Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan.

No abstract is available for this paper.

• Publication year

  1982

• Venue

  The Lancet

• Publication date

  1982-10-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0140-6736(82)92722-2PMID 6126701
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Racial differences in biological sensitivity to ethanol: the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes.

  2008cited by this paper
• Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese.

  1981cited by this paper
• Genetic studies on alcohol-metabolizing enzymes: detection of isozymes in human hair roots.

  1980cited by this paper
• Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication.

  1980cited by this paper
• Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues.

  1980cited by this paper
• Racial differences in alcohol sensitivity: A new hypothesis

  1979cited by this paper
• Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.

  1977cited by this paper

• Alcohol consumption, smoking, and the implications of their cessations for field carcinogenesis in the esophagus: a 10-year prospective cohort study.

  2026cites this paper
• Investigating the contribution of coding variants in alcohol use disorder using whole-exome sequencing across ancestries.

  2025cites this paper
• Associations of ADH1B and ALDH2 genotypes and alcohol flushing with drinking history, withdrawal symptoms, and ICD-10 criteria in Japanese alcohol-dependent men

  2024cites this paper
• High serum gamma‐glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinoma

  2024cites this paper
• Multi-ancestry Whole-exome Sequencing Study of Alcohol Use Disorder in Two Cohorts

  2024cites this paper
• Human genetics and epigenetics of alcohol use disorder

  2024cites this paper
• Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study.

  2024cites this paper
• The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project

  2023cites this paper
• Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism

  2023cites this paper
• Genes in Alcoholic Liver Disease: A Complex Interplay

  2023cites this paper
• Variation in Genotype and DNA Methylation Patterns Based on Alcohol Use and CVD in the Korean Genome and Epidemiology Study (KoGES)

  2022cites this paper
• Transcriptome landscape of the late-stage alcohol-induced osteonecrosis of the human femoral head.

  2021cites this paper
• Association of Alcohol Drinking and Helicobacter pylori Infection

  2021cites this paper
• Effects of Rapid Recovery on Alcohol Hangover Severity: A Double-Blind, Placebo-Controlled, Randomized, Balanced Crossover Trial

  2020cites this paper
• Influence of comorbid psychiatric disorders on the risk of development of alcohol dependence by genetic variations of ALDH2 and ADH1B.

  2020cites this paper
• A Systemic Understanding of Addiction Formation and the Recovery Process

  2020cites this paper
• ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension.

  2020cites this paper
• Genetics and Epigenetics of Substance Use

  2019cites this paper
• From a computational point of view: deciphering the molecular synergism between oxidative stress-induced lipid peroxidation products and metabolic dysfunctionality of human liver mitochondrial aldehyde dehydrogenase-2

  2019cites this paper
• Acetaldehyde in the Brain After Ethanol Exposure: Research Progress and Challenges

  2019cites this paper
• Shared and specific associations of substance use disorders on adverse outcomes: A national prospective study.

  2019cites this paper
• Lesions Induced by Toxins

  2018cites this paper
• Aldehyde dehydrogenase II rs671 polymorphism in essential hypertension.

  2018cites this paper
• Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review

  2018cites this paper
• Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

  2018cites this paper
• Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

  2017cites this paper
• ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective

  2017cites this paper
• Effects of alcohol consumption, ALDH2 rs671 polymorphism, and Helicobacter pylori infection on the gastric cancer risk in a Korean population

  2016cites this paper
• Changing epidemiology of chronic liver disease among ethnic groups in the United States

  2016cites this paper
• Facial flushing response to alcohol and the risk of esophageal squamous cell carcinoma: A comprehensive systematic review and meta-analysis.

  2016cites this paper
• Alcohol and Aldehyde Dehydrogenases: Molecular Aspects

  2016cites this paper
• Measurement of Liability to Addiction: Dimensional Approaches

  2016cites this paper
• An evaluation of the primary care providers' perspective of the effects of moderate alcohol consumption on health

  2015cites this paper
• The pharmacogenetics of alcohol use disorder.

  2015cites this paper
• Genetics of Alcoholic Liver Disease

  2015cites this paper
• The "first hit" toward alcohol reinforcement: role of ethanol metabolites.

  2015cites this paper
• Effect of the allelic variant of alcohol dehydrogenase ADH1B*2 on ethanol metabolism.

  2014cites this paper
• Eleven synchronous/metachronous primary carcinomas of the upper gastrointestinal tract: a case report

  2014cites this paper
• Asian Flushing: Genetic and Sociocultural Factors of Alcoholism Among East Asians

  2014cites this paper
• Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns.

  2014cites this paper
• Efficacy of disulfiram for the treatment of alcohol dependence assessed with a multicenter randomized controlled trial.

