Carcinogen-induced impairment of enzymes for replicative fidelity of DNA and the initiation of tumours.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Carcinogenesis

• Publication date

  2003-11-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/CARCIN/BGH013PMID 14604890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hereditary cancer: Two hits revisited

  2005cited by this paper
• DNA Replication Fidelity*

  2004cited by this paper
• Role of telomeres and telomerase in the pathogenesis of human cancer.

  2003cited by this paper
• Regulatory recognition of indirect genotoxicity mechanisms in the European Union.

  2003cited by this paper
• Initiation of genetic instability and tumour formation: a review and hypothesis of a nongenotoxic mechanism

  2003cited by this paper
• Uncoupling of Leading- and Lagging-Strand DNA Replication During Lesion Bypass in Vivo

  2003cited by this paper
• Singlet oxygen-mediated damage to proteins and its consequences.

  2003cited by this paper
• Cancer, cadmium and genome integrity

  2003cited by this paper
• Cadmium is a mutagen that acts by inhibiting mismatch repair

  2003cited by this paper
• Different patterns of 11q allelic losses in digestive endocrine tumors.

  2002cited by this paper
• Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas.

  2002cited by this paper
• Endogenous mutagenesis and cancer.

  2002cited by this paper
• Cancer genetics.

  2002cited by this paper
• DNA methylation in cancer: too much, but also too little

  2002cited by this paper
• How DNA lesions are turned into mutations within cells?

  2002cited by this paper
• The mutator phenotype theory can explain the complex morphology and behaviour of cancers

  2002cited by this paper
• Two genetic hits (more or less) to cancer

  2001cited by this paper
• A mutator phenotype in cancer.

  2001cited by this paper
• Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway.

  2001cited by this paper
• Genetic Instability in Epithelial Tissues at Risk for Cancer

  2001cited by this paper
• Zinc Finger Proteins as Potential Targets for Toxic Metal Ions: Differential Effects on Structure and Function

  2001cited by this paper
• The contribution of endogenous sources of DNA damage to the multiple mutations in cancer.

  2001cited by this paper
• Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer.

  2001cited by this paper
• Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen.

  2001cited by this paper
• Epigenetic gene silencing in cancer.

  2000cited by this paper
• Chasing the cancer demon.

  2000cited by this paper
• DNA replication fidelity.

  2000cited by this paper
• Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens.

  2000cited by this paper
• Significance of multiple mutations in cancer.

  2000cited by this paper
• Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis.

  2000cited by this paper
• DNA hypermethylation in tumorigenesis: epigenetics joins genetics.

  2000cited by this paper
• The onset and extent of genomic instability in sporadic colorectal tumor progression.

  1999cited by this paper
• Translational control: the cancer connection.

  1999cited by this paper
• Cancer-epigenetics comes of age

  1999cited by this paper
• Chromosome segregation and cancer.

  1999cited by this paper
• The mitotic machinery as a source of genetic instability in cancer.

  1999cited by this paper
• Carcinogenicity of metal compounds: possible role of DNA repair inhibition.

  1998cited by this paper
• The cellular basis of tumor progression.

  1998cited by this paper
• Genetic instability and cancer.

  1998cited by this paper
• Mutations of mitotic checkpoint genes in human cancers

  1998cited by this paper
• Comparison of spontaneous and induced mutation rates in an immortalized human bronchial epithelial cell line and its tumorigenic derivative.

  1997cited by this paper
• Genomic stability and instability: a working paradigm.

  1997cited by this paper
• DNA synthesis errors, mutators and cancer.

  1996cited by this paper
• Toxicological significance of DNA adducts: summary of discussions with an expert panel.

  1996cited by this paper
• Analyzing the fidelity of reverse transcription and transcription.

  1996cited by this paper
• Lessons from Hereditary Review Colorectal Cancer

  1996cited by this paper
• A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta.

  1996cited by this paper
• The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems.

  1996cited by this paper
• Multiple mechanisms account for genomic instability and molecular mutation in neoplastic transformation.

  1995cited by this paper
• [Genetic instability and cancer].

  1995cited by this paper
• Analyzing fidelity of DNA polymerases.

  1995cited by this paper
• DNA adducts of chemical carcinogens.

  1995cited by this paper
• IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

  1995cited by this paper
• Hypomethylation of DNA: An epigenetic mechanism involved in tumor promotion

  1994cited by this paper
• Cadmium in the Human Environment: Toxicity and Carcinogenicity

  1994cited by this paper
• Effects of chromium on DNA replication in vitro.

  1994cited by this paper
• DNA adducts : identification and biological significance

  1994cited by this paper
• From fluorescence spectra to mutational spectra, a historical overview of DNA-reactive compounds.

  1994cited by this paper
• From fluorescence spectra to mutational spectra, a historical overview of DNA-reactive compounds.

  1994cited by this paper
• The stimulatory effect of nickel chloride on DNA replication in human HeLa cells and Escherichia coli.

  1994cited by this paper
• The multistep nature of cancer.

  1993cited by this paper
• Fidelity of DNA replication by extracts of normal and malignantly transformed human cells.

  1993cited by this paper
• Exposures in the glass manufacturing industry.

  1993cited by this paper
• Genomic instability and tumor progression: mechanistic considerations.

