A Receptor Presentation Hypothesis for T Cell Help That Recruits Autoreactive B Cells1

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Immunology

• Publication date

  2001-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.166.3.1562PMID 11160197
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mouse T-cell receptor variable gene segment families

  2004cited by this paper
• Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions

  2004cited by this paper
• Somatic Mutation and Light Chain Rearrangement Generate Autoimmunity in Anti–Single-Stranded DNA Transgenic Mrl/lpr Mice

  1999cited by this paper
• MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti–double-stranded DNA B Cells

  1999cited by this paper
• Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition.

  1999cited by this paper
• A kinetic basis for T cell receptor repertoire selection during an immune response.

  1999cited by this paper
• Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: preservation of kidney function.

  1998cited by this paper
• Genetic susceptibility to systemic lupus erythematosus.

  1998influential reference
• Reciprocal T‐B determinant spreading develops spontaneously in murine lupus: implications for pathogenesis

  1998cited by this paper
• Promiscuous Presentation and Recognition of Nucleosomal Autoepitopes in Lupus: Role of Autoimmune T Cell Receptor α Chain

  1998cited by this paper
• Efficient Peripheral Clonal Elimination of B Lymphocytes in MRL/lpr Mice Bearing Autoantibody Transgenes

  1998cited by this paper
• Susceptibility to lupus nephritis in the NZB/W model system.

  1998influential reference
• Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes.

  1998cited by this paper
• Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes

  1998cited by this paper
• alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity.

  1997cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997cited by this paper
• Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

  1996cited by this paper
• Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes.

  1996cited by this paper
• T cell recognition and tolerance of antibody diversity.

  1996influential reference
• Tracing the development of single memory-lineage B cells in a highly defined immune response

  1996cited by this paper
• Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody response.

  1996cited by this paper
• Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.

  1996cited by this paper
• Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice.

  1996cited by this paper
• Murine lupus in the absence of αβ T cells

  1996cited by this paper
• B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice.

  1995cited by this paper
• Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.

  1995cited by this paper
• An early post-mutational selection event directs expansion of autoreactive B cells in murine lupus.

  1995influential reference
• T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus

  1995cited by this paper
• Substitution of class II alpha chain polymorphic residues defines location of A alpha k serologic epitopes and alters association between alpha beta and Ii polypeptides.

  1994cited by this paper
• T cell recognition of somatically-generated Ab diversity.

  1994cited by this paper
• Genetic and structural evidence for antigen selection of anti-DNA antibodies.

  1994influential reference
• The anti‐La response of a single MRL/Mp‐lpr/lpr mouse: Specificity for DNA and VH gene usage

  1994cited by this paper
• Substitution of class II α chain polymorphic residues defines location of Akαserologic epitopes and alters association between αβ and li polypeptides

  1994cited by this paper
• T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted.

  1994cited by this paper
• An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation.

  1994cited by this paper
• The mechanism of autoantibody production in an autoimmune MRL/lpr mouse.

  1994cited by this paper
• Verification of a model of a F(ab) complex with phenylarsonate by oligonucleotide-directed mutagenesis.

  1993cited by this paper
• Receptor editing in self-reactive bone marrow B cells

  1993cited by this paper
• Relationships among antinuclear antibodies from autoimmune MRL mice reacting with histone H2A-H2B dimers and DNA.

  1993cited by this paper
• Receptor editing: an approach by autoreactive B cells to escape tolerance

  1993cited by this paper
• Residues that mediate DNA binding of autoimmune antibodies.

  1993cited by this paper
• Monoclonal autoantibodies to subnucleosomes from a MRL/Mp(-)+/+ mouse. Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA.

  1992cited by this paper
• Development of murine lupus in CD4-depleted NZB/NZW mice. Sustained inhibition of residual CD4+ T cells is required to suppress autoimmunity.

  1992cited by this paper
• Gene conversion of immunoglobulin variable regions in mutagenesis cassettes by replacement PCR mutagenesis.

  1992cited by this paper
• B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro.

  1992cited by this paper
• Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice

  1990cited by this paper
• Interclonal and intraclonal diversity among anti-DNA antibodies from an (NZB x NZW)F1 mouse.

  1990cited by this paper
• Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation

  1990cited by this paper
• Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte

  1989cited by this paper
• Immunoglobulin‐specific T‐B cell interaction

  1989cited by this paper
• B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells.

  1989cited by this paper
• Two better cell lines for making hybridomas expressing specific T cell receptors.

