MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Hepatology

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/HEP.510300236PMID 10421655
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinases MT1-MMP and MMP-2 in microvascular endothelial cells.

  1998cited by this paper
• The cell biology of liver fibrogenesis – an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts

  1998cited by this paper
• Fibrosis and Altered Matrix Degradation

  1998cited by this paper
• Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells

  1998cited by this paper
• The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

  1998cited by this paper
• The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form.

  1998cited by this paper
• SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines.

  1998cited by this paper
• Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers.

  1998cited by this paper
• Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface.

  1998cited by this paper
• TIMP-2 Promotes Activation of Progelatinase A by Membrane-type 1 Matrix Metalloproteinase Immobilized on Agarose Beads*

  1998cited by this paper
• Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts.

  1997cited by this paper
• Dual expression of matrix metalloproteinase‐2 and membrane‐type 1‐matrix metalloproteinase in fibrotic human livers

  1997cited by this paper
• Activation of gelatinase A (72-kDa type IV collagenase) induced by monensin in normal human fibroblasts.

  1997cited by this paper
• Overexpression of matrix metalloproteinase‐2 and tissue inhibitor of matrix metalloproteinase‐2 in liver from patients with gastrointestinal adenocarcinoma and no detectable metastasis

  1997cited by this paper
• Metalloproteinases in multiple myeloma: production of matrix metalloproteinase-9 (MMP-9), activation of proMMP-2, and induction of MMP-1 by myeloma cells.

  1997cited by this paper
• Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.

  1997cited by this paper
• Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes.

  1997cited by this paper
• Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma.

  1997cited by this paper
• MMP-2: expression, activation and inhibition.

  1996cited by this paper
• Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.

  1996cited by this paper
• Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver.

  1996cited by this paper
• Membrane Type Matrix Metalloproteinase 1 Activates Pro-gelatinase A without Furin Cleavage of the N-terminal Domain*

  1996cited by this paper
• The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

  1996cited by this paper
• Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

  1995cited by this paper
• Modulation of the expression of interstitial and type-IV collagenases in coculture of HT1080 fibrosarcoma cells and fibroblasts.

  1995cited by this paper
• Tissue Inhibitor of Metalloproteinase-1 and Interstitial Collagenase Expression in Autoimmune Chronic Active Hepatitis and Activated Human Hepatic Lipocytes

  1995cited by this paper
• Proteolytic remodeling of extracellular matrix.

  1995cited by this paper
• The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation (*)

  1995cited by this paper
• Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells.

  1995cited by this paper
• Complex regulation of membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation by concanavalin A in MDA-MB-231 human breast cancer cells.

  1995cited by this paper
• Increased expression of matrix metalloproteinase‐II in experimental liver fibrosis in rats

  1995cited by this paper
• Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes (*)

  1995cited by this paper
• A matrix metalloproteinase expressed on the surface of invasive tumour cells

  1994cited by this paper
• Activation of 72-kDa type IV collagenase/gelatinase by normal fibroblasts in collagen lattices is mediated by integrin receptors but is not related to lattice contraction.

  1994cited by this paper
• Cooperation of Ito cells and hepatocytes in the deposition of an extracellular matrix in vitro.

  1993cited by this paper
• The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

  1993cited by this paper
• Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.

  1993cited by this paper
• Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity.

  1992cited by this paper
• Distribution and cellular origin of collagen VI during development and in cirrhosis.

  1992cited by this paper
• A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

  1992cited by this paper
• Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

  1990cited by this paper
• Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation.

  1988cited by this paper
• Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen.

  1988cited by this paper
• Type VI collagen represents a major fraction of connective tissue collagens.

  1987cited by this paper
• Basement membrane complexes with biological activity.

