Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection

It has been a long-standing dogma that host sensitization against fully- vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.

• Publication year

  1990

• Venue

  Journal of Experimental Medicine

• Publication date

  1990-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.171.1.307PMID 2404081PMCID 2187651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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