Expression of the REG IV gene in ulcerative colitis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Laboratory Investigation

• Publication date

  2007-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/labinvest.3700507PMID 17260007
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas.

  2006cited by this paper
• Possible role of REG Iα protein in ulcerative colitis and colitic cancer

  2005cited by this paper
• Expression and localization of Reg IV in human neoplastic and non‐neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma

  2005cited by this paper
• Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel disease

  2005cited by this paper
• REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.

  2005cited by this paper
• Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.

  2004cited by this paper
• Expression of Reg Iα Protein in Human Gastric Cancers

  2004cited by this paper
• Expression of reg I alpha protein in human gastric cancers.

  2004cited by this paper
• HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti‐apoptotic functions through the PKA signaling pathway

  2003cited by this paper
• Effects of Helicobacter pylori Infection on the Link between Regenerating Gene Expression and Serum Gastrin Levels in Mongolian Gerbils

  2003cited by this paper
• RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa.

  2003cited by this paper
• Increased Expression of HIP/PAP and Regenerating Gene III in Human Inflammatory Bowel Disease and a Murine Bacterial Reconstitution Model

  2003cited by this paper
• Animal lectins: a historical introduction and overview.

  2002cited by this paper
• Cytokine/chemokine messenger-RNA expression profiles in ulcerative colitis and Crohn's disease

  2002cited by this paper
• C-type lectin receptors on dendritic cells and langerhans cells

  2002cited by this paper
• Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis.

  2002cited by this paper
• Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes.

  2001influential reference
• Inflammatory bowel disease: pathogenesis and targets for therapeutic interventions.

  2001cited by this paper
• The Immuno-Inflammatory Mechanism for Tissue Injury in Inflammatory Bowel Disease and Helicobacter pylori-Infected Chronic Active Gastritis

  2001cited by this paper
• Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV.

  2001cited by this paper
• Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation.

  2001cited by this paper
• A recombinant rat regenerating protein is mitogenic to pancreatic derived cells.

  2000cited by this paper
• Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays.

  2000influential reference
• pap, reg Iα and reg Iβ mRNAs are concomitantly up‐regulated during human colorectal carcinogenesis

  1999cited by this paper
• pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis.

  1999cited by this paper
• Growth factors in inflammatory bowel disease.

  1999influential reference
• Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats.

  1998cited by this paper
• Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor.

  1998cited by this paper
• Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor.

  1998cited by this paper
• Inflammatory bowel disease: etiology and pathogenesis.

  1998cited by this paper
• Fibroblast growth factors and their receptors.

  1997cited by this paper
• Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease.

  1996cited by this paper
• Growth factor mRNA expression in normal colorectal mucosa and in uninvolved mucosa from ulcerative colitis patients

  1996influential reference
• Induction of lithostathine/reg mRNA expression by serum from rats with acute pancreatitis and cytokines in pancreatic acinar AR-42J cells.

  1996cited by this paper
• Pancreatitis-associated Protein I (PAP I), an Acute Phase Protein Induced by Cytokines

  1995cited by this paper
• Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

  1994cited by this paper
• Identification and characterization of "injurin," an inducer of expression of the gene for hepatocyte growth factor.

  1992cited by this paper
• Expression of basic fibroblast growth factor in normal human tissues.

  1990cited by this paper
• The value of rectal biopsy in the diagnosis of ulcerative colitis.

  1961cited by this paper
• THE VALUE OF RECTAL BIOPSY IN THE DIAGNOSIS OF ULCERATIVE COLITIS1

  1961cited by this paper

• Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis

  2025cites this paper
• Intestinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD

  2025cites this paper
• Effects of the regenerating gene family on DSS-induced ulcerative colitis in a mouse model.

  2025cites this paper
• REG4 induces angiogenesis in ulcerative colitis by upregulating MMP-7 expression and downregulating sVEGFR1 level

  2025cites this paper
• Regenerating islet derived Family Member 4 (REG4) does not influence parameters of hemostasis in colorectal cancer.

  2025cites this paper
• Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification.

  2024cites this paper
• Elevated Risk of Adverse Prognosis in Patients with T2-3 Stage Breast Cancer Exhibiting Non-Pathological Complete Response Following Neoadjuvant Chemotherapy: Significance of Regenerating Islet-Derived Family Member 4

  2024cites this paper
• Potential carcinogenic role of Reg IV in ulcerative colitis-associated colorectal neoplasia

  2024cites this paper
• Intestinal Reg4 deficiency confers susceptibility to high-fat diet-induced liver steatosis by increasing intestinal fat absorption in mice

  2023cites this paper
• Clinical efficacy of moxibustion for ulcerative colitis and its influence on vitamin D receptor

  2023cites this paper
• REG4 promotes the proliferation and anti-apoptosis of cancer

  2022cites this paper
• Reg4 protects against Salmonella infection-associated intestinal inflammation via adopting a calcium-dependent lectin-like domain.

  2022cites this paper
• Role of the β-Catenin/REG Iα Axis in the Proliferation of Sessile Serrated Adenoma/Polyps Associated with Fusobacterium nucleatum

  2021cites this paper
• Protective and anti-inflammatory role of REG1A in inflammatory bowel disease induced by JAK/STAT3 signaling axis.