  1986cited by this paper
• Structure of a human smooth muscle actin gene (aortic type) with a unique intron site

  1984cited by this paper
• Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

  1979cited by this paper
• Complex Regulation of Membrane-type Matrix Metalloproteinase Expression and Matrix Metalloproteinase-2 Activation by Concanavalin a in Mda-mb-231 Human Breast Cancer Cells1 Activation of Which Has Been Associated with Metastatic Progression in Human Breast Cancer (hbc). Concanavalin a (con A) Has Be

  year unknowncited by this paper

• Insulin-like Growth Factor-I Reduces Collagen Production by Hepatic Stellate Cells Through Stimulation of Collagen Degradation System via mTOR-Dependent Signaling Pathway

  2025cites this paper
• Both asparagine and proline are required to decrease Sestrin2 mRNA levels via ATF4 reduction and regulate collagen type I alpha 1 chain production and the proliferation of quiescent RI-T hepatic stellate cells

  2025cites this paper
• Pharmacological modulation of gp130 signalling enhances Achilles tendon repair by regulating tenocyte migration and collagen synthesis via SHP2-mediated crosstalk of the ERK/AKT pathway.

  2024cites this paper
• Preclinical Development of SGN-CD47M: Protease-Activated Antibody Technology Enables Selective Tumor Targeting of the Innate Immune Checkpoint Receptor CD47

  2024cites this paper
• Zbtb14 Promotes Non-Alcoholic Fatty Liver Disease-Associated Fibrosis in Gerbils via the β-Catenin Pathway.

  2023cites this paper
• 3D Culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes.

  2023cites this paper
• Fetal liver development and implications for liver disease pathogenesis

  2023cites this paper
• Turnera diffusa extract attenuates profibrotic, extracellular matrix and mitochondrial markers in activated human hepatic stellate cells (HSC).

  2020cites this paper
• Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity.

  2020cites this paper
• Cold Press Pomegranate Seed Oil Attenuates Dietary-Obesity Induced Hepatic Steatosis and Fibrosis through Antioxidant and Mitochondrial Pathways in Obese Mice

  2020cites this paper
• Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing

  2019cites this paper
• Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells.

  2019cites this paper
• Cell Biology International

  2019cites this paper
• The multifaceted roles of perlecan in fibrosis.

  2018cites this paper
• Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease

  2018cites this paper
• Explorer Selective depletion of macrophages reveals distinct , opposing roles during liver injury and repair

  2017cites this paper
• The stellate cell system (vitamin A-storing cell system)

  2017cites this paper
• Expression of glia maturation factor γ is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro.

  2017cites this paper
• Effets phénotypiques de deux mécanismes d’activation de la voie Wnt/beta caténine dans le carcinome hépatocellulaire

  2016cites this paper
• The role of cytokines TGF-beta1 and FGF-1 in the expression of characteristic markers of rat liver myofibroblasts cultured in three-dimensional collagen gel.

  2016cites this paper
• MMP2-sensing up-conversion nanoparticle for fluorescence biosensing in head and neck cancer cells.

  2016cites this paper
• MMP 2-sensing up-conversion nanoparticle for fl uorescence biosensing in head and neck cancer cells

  2016cites this paper
• Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet

  2015cites this paper
• Matrix Metalloproteinases and Their Inhibitors

  2015cites this paper
• Collagen matrix as a tool in studying fibroblastic cell behavior

  2015cites this paper
• The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells

  2015cites this paper
• Src‐dependent Tks5 phosphorylation regulates invadopodia‐associated invasion in prostate cancer cells

  2014cites this paper
• Role of discoidin domain receptor 2 in wound healing.

  2014cites this paper
• Association of inflammation, myocardial fibrosis and cardiac remodelling in patients with mild aortic stenosis as assessed by biomarkers and echocardiography

  2014cites this paper
• Effect of Bone Marrow-derived Mesenchymal Stem Cells and Umbilical Cord Blood-CD34 + cells on Experimental Rat liver Fibrosis

  2014cites this paper
• S-adenosylmethionine inhibits the activated phenotype of human hepatic stellate cells via Rac1 and matrix metalloproteinases.

  2014cites this paper
• Role of cannabinoid receptors in hepatic fibrosis and apoptosis associated with bile duct ligation in rats.

