Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12037571
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.

  2002cited by this paper
• Positive and Negative TAFII Functions That Suggest a Dynamic TFIID Structure and Elicit Synergy with TRAPs in Activator-Induced Transcription

  2001cited by this paper
• Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.

  2000cited by this paper
• Deletion of PBP/PPARBP, the Gene for Nuclear Receptor Coactivator Peroxisome Proliferator-activated Receptor-binding Protein, Results in Embryonic Lethality*

  2000cited by this paper
• Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells.

  2000cited by this paper
• Discrete Roles for Peroxisome Proliferator-Activated Receptor γ and Retinoid X Receptor in Recruiting Nuclear Receptor Coactivators

  2000cited by this paper
• The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.

  2000cited by this paper
• PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.

  1999cited by this paper
• Composite co-activator ARC mediates chromatin-directed transcriptional activation

  1999cited by this paper
• PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.

  1999cited by this paper
• A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

  1999cited by this paper
• Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.

  1999cited by this paper
• Activation of PPARgamma coactivator-1 through transcription factor docking.

  1999cited by this paper
• PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function.

  1999cited by this paper
• Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.

  1999cited by this paper
• Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein

  1999cited by this paper
• PPAR gamma is required for placental, cardiac, and adipose tissue development.

  1999cited by this paper
• Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

  1999cited by this paper
• Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.

  1999cited by this paper
• The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.

  1998cited by this paper
• Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.

  1998cited by this paper
• NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.

  1998cited by this paper
• Isolation and Characterization of PBP, a Protein That Interacts with Peroxisome Proliferator-activated Receptor*

  1997cited by this paper
• Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle

  1996cited by this paper
• Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

  1996cited by this paper
• Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.

  1995cited by this paper
• Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

  1994cited by this paper
• Production of high-titer helper-free retroviruses by transient transfection.

  1993cited by this paper
• QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

  1963cited by this paper

• Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy

  2026cites this paper
• Compromised PPARγ Mediated Impaired Placental Glucose Transport via the PI3K/AKT Signaling Pathway is Associated with FGR.

  2025cites this paper
• The Mediator Complex: A Regulatory Hub for Transcriptional Activity of Nuclear Receptors

  2025cites this paper
• Med14 phosphorylation shapes genomic response to GLP-1 Agonist

  2025cites this paper
• Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

  2025cites this paper
• A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

  2025cites this paper
• MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment

  2025cites this paper
• The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

  2025cites this paper
• Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ

  2024cites this paper
• Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ

  2024cites this paper
• A Closer Look into White Adipose Tissue Biology and the Molecular Regulation of Stem Cell Commitment and Differentiation

  2024cites this paper
• Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators

  2023cites this paper
• TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice.

  2023cites this paper
• Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice

  2022cites this paper
• Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.

  2022cites this paper
• The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation

  2022influential citation
• Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression

  2022cites this paper
• Genes and Longevity of Lifespan

  2022cites this paper
• Functional partitioning of transcriptional regulators by patterned charge blocks.

  2022cites this paper
• Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR205 and ErbB

  2021cites this paper
• Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions

  2021cites this paper
• The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.

  2021cites this paper
• Transcriptional and epigenetic control of adipocyte remodeling during obesity

  2021cites this paper
• The Oxidative Stress and Chronic Inflammatory Process in Chagas Disease: Role of Exosomes and Contributing Genetic Factors

  2021cites this paper
• Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice

  2021cites this paper
• Mediator structure and conformation change.

  2021cites this paper
• Galangin 3-benzyl-5-methylether derivatives function as an adiponectin synthesis-promoting peroxisome proliferator-activated receptor γ partial agonist.

  2021cites this paper
• Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues

  2021cites this paper
• Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine

  2021cites this paper
• Mediator subunit MED1 is required for E2A-PBX1–mediated oncogenic transcription and leukemic cell growth

  2021cites this paper
• Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.

  2020cites this paper
• MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression.

  2020cites this paper
• Autophagy in tumor and tumor microenvironment

  2020cites this paper
• MED1 is a lipogenesis coactivator required for postnatal adipose expansion

  2020cites this paper
• Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer

  2020cites this paper
• RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes

  2019cites this paper
• 50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms

  2019cites this paper
• A novel specific peroxisome proliferator‐activated receptor γ (PPARγ) modulator YR4‐42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet‐induced obese mice

  2019cites this paper
• Quantitative structural assessment of graded receptor agonism

  2019cites this paper
• Instructions for use Title The E 3 ubiquitin ligase TRIM 23 regulates adipocyte differentiation via stabilization of the adipogenic activatorPPARγ

  2019cites this paper
• miR-146a improves hepatic lipid and glucose metabolism by targeting MED1

  2019cites this paper
• Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone.

