distribution of idebenone and its effect on local cerebral glucose utilization in rats.

  1989cited by this paper
• Effects of idebenone and related compounds on respiratory activities of brain mitochondria, and on lipid peroxidation of their membranes.

  1989cited by this paper
• Inhibition of lipid peroxidation by idebenone in brain mitochondria in the presence of succinate.

  1989cited by this paper
• Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia.

  1989cited by this paper
• Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.

  1989cited by this paper
• Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia.

  1989cited by this paper
• Regional cerebral blood flow in chronic stroke patients with dementia.

  1988cited by this paper
• Focal cerebral hypoperfusion and selective cognitive deficit in dementia of the Alzheimer type.

  1987cited by this paper
• Cerebral blood flow in severity‐matched Alzheirner and multi‐infarct patients

  1987cited by this paper
• Characteristics of memory impairment following lesioning of the basal forebrain and medial septal nucleus in rats.

  1987cited by this paper
• A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study

  1986cited by this paper
• Decreased cerebral blood flow precedes multi‐infarct dementia, but follows senile dementia of Alzheimer type

  1986cited by this paper
• EXPERIMENTAL BILATERAL CAROTID ARTERY OCCLUSION: A STUDY OF THE OPTIC NERVE IN THE RAT

  1984cited by this paper
• Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain

  1984cited by this paper
• Spatial Localization Does Not Require the Presence of Local Cues

  1981cited by this paper
• Hippocampus, space, and memory

  1979cited by this paper
• Long-term prognosis in stroke related to cerebral blood flow.

  1977cited by this paper
• Remembrance of places passed: Spatial memory in rats.

  1976cited by this paper
• Cerebral blood flow in dementia.

  1975cited by this paper

• The Bidirectional Role of Hypoxia-Inducible Factor 1 Alpha in Vascular Dementia Caused by Chronic Cerebral Hypoperfusion

  2025cites this paper
• Stroke risk management in carotid atherosclerotic disease: A Clinical Consensus Statement of the ESC Council on Stroke and the ESC Working Group on Aorta and Peripheral Vascular Diseases.

  2023cites this paper
• Remote Ischemic Conditioning: A Potential Treatment for Chronic Cerebral Hypoperfusion

  2022cites this paper
• Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors.

  2021cites this paper
• Submitted to Neurochem int potential therapeutic agents for ischemic white matter damage.

  2021cites this paper
• The Impact of SARS-CoV-2 Infection on the Development of Neurodegeneration in Multiple Sclerosis

  2021cites this paper
• Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits.

  2021cites this paper
• Time-dependent effects of platelet-rich plasma on the memory and hippocampal synaptic plasticity impairment in vascular dementia induced by chronic cerebral hypoperfusion.

  2020cites this paper
• Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis

  2020cites this paper
• Combined structural and diffusion tensor imaging detection of ischemic injury in moyamoya disease: relation to disease advancement and cerebral hypoperfusion.

  2020cites this paper
• The nootropic and anticholinesterase activities of Clitoria ternatea Linn. root extract: Potential treatment for cognitive decline.

  2020cites this paper
• The protective effect of Thai Herbal Sahatsatara formula against white matter injury after chronic cerebral hypoperfusion in middle-aged rats

  2020cites this paper
• 3′-Daidzein Sulfonate Sodium Protects Against Chronic Cerebral Hypoperfusion-Mediated Cognitive Impairment and Hippocampal Damage via Activity-Regulated Cytoskeleton-Associated Protein Upregulation

  2019cites this paper
• Cranial burr hole with erythropoietin administration induces reverse arteriogenesis from the enriched extracranium.

  2019cites this paper
• Huoluo Yinao decoction mitigates cognitive impairments after chronic cerebral hypoperfusion in rats.

  2019cites this paper
• A Rodent Model for Chronic Brain Hypoperfusion Related Diseases: Permanent Bilateral Occlusion of the Common Carotid Arteries (2VO) in Rats.

  2018cites this paper
• An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells

  2018cites this paper
• Gradual common carotid artery occlusion as a novel model for cerebrovascular Hypoperfusion

  2018cites this paper
• Stepwise occlusion of the carotid arteries of the rat: MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes

  2018cites this paper
• Scutellarin Ameliorates Learning and Memory Deficit via Suppressing β-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion.

  2018cites this paper
• Common Carotid Arteries Occlusion Surgery in Adult Rats as a Model of Chronic Cerebral Hypoperfusion.

