Exercise and Nutrition to Target Protein Synthesis Impairments in Aging Skeletal Muscle

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Exercise and sport sciences reviews

• Publication date

  2013-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/JES.0b013e3182a4e699PMID 23873131PMCID PMC3790587
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Resistance training induced increase in muscle fiber size in young and older men

  2013cited by this paper
• Protein blend ingestion following resistance exercise promotes human muscle protein synthesis.

  2013cited by this paper
• Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis

  2013cited by this paper
• Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.

  2012cited by this paper
• Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis.

  2012cited by this paper
• Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein.

  2012cited by this paper
• Aerobic exercise training induces skeletal muscle hypertrophy and age-dependent adaptations in myofiber function in young and older men.

  2012cited by this paper
• Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men.

  2012cited by this paper
• Influence of resistance exercise on lean body mass in aging adults: a meta-analysis.

  2011cited by this paper
• Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men.

  2011cited by this paper
• Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.

  2011cited by this paper
• Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

  2011influential reference
• Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults

  2010cited by this paper
• Sarcopenia: European consensus on definition and diagnosis

  2010cited by this paper
• European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people

  2010cited by this paper
• Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling.

  2010cited by this paper
• Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women.

  2010cited by this paper
• Muscle mitochondrial changes with aging and exercise.

  2009cited by this paper
• Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian women.

  2009cited by this paper
• Protein synthesis and the expression of growth-related genes are altered by running in human vastus lateralis and soleus muscles.

  2009cited by this paper
• Dietary protein recommendations and the prevention of sarcopenia

  2009cited by this paper
• Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis

  2009cited by this paper
• Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men

  2009cited by this paper
• Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism

  2009cited by this paper
• Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity.

  2008cited by this paper
• Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging.

  2008influential reference
• Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

  2008cited by this paper
• Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling

  2007cited by this paper
• Insulin resistance of muscle protein metabolism in aging

  2006influential reference
• A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.

  2006influential reference
• Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults.

  2006cited by this paper
• Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

  2005cited by this paper
• Age and aerobic exercise training effects on whole body and muscle protein metabolism.

  2004cited by this paper
• Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium

  2003cited by this paper
• Single Muscle Fibre Contractile Properties in Young and Old Men and Women

  2003cited by this paper
• Basal muscle amino acid kinetics and protein synthesis in healthy young and older men.

  2001cited by this paper
• The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly.

  2000cited by this paper
• Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction.

  1999cited by this paper
• Effect of exercise and recovery on muscle protein synthesis in human subjects.

  1990cited by this paper
• What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men.

  1988influential reference
• Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People . Sarcopenia: European consensus on definition and diagnosis: Report the European Working Group on Sarcopenia in Older People.

  year unknowncited by this paper

• Reversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies

  2025cites this paper
• Association of Nutritional Status and Possible Sarcopenia Among Formerly Older Homeless Adults in Supportive Housing, Thailand

  2025cites this paper
• Physical activity and risk of sarcopenia in 6500 community-dwelling Japanese people aged 40–74 years: an 8-year follow-up study

  2025cites this paper
• The Dual Burden of Malnutrition and Oral Disease: An Updated Framework for Family Medicine, Dental Care, Nutrition Care, and Community Health Security

  2025cites this paper
• Clinical significance of serum irisin, 25(OH)D3 and albumin in older adults with chronic disease and sarcopenia

  2025cites this paper
• Muscle loss in cancer cachexia: what is the basis for nutritional support?

  2025cites this paper
• Prehabilitation Strategies: Enhancing Surgical Resilience with a Focus on Nutritional Optimization and Multimodal Interventions

  2025cites this paper
• Evaluation of Insulin-like Growth Factor-1 as a Potential Biomarker for Sarcopenia among Elderly Patients with Rheumatoid Arthritis

  2025cites this paper
• Effects of Exergaming on Frailty: A Systematic Review and Meta‐Analysis

  2025cites this paper
• Greater Protein Intake Emphasizing Lean Beef Does Not Affect Resistance Training-Induced Adaptations in Skeletal Muscle and Tendon of Older Women: A Randomized Controlled Feeding Trial

  2024cites this paper
• [Strength training for older adults].

  2024cites this paper
• Prazosin improves insulin-induced anabolic signaling by protecting capillary regression in the soleus muscle of hindlimb-unloaded rats

  2024cites this paper
• Sexual dimorphisms in skeletal muscle: current concepts and research horizons

  2024cites this paper
• Network meta-analysis of the intervention effects of different exercise measures on Sarcopenia in cancer patients

  2024cites this paper
• The effectiveness of protein supplementation combined with resistance exercise programs among community-dwelling older adults with sarcopenia: a systematic review and meta-analysis

  2024cites this paper
• Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review

  2023cites this paper
• Post-operative protein supplementation following orthopaedic surgery: A systematic review

  2023cites this paper
• The role of the mechanistic target of rapamycin complex 1 in the regulation of mitochondrial adaptation during skeletal muscle atrophy under denervation or calorie restriction in mice.

