Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage, Leading to Diminished Zidovudine Excision

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular Pharmacology

• Publication date

  2008-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/mol.107.038596PMID 18024510
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Probing nonnucleoside inhibitor‐induced active‐site distortion in HIV‐1 reverse transcriptase by transient kinetic analyses

  2007cited by this paper
• Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).

  2007influential reference
• Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel.

  2006cited by this paper
• Treatment for Adult HIV Infection 2006 Recommendations of the International AIDS Society–USA Panel

  2006cited by this paper
• Molecular Mechanism by Which the K70E Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Resistance to Nucleoside Reverse Transcriptase Inhibitors

  2006cited by this paper
• Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3'-azido-3'-deoxythymidine with nonnucleoside inhibitors.

  2005cited by this paper
• Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.

  2005influential reference
• The 3′-Azido Group Is Not the Primary Determinant of 3′-Azido-3′-deoxythymidine (AZT) Responsible for the Excision Phenotype of AZT-resistant HIV-1*

  2005cited by this paper
• Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision.

  2005influential reference
• Defining a Molecular Mechanism of Synergy between Nucleoside and Nonnucleoside AIDS Drugs*

  2004influential reference
• Treatment for adult HIV infection.

  2004cited by this paper
• Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase Inhibit Phosphorolysis and Resensitize the 3′-Azido-3′-deoxythymidine (AZT)-resistant Polymerase to AZT-5′-triphosphate*

  2003cited by this paper
• Inhibitor binding alters the directions of domain motions in HIV‐1 reverse transcriptase

  2002cited by this paper
• Potency of Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) Used in Combination with Other Human Immunodeficiency Virus NNRTIs, NRTIs, or Protease Inhibitors

  2002cited by this paper
• Selective Interaction of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Nonnucleoside Inhibitor Efavirenz and Its Thio-Substituted Analog with Different Enzyme-Substrate Complexes

  2000cited by this paper
• The Thiocarboxanilide Nonnucleoside Inhibitor UC781 Restores Antiviral Activity of 3′-Azido-3′-Deoxythymidine (AZT) against AZT-Resistant Human Immunodeficiency Virus Type 1

  1999cited by this paper
• Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro.

  1996cited by this paper
• Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase.

  1995cited by this paper
• [13] Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase

  1995cited by this paper
• Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors

  1995cited by this paper
• Nevirapine Alters the Cleavage Specificity of Ribonuclease H of Human Immunodeficiency Virus 1 Reverse Transcriptase (*)

  1995cited by this paper
• Effect of a thiobenzimidazolone derivative on DNA strand transfer catalyzed by HIV-1 reverse transcriptase.

  1994cited by this paper
• Bisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3'-azido-3'-deoxythymidine or 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 replication in vitro

  1994cited by this paper
• New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs

  1994cited by this paper
• BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

  1991cited by this paper

• Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities

  2024cites this paper
• Retroviral reverse transcriptase: Structure, function and inhibition.

  2021cites this paper
• Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction

  2021cites this paper
• Retroviral RNase H: Structure, mechanism, and inhibition.

  2021cites this paper
• INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay

  2021cites this paper
• Nucleocapsid Protein Precursors NCp9 and NCp15 Suppress ATP-Mediated Rescue of AZT-Terminated Primers by HIV-1 Reverse Transcriptase

  2020cites this paper
• Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid

  2018cites this paper
• The role of Gag in HIV-1 DNA synthesis and sensitivity to reverse transcriptase inhibitor drugs

  2018cites this paper
• Resistance Mechanisms to HIV-1 Nucleoside Reverse Transcriptase Inhibitors

  2017cites this paper
• HIV-1 Resistance to the Nonnucleoside Reverse Transcriptase Inhibitors

  2017cites this paper
• Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication.

  2016cites this paper
• Efavirenz versus Nevirapina : comparação da efectividade e do perfil de segurança, a longo prazo, no tratamento da infecção por vírus da imunodeficiência humana tipo 1

  2016cites this paper
• When biologist meets chemist: a search for HIV-1 inhibitors

  2015cites this paper
• Exploring the Impact of Antiretroviral Drugs on the Cell-to-Cell spread of HIV-1

  2015cites this paper
• Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

  2015cites this paper
• Double Variational Binding—(SMILES) Conformational Analysis by Docking Mechanisms for Anti-HIV Pyrimidine Ligands

  2015cites this paper
• Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

  2015cites this paper
• Inhibition of the DNA polymerase and RNase H activities of HIV-1 reverse transcriptase and HIV-1 replication by Brasenia schreberi (Junsai) and Petasites japonicus (Fuki) components

  2015cites this paper
• Fragment Based Strategies for Discovery of Novel HIV-1 Reverse Transcriptase and Integrase Inhibitors.

  2015cites this paper
• Substrate-Competitive Inhibitors of c-Src Kinase.

  2014cites this paper
• Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action.

