IL-18 Directs Autoreactive T Cells and Promotes Autodestruction in the Central Nervous System Via Induction of IFN-γ by NK Cells1

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Immunology

• Publication date

  2000-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.165.6.3099PMID 10975822
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis.

  2000cited by this paper
• Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells.

  1999cited by this paper
• Natural Killer Cells Determine Development of Allergen-induced Eosinophilic Airway Inflammation in Mice

  1999influential reference
• IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.

  1999cited by this paper
• Remembering MOG: Autoantibody mediated demyelination in multiple sclerosis?

  1999influential reference
• Progress in determining the causes and treatment of multiple sclerosis

  1999cited by this paper
• Viruses, host responses, and autoimmunity

  1999cited by this paper
• Natural killer cells in antiviral defense: function and regulation by innate cytokines.

  1999cited by this paper
• Cytokines induce the development of functionally heterogeneous T helper cell subsets.

  1998cited by this paper
• Challenging Cytokine Redundancy: Inflammatory Cell Movement and Clinical Course of Experimental Autoimmune Encephalomyelitis Are Normal in Lymphotoxin-deficient, but Not Tumor Necrosis Factor–deficient, Mice

  1998cited by this paper
• Defective NK cell activity and Th1 response in IL-18-deficient mice.

  1998cited by this paper
• Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis.

  1998cited by this paper
• Seeking wisdom in innate immunity

  1997cited by this paper
• Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells

  1997cited by this paper
• IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

  1997cited by this paper
• Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

  1997cited by this paper
• IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

  1997cited by this paper
• Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)

  1996cited by this paper
• IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

  1996cited by this paper
• A newly defined interleukin-1?

  1996cited by this paper
• The Instructive Role of Innate Immunity in the Acquired Immune Response

  1996cited by this paper
• Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking

  1996cited by this paper
• Women Fight Uphill Battle for Equity

  1996cited by this paper
• Cloning of a new cytokine that induces IFN-γ production by T cells

  1995cited by this paper
• A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells

  1995cited by this paper
• Cloning of a new cytokine that induces IFN-gamma production by T cells.

  1995cited by this paper
• Organ-specific autoimmunity.

  1995cited by this paper
• Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.

  1993cited by this paper
• RAG-1-deficient mice have no mature B and T lymphocytes.

  1992influential reference
• Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?

  1992cited by this paper
• Establishment of Monoclonal Anti-Nk-1.1 Antibody

  1984cited by this paper

• Is Obesity a Modifiable Risk Factor in Multiple Sclerosis? Mechanistic Insights into Neuroinflammation and Oxidative Damage

  2026cites this paper
• The innate cytokine IL-18 inhibits CNS autoimmunity through preferential activation of protective CD8 T-cells

  2026cites this paper
• Synergistic Targeting of Innate Receptors TLR7 and NOD2 for Therapeutic Intervention in Multiple Sclerosis

  2024cites this paper
• The NLRP3 inflammasome: A central player in multiple sclerosis.

  2024cites this paper
• Pyroptosis the Emerging Link Between Gut Microbiota and Multiple Sclerosis

  2024cites this paper
• Inflammasomes and their roles in autoimmune diseases

  2024cites this paper
• The Mechanisms of Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Encephalomyelitis.

  2024cites this paper
• The dichotomic role of cytokines in aging

  2024cites this paper
• IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation

  2024cites this paper
• Biological and clinical roles of IL-18 in inflammatory diseases

  2023cites this paper
• Confirmation of CD19+ B-Lymphocyte Depletion Prior to Intake of the Second Dose of Ocrelizumab in Multiple Sclerosis Patients

  2023cites this paper
• Immunogenetics of autism spectrum disorder: A systematic literature review.

  2023cites this paper
• Epigenetic control of ataxin‐1 in multiple sclerosis

  2022cites this paper
• IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes

  2022cites this paper
• Natural Killer Cells in Multiple Sclerosis: Entering the Stage

  2022cites this paper
• Heat‐killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome

  2022cites this paper
• Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis

  2022influential citation
• Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics

  2022cites this paper
• Artemisinin derivative TPN10466 suppresses immune cell migration and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.

