Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state

No abstract is available for this paper.

• Publication year

  2012

• Venue

  EMBO Journal

• Publication date

  2012-06-15

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1038/emboj.2012.165PMID 22705944PMCID PMC3400016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol

  2011cited by this paper
• Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol‐redox control

  2011cited by this paper
• Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum

  2011cited by this paper
• Measuring E(GSH) and H2O2 with roGFP2-based redox probes.

  2011influential reference
• Subcellular distribution of glutathione and its dynamic changes under oxidative stress in the yeast Saccharomyces cerevisiae

  2011cited by this paper
• Measuring E GSH and H 2 O 2 with roGFP 2-based redox probes

  2011cited by this paper
• Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione.

  2010influential reference
• Fluorescent Protein-Based Redox Probes

  2010influential reference
• Proteins at the Polypeptide Tunnel Exit of the Yeast Mitochondrial Ribosome*

  2010cited by this paper
• Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

  2010cited by this paper
• The Intermembrane Space of Mitochondria

  2010cited by this paper
• VDAC, a multi-functional mitochondrial protein regulating cell life and death.

  2010cited by this paper
• Origami in outer membrane mimetics: correlating the first detailed images of refolded VDAC with over 20 years of biochemical data.

  2010cited by this paper
• Structure and evolution of mitochondrial outer membrane proteins of beta-barrel topology.

  2010cited by this paper
• The yeast CLC protein counteracts vesicular acidification during iron starvation

  2010cited by this paper
• Importing mitochondrial proteins: machineries and mechanisms.

  2009cited by this paper
• Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.

  2009cited by this paper
• Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins.

  2009cited by this paper
• Disulfide Formation in the ER and Mitochondria: Two Solutions to a Common Process

  2009cited by this paper
• Disulphide bond formation in the intermembrane space of mitochondria.

  2009cited by this paper
• Two Sources of Mitochondrial NADPH in the Yeast Saccharomyces cerevisiae*

  2009cited by this paper
• Real-time imaging of the intracellular glutathione redox potential

  2008cited by this paper
• The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix*

  2008influential reference
• Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions.

  2008cited by this paper
• Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide.

  2007cited by this paper
• Measurement of VDAC permeability in intact mitochondria and in reconstituted systems.

  2007cited by this paper
• The disulfide relay system of mitochondria is connected to the respiratory chain

  2007cited by this paper
• Redox-sensitive GFP in Arabidopsis thaliana is a quantitative biosensor for the redox potential of the cellular glutathione redox buffer.

  2007cited by this paper
• What is the Functional Significance of the Unique Location of Glutaredoxin 1 (GRx1) in the Intermembrane Space of Mitochondria?

  2007cited by this paper
• Glutaredoxins in fungi

  2006cited by this paper
• Thiol redox control via thioredoxin and glutaredoxin systems.

  2005cited by this paper
• Overlapping Roles of the Cytoplasmic and Mitochondrial Redox Regulatory Systems in the Yeast Saccharomyces cerevisiae

  2005cited by this paper
• A disulfide relay system in the intermembrane space of mitochondria that mediates protein import.

  2005influential reference
• Glutathione Directly Reduces an Oxidoreductase in the Endoplasmic Reticulum of Mammalian Cells*

  2004cited by this paper
• Monitoring disulfide bond formation in the eukaryotic cytosol

  2004cited by this paper
• Identification of Tim40 That Mediates Protein Sorting to the Mitochondrial Intermembrane Space*

  2004cited by this paper
• Alternative Start Sites in the Saccharomyces cerevisiae GLR1 Gene Are Responsible for Mitochondrial and Cytosolic Isoforms of Glutathione Reductase*

  2004cited by this paper
• Processes Underlying the Upregulation of Tom Proteins in S. cerevisiae Mitochondria Depleted of the VDAC Channel

  2004cited by this paper
• Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators*

  2004cited by this paper
• Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins

  2004cited by this paper
• Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators*

  2004cited by this paper
• The ALD6 Gene Product Is Indispensable for Providing NADPH in Yeast Cells Lacking Glucose-6-phosphate Dehydrogenase Activity*

  2003cited by this paper
• A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae

  2003cited by this paper
• The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain.

  2001cited by this paper
• Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein

  2001cited by this paper
• An interplay between the TOM complex and porin isoforms in the yeast Saccharomyces cerevisiae mitochondria

  2001cited by this paper
• Control of Mitochondrial Redox Balance and Cellular Defense against Oxidative Damage by Mitochondrial NADP+-dependent Isocitrate Dehydrogenase*

  2001cited by this paper
• Role of voltage-dependent anion channels in glutathione transport into yeast mitochondria.

  2000cited by this paper
• Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport.