  1993cited by this paper
• Nuclear receptors and chemical carcinogenesis.

  1992cited by this paper
• Metal carcinogenesis: mechanistic implications.

  1992cited by this paper
• Cadmium in the Human Environment: Toxicity and Carcinogenicity

  1992cited by this paper
• DNA replication, 2nd edn

  1992cited by this paper
• Site-specific mutagenesis: retrospective and prospective.

  1991cited by this paper
• Chemical and physical carcinogenesis: advances and perspectives for the 1990s.

  1991cited by this paper
• Transcription and cancer.

  1991cited by this paper
• DNA polymerase alpha-primase complexes from carcinogen-treated Chinese hamster ovary cells.

  1990cited by this paper
• DNA Polymerase α-Primase Complexes from Carcinogen-treated Chinese Hamster Ovary Cells

  1990cited by this paper
• The Final Common Pathway of Cancer: Presidential Address

  1990cited by this paper
• The final common pathway of cancer.

  1990cited by this paper
• Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis.

  1990cited by this paper
• Multistage models for carcinogenesis.

  1989cited by this paper
• Pathways of human cell post-replication repair.

  1989cited by this paper
• Toxicity and carcinogenicity of nickel compounds.

  1989cited by this paper
• Normal sensitivity to mutagens, spontaneous chromosome breakage, and mutation frequency in nevoid basal cell carcinoma syndrome.

  1988cited by this paper
• Mutation rates and mutational spectra in tumorigenic cell lines.

  1988cited by this paper
• Trace metals and neoplasia.

  1986cited by this paper
• Trace metals and neoplasia.

  1986cited by this paper
• Metastatic potential and spontaneous mutation rates: studies with two murine cell lines and their recently induced metastatic variants.

  1986cited by this paper
• Correlation of frequency of induced mutation and metastatic potential in tumor cell lines from a single mouse mammary tumor.

  1985cited by this paper
• Multistage models of carcinogenesis.

  1985cited by this paper
• Recent advances in metal carcinogenesis.

  1984cited by this paper
• Recent advances in metal carcinogenesis

  1984cited by this paper
• Fidelity of DNA synthesis.

  1982cited by this paper
• Presidential address. Recent concepts of initiation and promotion in carcinogenesis.

  1981cited by this paper
• The role of metals in carcinogenesis: biochemistry and metabolism.

  1981cited by this paper
• Presidential address. Recent concepts of initiation and promotion in carcinogenesis.

  1981cited by this paper
• INteractions between carcinogens and proteins.

  1980cited by this paper
• On the fidelity of DNA replication.

  1979cited by this paper
• Decreased fidelity of DNA polymerase activity during N-2-fluorenylacetamide hepatocarcinogenesis.

  1979cited by this paper
• Tumor heterogeneity and the biology of cancer invasion and metastasis.

  1978cited by this paper
• Cancer: Experiments and Concepts

  1977cited by this paper
• Infidelity of DNA synthesis as related to mutagenesis and carcinogenesis.

  1977cited by this paper
• Relationship between differentiation and carcinogenesis.

  1977cited by this paper
• On the fidelity of DNA replication. Effect of metal activators during synthesis with avian myeloblastosis virus DNA polymerase.

  1977cited by this paper

• Interpreting cancer genetics through a two-step "evolutionary cascade hypothesis": bridging neutral and selective perspectives.

  2026cites this paper
• Tumor Biology and Natural History

  2021cites this paper
• Fixed genomic events and possible mechanisms of their causation by etiological agents

  2020cites this paper
• Exposure to Carcinogens and its effects in the Formation of Cancer

  2020cites this paper
• Apoptosis-A Distinctive Form of Cell Death as Biochemical, Molecular and Morphological Changes

  2016cites this paper
• Etio-Pathogenesis II: Genomic Events and Processes Potentially Caused by Etiological Agents

  2015cites this paper
• Etio-Pathogenesis III

  2015cites this paper
• Novel Mechanisms through which translesion synthesis protects genome integrity

  2013influential citation
• Generation of in vitro data to model dose dependent in vivo DNA binding of genotoxic carcinogens and its consequences: the case of estragole

  2012cites this paper
• Correlation between electron localization and metal ion mutagenicity in DNA synthesis from QM/MM calculations.

  2011cites this paper
• Tutorial on physiologically based kinetic modeling in molecular nutrition and food research.

  2011cites this paper
• A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes.

  2010cites this paper
• Genetic Theory of Cancer. Short Review

  2009cites this paper
• Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors.

  2007cites this paper
• Variation, "evolution", immortality and genetic instabilities in tumour cells.

  2007influential citation
• Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors.

  2007cites this paper
• Las Bases Moleculares del Cáncer

  2006influential citation
• Cancer morphology, carcinogenesis and genetic instability: a background.

  2006cites this paper
• Alkylating agents and DNA polymerases.

  2006cites this paper
• Embryonic reversions and lineage infidelities in tumour cells: genome‐based models and role of genetic instability

  2005influential citation
• Cytogenetic alterations in nonmelanoma skin cancer: A review

  2005cites this paper
• Molecular Mechanisms of Carcinogenesis

  2005cites this paper
• The cell-type-specificity of inherited predispositions to tumours: review and hypothesis.

  2004influential citation