THE MANAGEMENT OF PATIENTS WITH LEUKAEMIA: THE ROLE OF CYTOGENETICS IN THIS MOLECULAR ERA

No abstract is available for this paper.

• Publication year

  2000

• Venue

  British Journal of Haematology

• Publication date

  2000-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1046/j.1365-2141.2000.01801.xPMID 10651720
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability.

  2009cited by this paper
• High resolution studies on the pattern of induced exchanges in the human karyotype

  2004cited by this paper
• Real-Time Quantitative PCR

  2002cited by this paper
• Detection of the Chromosome 16 CBFP-MYH 11 Fusion Transcript in Myelomonocytic Leukemias

  2002influential reference
• A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG)

  1999cited by this paper
• Spectral karyotype analysis of T-cell acute leukemia.

  1999cited by this paper
• The impact of the new FISH technologies on the cytogenetics of haematological malignancies

  1999influential reference
• INVESTIGATION OF MINIMAL RESIDUAL DISEASE IN CHILDHOOD AND ADULT ACUTE LYMPHOBLASTIC LEUKAEMIA BY MOLECULAR ANALYSIS

  1999cited by this paper
• Investigation of clonal involvement of myeloid cells in Philadelphia-positive and high hyperdiploid acute lymphoblastic leukemia

  1999cited by this paper
• Molecular genetics, natural history and the demise of childhood leukaemia.

  1999cited by this paper
• Loss of heterozygosity and microsatellite instability at the MLL locus are common in childhood acute leukemia, but not in infant acute leukemia.

  1999cited by this paper
• Centric and pericentric chromosome rearrangements in hematopoietic malignancies

  1999cited by this paper
• Characterization of the human myeloid leukemia‐derived cell line GF‐D8 by multiplex fluorescence in situ hybridization, subtelomeric probes, and comparative genomic hybridization

  1999cited by this paper
• Molecular genetics, natural history and the demise of childhood leukaemia.

  1999cited by this paper
• Fluorescence in situ hybridization analysis of masked (8;21)(q22;q22) translocations.

  1999cited by this paper
• Mutation detection and single-molecule counting using isothermal rolling-circle amplification

  1998cited by this paper
• Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping.

  1998cited by this paper
• Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma.

  1998cited by this paper
• Highly sensitive fluorescence in situ hybridization method to detect double BCR/ABL fusion and monitor response to therapy in chronic myeloid leukemia.

  1998cited by this paper
• Identification of New Nonrandom Translocations in Multiple Myeloma With Multicolor Spectral Karyotyping

  1998cited by this paper
• A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood AML.

  1998cited by this paper
• Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood.

  1998cited by this paper
• Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia.

  1998cited by this paper
• RT-PCR in diagnosis and disease monitoring of acute promyelocytic leukemia (APL).

  1998influential reference
• The importance of cytogenetics and associated molecular techniques in the management of patients with leukaemia.

  1998cited by this paper
• The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties.

  1998influential reference
• Detection of minimal residual disease in patients with AML1/ETO-associated acute myeloid leukemia using a novel quantitative reverse transcription polymerase chain reaction assay

  1998cited by this paper
• General Report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997

  1998cited by this paper
• Molecular cytogenetic delineation of the critical deleted region in the 5q− syndrome

  1998cited by this paper
• Ten novel 11q23 chromosomal partner sites

  1998cited by this paper
• Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants.

  1998cited by this paper
• Padlock probes reveal single-nucleotide differences, parent of origin and in situ distribution of centromeric sequences in human chromosomes 13 and 21

  1997cited by this paper
• Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.

  1997cited by this paper
• Improved sensitivity of BCR-ABL detection: a triple-probe three-color fluorescence in situ hybridization system.

  1997cited by this paper
• Rapid molecular cloning of rearrangements of the IGHJ locus using long-distance inverse polymerase chain reaction.

  1997cited by this paper
• Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21

  1997cited by this paper
• Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping

  1997cited by this paper
• Increased sensitivity of minimal residual disease detection by interphase FISH in acute lymphoblastic leukemia with hyperdiploidy

  1997cited by this paper
• Matrix‐based comparative genomic hybridization: Biochips to screen for genomic imbalances

  1997cited by this paper
• Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse.

