Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Journal of the American Medical Association (JAMA)

• Publication date

  1997-06-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1001/JAMA.1997.03540460039030PMID 9178790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biological chemistry of thiols in the vasculature and in vascular-related disease.

  2009cited by this paper
• Homocysteine, a risk factor for cardiovascular disease

  1999cited by this paper
• Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group.

  1998cited by this paper
• Plasma Homocysteine and Coronary Heart Disease: Systematic Review of Published Epidemiological Studies

  1998cited by this paper
• Glutathione: an overview of biosynthesis and modulation.

  1998cited by this paper
• Plasma homocysteine levels and mortality in patients with coronary artery disease.

  1997cited by this paper
• Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study.

  1997cited by this paper
• Homocysteine, oxidative stress, and vascular disease.

  1997cited by this paper
• Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.

  1996cited by this paper
• Homocysteine species as components of plasma redox thiol status.

  1995cited by this paper
• Reduced, free and total fractions of homocysteine and other thiol compounds in plasma from patients with renal failure.

  1995cited by this paper
• Plasma homocysteine in acute myocardial infarction: homocysteine‐lowering effect of folic acid

  1995cited by this paper
• Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study.

  1995cited by this paper
• Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis.

  1995cited by this paper
• Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease. Homocysteine and peripheral vascular disease.

  1995cited by this paper
• Serum total homocysteine and coronary heart disease.

  1995cited by this paper
• A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.

  1995cited by this paper
• Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men.

  1995cited by this paper
• Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from the NHLBI Family Heart Study.

  1995cited by this paper
• Plasma homocysteine in the acute and convalescent phases after stroke.

  1995cited by this paper
• 802-5 High Homocysteine Concentrations: An Independent Risk Factor for Coronary Atherosclerosis in Women

  1995cited by this paper
• Homocysteine and cysteine: determinants of plasma levels in middle‐aged and elderly subjects

  1994cited by this paper
• Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease.

  1994cited by this paper
• Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.

  1994cited by this paper
• Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study.

  1994cited by this paper
• A Prospective Study of Plasma Homocyst(e)ine and Risk of Ischemic Stroke

  1994cited by this paper
• Homocysteine metabolism and the oxidative modification of proteins and lipids.

  1993cited by this paper
• Atherosclerotic Cardiovascular Disease, Hemostasis and Endothelial Function

  1993cited by this paper
• Redox status and protein binding of plasma aminothiols during the transient hyperhomocysteinemia that follows homocysteine administration.

  1993cited by this paper
• Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.

  1993cited by this paper
• Homocysteine and other thiols in plasma and urine: automated determination and sample stability.

  1993cited by this paper
• Vitamin status and intake as primary determinants of homocysteinemia in an elderly population.

  1993cited by this paper
• Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia.

  1993cited by this paper
• A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians.

  1992cited by this paper
• The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease.

  1991cited by this paper
• Homocysteine as a risk factor for cardiovascular disease.

  1991cited by this paper
• Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment.

  1990cited by this paper
• Estimating the benefits of cholesterol lowering: are risk factors for coronary heart disease multiplicative?

  1990cited by this paper
• DNA polymerase delta: A second eukaryotic DNA replicase

  1990cited by this paper
• Inherited disorders of vitamin B12 utilization

  1990cited by this paper
• Fully automated fluorescence assay for determining total homocysteine in plasma.

  1989cited by this paper
• Plasma homocysteine and methionine tolerance in early-onset vascular disease.

  1989cited by this paper
• Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects.

  1989cited by this paper
• Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

  1988cited by this paper
• Higher total plasma homocysteine in vitamin B12 deficiency than in heterozygosity for homocystinuria due to cystathionine beta-synthase deficiency.

  1988cited by this paper
• [The homocysteine theory of arteriosclerosis].

  1988cited by this paper
• Inherited defects of vitamin B12 metabolism.