  2014cites this paper
• Characterisation of T cells induced by candidate conserved region HIV-1 vaccines in healthy HIV-1/2 negative volunteers

  2014cites this paper
• Recent Findings on the Mechanisms Involved in Tenofovir Resistance

  2014cites this paper
• Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine.

  2014cites this paper
• Clinically Used Antiretroviral Drugs -Deoxyadenosine with ' -Ethynyl-2-Fluoro-2 ' Evaluation of Combinations of 4

  2014cites this paper
• A Cell-Based Strategy To Assess Intrinsic Inhibition Efficiencies of HIV-1 Reverse Transcriptase Inhibitors

  2014cites this paper
• Mechanistic insights into the role of secondary mutations of HIV-1 reverse transcriptase in the acquisition of antiretroviral drug resistance

  2013cites this paper
• Impact of nonnucleoside reverse transcriptase (RT) inhibitors on the enzyme-substrate interactions and intramolecular dynamics of wild-type and drug resistant HIV-1 RT

  2013cites this paper
• Nucleoside RT Inhibitors: Structural and Molecular Biology

  2013cites this paper
• Evaluation of Combinations of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine with Clinically Used Antiretroviral Drugs

  2013cites this paper
• Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

  2013cites this paper
• Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

  2013cites this paper
• Activity Profiles & Mechanisms of Resistance of 3'-Azido-2',3'-Dideoxynucleoside Analog Reverse Transcriptase Inhibitors of HIV-1

  2013cites this paper
• The interplay of structure and dynamics: Insights from a survey of HIV‐1 reverse transcriptase crystal structures

  2013cites this paper
• Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue.

  2013cites this paper
• Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity.

  2013cites this paper
• Zidovudine (AZT) Monotherapy Selects for the A360V Mutation in the Connection Domain of HIV-1 Reverse Transcriptase

  2012cites this paper
• The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets

  2012cites this paper
• Dihydro-alkoxyl-benzyl-oxopyrimidine derivatives (DABOs) as non-nucleoside reverse transcriptase inhibitors: an update review (2001-2011).

  2012cites this paper
• Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract.

  2012influential citation
• N348I in HIV-1 Reverse Transcriptase Counteracts the Synergy Between Zidovudine and Nevirapine

  2012influential citation
• Global Conformational Dynamics of HIV-1 Reverse Transcriptase Bound to Non-Nucleoside Inhibitors

  2012cites this paper
• Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents

  2012cites this paper
• A Role of Template Cleavage in Reduced Excision of Chain-Terminating Nucleotides by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing the M184V Mutation

  2012cites this paper
• Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

  2011cites this paper
• Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase

  2011cites this paper
• Nonnucleoside Reverse Transcriptase Inhibitor-Resistant HIV Is Stimulated by Efavirenz during Early Stages of Infection

  2011cites this paper
• Allosteric suppression of HIV-1 reverse transcriptase structural dynamics upon inhibitor binding.

  2011cites this paper
• In Vitro Resistance Profile of the Candidate HIV-1 Microbicide Drug Dapivirine

  2011cites this paper
• HIV-1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitors.

  2011cites this paper
• The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC.

  2011cites this paper
• N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

  2010cites this paper
• HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors

  2010cites this paper
• Mutations in the C-terminal region of the HIV-1 reverse transcriptase and their correlation with drug resistance associated mutations and antiviral treatment

  2010cites this paper
• A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

  2010cites this paper
• The “Connection” Between HIV Drug Resistance and RNase H

  2010influential citation
• Mechanisms by which Nonnucleoside Reverse Transcriptase Inhibitors Block HIV-1 Replication Alone and in Combination with other Reverse Transcriptase Inhibitors

  2010cites this paper
• The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance

  2010cites this paper
• Novel Mechanisms of Resistance to HIV-1 Reverse Transcriptase (RT) Inhibitors: A Molecular and Clinical Characterization of Mutations in the Connection and RNase H Domains of RT

  2010cites this paper
• N348I in HIV-1 Reverse Transcriptase Can Counteract the Nevirapine-mediated Bias toward RNase H Cleavage during Plus-strand Initiation*

  2010cites this paper
• The non-nucleoside reverse transcriptase inhibitor efavirenz stimulates replication of human immunodeficiency virus type 1 harboring certain non-nucleoside resistance mutations.

  2010cites this paper
• Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989-2009).

  2010cites this paper
• The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study

  2009cites this paper
• Nucleoside Analogue Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase

  2009cites this paper
• Derivatives of 5-nitro-furan-2-carboxylic acid carbamoylmethyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase.

  2009cites this paper
• Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase.

  2008cites this paper
• Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility.

  2008cites this paper
• HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

  2008cites this paper
• DISTINCT MECHANISMS OF HIV-1 HYPERSUSCEPTIBILITY TO NON- NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS: A DISCUSSION OF NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR INDUCED MUTATIONS V118I, H208Y, AND T215Y

  2008cites this paper
• Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.

  2008cites this paper
• Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors.

  2008cites this paper
• Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance.

  2008cites this paper
• Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

  2008cites this paper