  1997cited by this paper
• Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA

  1997cited by this paper
• A novel source of highly specific chromosome painting probes for human karyotype analysis derived from primate homologues

  1997cited by this paper
• Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response

  1997cited by this paper
• Development and Clinical Application of an Innovative Fluorescence in situ Hybridization Technique Which Detects Submicroscopic Rearrangements Involving Telomeres

  1997cited by this paper
• Reverse transcriptase/polymerase chain reaction follow‐up and minimal residual disease detection in t(1;19)‐positive acute lymphoblastic leukaemia

  1996cited by this paper
• Karyotyping human chromosomes by combinatorial multi-fluor FISH

  1996cited by this paper
• Multicolor Spectral Karyotyping of Human Chromosomes

  1996cited by this paper
• Real time quantitative PCR.

  1996cited by this paper
• Prediction of relapse of pediatric acute myeloid leukemia by use of multidimensional flow cytometry.

  1996cited by this paper
• Improved outcome in adult B-cell acute lymphoblastic leukemia.

  1996cited by this paper
• Molecular detection of t(8;21)/AML1‐ETO in AML M1/M2: correlation with cytogenetics, morphology and immunophenotype

  1996cited by this paper
• Design and validation of DNA probe sets for a comprehensive interphase cytogenetic analysis of acute myeloid leukemia.

  1996cited by this paper
• Dicentric (9;20)(p11;q11) identified by fluorescence in situ hybridization in four pediatric acute lymphoblastic leukemia patients.

  1996cited by this paper
• Classification of deletions and identification of cryptic translocations involving 7q by fluorescence in situ hybridization (FISH).

  1996cited by this paper
• The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia.

  1996cited by this paper
• Detection of BCR‐ABL and E2A‐PBX1 fusion genes by RT‐PCR in acute lymphoblastic leukaemia with failed or normal cytogenetics

  1995cited by this paper
• Detection of minimal residual disease in acute leukemia: methodologic advances and clinical significance.

  1995cited by this paper
• Interphase cytogenetics of the t(8;21)(q22;q22) associated with acute myelogenous leukemia by two-color fluorescence in situ hybridization.

  1995cited by this paper
• Detection of the chromosome 16 CBF beta-MYH11 fusion transcript in myelomonocytic leukemias.

  1995influential reference
• Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features.

  1995cited by this paper
• The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

  1995cited by this paper
• High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

  1995influential reference
• Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

  1995cited by this paper
• dic(9; 20): A new recurrent chromosome abnormality in adult acute lymphoblastic leukemia

  1995cited by this paper
• A non-random chromosome abnormality found in precursor-B lineage acute lymphoblastic leukaemia: dic(9;20)(p1?3;q11).

  1995cited by this paper
• Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remission

  1995cited by this paper
• Detection of the BCR‐ABL gene by reverse transcription/polymerase chain reaction and fluorescence in situ hybridization in a patient with Philadelphia chromosome negative acute lymphoblastic leukaemia

  1995cited by this paper
• Combined cytogenetic, FISH and molecular analysis in acute promyelocytic leukaemia at diagnosis and in complete remission

  1995cited by this paper
• ALL-1 partial duplication in acute leukemia.

  1994cited by this paper
• Acute promyelocytic leukemia: from genetics to treatment.

  1994cited by this paper
• Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction.

  1994cited by this paper
• Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group.

  1994cited by this paper
• t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia

  1994cited by this paper
• The t(8;21) translocation in acute myeloid leukemia results in production of an AML1‐MTG8 fusion transcript.

  1993cited by this paper
• Identification of yeast artificial chromosomes containing the inversion 16 p-arm breakpoint associated with acute myelomonocytic leukemia.

  1993cited by this paper
• Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations.

  1993cited by this paper
• Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

  1993cited by this paper
• Detection of trisomy 8 on blood smears using fluorescence in situ hybridization.

  1993cited by this paper
• Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation.

  1993cited by this paper
• Rapid immunophenotypic characterization of chromosomally aberrant cells by the new FICTION method.

  1993cited by this paper
• Collaborative study of karyotypes in childhood acute lymphoblastic leukemias. Groupe Français de Cytogénétique Hématologique.

  1993cited by this paper
• Different Molecular Consequences of the 1;19 Chromosomal Translocation in Childhood B - Cell Precursor Acute Lymphoblastic Leukemia

  1992cited by this paper
• Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method.

  1992cited by this paper
• Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia.

  1992cited by this paper
• Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors.

  1992cited by this paper
• Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.