  1987cited by this paper
• The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

  1987cited by this paper
• Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor.

  1987cited by this paper
• An insight on the use of multiple logistic regression analysis to estimate association between risk factor and disease occurrence.

  1986cited by this paper
• Homocysteine theory of arteriosclerosis: development and current status

  1983cited by this paper
• Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine‐homocysteine mixed disulphide

  1979cited by this paper
• Homocysteine theory of arteriosclerosis.

  1975cited by this paper
• [Modern epidemiology].

  1971cited by this paper

• Study of Plasma Homocysteine Levels in Subjects with Cerebral Infarct and Myocardial Infarction

  2025influential citation
• Reduced DTI-ALPS in H-type hypertension: insights into perivascular space function

  2025cites this paper
• Homocysteine and Stroke: A 30-Year Bibliometric Study Uncovering Research Trends and Future Directions

  2025cites this paper
• A review of metal ion complexation/decomplexation reaction-based fluorescent sensors for detecting biological thiols

  2025cites this paper
• A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population

  2025cites this paper
• Efficacy, safety, and vascular endothelial function improvement of enalapril maleate-folic acid tablets in H-Type hypertension.

  2025cites this paper
• Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults

  2025influential citation
• A mercury complex-based fluorescent sensor for biological thiols

  2025cites this paper
• The differences in intestinal flora and metabolites between H-type hypertension and non-H-type hypertension

  2025cites this paper
• Anti-atherosclerotic effect of antioxidant and homocysteine lowering therapy in experimental atherosclerosis model

  2025cites this paper
• Cross-sectional study on the association between 24-hour urinary potassium excretion and the risk of H-type hypertension and non-H-type hypertension in Chinese adults

  2025cites this paper
• RETRACTED ARTICLE: Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats

  2025cites this paper
• Homocysteine modifies the association of coronary stenosis and HIV infection in an inner city African American population

  2024cites this paper
• Optimal Federated Learning for Nonparametric Regression with Heterogeneous Distributed Differential Privacy Constraints

  2024cites this paper
• Gender differences in cardiovascular disease

  2024cites this paper
• Values of H-Type Hypertension in Patients with Large Vessel Occlusion

  2024cites this paper
• The Multitarget Action of Vitamins in the Ischemic Stroke.

  2024cites this paper
• Concentración plasmática de homocisteína en ayunas en individuos sanos de la ciudad de Medellín

  2024cites this paper
• Optimal folic acid dosage in lowering homocysteine: Precision Folic Acid Trial to lower homocysteine (PFAT-Hcy)

  2024cites this paper
• Folic acid enhances the cardiovascular protective effect of amlodipine in renal hypertensive rats with elevated homocysteine

  2023cites this paper
• Familial case of encephalocele with autosomal dominant inheritance

  2023cites this paper
• Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia

  2023cites this paper
• An unusual case of thrombotic storm in an amateur cricketer—a case report

  2023cites this paper
• Development and Validation of a Novel Model for Predicting Coronary Heart Disease in Snoring Hypertensive Patients with Hyperhomocysteinemia.

  2023cites this paper
• Association of Serum Homocysteine Level with Acute Ischaemic Stroke among Young Adult Patients: Experience at a Largest Medical College Hospital in Bangladesh

  2023cites this paper
• Genistein effectiveness in improvement of glucose and lipid metabolism and homocysteine levels: A systematic review and meta-analysis

  2023cites this paper
• Lifestyle approach and medical therapy of lower extremity peripheral artery disease.

