Elevated interleukin-18 serum levels in chronic schizophrenia: Association with psychopathology.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Psychiatric Research

• Publication date

  2012-08-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.jpsychires.2012.04.026PMID 22647522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls

  2011cited by this paper
• Association Between Promoter Variants of Interleukin-18 and Schizophrenia in a Han Chinese Population

  2011cited by this paper
• Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects.

  2011influential reference
• Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models

  2010cited by this paper
• Interleukin 18 in the CNS

  2010cited by this paper
• A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population.

  2009cited by this paper
• Interleukin-18 and stress.

  2008cited by this paper
• Comprehensive evaluation of positional candidates in the IL‐18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity

  2008cited by this paper
• Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review.

  2008cited by this paper
• A role for inflammatory mediators in the IL-18 mediated attenuation of LTP in the rat dentate gyrus.

  2007cited by this paper
• Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency

  2007cited by this paper
• Interleukin-18 and the pathogenesis of inflammatory diseases.

  2007cited by this paper
• Association of schizophrenia and autoimmune diseases: linkage of Danish national registers.

  2006cited by this paper
• Impaired niacin sensitivity in acute first-episode but not in multi-episode schizophrenia.

  2005cited by this paper
• IL-18: a key player in neuroinflammation and neurodegeneration?

  2005cited by this paper
• Cytokine networks in patients with schizophrenia and their possible role in its pathophysiology

  2004cited by this paper
• [Cytokine network in patients with schizophrenia and its significance for the pathophysiology of the illness].

  2004cited by this paper
• Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia.

  2004cited by this paper
• Multiple sclerosis: Cytokine receptors on oligodendrocytes predict innate regulation

  2004cited by this paper
• Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone.

  2002cited by this paper
• In utero infection and adult schizophrenia.

  2002cited by this paper
• Plasma Interleukin-18 Levels in Patients With Psychiatric Disorders

  2002cited by this paper
• Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology.

  2002cited by this paper
• Review of immunological and immunopathological findings in schizophrenia.

  2001cited by this paper
• The Th2-hypothesis of schizophrenia: a strategy to identify a subgroup of schizophrenia caused by immune mechanisms.

  2001cited by this paper
• Interleukin-18 promotes sleep in rabbits and rats.

  2001cited by this paper
• Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenics.

  2000cited by this paper
• Serum interleukin-18 levels are elevated in schizophrenia.

  2000cited by this paper
• IL-18 Directs Autoreactive T Cells and Promotes Autodestruction in the Central Nervous System Via Induction of IFN-γ by NK Cells1

  2000cited by this paper
• The role of immune function in schizophrenia: an overview

  1999cited by this paper
• Treatment with interferon-alpha in patients with chronic hepatitis and mood or anxiety disorders.

  1999cited by this paper
• Treatment with interferon-α in patients with chronic hepatitis and mood or anxiety disorders

  1999cited by this paper
• Clinical features of esophageal cancer in the octogenarian treated by definitive radiotherapy: a multi-institutional retrospective survey.

  1998cited by this paper
• Direct Activation of Human CD8+ Cytotoxic T Lymphocytes by Interleukin‐18

  1998cited by this paper
• Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

  1998cited by this paper
• Lower plasma CC16, a natural anti-inflammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs.

  1996cited by this paper
• [A case of perforated appendix caused by secondary amyloidosis associated with rheumatoid arthritis].

  1996cited by this paper
• The macrophage-T-lymphocyte theory of schizophrenia: additional evidence.

  1995cited by this paper
• Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers.

  1995cited by this paper
• Impaired mitogen (PHA) responsiveness and increased autoantibodies in Caucasian schizophrenic patients with the HLA B8/DR3 phenotype.

  1995cited by this paper
• Increased prevalence of antibrain antibodies in the sera from schizophrenic patients.

  1994cited by this paper
• Plasma and cerebrospinal fluid interleukin-1 beta and interleukin-6 in hospitalized schizophrenic patients.

  1994cited by this paper
• Plasma and Cerebrospinal Fluid lnterleukin-1 β and lnterleukin-6 in Hospitalized Schizophrenic Patients

  1994cited by this paper
• Infection and autoimmunity as etiologic factors in schizophrenia: a review and reappraisal.

  1993cited by this paper
• Autoimmunity in schizophrenia: a review of recent findings.

  1993cited by this paper
• T‐cells and psychopathology in schizophrenia: relationship to the outcome of neuroleptic therapy

  1993cited by this paper
• A comprehensive macrophage-T-lymphocyte theory of schizophrenia.

  1992cited by this paper
• Journal of Neuroinflammation Interleukin 18 in the Cns

  year unknowncited by this paper

• Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review

  2025cites this paper
• The relationship between serum Interleukin- 6, Interleukin- 18, Interleukin- 2, Eotaxin-1, Monocyte Chemoattractant Protein 1 levels and cognitive functions in treatment-resistant schizophrenia.

  2025cites this paper
• Dual role of Interleukin-18 in linking metabolic and psychiatric symptoms: Insights from machine learning in schizophrenia.

