A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer’s disease

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Neurology

• Publication date

  2000-09-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1212/WNL.55.6.763PMID 10993992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• α1-Antichymotrypsin Polymorphism

  2001cited by this paper
• Vascular risk factors in dementia

  2000cited by this paper
• Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland

  2000cited by this paper
• Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease.

  2000cited by this paper
• Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

  1999cited by this paper
• Association between Alzheimer's disease and the NOS3 gene

  1999cited by this paper
• Aging and the occurrence of dementia: findings from a population-based cohort with a large sample of nonagenarians.

  1999cited by this paper
• The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage.

  1999cited by this paper
• No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples.

  1999cited by this paper
• Vascular factors and Alzheimer disease.

  1999cited by this paper
• Factors associated with vascular dementia in an elderly community population

  1999cited by this paper
• Cellular processing of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type.

  1999cited by this paper
• The Apolipoprotein E ∈2 Allele and the Pathological Features in Cerebral Amyloid Angiopathy-related Hemorrhage

  1999cited by this paper
• The relationship between apolipoprotein E, dementia, and vascular illness.

  1998cited by this paper
• Intracellular accumulation of the amyloidogenic L68Q variant of human cystatin C in NIH/3T3 cells.

  1998cited by this paper
• Alpha-2 macroglobulin is genetically associated with Alzheimer disease

  1998cited by this paper
• The prevalence of apoE-epsilon4 in Alzheimer's disease is age dependent.

  1998cited by this paper
• Apolipoprotein E Polymorphism in Patients with Alzheimer’s Disease, Vascular Dementia and Ischemic Cerebrovascular Disease

  1998cited by this paper
• The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.

  1998cited by this paper
• The prevalence of apoE-ε4 in Alzheimer’s disease is age dependent

  1998cited by this paper
• The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations.

  1998cited by this paper
• Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis

  1997cited by this paper
• Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.

  1997cited by this paper
• Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

  1997cited by this paper
• Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.

  1997cited by this paper
• Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.

  1997cited by this paper
• Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population.

  1997cited by this paper
• Coronary Artery Disease, Hypertension, ApoE, and Cholesterol: A Link to Alzheimer's Disease?

  1997cited by this paper
• Brain infarction and the clinical expression of Alzheimer disease.

  1997cited by this paper
• Microvascular degeneration in hereditary cystatin C amyloid angiopathy of the brain

  1997influential reference
• Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.

  1997cited by this paper
• ApoE-4 and Age at Onset of Alzheimer's Disease

  1997cited by this paper
• Dietary fat intake and the risk of incident dementia in the Rotterdam study

  1997cited by this paper
• Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease.

  1997cited by this paper
• Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.

  1996cited by this paper
• Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease

  1996cited by this paper
• APOE-epsilon 4 in patients with Alzheimer disease and vascular dementia.

  1996cited by this paper
• APOE-ε4 in Patients with Alzheimer Disease and Vascular Dementia

  1996cited by this paper
• Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia

  1996cited by this paper
• Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease.

  1996cited by this paper
• APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.

  1995cited by this paper
• A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

  1995cited by this paper
• Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

  1995cited by this paper
• Co‐localization of β/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis

  1994cited by this paper
• An Ala/Thr variation in the coding region of the human cystatin C gene (CST3) detected as a SstII polymorphism

  1993cited by this paper
• On the role of monocytes/macrophages in the pathogenesis of central nervous system lesions in hereditary cystatin C amyloid angiopathy.

  1992cited by this paper
• Apolipoprotein E genotyping by one-stage PCR.

  1991cited by this paper
• Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease.

  1990cited by this paper
• Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases

  1989cited by this paper
• Hereditary cystatin C (γ‐trace) amyloid angiopathy of the CNS causing cerebral hemorrhage

  1987cited by this paper
• Hereditary cystatin C (gamma-trace) amyloid angiopathy of the CNS causing cerebral hemorrhage.

  1987cited by this paper

• Cystatins: unravelling the biological implications for neuroprotection

  2023cites this paper
• Type 2 Cystatins and Their Roles in the Regulation of Human Immune Response and Cancer Progression

  2023cites this paper
• The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches.

