Iron and transfusion medicine.

Blood bankers have focused their energy to secure blood transfusion, and only recently have studies been published on the effect of blood donation on iron metabolism. In many facilities, hemoglobin measurement is only performed just before or even during blood donation, but the determination of iron stores is largely ignored. The 2013 paradox of transfusion medicine is due to the fact that blood donation may be harmful and leads to iron deficiency with or without anemia, but for other individuals, it may be a healthy measure preventing type 2 diabetes. The purpose of this review is to discuss iron metabolism in the perspective of blood donation, notably regarding their possible genetic profiles that eventually will discriminate "good" iron absorbers from "bad" iron responders.

• Publication year

  2013

• Venue

  Blood reviews

• Publication date

  2013-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.blre.2013.10.001PMID 24148756
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Iron status and dietary iron intake of female blood donors

  2014cited by this paper
• External validation and updating of a Dutch prediction model for low hemoglobin deferral in Irish whole blood donors

  2014cited by this paper
• Monogenic diseases that can be cured by liver transplantation.

  2013cited by this paper
• Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry-based blood group genotyping--the alternative approach.

  2013cited by this paper
• Hereditary hemochromatosis.

  2013cited by this paper
• Laboratory variables for assessing iron deficiency in REDS‐II Iron Status Evaluation (RISE) blood donors

  2013cited by this paper
• Measuring the global burden of disease.

  2013cited by this paper
• Molecular diagnosis of hemochromatosis.

  2013cited by this paper
• Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy

  2013cited by this paper
• Ascertainment of iron deficiency and depletion in blood donors through screening questions for pica and restless legs syndrome

  2013cited by this paper
• Iron and diabetes risk.

  2013cited by this paper
• Iron and hepatic carcinogenesis.

  2013cited by this paper
• Validation of hepcidin quantification in plasma using LC-HRMS and discovery of a new hepcidin isoform.

  2013cited by this paper
• Development of GMDR-GPU for Gene-Gene Interaction Analysis and Its Application to WTCCC GWAS Data for Type 2 Diabetes

  2013cited by this paper
• Ferritin levels and risk of type 2 diabetes mellitus: an updated systematic review and meta‐analysis of prospective evidence

  2013cited by this paper
• High prevalence of subclinical iron deficiency in whole blood donors not deferred for low hemoglobin

  2013cited by this paper
• Zinc protoporphyrin levels have added value in the prediction of low hemoglobin deferral in whole blood donors

  2013cited by this paper
• Restless legs syndrome, pica, and iron status in blood donors

  2013cited by this paper
• On myocardial siderosis and left ventricular dysfunction in hemochromatosis

  2013cited by this paper
• The difference between fingerstick and venous hemoglobin and hematocrit varies by sex and iron stores

  2012cited by this paper
• Mechanisms of mammalian iron homeostasis.

  2012cited by this paper
• Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis

  2012cited by this paper
• Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial

  2012cited by this paper
• Etiology of anemia of blood donor candidates deferred by hematologic screening

  2012cited by this paper
• Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis

  2012cited by this paper
• Non-HFE hemochromatosis

  2012cited by this paper
• Development and validation of a prediction model for low hemoglobin deferral in a large cohort of whole blood donors

  2012cited by this paper
• Blood donation, blood supply, iron deficiency and anemia - it is time to shift attention back to donor health

  2012cited by this paper
• Iron deficiency in blood donors: the REDS‐II Donor Iron Status Evaluation (RISE) study

  2012cited by this paper
• Review article: the iron overload syndromes

  2012cited by this paper
• W472 A SINGLE 1000 MG IRON DOSE OF FERRIC CARBOXYMALTOSE IMPROVES FATIGUE IN IRON DEFICIENT, NON‐ANAEMIC PREMENOPAUSAL WOMEN – RESULTS OF THE RANDOMISED, PLACEBO‐CONTROLLED PREFER STUDY

  2012cited by this paper
• [Iron deficiency without anemia: where are we in 2012?].

  2012cited by this paper
• Accuracy of Noninvasive and Invasive Point-of-Care Total Blood Hemoglobin Measurement in an Outpatient Setting

  2012cited by this paper
• Prognostic value of red blood cell parameters and ferritin in predicting deferral due to low hemoglobin in whole blood donors

  2012cited by this paper
• Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial

  2012cited by this paper
• CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients

  2012cited by this paper
• Haematocrit is invalid for estimating red cell volume: a prospective study in male volunteers.

  2012cited by this paper
• Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population.

  2012cited by this paper
• Non-Invasive Measurement of Hemoglobin: Assessment of Two Different Point-of-Care Technologies

  2012cited by this paper
• Switching iron‐deficient whole blood donors to plateletpheresis

  2012cited by this paper
• Ironing out fatigue.

  2011cited by this paper
• Genotyping of the hemochromatosis HFE p.H63D and p.C282Y mutations by high-resolution melting with the Rotor-Gene 6000® instrument

  2011cited by this paper
• Hepcidin and iron regulation, 10 years later.

  2011cited by this paper
• Use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for multiplex genotyping.

  2011cited by this paper
• Hemoglobin and iron indices in nonanemic premenopausal blood donors predict future deferral from whole blood donation

  2011cited by this paper
• Hereditary hemochromatosis: mutations in genes involved in iron homeostasis in Brazilian patients.

  2011cited by this paper
• Medium-throughput SNP genotyping using mass spectrometry: multiplex SNP genotyping using the iPLEX® Gold assay.

  2011cited by this paper
• The molecular basis of iron overload disorders and iron-linked anemias

  2011cited by this paper
• Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors

  2011cited by this paper
• Iron restriction improves type 2 diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats.

  2010cited by this paper
• The value of routine ferritin measurement in blood donors

  2010cited by this paper
• Hepcidin: the link to understanding iron regulation.