  2019cites this paper
• Transcriptional and Epigenomic Regulation of Adipogenesis

  2019cites this paper
• Therapeutic potential of Mediator complex subunits in metabolic diseases.

  2018cites this paper
• Control of Muscle Metabolism by the Mediator Complex.

  2018influential citation
• TET2 facilitates PPARγ agonist-mediated gene regulation and insulin sensitization in adipocytes.

  2018cites this paper
• Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes.

  2018cites this paper
• Differential effects of dietary flavonoids on adipogenesis

  2018cites this paper
• A structural mechanism for directing inverse agonism of PPARγ

  2018cites this paper
• Edinburgh Research Explorer Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance

  2018cites this paper
• Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

  2018cites this paper
• Structure-function analysis of 1-hydroxypioglitazone, a major in vivo metabolite of the PPARγ agonist pioglitazone

  2018cites this paper
• Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone

  2018cites this paper
• Adipose Organ Development and Remodeling.

  2018cites this paper
• Development of an In Vitro Screening Platform for the Identification of Partial PPARγ Agonists as a Source for Antidiabetic Lead Compounds

  2018cites this paper
• Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation[S]

  2018cites this paper
• A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

  2018cites this paper
• Chapter 2 Adipocyte Differentiation

  2017cites this paper
• Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α

  2017cites this paper
• Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization

  2017cites this paper
• ETV4 and AP1 transcription factors form multivalent interactions with three sites on the MED25 activator-interacting domain

  2017cites this paper
• Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells.

  2017cites this paper
• Roles of Mediator subunit CDK-8 in developmental and physiological responses in Caenorhabditis elegans

  2016influential citation
• Regulation of metabolism by the Mediator complex

  2016cites this paper
• The roles of SOX4 and MED15 in the development and maintenance of pancreatic β-cells

  2016cites this paper
• Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development

  2016cites this paper
• Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.

  2016cites this paper
• Promoter–enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase

  2016cites this paper
• Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma

  2015cites this paper
• Maintaining ancient organelles: mitochondrial biogenesis and maturation.

  2015cites this paper
• Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling

  2015cites this paper
• Pathophysiology of the hepoxilins.

  2015cites this paper
• The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

  2015cites this paper
• Mitochondrial Biogenesis and Maturation

  2015cites this paper
• Clinical Significance of Peroxisome Proliferator-Activated Receptor γ and TRAP220 in Patients with Operable Colorectal Cancer

  2015cites this paper
• Auswirkungen ausgewählter Einflussfaktoren auf die genomweite DNA-Methylierung beim Menschen

  2015cites this paper
• PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1

  2015cites this paper
• IGF1 Promotes Adipogenesis by a Lineage Bias of Endogenous Adipose Stem/Progenitor Cells

  2015cites this paper
• Mitochondrial biogenesis and dynamics in the developing and diseased heart

  2015cites this paper
• Implication des microARNs dans la conversion des adipocytes blancs en adipocytes thermogéniques

  2015cites this paper
• Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα.

  2015cites this paper
• Understanding the variegation of fat: novel regulators of adipocyte differentiation and fat tissue biology.

  2014cites this paper
• Transcriptional coregulators: fine-tuning metabolism.

  2014cites this paper
• Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers

  2014cites this paper
• CCAR1/CoCoA pair‐mediated recruitment of the Mediator defines a novel pathway for GATA1 function

  2014cites this paper
• Genome-wide analysis of enhancer-RNA transcription reveals regulatory mechanisms by an anti-diabetic drug in adipocyte

  2014cites this paper
• The roles of mediator complex in cardiovascular diseases.

  2014cites this paper
• The Mediator complex: a master coordinator of transcription and cell lineage development

  2014influential citation
• Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

  2014cites this paper
• Loss of MED1 triggers mitochondrial biogenesis in C2C12 cells.

  2014cites this paper
• Regulation of Adipocyte Transcription by PPARgamma Ligands

  2014cites this paper
• Reconstitution of active human core Mediator complex reveals a pivotal role of the MED14 subunit

  2014cites this paper
• Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

  2014cites this paper
• Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice

  2014cites this paper
• Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis.

  2014cites this paper
• TIPping the balance in adipogenesis

  2014cites this paper
• The Mediator Complex and Lipid Metabolism.

  2013cites this paper
• [The role of peroxisome proliferator-activated receptors γ (PPARγ) in obesity and insulin resistance].

  2013cites this paper
• Honokiol: A non-adipogenic PPARγ agonist from nature☆

  2013cites this paper
• H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

  2013cites this paper