  2023cites this paper
• Sarcopenia definition: does it really matter? Implications for resistance training?

  2022cites this paper
• Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

  2022cites this paper
• Emerging Nutrition Approaches to Support the Mind and Muscle for Healthy Aging

  2022cites this paper
• Association of Plant Protein Intake with Change in Physical Performance in Chinese Community-Dwelling Older Adults

  2022cites this paper
• Rehabilitation of Older Adults with Sarcopenia: From Cell to Functioning

  2022cites this paper
• The relationship between sarcopenia, dysphagia, malnutrition, and frailty: making the case for proactive swallowing exercises to promote healthy aging

  2022cites this paper
• Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA)

  2022cites this paper
• Association between sarcopenia and osteoarthritis: A protocol for meta-analysis

  2022cites this paper
• Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia

  2022cites this paper
• Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

  2022cites this paper
• Applications of Medium-Chain Triglycerides in Foods

  2022cites this paper
• Nutrition and Physical Therapy: A Position Paper by the Physical Therapist Section of the Japanese Association of Rehabilitation Nutrition (Secondary Publication)

  2022cites this paper
• l-Arginine and Beetroot Extract Supplementation in the Prevention of Sarcopenia

  2022cites this paper
• Age-Related Alterations at Neuromuscular Junction: Role of Oxidative Stress and Epigenetic Modifications

  2021cites this paper
• A Whole-Grain Diet Increases Whole-Body Protein Balance Compared with a Macronutrient-Matched Refined-Grain Diet

  2021cites this paper
• Malnutrition Prevention

  2021cites this paper
• Sarcopenia Management for Clinicians

  2021cites this paper
• Electrical muscle stimulation: Application and potential role in aging society.

  2021cites this paper
• Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

  2021cites this paper
• Malnutrition in Older Adults—Recent Advances and Remaining Challenges

  2021cites this paper
• Sarcopenia, Ectopic Fat Infiltration Into the Lumbar Paravertebral Muscles, and Lumbo-Pelvic Deformity in Older Adults Undergoing Lumbar Surgery

  2021cites this paper
• Adding Branched-Chain Amino Acids to an Enhanced Standard-of-Care Treatment Improves Muscle Mass of Cirrhotic Patients With Sarcopenia: A Placebo-Controlled Trial

  2021cites this paper
• L-Glutamine Supplementation Enhances Strength and Power of Knee Muscles and Improves Glycemia Control and Plasma Redox Balance in Exercising Elderly Women

  2021cites this paper
• Identifying Codium fragile extract components and their effects on muscle weight and exercise endurance.

  2021cites this paper
• Fish Protein Ingestion Induces Neural, but Not Muscular Adaptations, Following Resistance Training in Young Adults

  2021influential citation
• Eicosapentaenoic acid enhances skeletal muscle hypertrophy without altering the protein anabolic signaling pathway.

  2021cites this paper
• miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition

  2021cites this paper
• Sarcopenia and Frailty

  2020cites this paper
• Interaction of recommended levels of physical activity and protein intake is associated with greater physical function and lower fat mass in older women: Kuopio Osteoporosis Risk Factor- (OSTPRE) and Fracture-Prevention Study

  2020cites this paper
• A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise

  2020cites this paper
• Analysis and evaluation of nucleosides, nucleobases and amino acids in safflower from different regions based on ultra-performance liquid chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry.

  2020cites this paper
• The Effect of MicroRNA-Mediated Exercise on Delaying Sarcopenia in Elderly Individuals

  2020cites this paper
• Sarcopenia: Molecular Pathways and Potential Targets for Intervention

  2020cites this paper
• A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly

  2020influential citation
• Animal protein intake reduces risk of functional impairment and strength loss in older adults.

  2020cites this paper
• Effect of milk fat globule membrane supplementation on motor unit adaptation following resistance training in older adults

  2020cites this paper
• Exercise as a therapy for cancer-induced muscle wasting

  2020cites this paper
• Myokines: The endocrine coupling of skeletal muscle and bone.

  2020cites this paper
• Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia

  2019cites this paper
• Considering Type 1 Diabetes as a Form of Accelerated Muscle Aging

  2019cites this paper
• The Underappreciated Role of Low Muscle Mass in the Management of Malnutrition.