  2022cites this paper
• High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota

  2021cites this paper
• Relationship of Cystatin C With the Pathophysiology of CNS Diseases

  2020cites this paper
• Increased Rate of Retinal Pigment Epithelial Cell Migration and Pro-Angiogenic Potential Ensuing From Reduced Cystatin C Expression

  2020cites this paper
• Mammalian cystatin and protagonists in brain diseases

  2020cites this paper
• Effects of CST3 Gene G73A Polymorphism on Cystatin C in a Prospective Multiethnic Cohort Study

  2020cites this paper
• The Functional Mammalian CRES (Cystatin-Related Epididymal Spermatogenic) Amyloid is Antiparallel β-Sheet Rich and Forms a Metastable Oligomer During Assembly

  2019cites this paper
• Correlations of serum cystatin C level and gene polymorphism with vascular cognitive impairment after acute cerebral infarction

  2019cites this paper
• Cystatin C promotes tau protein phosphorylation and causes microtubule instability by inhibiting intracellular turnover of GSK3&bgr; in neurons

  2018cites this paper
• Psychiatric and cognitive symptoms in Huntington's disease are modified by polymorphisms in catecholamine regulating enzyme genes

  2016cites this paper
• Biomarkers of Renal Function in Type 2 Diabetic Patients with Cognitive Impairment.

  2016cites this paper
• Molecular Biomarkers for Diagnosis & Therapies of Alzheimer’s Disease

  2016cites this paper
• Natural Modulators of Amyloid formation in Alzheimer's disease

  2016cites this paper
• Cystatin C in aging and in Alzheimer's disease.

  2016cites this paper
• Evidence of Alternative Cystatin C Signal Sequence Cleavage Which Is Influenced by the A25T Polymorphism

  2016cites this paper
• Identifying biomarkers of dementia prevalent among amnestic mild cognitively impaired ethnic female patients

  2016cites this paper
• Cystatin C is differentially involved in multiple system atrophy phenotypes

  2015cites this paper
• Cystatin C and Alzheimer's Disease

  2014cites this paper
• Fertility Defects in Mice Expressing the L68Q Variant of Human Cystatin C

  2014cites this paper
• Autophagic/lysosomal dysfunction in Alzheimer’s disease

  2013cites this paper
• Alterations of CSF Cystatin C Levels and Their Correlations with CSF Αβ40 and Αβ42 Levels in Patients with Alzheimer's Disease, Dementia with Lewy Bodies and the Atrophic Form of General Paresis

  2013cites this paper
• β-Amyloid Precursor Protein: Function in Stem Cell Development and Alzheimer's Disease Brain

  2013cites this paper
• The genetics of Alzheimer's disease.

  2012cites this paper
• The genetics of Alzheimer disease.

  2012cites this paper
• Meta-Analysis of the Cystatin C(CST3) Gene G73A Polymorphism and Susceptibility to Alzheimer's Disease

  2012influential citation
• Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer’s disease?

  2012cites this paper
• Cystatin C in Alzheimer's disease

  2012cites this paper
• Genetics of Late-Onset Alzheimer's Disease: Update from the Alzgene Database and Analysis of Shared Pathways

  2011cites this paper
• Biomarkers of Renal Function and Cognitive Impairment in Patients With Diabetes

  2011cites this paper
• Association between CST3 rs2424577 Polymorphism and Corpulence Related Phenotypes during Lifetime in Populations of European Ancestry

  2011cites this paper
• Protective mechanisms by cystatin C in neurodegenerative diseases.

  2011cites this paper
• DNA methylation in neurodegenerative disorders: a missing link between genome and environment?

  2011cites this paper
• Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3.

  2010cites this paper
• Polypeptide biomarkers for diagnosing alzheimer's disease-European Patent Office-EP 1953556 B1

  2010cites this paper
• Cystatin C in macular and neuronal degenerations: implications for mechanism(s) of age-related macular degeneration.

  2010cites this paper
• The CST3 BB Genotype and Low Cystatin C Cerebrospinal Fluid Levels are Associated with Dementia in Lewy Body Disease

  2010cites this paper
• Avaliação de polimorfismos de DNA em genes candidatos de pacientes com comprometimento cognitivo leve e doença de Alzheimer.

  2010cites this paper
• The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects.

  2009cites this paper
• Proteinase inhibitors in the cerebrospinal fluid in neurological diseases

  2009cites this paper
• Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle

  2008cites this paper
• The in Vivo Brain Interactome of the Amyloid Precursor Protein*S

  2008cites this paper
• Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.

  2008cites this paper
• Das lysosomale Enzym Cathepsin D als genetischer Risikofaktor für Morbus Alzheimer

  2008cites this paper
• Serum cystatin C and the risk of Alzheimer disease in elderly men

  2008cites this paper
• APPSWE Microinjected Mouse Model | Taconic Biosciences

  2008cites this paper
• Involvement of cystatin C in pathophysiology of CNS diseases.