  2014cites this paper
• RNA Interference against Discoidin Domain Receptor 2 Ameliorates Alcoholic Liver Disease in Rats

  2013cites this paper
• Multimechanistic Antifibrotic Effect of Biochanin A in Rats: Implications of Proinflammatory and Profibrogenic Mediators

  2013cites this paper
• Mechanism of SOX9 action as a route to diagnostic strategies in liver fibrosis

  2013cites this paper
• Characterisation of clonal dental pulp progenitors and the effects of in vitro expansion and hydrogen peroxide

  2013cites this paper
• Lipocalin: A Novel Diagnostic Marker for Hepatocellular Carcinoma in Chronic Liver Disease Patients in Egypt

  2013cites this paper
• Crosstalk between monocytes and renal mesangial cells via interaction of metalloproteinases and fractalkine in diabetic nephropathy.

  2013cites this paper
• Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice

  2012cites this paper
• Contrôle de la progression du carcinome hépatocellulaire par le micro-environnement tumoral

  2012cites this paper
• HPV16 Oncoproteins Induce MMPs/RECK-TIMP-2 Imbalance in Primary Keratinocytes: Possible Implications in Cervical Carcinogenesis

  2012cites this paper
• Physiological type I collagen organization induces the formation of a novel class of linear invadosomes

  2012cites this paper
• [Control of hepatocellular carcinoma progression by the tumor microenvironment].

  2012cites this paper
• Magnesium chenoursodeoxycholic acid ameliorates carbon tetrachloride-induced liver fibrosis in rats

  2012cites this paper
• [Psychological and social impact of online gambling].

  2012cites this paper
• Matrix metalloproteinases in health and disease: regulation by melatonin

  2011cites this paper
• Hepatic Fibrosis and Cirrhosis

  2011cites this paper
• Collagen I Induces Discoidin Domain Receptor (DDR) 1 Expression through DDR2 and a JAK2-ERK1/2-mediated Mechanism in Primary Human Lung Fibroblasts*

  2011cites this paper
• Fibronectin Protects from Excessive Liver Fibrosis by Modulating the Availability of and Responsiveness of Stellate Cells to Active TGF-β

  2011cites this paper
• Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice

  2011cites this paper
• Asialoglycoprotein receptor promotes cancer metastasis by activating the EGFR-ERK pathway.

  2011cites this paper
• The Treponema denticola Chymotrypsin-Like Protease Dentilisin Induces Matrix Metalloproteinase-2-Dependent Fibronectin Fragmentation in Periodontal Ligament Cells

  2010influential citation
• Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis.

  2010cites this paper
• Endothelial cell toll‐like receptor 4 regulates fibrosis‐associated angiogenesis in the liver

  2010cites this paper
• In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces disruption of glands of the prostate and fibrosis in rhesus monkeys.

  2010cites this paper
• NON INVASIVE EVALUATION OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B AND C

  2009cites this paper
• CX3CL1/fractalkine shedding by human hepatic stellate cells: contribution to chronic inflammation in the liver

  2009cites this paper
• Erythropoietin inhibits liver gelatinases during galactosamine-induced hepatic damage in rats

  2009cites this paper
• Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review.

  2009cites this paper
• Molecular and cellular mechanisms of aortic stenosis.

  2009cites this paper
• Collagen I regulates matrix metalloproteinase‐2 activation in osteosarcoma cells independent of S100A4

  2009cites this paper
• The Inactive 44-kDa Processed Form of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Enhances Proteolytic Activity via Regulation of Endocytosis of Active MT1-MMP*

  2008cites this paper
• Herbal compound 861 regulates mRNA expression of collagen synthesis- and degradation-related genes in human hepatic stellate cells.

  2008cites this paper
• Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.

  2008cites this paper
• Hepatic fibrosis -- overview.