  2014cites this paper
• Impulsivity, peer influence, and adolescent substance use

  2013cites this paper
• Moderate Alcohol Use and Cardiovascular Disease from Mendelian Randomization

  2013cites this paper
• Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population

  2013cites this paper
• Title Moderate alcohol use and cardiovascular disease frommendelian randomization

  2013cites this paper
• Gene specific modifications unravel ethanol and acetaldehyde actions

  2013cites this paper
• The relationship of alcohol to blood pressure : the INTERMAP Study

  2012cites this paper
• Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: A case control study

  2012cites this paper
• Personal Genetic Tests of Alcohol Intolerance for Moderate and Responsible Drinking; Actions for Reducing Harmful Drinking.

  2012cites this paper
• Anxiogenic and stress-inducing effects of peripherally administered acetaldehyde in mice: similarities with the disulfiram-ethanol reaction.

  2012cites this paper
• The impact of genetic variability on liver disease in the Hispanic/Latin-American population

  2011cites this paper
• Developmental Changes in Genetic Influences on Alcohol Use and Dependence

  2011cites this paper
• Genetics of Alcoholic and Nonalcoholic Fatty Liver Disease

  2011cites this paper
• Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence

  2011cites this paper
• Genetics of alcoholic and nonalcoholic fatty liver disease.

  2011cites this paper
• Place conditioning with ethanol in rats bred for high (UChB) and low (UChA) voluntary alcohol drinking.

  2011cites this paper
• Genetic Vulnerability and Susceptibility to Substance Dependence

  2011cites this paper
• Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption?

  2011cites this paper
• Difference between urban and rural regions in Japan in estimated risk of esophageal cancer based on a health risk appraisal model that includes an alcohol flushing questionnaire

  2011cites this paper
• Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism.

  2011cites this paper
• Genetic vulnerability and susceptibility to substance dependence.

  2011cites this paper
• Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.

  2011cites this paper
• An Interdisciplinary Approach to Studying Gene–Environment Interactions: From Twin Studies to Gene Identification and Back

  2011cites this paper
• Preface: Promises kept: robust discovery in psychiatric genetics.

  2010cites this paper
• Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model

  2010cites this paper
• The End of Behavioral Genetics?

  2010cites this paper
• Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele.

  2010cites this paper
• Genetics of addictions.

  2010cites this paper
• Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males.

  2010cites this paper
• Genetics of addictions.

  2010cites this paper
• The Genetics of Substance Use and Substance Use Disorders

  2009cites this paper
• RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research.

  2009cites this paper
• The End of Behavioral Genetics?

  2009cites this paper
• Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat

  2009cites this paper
• Alcohol sensitivity, alcohol use and hypertension in an older Chinese population: the Guangzhou Biobank Cohort Study

  2009cites this paper
• Acetaldehyde and the hypothermic effects of ethanol in mice.

  2009cites this paper
• Enhanced 5-HT2A Receptors in Brain Stem and ALDH Activity in Brain Stem and Liver: 5-HT2A Regulation on ALDH in Primary Hepatocytes Cultures In Vitro

  2009cites this paper
• The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

  2009cites this paper
• Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.

  2009cites this paper
• Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

  2009cites this paper
• The case-only method for gene-environment interaction studies: The independence assumption illustrated with empirical data from the published literature and two population-based control groups, the Carolina breast cancer study and the North Carolina colon cancer study

  2009cites this paper
• Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics.

  2009cites this paper
• Phytophenols in whisky lower blood acetaldehyde level by depressing alcohol metabolism through inhibition of alcohol dehydrogenase 1 (class I) in mice.

  2008cites this paper
• Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase.

  2008cites this paper
• Tolerance to disulfiram induced by chronic alcohol intake in the rat.

  2008cites this paper
• The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors.

  2008cites this paper
• Approach to the genetics of alcoholism: a review based on pathophysiology.

  2008cites this paper
• Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males.

  2008cites this paper
• Risks of combined alcohol/medication use in older adults.

  2007cites this paper
• Alkoholbedingte Störungen – ein kleines Alphabet der Neurobiologie

  2007cites this paper
• Genes associated with addiction

  2007cites this paper
• A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men.

  2007cites this paper
• Predisposición genética en el consumo de alcohol: el caso de la Alcohol Deshidrogenasa 1C

  2007cites this paper
• Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective.

  2007cites this paper
• Alcohol as a toxic and disease‐forming agent: Not just the liver and brain and not every drinker

  2007cites this paper
• Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population.

  2007cites this paper
• Gene therapy reduces ethanol intake in an animal model of alcohol dependence.

  2007cites this paper
• Accumulation of hepatic acetaldehyde and reduced alcohol drinking in transgenic mice carrying the Oriental variant of the human aldehyde dehydrogenase 2 gene

  2006cites this paper
• The genetics of alcohol dependence

  2006cites this paper
• Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females.

  2006cites this paper