  2000cited by this paper
• Identification and Functional Characterization of a Novel Mitochondrial Thioredoxin System in Saccharomyces cerevisiae *

  1999cited by this paper
• Preferential Transport of Glutathione versusGlutathione Disulfide in Rat Liver Microsomal Vesicles*

  1999cited by this paper
• The Role of Yeast VDAC Genes on the Permeability of the Mitochondrial Outer Membrane

  1998cited by this paper
• Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.

  1998cited by this paper
• On the Structure and Gating Mechanism of the Mitochondrial Channel, VDAC

  1997cited by this paper
• Glutathione is an essential metabolite required for resistance to oxidative stress in the yeastSaccharomyces cerevisiae

  1996cited by this paper
• Oxidized redox state of glutathione in the endoplasmic reticulum.

  1992cited by this paper
• Uptake of glutathione by renal cortical mitochondria.

  1991cited by this paper
• Ionic strength of the intermembrane space of intact mitochondria as estimated with fluorescein-BSA delivered by low pH fusion

  1991cited by this paper
• Voltage gating in the mitochondrial channel, VDAC

  1989cited by this paper
• Origin and turnover of mitochondrial glutathione.

  1985cited by this paper

• The mitochondrial intermembrane space – a permanently proteostasis-challenged compartment

  2025cites this paper
• Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates

  2025cites this paper
• Illuminating plant metabolism with genetically encoded biosensors.

  2025cites this paper
• Impact of Oxygen Availability on the Organelle‐Specific Redox Potentials and Stress in Recombinant Protein Producing Komagataella phaffii

  2025cites this paper
• Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation

  2024cites this paper
• Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

  2024cites this paper
• Validation and optimisation of reduced glutathione quantification in erythrocytes by means of a coulometric high-performance liquid chromatography analytical method.

  2024cites this paper
• Methods to monitor mitochondrial disulfide bonds.

  2024cites this paper
• Approaches for the analysis of redox-dependent protein import into mitochondria of mammalian cells.

  2024cites this paper
• Cysteine import via the high-affinity GSH transporter Hgt1 rescues GSH auxotrophy in yeast

  2024cites this paper
• Fmp40 ampylase regulates cell survival upon oxidative stress by controlling Prx1 and Trx3 oxidation

  2024influential citation
• Protein insertion into the inner membrane of mitochondria: routes and mechanisms

  2024cites this paper
• Oxidative protein folding in the intermembrane space of human mitochondria

  2024cites this paper
• Glutathione dynamics in subcellular compartments and implications for drug development.

  2024cites this paper
• Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.

  2024cites this paper
• Absence of mitochondrial CX9C-CX10C protein Cox12 generates oxidative and nitrosative stress in Saccharomyces cerevisiae: Implication on cellular redox homeostasis

  2024cites this paper
• Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies

  2023cites this paper
• The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis

  2023cites this paper
• Real-Time Monitoring of Hydrogen Peroxide Levels in Yeast and Mammalian Cells.

  2023cites this paper
• All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ

  2023cites this paper
• Glutathione and peroxisome redox homeostasis

  2023cites this paper
• Remodeling of the focal adhesion complex by hydrogen-peroxide-induced senescence

  2023cites this paper
• Oxidation of Arabidopsis thaliana COX19 Using the Combined Action of ERV1 and Glutathione

  2023influential citation
• Effect of RONS-Induced Intracellular Redox Homeostasis in 6-NBDG/Glucose Uptake in C2C12 Myotubes and Single Isolated Skeletal Muscle Fibres

  2023influential citation
• All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ

  2023cites this paper
• Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells

  2023cites this paper
• Glutathione-Related Enzymes and Proteins: A Review

  2023cites this paper
• Maintenance of small molecule redox homeostasis in mitochondria

  2022cites this paper
• Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells

  2021cites this paper
• Erv1 and cytochrome c mediate rapid electron transfer via a collision-type interaction.

  2021cites this paper
• A Thioredoxin reductive mechanism balances the oxidative protein import pathway in the intermembrane space of mitochondria

  2021influential citation
• Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER.

  2021cites this paper
• Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control

  2021cites this paper
• The role of mitochondrial reactive oxygen species in insulin resistance.

  2021cites this paper
• Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

  2021cites this paper
• Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy

  2021influential citation
• Changes in Glutathione Content in Liver Diseases: An Update

  2021cites this paper
• The Mia40/CHCHD4 Oxidative Folding System: Redox Regulation and Signaling in the Mitochondrial Intermembrane Space

  2021cites this paper
• Nutrient metabolism, subcellular redox state and oxidative stress in pancreatic islets and β-cells.

  2020cites this paper
• Interplay between NADH oxidation by complex I, glutathione redox state and sirtuin-3, and its role in the development of insulin resistance.

