Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Phytomedicine

• Publication date

  2016-11-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.phymed.2016.08.001PMID 27765358
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

  2015cited by this paper
• Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.

  2015cited by this paper
• Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

  2015cited by this paper
• Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.

  2015cited by this paper
• Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors

  2014cited by this paper
• Past and Future. Current Drugs Targeting HIV-1 Integrase and Reverse Transcriptase-Associated Ribonuclease H Activity: Single and Dual Active Site Inhibitors

  2014cited by this paper
• Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

  2014cited by this paper
• Rhubarb root and rhizome-based Chinese herbal prescriptions for acute ischemic stroke: a systematic review and meta-analysis.

  2014cited by this paper
• Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

  2014cited by this paper
• The traditional Chinese medicine plant Schisandra Chinensis as source of new HIV-1 reverse transcriptase inhibitor scaffolds effective also on non-nucleoside resistant reverse transcriptases

  2014cited by this paper
• Study on the extraction process of total anthraquinones in Radix et Rhizoma Rhei and their antilipemic effects.

  2014cited by this paper
• Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.

  2013cited by this paper
• Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.

  2013cited by this paper
• 6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.

  2013cited by this paper
• Molecular aspects of the RT/drug interactions. Perspective of dual inhibitors.

  2013cited by this paper
• Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle

  2013cited by this paper
• Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.

  2012cited by this paper
• New Anthraquinone Derivatives as Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function

  2012cited by this paper
• HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions

  2012cited by this paper
• Alizarine derivatives as new dual inhibitors of the HIV‐1 reverse transcriptase‐associated DNA polymerase and RNase H activities effective also on the RNase H activity of non‐nucleoside resistant reverse transcriptases

  2011cited by this paper
• Herpes simplex virus type 2 infection increases human immunodeficiency virus type 1 entry into human primary macrophages

  2011cited by this paper
• A time-of–drug addition approach to target identification of antiviral compounds

  2011cited by this paper
• Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities

  2011cited by this paper
• Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei.

  2011cited by this paper
• Synthesis and characterization of phenolic antioxidants with surfactant properties: glucosyl- and glucuronosyl alkyl gallates

  2011cited by this paper
• Interferon-Alpha Mediates Restriction of Human Immunodeficiency Virus Type-1 Replication in Primary Human Macrophages at an Early Stage of Replication

  2010cited by this paper
• Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue.

  2010cited by this paper
• Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR.

  2009cited by this paper
• HIV-1-Inhibiting Activity of the Essential Oil of Ridolfia segetum and Oenanthe crocata

  2009cited by this paper
• Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.

  2009cited by this paper
• Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

  2009cited by this paper
• Inhibition of HIV-1 ribonuclease H activity by novel frangula-emodine derivatives.

  2009cited by this paper
• A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients.

  2008cited by this paper
• Plant-Derived Leading Compounds for Chemotherapy of Human Immunodefiency Virus (HIV) Infection – An Update (1998 – 2007)

  2008cited by this paper
• Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage, Leading to Diminished Zidovudine Excision

  2008cited by this paper
• Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry

  2007cited by this paper
• New developments in natural products‐based anti‐AIDS research

  2007cited by this paper
• Inhibition of the replication of hepatitis B virus in vitro by emodin.

  2006cited by this paper
• 6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro.

  2005cited by this paper
• New Anti-Human Immunodeficiency Virus Type 1 6-Aminoquinolones: Mechanism of Action

  2003cited by this paper
• In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus.

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Anti-human cytomegalovirus activity and toxicity of sulfonated anthraquinones and anthraquinone derivatives.

  1995cited by this paper
• Nevirapine Alters the Cleavage Specificity of Ribonuclease H of Human Immunodeficiency Virus 1 Reverse Transcriptase (*)

  1995cited by this paper
• Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.

  1992cited by this paper
• Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase.

  1991cited by this paper
• Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

  1990cited by this paper
• Use of eukaryotic expression technology in the functional analysis of cloned genes.

  1987cited by this paper
• Complete nucleotide sequence of the AIDS virus, HTLV-III

  1985cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• The Yonetani-Theorell graphical method for examining overlapping subsites of enzyme active centers.

  1982cited by this paper
• Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line.

  1981cited by this paper
• [A preliminary study of the correlation between phylogeny, chemical constituents and therapeutic effects of Rheum species].

