Functional analysis of the glaucoma-causing TIGR/myocilin protein: integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretion.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Experimental Eye Research

• Publication date

  2006-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.EXER.2005.11.002PMID 16466712
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• TIGR/MYOC gene sequence alterations in individuals with and without primary open-angle glaucoma.

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• Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.

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• Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma.

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