  2022cites this paper
• Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis.

  2021cites this paper
• DNA Damage Response in the Adaptive Arm of the Immune System: Implications for Autoimmunity

  2021cites this paper
• Focus on the Role of NLRP3 Inflammasome in Diseases

  2020cites this paper
• Association Between Multiple Sclerosis and Alcohol Consumption: One Hypothesis Based on Immunological Studies

  2020cites this paper
• Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis

  2020cites this paper
• OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis

  2019cites this paper
• Migrant or resident? The identification of group 1 innate lymphoid cells in the murine central nervous system

  2019cites this paper
• The immunological response to traumatic brain injury.

  2019cites this paper
• The differential expression of natural killer cells in NMOSD and MS.

  2019cites this paper
• NKG 2 D and DNAM-1 activating receptors and their ligands in NKT cell interactions : role in the NK cell-mediated negative regulation of T cell responses

  2019cites this paper
• NLRs as Helpline in the Brain: Mechanisms and Therapeutic Implications

  2018cites this paper
• The immunogenetics of neurological disease

  2018cites this paper
• Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation

  2018cites this paper
• NK cells in autoimmune diseases: Linking innate and adaptive immune responses.

  2018cites this paper
• Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus

  2017cites this paper
• NK cell compartment in the peripheral blood and spleen in adult patients with primary immune thrombocytopenia.

  2017cites this paper
• High Resolution HLA Analysis Reveals Independent Class I Haplotypes and Amino-Acid Motifs Protective for Multiple Sclerosis

  2017cites this paper
• Differential Expression of CD 16 and CD 56 on Natural Killer ( NK ) Cell Subsets in Multiple Sclerosis and Neuromyelitis Optica

  2016cites this paper
• Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis

  2016cites this paper
• Effects of interleukin-1 receptor-associated kinase 1 RNA interference in dendritic cells on inflammatory cytokine release and T-cell proliferation.

  2016cites this paper
• iNKT cell regulation of B cell activation in inflammation

  2016cites this paper
• Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid.

  2016cites this paper
• The Emerging Roles of Gamma–Delta T Cells in Tissue Inflammation in Experimental Autoimmune Encephalomyelitis

  2016cites this paper
• Functional effects of the antigen glatiramer acetate are complex and tightly associated with its composition.

  2016cites this paper
• Animal models of myasthenia gravis: utility and limitations

  2016cites this paper
• γδ T Cells and NK Cells – Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity

  2015cites this paper
• Investigating the Role of Innate Inflammatory Pathways During Infection With Murine Coronavirus

  2015cites this paper
• The immunogenetics of multiple sclerosis: A comprehensive review.

  2015cites this paper
• Inflammasomes: mechanism of action, role in disease, and therapeutics

  2015cites this paper
• Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration.

  2015cites this paper
• In�a��a�o�e andMS����

  2015cites this paper
• Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

  2015cites this paper
• Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset

  2015influential citation
• NK Cell Subset Disease by Adoptive Transfer of an Atypical Cutting Edge: Induction of Inflammatory

  2015influential citation
• Differential Expression of CD16 and CD56 on Natural Killer (NK) Cell Subsets in Multiple Sclerosis and Neuromyelitis Optica

  2015cites this paper
• Innate IFN‐γ promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages

  2014cites this paper
• The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs)

  2014cites this paper
• Hematopoietic progenitor populations for cell therapy of autoimmune diseases : characterization and comparison of their mechanism of action in Type I Diabetes and Experimental Autoimmune Encephalomyelitis

  2014cites this paper
• Implication des cellules NK au cours des maladies auto-immunes

  2014cites this paper
• Analyzing the effects of laquinimod on innate and adaptive immunity in mice with experimental autoimmune encephalomyelitis

  2014cites this paper
• Regulation of CD4+ Autoimmune Memory by CTLA4

  2014cites this paper
• Experimental Autoimmune Myasthenia Gravis (EAMG): from immunochemical characterization to therapeutic approaches.