  1980cited by this paper
• Selective Inhibition of Pyrimidine Biosynthesis and Effect on Proliferative Growth of Colonic Cancer Cells

  1977cited by this paper
• Selective inhibition of pyrimidine biosynthesis and effect on proliferative growth of colonic cancer cells.

  1977cited by this paper
• Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 5. Bis-basic ethers of anthraquinone and bisalkamine esters of anthraquinonedicarboxylic acids.

  1974cited by this paper
• THE SENNOSIDE CONTENT OF RHEUM PALMATUM

  1972cited by this paper
• A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS

  1938cited by this paper

• Phytochemicals in the Transmission Control of Epidemic Viruses: A Review Focused on SARS-CoV-2, Zika, and Dengue

  2025cites this paper
• Bird's eye view of natural products for the development of new anti‐HIV agents: Understanding from a therapeutic viewpoint

  2025cites this paper
• Structural elucidation of Langat virus helicase unveils dual-target inhibition for broad-spectrum anti-flaviviruses strategy

  2025cites this paper
• Bioactive compositions and identification of functional groups of selected medicinal plants

  2024cites this paper
• Sennoside A represses the malignant phenotype and tumor immune microenvironment of non-small cell lung cancer cells by inhibiting the TRAF6/NF-κB pathway

  2024cites this paper
• Determination of Sennoside A in Rat Plasma by Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry and Its Application to a Rat Pharmacokinetic Study.

  2024cites this paper
• Determination of the Mineral Content, Phytochemical Properties, and the Antimicrobial Properties of the Seed Extracts of Carica papaya on some Clinical Isolates

  2024cites this paper
• Unveiling potential inhibitors targeting the nucleocapsid protein of SARS-CoV-2: Structural insights into their binding sites.

  2024cites this paper
• Revealing and evaluation of antivirals targeting multiple druggable sites of RdRp complex in SARS-CoV-2

  2023influential citation
• α-Stereoselective 3-Deoxy-d-manno-oct-2-ulosonoic Acid (Kdo) O-Glycosylation with a p-Toluenethioglycoside Donor by the (p-Tol)2SO/Tf2O Preactivation Strategy.

  2023cites this paper
• Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation

  2023cites this paper
• Role of phytocompounds as the potential anti-viral agent: an overview

  2023influential citation
• Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases

  2023influential citation
• Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors

  2023cites this paper
• Phytochemical screening and antimicrobial activity of methanolic leaf extract of Securidaca longipedunculata Fresen (Polygalaceae)

  2023cites this paper
• The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

  2023cites this paper
• Senna (Cassia angustifolia Vahl.): A Comprehensive Review of Ethnopharmacology and Phytochemistry

  2023cites this paper
• Antiviral Activity of Natural Herbs and their Isolated Bioactive Compounds: A Review.

  2023cites this paper
• Turkish Plants, Including Quercetin and Oenothein B, Inhibit the HIV-1 Release and Accelerate Cell Apoptosis.

  2023cites this paper
• Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase.

  2023cites this paper
• Modulation of HIV-1 capsid multimerization by sennoside A and sennoside B via interaction with the NTD/CTD interface in capsid hexamer

  2023cites this paper
• An integrative approach to harnessing the potential of Traditional Indian Medicinal plants for acute viral infections

  2022cites this paper
• Network Pharmacology and Molecular Docking Study on the Multi-Target Mechanisms of Aloe vera for Non-Alcoholic Steatohepatitis Treatment

  2022cites this paper
• Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour

  2022influential citation
• Journal Pre-proof Antiviral potential of anthraquinones from Polygonaceae, Rubiaceae and Asphodelaceae: potent candidates in the treatment of SARS-COVID-19, A comprehensive review

  2022influential citation
• Wenshen Jianpi recipe induced immune reconstruction and redistribution of natural killer cell subsets in immunological non-responders of human immunodeficiency virus/acquired immune deficiency syndrome: a randomized controlled trial.