  1992cited by this paper
• Prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia.

  1992cited by this paper
• Simultaneous genotypic and immunophenotypic analysis of interphase cells using dual-color fluorescence: a demonstration of lineage involvement in polycythemia vera.

  1992cited by this paper
• The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.

  1991cited by this paper
• Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.

  1991cited by this paper
• Interphase cytogenetic analysis detects minimal residual disease in a case of acute lymphoblastic leukemia and resolves the question of origin of relapse after allogeneic bone marrow transplantation.

  1991cited by this paper
• Trisomy 21 in transient myeloproliferative disorder.

  1990cited by this paper
• Molecular methods to detect the Philadelphia chromosome.

  1990cited by this paper
• Detection of numerical chromosomal abnormalities in neoplastic hematopoietic cells by in situ hybridization with a chromosome-specific probe.

  1990cited by this paper
• Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization

  1990cited by this paper
• Molecular methods to detect the Philadelphia chromosome.

  1990influential reference
• Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

  1990cited by this paper
• Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

  1988cited by this paper
• Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).

  1988cited by this paper
• The BCR/ABL hybrid gene.

  1987cited by this paper

• Initial Diagnostic Workup of Acute Leukemia: Guideline From the College of American Pathologists and the American Society of Hematology.

  2017cites this paper
• Cytogenetic analysis of hematologic malignant diseases

  2017cites this paper
• Multiplex RT-PCR Assay for Detection of Common Fusion Transcripts in Acute Lymphoblastic Leukemia and Chronic Myeloid Leukemia Cases.

  2016cites this paper
• Acute lymphoblastic leukaemia.

  2013cites this paper
• The synthesis of art and science is lived by the nurse in the nursing act

  2012cites this paper
• Phenomenon of evolution of clonal chromosomal abnormalities in childhood acute myeloid leukemia

  2010cites this paper
• Rearrangements of chromosome 9 in different hematological neoplasias

  2008influential citation
• One-step multiplex RT-PCR for detection of BCR/ABL gene in Malay patients with chronic myeloid leukaemia

  2008cites this paper
• Cytogenetic and genomic characterization of cell line ARH77.

  2008cites this paper
• A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device.

  2007cites this paper
• A FISH comparison of variant derivatives of the recurrent dic(17;20) of myelodysplastic syndromes and acute myeloid leukemia: Obligatory retention of genes on 17p and 20q may explain the formation of dicentric chromosomes

  2007cites this paper
• Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study

  2005cites this paper
• Split-signal FISH for detection of chromosome aberrations

  2005cites this paper
• Complex karyotypic abnormalities in a case of acute myeloid leukaemia--M4Eo.

  2005cites this paper
• Genetische Diagnostik in der pädiatrischen Onkologie Genetic diagnosis in pediatric oncology

  2005cites this paper
• Cancer Diagnostics

  2004cites this paper
• LEADING ARTICLE Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia

  2004cites this paper
• FISH—Blood and Bone Marrow

  2004cites this paper
• Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia

  2004cites this paper
• Molecular Diagnostics in Neoplastic Hematopathology

  2004cites this paper
• [The role of molecular genetics in childhood cancer].

  2003cites this paper
• WT1 mRNA in Cerebrospinal Fluid Associated With Relapse in Pediatric Lymphoblastic Leukemia

  2003cites this paper
• Different effects of metabolic inhibitors and cyclosporin A on daunorubicin transport in leukemia cells from patients with AML.

  2003cites this paper
• Molecular Investigation of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia of B Lineage

  2003cites this paper
• Papel de la genética molecular en el cáncer infantil

  2003cites this paper
• Recent advances in the management of leukaemia

  2003cites this paper
• Molecular analysis of minimal residual disease in adult acute lymphoblastic leukaemia.

  2002cites this paper
• Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987–1999

  2002cites this paper
• Acute Myelogenous Leukemia Concurrent With Untreated Chronic Lymphocytic Leukemia

  2002cites this paper
• Hypothesis: Phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia

  2001cites this paper
• Alteraciones cromosómicas en la leucemia linfoblástica aguda

  2001cites this paper
• Acute lymphoblastic leukaemia.

  2001cites this paper
• The Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype Database in acute lymphoblastic leukaemia: a valuable resource for patient management

  2001cites this paper
• Avaliação de doença residual mínima pós-transplante de medula óssea

  2000cites this paper