  2008cites this paper
• The Effect of Ras Inhibition on the Proliferation, Apoptosis and Matrix Metalloproteases Activity in Rat Hepatic Stellate Cells

  2008cites this paper
• Extracellular matrix remodelling and matrix metalloproteinases in the liver

  2008cites this paper
• The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis

  2008cites this paper
• Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis.

  2007cites this paper
• Effects of extracellular signal‐regulated kinase on rat cultured hepatic stellate cells stimulated by acetaldehyde

  2007cites this paper
• Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase‐2 inhibits hepatic fibrogenesis in rats

  2007cites this paper
• Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies.

  2007cites this paper
• The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis

  2007cites this paper
• Expression of Angiotensin II Receptor Type 1 Is Reduced in Advanced Rat Liver Fibrosis

  2007influential citation
• Type I collagen-induced pro-MMP-2 activation is differentially regulated by H-Ras and N-Ras in human breast epithelial cells.

  2007cites this paper
• Identificación y caracterización funcional de la molécula de membrana CD38 en células hepáticas estrelladas

  2006cites this paper
• Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis

  2006cites this paper
• The role of matrix metalloproteinase inhibitors in ischemia-reperfusion injury in the liver.

  2006cites this paper
• Green tea polyphenol epigallocatechin-3-gallate suppresses rat hepatic stellate cell invasion by inhibition of MMP-2 expression and its activation

  2006cites this paper
• Mechanisms of liver fibrosis.

  2006cites this paper
• [Pathogenesis of calcific aortic valve stenosis].

  2006cites this paper
• Pathogenese der kalzifizierenden Aortenklappenstenose

  2006cites this paper
• Associação entre alta expressão e atividade de metaloproteinases e presença de HPV em linhagens de carcinomas cervicais humanos

  2006cites this paper
• Reversibility of Liver Fibrosis

  2005cites this paper
• Faculdade de Ciências Farmacêuticas Programa de Pós-Graduação em Farmácia Área de Análises Clínicas Ação do gene supressor de tumor e de metástase RECK no processo de invasão tumoral: modelo de interação célula-matriz extracelular em gliomas humanos

  2005cites this paper
• Matrix metalloproteinase-2 and -9 in the granulomatous fibrosis of rats infected with Angiostrongylus cantonensis

  2005cites this paper
• Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.

  2005cites this paper
• Immunological and molecular aspects of liver fibrosis in chronic hepatitis C virus infection.

  2005cites this paper
• Binding of Hepatitis C Virus Envelope Protein E2 to CD81 Up-regulates Matrix Metalloproteinase-2 in Human Hepatic Stellate Cells*

  2005cites this paper
• Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing*

  2005cites this paper
• Peroxynitrite‐mediated matrix metalloproteinase‐2 activation in human hepatic stellate cells

  2005cites this paper
• Effects of adrenomedullin gene overexpression on biological behavior of hepatic stellate cells.

  2005cites this paper
• Interaction of Tumour with Host Stroma in Hepatocellular Carcinoma

  2005cites this paper
• Herbal medicine Rhei rhizome prevents liver fibrosis in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.

  2005cites this paper
• Cell Proliferation Activity of Proliferating Bile Duct after Bile Duct Ligation in Rats

  2005cites this paper
• Expression Pattern of Matrix Metalloproteinases in Alcohol- and Thermally Oxidized Sunflower Oil-Induced Toxicity: Protective Role of an Aminothiazole Derivative

  2005cites this paper
• Circulating Matrix Metalloproteinases 1, 2, 9 and Their Inhibitors TIMP-1 and TIMP-2 as Serum Markers of Liver Fibrosis in Patients With Chronic Hepatitis C: Comparison With PIIINP and Hyaluronic Acid

  2004cites this paper
• 19. THE ROLE OF THE HEPATIC STELLATE CELL IN LIVER FIBROSIS

  2004cites this paper
• Stimulation of MMP-11 (stromelysin-3) expression in mouse fibroblasts by cytokines, collagen and co-culture with human breast cancer cell lines

  2004cites this paper
• Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis

  2004cites this paper