  2010cited by this paper
• DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA.

  2010cited by this paper
• The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis

  2010cited by this paper
• A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes

  2010cited by this paper
• Glucose metabolism after normalization of markers of iron overload by venesection in subjects with hereditary hemochromatosis.

  2010cited by this paper
• A genome-wide association analysis of serum iron concentrations.

  2010cited by this paper
• Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.

  2010cited by this paper
• HJV Hemochromatosis, Iron Overload, and Hypogonadism in a Brazilian Man: Treatment with Phlebotomy and Deferasirox

  2010cited by this paper
• BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies

  2010cited by this paper
• Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis.

  2010cited by this paper
• Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

  2009cited by this paper
• Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.

  2009cited by this paper
• Detecting gene–gene interactions that underlie human diseases

  2009cited by this paper
• The effect of blood donation frequency on iron status.

  2009cited by this paper
• Assessment of iron deficiency in US preschool children and nonpregnant females of childbearing age: National Health and Nutrition Examination Survey 2003-2006.

  2009cited by this paper
• Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MassARRAY).

  2009cited by this paper
• Ferric carboxymaltose in patients with heart failure and iron deficiency.

  2009cited by this paper
• Iron-Mediated Inhibition of Mitochondrial Manganese Uptake Mediates Mitochondrial Dysfunction in a Mouse Model of Hemochromatosis

  2008cited by this paper
• Behavioral, biochemical, and genetic analysis of iron metabolism in high‐intensity blood donors

  2008cited by this paper
• Regulation of iron acquisition and storage: consequences for iron-linked disorders

  2008cited by this paper
• Enhanced detection of genetic association of hypertensive heart disease by analysis of latent phenotypes

  2008cited by this paper
• The regulation of hepcidin and its effects on systemic and cellular iron metabolism.

  2008cited by this paper
• Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study

  2007cited by this paper
• Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice.

  2007cited by this paper
• Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression

  2007cited by this paper
• Guide to the Preparation, Use and Quality Assurance of Blood Components (13th edn)

  2007cited by this paper
• Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial.

  2007cited by this paper
• Sensitivity and Uncertainty Analyses for Burden of Disease and Risk Factor Estimates

  2006cited by this paper
• Ferritin and Transferrin Are Both Predictive of the Onset of Hyperglycemia in Men and Women Over 3 Years

  2006cited by this paper
• High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis

  2006cited by this paper
• Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes

  2006cited by this paper
• Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis

  2006cited by this paper
• Iron depletion by whole‐blood donation harms menstruating females: The current whole‐blood‐collection paradigm needs to be changed

  2006cited by this paper
• Regulation of iron metabolism by hepcidin.

  2006cited by this paper
• Measuring the Global Burden of Disease and Risk Factors, 1990–2001

  2006cited by this paper
• IRON BALANCE REMAINS STABLE IN LIFE-LONG BLOOD DONORS

  2005cited by this paper
• The restless legs syndrome.

  2005cited by this paper
• Iron stores, blood donation, and insulin sensitivity and secretion.

  2005cited by this paper
• Body iron stores in relation to risk of type 2 diabetes in apparently healthy women.

  2004cited by this paper
• Cross talk between iron metabolism and diabetes.

  2004cited by this paper
• Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women.

  2004cited by this paper
• Transferrin receptor in serum. A new tool in the diagnosis and prevention of iron deficiency in blood donors.

  2004cited by this paper
• Role of Oxidative Stress in the Etiology of Type 2 Diabetes and the Effect of Antioxidant Supplementation on Glycemic Control

  2004cited by this paper
• Restless legs syndrome

  2003cited by this paper
• A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS

  2003cited by this paper
• Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial

  2003cited by this paper
• High serum ferritin is not identical to high iron stores.

  2003cited by this paper
• Iron status in Danish men 1984–94: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload

  2002cited by this paper
• Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity.

  2002cited by this paper

• Impact of Frequent Blood Donations on Red Blood Cell Indices, Reticulocyte Parameters, and Iron Metabolism

  2026cites this paper
• Consensus Statement on the definition and classification of metabolic hyperferritinaemia

  2023cites this paper
• Relation of Iron, TIBC and Oxidative Stress with Glycosylated Haemoglobin in Diabetes Mellitus

  2020cites this paper
• Donor iron depletion: beneficial or burdensome?

  2019cites this paper
• Iron deficiency among blood donors: experience from the Danish Blood Donor Study and from the Copenhagen ferritin monitoring scheme

  2019cites this paper
• Utility of zinc protoporphyrin in management of whole blood donors

  2018cites this paper
• FinDonor 10 000 study: a cohort to identify iron depletion and factors affecting it in Finnish blood donors

  2018cites this paper
• Blood donation and iron deficiency

  2017cites this paper
• Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns.

  2017cites this paper
• Iron: how much is too much?

  2017cites this paper
• Hepcidin as a new biomarker for detecting autologous blood transfusion

  2016cites this paper
• Blood donation and/or donated blood acceptance: The different stakeholders’ ethical considerations

  2016cites this paper
• Ethics and blood donation: A marriage of convenience.

  2016cites this paper
• The association between frequency of blood donation and the occurrence of low birthweight, preterm delivery, and stillbirth: a retrospective cohort study

  2016cites this paper
• Bloodletting for non‐medical reasons: what about safety and quality?

  2015cites this paper
• Laboratory and genetic assessment of iron deficiency in blood donors.

  2015cites this paper
• Transfusion et inflammation : hier – aujourd’hui – demain

  2015cites this paper
• Método práctico para el diagnóstico de la anemia ferropénica en niños

  2015cites this paper
• [Blood transfusion and inflammation as of yesterday, today and tomorrow].

  2015cites this paper