  2019cites this paper
• Regular aerobic exercise‐ameliorated troponin I carbonylation to mitigate aged rat soleus muscle functional recession

  2019cites this paper
• Eccentric Muscle Contractions: Risks and Benefits

  2019cites this paper
• Mitochondria and Aging—The Role of Exercise as a Countermeasure

  2019cites this paper
• Whey Protein Hydrolysate Increases Amino Acid Uptake, mTORC1 Signaling, and Protein Synthesis in Skeletal Muscle of Healthy Young Men in a Randomized Crossover Trial.

  2019cites this paper
• Improvement in Nutritional Status is Associated with Achieving an Adequate Gait Speed at Discharge in Elderly Patients Hospitalized with Acute Heart Failure

  2019cites this paper
• Lifestyle medicine – An evidence based approach to nutrition, sleep, physical activity, and stress management on health and chronic illness

  2019cites this paper
• [Clinical Practice Guidelines for Sarcopenia].

  2019cites this paper
• Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.

  2019cites this paper
• [Protein and physical activity in prevention and treatment of sarcopenia].

  2019cites this paper
• Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults

  2019cites this paper
• Effects of treadmill with different intensities on bone quality and muscle properties in adult rats

  2019cites this paper
• Poor Oral Health as a Determinant of Malnutrition and Sarcopenia

  2019cites this paper
• Proper Protein Intake is a Strategy in the Treatment of Sarcopenia in the Elderly to Increase Muscle Mass Changes

  2019cites this paper
• Exercise preconditioning and TFAM overexpression diminish skeletal muscle atrophy.

  2018cites this paper
• The Body Composition Effects of Extra Protein in Elite Mixed Martial Artists Undergoing Frequent Training over a Six-Week Period

  2018cites this paper
• Exercise preconditioning diminishes skeletal muscle atrophy after hindlimb suspension in mice

  2018cites this paper
• Dyslipidaemia in the elderly: to treat or not to treat?

  2018cites this paper
• Avaliação do Estado Nutricional de Pessoas Idosas Utentes das Instituições Particulares de Solidariedade Social (Centros de Dia) do Concelho de Vila Nova de Gaia: Sarcopenia e Relação com Ingestão de Proteína

  2018cites this paper
• Glucose impairments and insulin resistance in prostate cancer: the role of obesity, nutrition and exercise

  2018cites this paper
• Effect of Resistance Training and Fish Protein Intake on Motor Unit Firing Pattern and Motor Function of Elderly

  2018influential citation
• Blood Flow Restriction Therapy for Stimulating Skeletal Muscle Growth: Practical Considerations for Maximizing Recovery in Clinical Rehabilitation Settings

  2018cites this paper
• Effect of prior chronic aerobic exercise on overload-induced skeletal muscle hypertrophy in mice.

  2018cites this paper
• 1 The Body Composition Effects of Extra Protein in 2 Elite Mixed Martial Artists Undergoing Frequent 3 Training over a Six-Week Period . 4

  2018cites this paper
• Effects of long-term exposures to low iron and branched-chain amino acid containing diets on aging skeletal muscle of Fisher 344 × Brown Norway rats.

  2018cites this paper
• Protein Requirements in Critically Ill Older Adults

  2018cites this paper
• Postexercise essential amino acid supplementation amplifies skeletal muscle satellite cell proliferation in older men 24 hours postexercise

  2017cites this paper
• The physiopathologic role of oxidative stress in skeletal muscle.

  2017cites this paper
• Effects of milk proteins supplementation in older adults undergoing resistance training: A meta-analysis of randomized control trials

  2017cites this paper
• Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention

  2017cites this paper
• Light-load resistance exercise increases muscle protein synthesis and hypertrophy signaling in elderly men.

  2017cites this paper
• An exploratory study on the efficacy and safety of a BCAA preparation used in combination with cardiac rehabilitation for patients with chronic heart failure

  2017cites this paper
• The impact of postexercise essential amino acid ingestion on the ubiquitin proteasome and autophagosomal-lysosomal systems in skeletal muscle of older men.

  2017cites this paper
• Effect of dietary protein, morning protein, and egg intake on cardiometabolic outcomes at different ages

  2017cites this paper
• Attenuation of Adverse Effects of Aging on Skeletal Muscle by Regular Exercise and Nutritional Support

  2017cites this paper
• Linking Cancer Cachexia-Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism

  2017cites this paper
• Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults

  2017influential citation
• The Role of Inflammation in Age-Related Sarcopenia

  2017cites this paper
• Characterising the muscle anabolic potential of dairy, meat and plant-based protein sources in older adults

  2017cites this paper
• Effect of small-sided team sport training and protein intake on muscle mass, physical function and markers of health in older untrained adults: A randomized trial

  2017cites this paper
• Efficacy of branched-chain amino acid supplementation and walking exercise for preventing sarcopenia in patients with liver cirrhosis

  2017cites this paper
• Atualidades sobre o tratamento da Sarcopenia revisão de literatura

  2016cites this paper