  2022cites this paper
• Formulation of Silver Nanoparticle of Cassia angustifoliaby Using Green Synthesis Method and Screening for In-Vitro Anti-Inflammatory Activity

  2022cites this paper
• Bioactive Based Nanocarriers for the Treatment of Viral Infections and SARS-CoV-2

  2022cites this paper
• Repurposing of Four Drugs as Anti-SARS-CoV-2 Agents and Their Interactions with Protein Targets

  2022influential citation
• Herbal glycosides in healthcare

  2022cites this paper
• HIV-1 Protease and Reverse Transcriptase Inhibitory Activities of Curcuma aeruginosa Roxb. Rhizome Extracts and the Phytochemical Profile Analysis: In Vitro and In Silico Screening

  2021cites this paper
• Bioactive Compounds of Rhubarb (Rheum Species)

  2021cites this paper
• Transcriptome Analysis of the Inhibitory Effect of Sennoside A on the Metastasis of Hepatocellular Carcinoma Cells

  2021cites this paper
• A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

  2021cites this paper
• Ethnobotanical Uses, Phytochemistry and Pharmacology of Different Rheum Species (Polygonaceae): A Review.

  2021cites this paper
• A Review on Analytical Methods for Antiviral Phytoconstituents

  2021cites this paper
• Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining

  2021cites this paper
• Antiviral Activity Exerted by Natural Products against Human Viruses

  2021influential citation
• A narrative review of herbal preparations against RNA viruses

  2021cites this paper
• Dual inhibition of COVID-19 spike glycoprotein and main protease 3CLpro by Withanone from Withania somnifera

  2021cites this paper
• Advances in Natural Products‐Based Antiviral Agents

  2021cites this paper
• Organ Specific Differences in Alteration of Aquaporin Expression in Rats Treated with Sennoside A, Senna Anthraquinones and Rhubarb Anthraquinones

  2021cites this paper
• Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates

  2021cites this paper
• Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound

  2021cites this paper
• 2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication

  2020cites this paper
• Traditional Chinese Medicine Can Improve the Immune Reconstruction of HIV/AIDS Patients

  2020cites this paper
• Prediction of SARS-CoV-2 Main Protease Inhibitors from Several Medicinal Plant Compounds by Drug Repurposing and Molecular Docking Approach.

  2020cites this paper
• Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules

  2020cites this paper
• An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

  2020influential citation
• In vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvae.

  2020cites this paper
• Antimicrobial Importance of Medicinal Plants in Nigeria

  2020cites this paper
• Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones.

  2020cites this paper
• Bioactive Phytocompounds to Fight Against Antimicrobial Resistance

  2020cites this paper
• Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

  2020cites this paper
• Variability for Sennoside A and B concentrations in eight Senna species

  2019cites this paper
• Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants

  2019influential citation
• Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.

  2019cites this paper
• Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy)

  2019cites this paper
• Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus.

  2019cites this paper
• Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.

  2019cites this paper
• Role of medicinal plants in HIV/AIDS therapy

  2019cites this paper
• Antiviral Evaluation of Herbal Drugs

  2019cites this paper
• Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication

  2018cites this paper
• A novel dual-luciferase assay for anti-HIV drug screening based on the CCR5/CXCR4 promoters.

  2018cites this paper
• Ethnomedicinal Wisdom

  2018cites this paper
• Genetic and functional diversity of central nervous system (CNS) derived Human Immunodeficiency Virus type 1 (HIV-1) tat from Tuberculous Meningitis (TBM) patients.

  2018cites this paper
• Drug-Repositioning Approach for the Discovery of Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicines In Vitro: Potent High Activity of Daio-Kanzo-To

  2018cites this paper
• Drug-Repositioning Approach for the Discovery of Anti-Influenza Virus Activity of Japanese Herbal ( Kampo ) Medicines In Vitro : Potent High Activity of Daio-Kanzo-To

  2018cites this paper
• Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

  2018cites this paper
• Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions

  2018cites this paper
• Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops

  2018cites this paper
• Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds

  2018cites this paper
• Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro

  2017cites this paper
• Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

  2017cites this paper
• Natural Products and HIV/AIDS

  2017cites this paper
• Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase.

  2017cites this paper
• Antioxidant Activity of Natural Plant Extracts from Mate (Ilex paraguariensis), Lotus Plumule (Nelumbo nucifera Gaertn.) and Rhubarb (Rheum rhabarbarum L.)

  2017cites this paper
• Antiviral Phytochemicals: An Overview

  2017cites this paper