  2025cites this paper
• Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress

  2025cites this paper
• Comparative Analysis of Serum BAFF and IL-17 Levels Pre- and Post-Antipsychotic Treatment for Acute Schizophrenia

  2025cites this paper
• Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder.

  2024cites this paper
• The effect of clozapine on immune-related biomarkers in schizophrenia patients.

  2024cites this paper
• Immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: A meta-analysis.

  2023cites this paper
• Increased prefrontal cortical cells positive for macrophage/microglial marker CD163 along blood vessels characterizes a neuropathology of neuroinflammatory schizophrenia.

  2023cites this paper
• Association between cognitive function and IL-18 levels in schizophrenia: Dependent on IL18 - 607 A/C polymorphism.

  2023cites this paper
• Increased NLRP3 inflammasome expression in peripheral blood mononuclear cells of patients with schizophrenia: a case-control study

  2022cites this paper
• Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation

  2021cites this paper
• Peripheral immune markers and antipsychotic non-response in psychosis

  2021influential citation
• Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1β levels in patients with schizophrenia spectrum disorder and their siblings.

  2021cites this paper
• Correlation between polymorphisms of IL-18-607A/C and -137G/C and allergic rhinitis in Chinese population.

  2021cites this paper
• Relationship Between Curative Effect and Serum Inflammatory Factors Level in Male Patients With First-Episode Schizophrenia Treated With Olanzapine

  2021cites this paper
• Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

  2021cites this paper
• Elevated levels of IL‐18 associated with schizophrenia and first episode psychosis: A systematic review and meta‐analysis

  2020influential citation
• Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms.

  2019cites this paper
• The TNF-Alpha Gene −1031T>C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population

  2019cites this paper
• Changes in serum TNF-α, IL-18, and IL-6 concentrations in patients with chronic schizophrenia at admission and at discharge.

  2019cites this paper
• Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

  2018cites this paper
• Bone Marrow-Derived Stem Cells Protect Against Haloperidol-Induced Brain and Liver Damage in Mice

  2018cites this paper
• The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia

  2018cites this paper
• Mice lacking interleukin-18 gene display behavioral changes in animal models of psychiatric disorders: Possible involvement of immunological mechanisms.

  2018cites this paper
• The role of aberrations in the immune-inflammatory reflex system (IRS) and the compensatory immune-regulatory reflex system (CIRS) in different phenotypes of schizophrenia: the IRS-CIRS theory of schizophrenia Short title: The IRS-CIRS theory of schizophrenia

  2018cites this paper
• Cytokines dysregulation in schizophrenia: A systematic review of psychoneuroimmune relationship.

  2017cites this paper
• Altered serum levels of TNF‐α, IL‐6, and IL‐18 in depressive disorder patients

  2017cites this paper
• First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction.

  2017cites this paper
• Potential involvement of the interleukin-18 pathway in schizophrenia.

  2016cites this paper
• Transcriptome sequencing of the choroid plexus in schizophrenia

  2016cites this paper
• Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population.

  2016cites this paper
• Characterization of peripheral cannabinoid receptor expression and clinical correlates in schizophrenia.

  2016cites this paper
• Altered serum levels of TNF-α, IL-6 and IL-18 in manic, depressive, mixed state of bipolar disorder patients.

  2016cites this paper
• Altered interleukin-18 levels are associated with cognitive impairment in chronic schizophrenia.

  2016influential citation
• A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

  2016cites this paper
• Metabolic and inflammatory genes in schizophrenia.

  2015cites this paper
• The role of genetic variation across IL-1β, IL-2, IL-6, and BDNF in antipsychotic-induced weight gain

  2015cites this paper
• Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers.

  2015cites this paper
• IL-6, IL-18, sIL-2R, and TNFα proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation.

  2015cites this paper
• Hippocampal volume and depressive symptoms are linked to serum IL-18 in schizophrenia

  2015cites this paper
• Short report Open Access

  2015cites this paper
• Increased IL-3 serum levels in chronic patients with schizophrenia: Associated with psychopathology.

  2015cites this paper
• Editorial: immunotherapy in central nervous system.

  2015cites this paper
• Increased Interleukin-17 and decreased BAFF serum levels in drug-free acute schizophrenia.

  2015cites this paper
• Changes in Serum Levels of Brain Derived Neurotrophic Factor and Nerve Growth Factor‐Beta in Schizophrenic Patients Before and After Treatment

  2014cites this paper
• Elevated serum levels of TNF-α, IL-6 and IL-18 in chronic schizophrenic patients.

  2014cites this paper
• The immune system and schizophrenia: An update for clinicians

  2014cites this paper
• Reduced serum TNF alpha level in chronic schizophrenia patients with or without tardive dyskinesia.

  2014cites this paper
• Cytokine function in medication-naive first episode psychosis: a systematic review and meta-analysis.

  2014influential citation
• Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication.

  2013cites this paper
• Interleukin 18 and cognitive impairment in first episode and drug naïve schizophrenia versus healthy controls.

  2013cites this paper
• Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia

  2013cites this paper
• The Immune Response in the Aetiology of Schizophrenia: A Review

  2013cites this paper
• Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia

  2012cites this paper
• Immune System and Schizophrenia.

  2010cites this paper