Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

The MAPK kinase kinase Wallenda is regulated by the Highwire E3 ubiquitin ligase and initiates injury signaling in axons.

• Publication year

  2010

• Venue

  Journal of Cell Biology

• Publication date

  2010-10-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201006039PMID 20921142PMCID 2953441
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
• Neuronal intrinsic barriers for axon regeneration in the adult CNS.

  2010cited by this paper
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• RESPONSES OF THE NERVE CELL BODY TO AXOTOMY

  2009cited by this paper
• Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.

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  2009influential reference
• A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

  2009cited by this paper
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  2009influential reference
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• Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve.

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  2008cited by this paper
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  2008cited by this paper
• Nerve injury signaling.

  2008cited by this paper
• The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.

  2007cited by this paper
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  2007influential reference
• Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.

  2007cited by this paper
• Control of a kinesin-cargo linkage mechanism by JNK pathway kinases.

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• Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury.

  2007cited by this paper
• The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.

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• Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases

  2006cited by this paper
• Retrograde signaling in injured nerve – the axon reaction revisited

  2006cited by this paper
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  2006influential reference
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  2006cited by this paper
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• APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila.

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  2005cited by this paper
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  2005influential reference
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  2005influential reference
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2000influential reference
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  2000influential reference
• Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye.

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998influential reference
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  1997cited by this paper
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  1996cited by this paper
• Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg.

  1996influential reference
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  1996cited by this paper
• Redistribution of synaptic vesicles and their proteins in temperature-sensitive shibire(ts1) mutant Drosophila.

  1995cited by this paper
• Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

  1990influential reference

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