  2014cites this paper
• Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease.

  2013cites this paper
• IL-18 in inflammatory and autoimmune disease

  2013cites this paper
• Natural killer cells and their receptors in multiple sclerosis.

  2013cites this paper
• Natural killer cells in human autoimmune disorders

  2013cites this paper
• On The Role of Natural Killer Cells in Neurodegenerative Diseases

  2013influential citation
• NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses

  2013cites this paper
• NLRP3 Inflammasome and MS/EAE

  2013cites this paper
• The role of inflammasome‐derived IL‐1 in driving IL‐17 responses

  2013cites this paper
• recruitment in ovalbumin-challenged OTII mice Mast cell-derived TNF can promote Th17 cell-dependent neutrophil

  2013cites this paper
• The role of interferon‐β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis – in the perspective of inflammasomes

  2013cites this paper
• The Role of Natural Killer Cells in Autoimmunity

  2013cites this paper
• Identification of interleukin‐1 receptor‐associated kinase 1 as a critical component that induces post‐transcriptional activation of IκB‐ζ

  2012cites this paper
• Involvement of IL-1R/TLR signalling in experimental autoimmune encephalomyelitis and multiple sclerosis.

  2012cites this paper
• NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice

  2012cites this paper
• The Role of Natural Killer Cells in Alzheimer’s Disease

  2012cites this paper
• Proatherogenic role of interleukin-18: effects on inflammation and action on vascular cells

  2012cites this paper
• Genetic and Immunological Regulation of Neuroinflammation

  2012cites this paper
• An Enhanced Immune Response of Mclk1 +/− Mutant Mice Is Associated with Partial Protection from Fibrosis, Cancer and the Development of Biomarkers of Aging

  2012cites this paper
• Regulatory NK cells in autoimmune disease.

  2012cites this paper
• Role of Natural Killer Cells in Multiple Sclerosis

  2012cites this paper
• Association of Killer Cell Immunoglobulin-Like Receptor and Human Leukocyte Antigen-C Genotype with Dry Eye Disease in a Chinese Han Population

  2012cites this paper
• The innate immune system in demyelinating disease

  2012cites this paper
• Antibody to α4 integrin suppresses natural killer cells infiltration in central nervous system in experimental autoimmune encephalomyelitis.

  2012cites this paper
• Interleukin‐32 enhances cytotoxic effect of natural killer cells to cancer cells via activation of death receptor 3

  2012cites this paper
• The Role of Natural Killer Cells in Multiple Sclerosis and Their Therapeutic Implications

  2012cites this paper
• Elevated interleukin-18 serum levels in chronic schizophrenia: Association with psychopathology.

  2012cites this paper
• CD4 T Cells That Mediate Autoimmunity and d g IL-18 Promote IL-17 Production by and b Processed Cytokines IL-1 - Caspase-1

  2011cites this paper
• NK cells: immune cross-talk and therapeutic implications.

  2011cites this paper
• It is still not for the old iron: adjuvant effects of carbonyl iron in experimental autoimmune encephalomyelitis induction

  2011cites this paper
• Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

  2011cites this paper
• Modeling and forecasting volatility of Shanghai Stock Exchange with GARCH family models

  2011cites this paper
• IL-1 and Innate Immunity in the Differentiation of T H 17 Cells

  2011cites this paper
• Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity

  2011cites this paper
• Multiple sclerosis, seizures, and antiepileptics: role of IL‐18, IDO, and melatonin

  2011cites this paper
• Establishment of serum ELISA tests against putative lung adenocarcinoma antigens

  2011cites this paper
• IL-18 is required for self-reactive T cell expansion in NOD mice.

  2011cites this paper
• IL-18 Binding Protein Induced - g Responses Are Inhibited by IFN-Inflammation in the CNS and Th17

  2010cites this paper
• Centrally Administered Pertussis Toxin Inhibits Microglia Migration to the Spinal Cord and Prevents Dissemination of Disease in an EAE Mouse Model

  2010cites this paper
• NK and NKT cells: The innate–adaptive interface including humoral responses

  2010cites this paper