  2021cites this paper
• The Clinical Significance and Mechanisms of REG4 in Human Cancers

  2021cites this paper
• Reg4 defenses the intestine against Salmonella infection via binding the flagellin

  2021cites this paper
• Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer

  2021cites this paper
• The Potential Role of REG Family Proteins in Inflammatory and Inflammation-Associated Diseases of the Gastrointestinal Tract

  2021cites this paper
• CDX2 and Reg IV expression and correlation in gastric cancer

  2020cites this paper
• Role of regenerating islet-derived proteins in inflammatory bowel disease

  2020cites this paper
• RETRACTED ARTICLE:Deficiency in intestinal epithelial Reg4 ameliorates intestinal inflammation and alters the colonic bacterial composition

  2019cites this paper
• The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues

  2019cites this paper
• Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges

  2019cites this paper
• Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids

  2019cites this paper
• REG 4 expression was a potential marker for carcinogenesis , aggressiveness and prognosis of gastric cancer : a meta and bioinformatics analysis

  2018cites this paper
• High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease

  2018cites this paper
• Expression of REG family genes in human inflammatory bowel diseases and its regulation

  2017cites this paper
• GlycoGAIT: A web database to browse glycogenes and lectins under gastric inflammatory diseases.

  2016cites this paper
• Regenerating gene (REG) product and its potential clinical usage

  2016cites this paper
• REG4 promotes peritoneal metastasis of gastric cancer through GPR37

  2016cites this paper
• Comparison of Gene Expression Between Pediatric and Adult Gastric Mucosa with Helicobacter pylori Infection

  2016cites this paper
• Up-regulated Reg proteins induced by Interleukin-22 treatment ameliorate acute liver injury in rat model.

  2015cites this paper
• The role of Reg IV in colorectal cancer, as a potential therapeutic target

  2015cites this paper
• The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma

  2015cites this paper
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  2014cites this paper
• Expression of REG4 in Ovarian Mucinous Tumors

  2014cites this paper
• The PAS positive material in gastric cancer cells of signet ring type is not mucin.

  2014cites this paper
• In Vivo Targeting of ADAM9 Gene Expression Using Lentivirus-Delivered shRNA Suppresses Prostate Cancer Growth by Regulating REG4 Dependent Cell Cycle Progression

  2013cites this paper
• Reg proteins and their roles in inflammation and cancer of the human digestive system.

  2013cites this paper
• Discovery of novel candidate oncogenes in pancreatic carcinoma using high-throughput microarrays.

  2013cites this paper
• Reg IV is differently expressed in enteroendocrine cells of human small intestine and colon.

  2013influential citation
• Reg IV in human body and diseases

  2012cites this paper
• Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis

  2012cites this paper
• Effect of oral hepatocyte growth factor gene mediated by attenuated salmonella on 2‐, 4‐, 6‐trinitro‐benzene‐sulfonic‐acid‐induced ulcerative colitis in rat

  2012cites this paper
• Regenerating (Reg) Gene Family

  2012cites this paper
• Regenerating islet‐derived family member, 4 modulates multiple receptor tyrosine kinases and mediators of drug resistance in cancer

  2012influential citation
• Reg IV Is a Direct Target of Intestinal Transcriptional Factor CDX2 in Gastric Cancer

  2012cites this paper
• Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations

  2012cites this paper
• Oncogenic reg IV is a novel prognostic marker for glioma patient survival

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• Regenerating proteins and their expression, regulation, and signaling

  2012cites this paper
• Reg IV protein and mRNA expression in different rat organs.

  2011cites this paper
• Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma.

  2011cites this paper
• Identification of RegIV as a Novel GLI1 Target Gene in Human Pancreatic Cancer

  2011cites this paper
• The role of Reg IV gene and its encoding product in gastric carcinogenesis.

  2010influential citation
• Involvement of the IL-22/REG Iα axis in ulcerative colitis

  2010cites this paper
• Expression of Reg IV and Hath1 in neuroendocrine neoplasms.

  2010cites this paper
• Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli.

  2010cites this paper
• Erratum to: RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor

  2010cites this paper
• REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells.

  2010cites this paper
• REG IV overexpression in an early stage of colorectal carcinogenesis: an immunohistochemical study.

  2010cites this paper
• Reg4 protects against acinar cell necrosis in experimental pancreatitis

  2010cites this paper
• REG 4 acts as a mitogenic , motility and pro-invasive factor for colon cancer cells

  2010cites this paper
• The reg4 Gene, Amplified in the Early Stages of Pancreatic Cancer Development, Is a Promising Therapeutic Target

  2009cites this paper
• REG Proteins and Other Growth Factors in Gastric Cancer

  2009cites this paper
• Reg IV expression and clinicopathologic features of gallbladder carcinoma.

  2009cites this paper
• REG4 is associated with carcinogenesis in the ‘intestinal’ pathway of intraductal papillary mucinous neoplasms

  2009cites this paper
• Reg IV enhances peritoneal metastasis in gastric carcinomas

  2009cites this paper
• RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor

  2009cites this paper
• Expression profile of REG family proteins REG Iα and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers

  2009cites this paper
• REG Iα is a Reliable Marker of Chemoradiosensitivity in Squamous Cell Esophageal Cancer Patients

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• Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer

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• Attenuated apoptosis response to Fas‐ligand in active ulcerative colitis

  2008cites this paper
• Reg IV protein is expressed in normal rat tissue.

  2008cites this paper
• Serum Concentration of Reg IV in Patients with Colorectal Cancer: Overexpression and High Serum Levels of Reg IV Are Associated with Liver Metastasis

  2008cites this paper
• Reg I protein in healthy and seminoma human testis.

  2008cites this paper
• World Journal of Gastroenterology

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