  2018cites this paper
• 3′-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused by chronic cerebral hypoperfusion

  2018cites this paper
• The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats

  2017cites this paper
• Oral administration of grape seed polyphenol extract restores memory deficits in chronic cerebral hypoperfusion rats

  2017cites this paper
• Animal Models for Ischemic Stroke

  2017cites this paper
• (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

  2017cites this paper
• Cinepazide Maleate Improves Cognitive Function and Protects Hippocampal Neurons in Diabetic Rats with Chronic Cerebral Hypoperfusion.

  2017cites this paper
• The impact of early aerobic exercise on brain microvascular alterations induced by cerebral hypoperfusion.

  2017influential citation
• Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion

  2017cites this paper
• Bilateral Common Carotid Artery Ligation in Sheep. Could These Animals be Used as Human Models for Vascular and Cerebral Research?

  2017cites this paper
• Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice

  2017cites this paper
• University of Groningen Permanent , bilateral common carotid artery occlusion in the rat

  2017influential citation
• Strategy for Comprehensive Profiling and Identification of Acidic Glycosphingolipids Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry.

  2017cites this paper
• Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

  2016cites this paper
• The pathophysiological role of astrocytic endothelin-1.

  2016cites this paper
• Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKA/CREB Signaling Pathway in Cerebral Hypoperfusion

  2016cites this paper
• Necrostatin-1 Attenuates Inflammatory Response and Improves Cognitive Function in Chronic Ischemic Stroke Mice

  2016cites this paper
• EPCs-Collagen Sponge Complex Promotes Neovascularization of Chronic Cerebral Ischemia following Multiple Burr Hole (MBH) Surgery

  2016cites this paper
• Effect of exercise-induced neurogenesis on cognitive function deficit in a rat model of vascular dementia

  2016cites this paper
• Bilateral common carotid artery stenosis in normotensive rats impairs endothelium-dependent dilation of parenchymal arterioles.

  2016cites this paper
• Induction of Genes Expressed in Endothelial Cells of the Corpus Callosum in the Chronic Cerebral Hypoperfusion Rat Model

  2016cites this paper
• (-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat Model

  2016cites this paper
• Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring.

  2016cites this paper
• Microparticles generated during chronic cerebral ischemia increase the permeability of microvascular endothelial barriers in vitro.

  2016cites this paper
• Impairment of intradimensional shift in an attentional set-shifting task in rats with chronic bilateral common carotid artery occlusion.

  2016cites this paper
• Neurocognitive Improvement in Patients Undergoing Carotid Endarterectomy for Atherosclerotic Occlusive Carotid Artery Disease.

  2016cites this paper
• Cilostazol reduces blood brain barrier dysfunction, white matter lesion formation and motor deficits following chronic cerebral hypoperfusion.

  2016cites this paper
• Involuntary, Forced and Voluntary Exercises Equally Attenuate Neurocognitive Deficits in Vascular Dementia by the BDNF–pCREB Mediated Pathway

  2015influential citation
• Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling

  2015cites this paper
• Cilostazol but not sildenafil prevents memory impairment after chronic cerebral hypoperfusion in middle-aged rats.

  2015cites this paper
• Effects on locomotion and memory in 2 models of cerebral hypoperfusion in male Wistar rats

  2015cites this paper
• Vascular Cognitive Impairment

  2015cites this paper
• Ignoring floor and ceiling effects may underestimate the effect of carotid artery stenting on cognitive performance

  2015cites this paper
• Effects on locomotion and memory in 2 models of cerebral hypoperfusion in male Wistar rats.

  2015cites this paper
• Blood Brain Barrier Dysfunction in Chronic Cerebral Ischemia

  2015cites this paper
• Lessons learned from animal models of vascular cognitive impairment

  2015cites this paper
• Ameliorating the Effect of Astragaloside IV on Learning and Memory Deficit after Chronic Cerebral Hypoperfusion in Rats

  2015cites this paper
• Comparison of cognitive performance between two rat models of vascular dementia

  2014cites this paper
• Effects of Polygalae Radix on β-Amyloid Accumulation and Memory Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

  2014influential citation
• Postural Effects on Brain Blood Flow and Cognition in Heart Failure

  2014cites this paper
• Inflammation and White Matter Injury in Animal Models of Ischemic Stroke

  2014cites this paper
• Effects of Fructusmume Extract onMAPK and NF-κ B Signaling and the Resultant Improvement in the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion

  2014cites this paper
• Apoptosis Signal–Regulating Kinase 1 Is a Novel Target Molecule for Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

  2014cites this paper
• Change of Nrf2 expression in rat hippocampus in a model of chronic cerebral hypoperfusion

  2014cites this paper
• Long-Term Vision and Non-Vision Dominant Behavioral Deficits in the 2-VO Rats Are Accompanied by Time and Regional Glial Activation in the White Matter

  2014cites this paper
• Vulnerability of white matter structure and function to chronic cerebral hypoperfusion and the effects of pharmacological modulation

  2014cites this paper
• Neuronal damage of the dorsal hippocampus induced by long-term right common carotid artery occlusion in rats

  2014cites this paper
• A Cognitive Rehabilitation Paradigm Effective in Male Rats Lacks Efficacy in Female Rats

  2014cites this paper
• Animal models of vascular dementia: translational potential at the present time and in 2050

  2014cites this paper
• Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1

  2013cites this paper
• Neurohistological and behavioral changes following the four-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion: comparison between normotensive and spontaneously hypertensive rats.

  2013cites this paper
• PI3K/Akt Signal Pathway Involved in the Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion in Rats

  2013cites this paper
• Case reports – common and external carotid artery resection in head and neck cancer patients

  2013cites this paper
• The Ins and Outs of the BCCAo Model for Chronic Hypoperfusion: A Multimodal and Longitudinal MRI Approach

  2013cites this paper
• Effects of Yangxue Qingnao Granules on chronic cerebral circulation insufficiency: a randomized, double‐blind, double‐dummy, controlled multicentre trial

  2013cites this paper
• Transient elevation of synaptosomal mitoenergetic proteins and Hsp70 early in a rat model of chronic cerebrovascular hypoperfusion

  2013cites this paper
• Cerebral hypoperfusion in the rat and its consequences

  2013influential citation
• Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats.

  2013cites this paper
• Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats.

  2013cites this paper
• Bilateral internal carotid arteries ligation temporary impairs brain vasculaturev in young rats.

  2013cites this paper
• Bone-marrow cell therapy induces differentiation of radial glia-like cells and rescues the number of oligodendrocyte progenitors in the subventricular zone after global cerebral ischemia.

  2013cites this paper
• Learning and survival memory undergoing a permanent bilateral carotid ligation in rats.

  2013cites this paper
• Effects of Fructus mume Extract on MAPK and NF-κB Signaling and the Resultant Improvement in the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion

  2012influential citation
• Decreased cerebral perfusion and oxidative stress result in acute and delayed cognitive impairment.

  2012cites this paper
• Forced treadmill exercise prevents oxidative stress and memory deficits following chronic cerebral hypoperfusion in the rat.

  2012cites this paper
• Impairments in Cognitive Function and Brain Connectivity in Severe Asymptomatic Carotid Stenosis

  2012cites this paper
• Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion

  2012cites this paper
• Effects of Altered Cerebral Hemodynamics on Cognitive Function

  2012cites this paper
• Pre-clinical models of human cerebral small vessel disease: utility for clinical application.

  2012cites this paper
• Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat.

  2012cites this paper
• Dendritic morphology of neurons in medial prefrontal cortex and hippocampus in 2VO rats

  2012cites this paper
• Carotid stenting improves cognitive function in asymptomatic cerebral ischemia.

  2012cites this paper
• Efeito neuroprotetor do resveratrol no modelo de demência por hipoperfusão encefálica crônica em ratos

  2012cites this paper
• Cerebral Hypoperfusion and Cognitive Impairment: The Pathogenic Role of Vascular Oxidative Stress

  2012cites this paper
• Time-course of neurodegeneration and memory impairment following the 4-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion in middle-aged rats.

  2012cites this paper
• Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes

  2011cites this paper
• Evaluation von Veränderungen der kognitiven Geschwindigkeit nach Stentangioplastie mittels funktioneller Kernspintomographie (fMRT)

  2011cites this paper
• Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments.

  2011cites this paper
• The Neuroprotective Effect of Methanol Extract of Gagamjungjihwan and Fructus Euodiae on Ischemia-Induced Neuronal and Cognitive Impairment in the Rat

  2011cites this paper
• Alternations of Septal-hippocampal System in the Adult Wistar Rat with Spatial Memory Impairments Induced by Chronic Cerebral Hypoperfusion

  2011influential citation