  2008cites this paper
• Lack of an Association between Alzheimer’s Disease and the Cystatin C (CST3) Gene G73A Polymorphism in Mainland Chinese

  2008cites this paper
• Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

  2008cites this paper
• Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide

  2007cites this paper
• Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons.

  2007cites this paper
• Cystatin C reduces the in vitro formation of soluble Aβ1‐42 oligomers and protofibrils

  2007cites this paper
• Genotype and Plasma Concentration of Cystatin C in Patients with Late-Onset Alzheimer Disease

  2007cites this paper
• Protease Inhibitors and their Involvement in Neurological Disorders

  2007cites this paper
• The Role of Cystatin C in Cerebral Amyloid Angiopathy and Stroke: Cell Biology and Animal Models

  2006cites this paper
• Studies on the first described Alzheimer's disease amyloid β mutant, the Dutch variant

  2006cites this paper
• Genetic analysis of the cystatin C gene in familial and sporadic ALS patients.

  2006cites this paper
• Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant.

  2006cites this paper
• Genetics, transcriptomics, and proteomics of Alzheimer's disease.

  2006cites this paper
• Genotype (cystatin C) and EEG phenotype in Alzheimer disease and mild cognitive impairment: A multicentric study

  2006cites this paper
• Cystatin C and apoe polymorphisms in Italian Alzheimer's disease.

  2006cites this paper
• Membership in Genetic Groups Predicts Alzheimer Disease

  2006cites this paper
• Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse.

  2005cites this paper
• No association between the cystatin C gene polymorphism and Alzheimer's disease: A case-control study in an Italian population

  2005influential citation
• Cystatin C expression is associated with granule cell dispersion in epilepsy

  2005cites this paper
• Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B.

  2005cites this paper
• Cystatin C as a risk factor for Alzheimer disease

  2005cites this paper
• Expression of cystatin C prevents oxidative stress-induced death in PC12 cells.

  2005cites this paper
• Age at Onset: An Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease

  2005cites this paper
• Genes involved in Alzheimer's disease, a survey of possible candidates

  2005cites this paper
• Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease.

  2005cites this paper
• Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation.

  2004cites this paper
• Human Evidence That the Cystatin C Gene Is Implicated in Focal Progression of Coronary Artery Disease

  2004cites this paper
• Cerebral amyloid angiopathy and dementia.

  2004cites this paper
• Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease

  2004cites this paper
• Cystathionine beta synthase as a risk factor for Alzheimer disease.

  2004cites this paper
• Cystatin forms a tetramer through structural rearrangement of domain-swapped dimers prior to amyloidogenesis.

  2004cites this paper
• Identification of up‐regulated genes by array analysis in scrapie‐infected mouse brains

  2004cites this paper
• Biochemistry and Clinical Role of Human Cystatin C

  2004cites this paper
• Molecular Genetics of Late‐Onset Alzheimer's Disease

  2004cites this paper
• Proteomic Characterization of Postmortem Amyloid Plaques Isolated by Laser Capture Microdissection*[boxs]

  2004cites this paper
• Genetic approach to the role of cysteine proteases in the expansion of abdominal aortic aneurysms

  2004cites this paper
• Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation

  2004cites this paper
• The homocysteine pathway: A new target for Alzheimer disease treatment?

  2004cites this paper
• Genetics of neurological disorders

  2004cites this paper
• Cerebral Amyloid Angiopathy: New Insights from Transgenic Mice

  2004cites this paper
• Fate of cystatin C lacking the leader sequence in RPE cells.

  2003cites this paper
• Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme.

  2003cites this paper
• Age-Dependent Association between the Q7R Polymorphism in the Saitohin Gene and Sporadic Alzheimer’s Disease

  2003cites this paper
• Genética y enfermedad de Alzheimer

  2003cites this paper
• A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer's disease

  2003cites this paper
• Alzheimer disease-associated cystatin C variant undergoes impaired secretion.

  2003cites this paper
• Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity.

  2003cites this paper
• The association of a cystatin C gene polymorphism with late-onset Alzheimer's disease and vascular dementia.

  2003cites this paper
• Cathepsin D Polymorphism in Italian Elderly Subjects with Sporadic Late-Onset Alzheimer’s Disease

  2003cites this paper
• Cerebral Amyloid Angiopathies: A Pathologic, Biochemical, and Genetic View

  2003cites this paper
• [Genetics and Alzheimer disease].

  2003cites this paper
• Causative and susceptibility genes for Alzheimer's disease: a review.

  2003cites this paper
• The Degradation of Amyloid β as a Therapeutic Strategy in Alzheimer's Disease and Cerebrovascular Amyloidoses

  2002cites this paper