  2023cites this paper
• The Effect of Folic Acid Supplementation on Endothelial Function and Arterial Stiffness Markers in Adults: A Systematic Review and Meta-Analysis

  2023cites this paper
• Micronutrient Status in Adult Crohn’s Disease during Clinical Remission: A Systematic Review

  2023cites this paper
• Genome-wide analysis of DNA methylation and its relationship with serum homocysteine levels in patients with hypertension

  2023cites this paper
• Clinical and laboratory findings and etiologies of genetic homocystinemia: a single-center experience

  2023cites this paper
• Predicting acute ischemic stroke using the revised Framingham stroke risk profile and multimodal magnetic resonance imaging

  2023cites this paper
• EPIDEMIC OF CAD IN YOUNG INDIANS : THE ACCELERATED ATHEROSCLEROTIC INSULIN RESISTANCE SYNDROME (AAIRS)

  2023cites this paper
• Prospective cohort study on potato intake and mortality from cardiovascular diseases: the Japan Collaborative Cohort Study (JACC study)

  2023cites this paper
• Metabolomics reveals serum metabolic signatures in H‐type hypertension based on mass spectrometry multi‐platform

  2023cites this paper
• Nutritional issues in stroke prevention

  2023cites this paper
• Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue

  2022cites this paper
• Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

  2022cites this paper
• Association between MTHFR C677T polymorphism and risk of coronary artery disease in the Chinese population: meta-analysis

  2022cites this paper
• A randomized, double-blind, controlled trial on the homocysteine-lowering effects of different doses of folic acid among patients with hypertension and elevated homocysteine according to methylenetetrahydrofolate reductase C677T genotypes: rationale and methods

  2022cites this paper
• Homocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysis

  2022cites this paper
• Central retinal vein occlusion post ChAdOx1 nCoV-19 vaccination – can it be explained by the two-hit hypothesis?

  2022cites this paper
• One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue

  2022cites this paper
• Relationship between serum homocysteine, fibrinogen, lipoprotein-a level, and peripheral arterial disease: a dose–response meta-analysis

  2022cites this paper
• Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension

  2022cites this paper
• Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition

  2022cites this paper
• Adolescent Afghan Refugees Display a High Prevalence of Hyperhomocysteinemia and Associated Micronutrients Deficiencies Indicating an Enhanced Risk of Cardiovascular Disease in Later Life

  2022cites this paper
• B vitamin supply in plants and humans: the importance of vitamer homeostasis

  2022cites this paper
• Endothelial Dysfunction in Psoriasis: An Updated Review

  2022influential citation
• ESTIMATION OF ROLE OF HYPERHOMOCYSTEINEMIA, BIOCHEMICAL PARAMETERS , AND CLINICAL MARKERS IN ATHEROSCLEROSIS PATIENTS IN AL-NAJAF AL-ASHRAF GOVERNORATE

  2022cites this paper
• Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

  2022cites this paper
• Thiol sensing: from current methods to nanoscale contribution

  2022cites this paper
• Epigenetic Upregulation of H19 and AMPK Inhibition Concurrently Contribute to S-Adenosylhomocysteine Hydrolase Deficiency-Promoted Atherosclerotic Calcification

  2022cites this paper
• Homocysteine as a marker for predicting disease severity in patients with COVID-19.

  2022cites this paper
• Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and H‐type hypertension: A systematic review and meta‐analysis

  2022cites this paper
• Homocysteine as a potential indicator of endothelial dysfunction and cardiovascular risk in female patients with borderline personality disorder

  2022cites this paper
• To study role of Homocysteine as a biochemical marker in various obstetrical complications

  2022influential citation
• Association between hyperhomocysteinaemia and the risk of all-cause and cause-specific mortality among adults in the USA

  2022cites this paper
• Role of plasma homocysteine levels and other associated factors with coronary artery disease among Palestinian patients in North Palestine: a case control study

  2022cites this paper
• Homocysteinemia and vascular disease: Where we stand in 2022.