  2020cites this paper
• Cysteine Oxidations in Mitochondrial Membrane Proteins: The Case of VDAC Isoforms in Mammals

  2020cites this paper
• Measuring Reactive Sulfur Species and Thiol Oxidation States: Challenges and Cautions in Relation to Alkylation-Based Protocols

  2020cites this paper
• Iron and Cadmium Entry Into Renal Mitochondria: Physiological and Toxicological Implications

  2020cites this paper
• Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

  2020cites this paper
• Role of Glutathione in Cancer: From Mechanisms to Therapies

  2020cites this paper
• In Vivo Imaging with Genetically Encoded Redox Biosensors

  2020influential citation
• Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation

  2020cites this paper
• A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

  2020cites this paper
• Protein import by the mitochondrial disulfide relay in higher eukaryotes

  2020cites this paper
• DEVELOPMENT OF METHODS FOR DETERMINATION OF SPECIFIC IMPURITIES IN THE GLUTATIONION RESTORED SUBSTANCE

  2019cites this paper
• Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress

  2019cites this paper
• Protein S-glutathionylation: The linchpin for the transmission of regulatory information on redox buffering capacity in mitochondria.

  2019cites this paper
• Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay.

  2019cites this paper
• Interspecific variation in brain mitochondrial complex I and II capacity and ROS emission in marine sculpins

  2019cites this paper
• Redox Regulation of the Mitochondrial Quality Control Protease Oma1

  2019cites this paper
• New red-shifted fluorescent biosensor for monitoring intracellular redox changes.

  2019cites this paper
• Glutathione: subcellular distribution and membrane transport 1.

  2019influential citation
• Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

  2019cites this paper
• Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane.

  2019cites this paper
• Hyperoxidation of mitochondrial peroxiredoxin limits H2O2‐induced cell death in yeast

  2019influential citation
• Mechanistic Studies of Cholesterol Lipotoxicity Pertinent to NASH

  2019cites this paper
• Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

  2019cites this paper
• Investigating the role of yeast Glutathione peroxidase 3 and related proteins in mitochondria and peroxisomes

  2019influential citation
• Regulation of protein import by a thioredoxin reductive pathway in the intermembrane space of mitochondria

  2019influential citation
• The role of thiols in antioxidant systems.

  2019cites this paper
• Structure-function analysis and membrane association of Leishmania tarentolae and Plasmodium falciparum Erv

  2019cites this paper
• Development of the Mitochondrial Intermembrane Space Disulfide Relay Represents a Critical Step in Eukaryotic Evolution.

  2019cites this paper
• Chloroplasts Require Glutathione Reductase to Balance Reactive Oxygen Species and Maintain Efficient Photosynthesis

  2019cites this paper
• Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting.

  2019cites this paper
• Mitochondrial Regulation and Signalling in the Photosynthetic Cell: Principles and Concepts

  2018cites this paper
• The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants

  2018cites this paper
• The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo

  2018cites this paper
• Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

  2018cites this paper
• Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

  2018cites this paper
• Split-DHFR as a protein complementation assay for localisation and interactions of yeast mitochondrial proteins

  2018cites this paper
• Endoplasmic reticulum (ER) stress–induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant

  2018cites this paper
• Cysteine residues in mitochondrial intermembrane space proteins: more than just import

  2018cites this paper
• Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

  2018influential citation
• Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis

  2018cites this paper
• Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells.

  2017cites this paper
• Oxygen-dependent activation of Cu,Zn-superoxide dismutase-1.

  2017cites this paper
• Temporal profiling of redox-dependent heterogeneity in single cells

  2017cites this paper
• Building the CuA site of cytochrome c oxidase: A complicated, redox-dependent process driven by a surprisingly large complement of accessory proteins

  2017cites this paper
• Subcellular Redox Signaling.

  2017cites this paper
• Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding

  2017cites this paper
• The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?

  2017cites this paper
• New tools for redox biology: From imaging to manipulation

  2017cites this paper
• Redox regulation of mitochondrial proteins and proteomes by cysteine thiol switches.

  2017cites this paper
• Mitochondrial Glutathione: Regulation and Functions

  2017influential citation
• Adaptive variation of mitochondrial function in response to oxygen variability in intertidal sculpins (Cottidae, Actinopterygii)

  2017cites this paper
• Oxidative regulation mechanisms in the mitochondrial intermembrane space

  2017influential citation
• ROS in Cancer: The Burning Question.

  2017cites this paper
• Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space

  2017cites this paper
• Cysteines as Redox Molecular Switches and Targets of Disease

  2017cites this paper
• Protein Translocation into the Intermembrane Space and Matrix of Mitochondria: Mechanisms and Driving Forces

  2017cites this paper
• Cytochrome c oxidase inhibition by calcium at physiological ionic composition of the medium: Implications for physiological significance of the effect.

  2017cites this paper
• Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40

  2017cites this paper
• Protein trafficking at the crossroads to mitochondria.

  2017cites this paper
• Mechanisms and Applications of Redox-Sensitive Green Fluorescent Protein-Based Hydrogen Peroxide Probes

  2017cites this paper
• Real‐time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues

  2017cites this paper