  2022cites this paper
• Betaine Supplementation Attenuates S-Adenosylhomocysteine Hydrolase-Deficiency-Accelerated Atherosclerosis in Apolipoprotein E-Deficient Mice

  2022cites this paper
• Lowering serum homocysteine in H-type hypertensive patients with atrial fibrillation after radiofrequency catheter ablation to prevent atrial fibrillation recurrence

  2022cites this paper
• Homocysteine, Vitamins B6, B12, and Folate and the Risk of Ischemic and Hemorrhagic Stroke: A Case-control Study from Northeast India

  2022cites this paper
• The Clinical Presentations of Nitrous Oxide Users in an Emergency Department

  2022cites this paper
• Protective effect of aqueous extract of Nigella sativa on Oxidative Enzymes, Homocysteine, and Lipids in Methionine induced Hyperhomocysteinemic rats

  2022cites this paper
• Relationship between sleep problems and chronotypes of children and adolescents with attention deficit and hyperactivity disorder and serum GABA, glutamate and homocysteine levels

  2021cites this paper
• Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

  2021cites this paper
• CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells

  2021cites this paper
• Stroke as a Complication of General Medical Disorders

  2021cites this paper
• Perfil lipídico y concentraciones séricas de ácido fólico, vitamina B12 y homocisteína en pacientes con obstrucción venosa retiniana

  2021cites this paper
• Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age

  2021cites this paper
• Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate

  2021cites this paper
• Using data mining technology to explore homocysteine at low levels

  2021cites this paper
• 13 (2) January 2021 CVJ.pmd

  2021cites this paper
• Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes

  2021cites this paper
• The interaction of hypertension and homocysteine increases the risk of mortality among middle-aged and older population in the United States

  2021cites this paper
• The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia

  2021cites this paper
• Could homocysteine, angiotensin and alamandine be used as potential biomarkers in management of COVID-19?

  2021cites this paper
• A Novel Review of Homocysteine and Pregnancy Complications

  2021cites this paper
• Предикторные сывороточные биомаркеры поражения сердечно-сосудистой системы при COVID-19 Serum biomarkers of cardiovascular complications in COVID-19

  2021cites this paper
• Effect of Patent Foramen Ovale Closure After Stroke on Circulatory Biomarkers

  2021cites this paper
• Folate Reverses NF-κB p65/Rela/IL-6 Level Induced by Hyperhomocysteinemia in Spontaneously Hypertensive Rats

  2021cites this paper
• Lipid profile and serum folate, vitamin B12 and homocysteine levels in patients with retinal vein occlusion

  2021cites this paper
• Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease

  2021cites this paper
• Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study

  2021cites this paper
• Association between H-type arterial hypertension and vascular stiffness (a pilot study)

  2021cites this paper
• Metabolomics: An Emerging Tool for Precision Medicine

  2021cites this paper
• COVID‐19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence

  2021cites this paper
• Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten

  2021cites this paper
• Serum biomarkers of cardiovascular complications in COVID-19

  2021cites this paper
• Homocysteine – from disease biomarker to disease prevention

  2021cites this paper
• Associations of Early Pregnancy and Neonatal Circulating Folate, Vitamin B-12, and Homocysteine Concentrations with Cardiometabolic Risk Factors in Children at 10 y of Age

  2021cites this paper
• Genetic Risk Factors in the Development of Hyperhomocysteinemia

  2021cites this paper
• Serum Homocysteine and Serum Lipids in Hypertensive Patients

  2021cites this paper
• Lipid profile and serum folate, vitamin B12 and homocysteine levels in patients with retinal vein occlusion.

  2020cites this paper
• Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach.

  2020cites this paper
• Low-molecular-weight peptides with potential cardiovascular regulatory functions from Atlantic salmon skin

  2020cites this paper
• The relationships of serum homocysteine levels and traditional lipid indicators with disease activity and coronary artery involvement in Takayasu arteritis

  2020cites this paper
• Autophagy activation is required for homocysteine-induced apoptosis in bovine aorta endothelial cells

  2020cites this paper
• To Evaluate the Significance of Hyperhomocysteinemia in Patients with Coronary Artery Disease

  2020cites this paper