  1989cited by this paper
• Immunoglobulin‐specific T‐B cell interaction

  1989cited by this paper
• The structure of Vα and Jα segments in the mouse

  1988cited by this paper
• The structure of V alpha and J alpha segments in the mouse.

  1988cited by this paper
• Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease.

  1988influential reference
• Antinuclear antibodies: diagnostic markers and clues to the basis of systemic autoimmunity

  1988cited by this paper
• T-cell-receptor beta- and I-A beta-chain genes of normal SWR mice are linked with the development of lupus nephritis in NZB x SWR crosses.

  1987cited by this paper
• Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

  1987cited by this paper
• The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice

  1987cited by this paper
• Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p- azophenylarsonate

  1987cited by this paper
• The lupus autoantigens and the pathogenesis of systemic lupus erythematosus.

  1986influential reference
• Somatic evolution of variable region structures during an immune response.

  1986cited by this paper
• Systemic lupus erythematosus.

  1986cited by this paper
• Requirement of H-2-subregion differences for graft-versus-host autoimmunity in mice: superiority of the differences at class-II H-2 antigens (I-A/I-E).

  1986influential reference
• Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin

  1985cited by this paper
• A rapid colorimetric assay for the determination of IL-2-producing helper T cell frequencies.

  1985cited by this paper
• Molecular events during maturation of the immune response to oxazolone

  1985cited by this paper
• The effect of thymectomy on lupus-prone mice.

  1984cited by this paper
• Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

  1984cited by this paper
• Monoclonal anti-histone autoantibodies derived from murine models of lupus.

  1984cited by this paper
• Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

  1984cited by this paper
• Antigen presentation by supported planar membranes containing affinity-purified I-Ad.

  1984cited by this paper
• The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti‐arsonate idiotype in the strain A mouse

  1983cited by this paper
• Idiotypes of anti-Ia antibodies. I. Expression of the 14-4-4S idiotype in humoral immune responses

  1981cited by this paper
• Concerning the specificity of histone and non-histone dissociation from calf thymus chromatin by salt.

  1972cited by this paper
• [Systemic lupus erythematosus].

  1955cited by this paper
• SURPRISINGLY UNEVEN DISTRIBUTION OF THE T CELL RECEPTOR V ( 3 REPERTOIRE IN WILD MICE BY

  year unknowncited by this paper

• Unravelling the role of the microenvironment in chronic lymphocytic leukaemia: T helper cell support of cancer cells

  2018cites this paper
• Cancer Vaccines

  2017cites this paper
• Limited in Nonautoimmune Mice Induction of Autoantibody Production Is

  2017cites this paper
• Secreted autoantibody repertoires in Sjögren's syndrome and systemic lupus erythematosus: A proteomic approach.

  2016cites this paper
• Antigen Receptor-Intrinsic Non-Self: The Key to Understanding Regulatory Lymphocyte-Mediated Idiotypic Control of Adaptive Immune Responses.

  2016cites this paper
• P 3 , a monoclonal antibody capable to activate B-1 a cells

  2016cites this paper
• Chromatin-mediated depression of fractionation performance on electronegative multimodal chromatography media, its prevention, and ramifications for purification of immunoglobulin G.

  2014cites this paper
• Nonspecific interactions of chromatin with immunoglobulin G and protein A, and their impact on purification performance.

  2014cites this paper
• Chimeric DNA Vaccines: An Effective Way to Overcome Immune Tolerance.

  2014cites this paper
• Chapter 21 – Autoantigenesis and Antigen-Based Therapy and Vaccination in SLE

  2013cites this paper
• Somatic mutagenesis in autoimmunity

  2013influential citation
• An immunodominant La/SSB autoantibody proteome derives from public clonotypes

  2013cites this paper
• Characterization and removal of aggregates formed by nonspecific interaction of IgM monoclonal antibodies with chromatin catabolites during cell culture production.

  2013cites this paper
• Reducing Protein Immunogenicity by Design: Deimmunization and Tolerance Induction

  2012cites this paper
• P3 mAb: An Immunogenic Anti-NeuGcGM3 Antibody with Unusual Immunoregulatory Properties

  2012cites this paper
• This information is current as for a B Cell Receptor V Region Peptide Cell Memory by Follicular T Cells Specific Aborted Germinal Center Reactions and B

  2011cites this paper
• Aborted Germinal Center Reactions and B Cell Memory by Follicular T Cells Specific for a B Cell Receptor V Region Peptide

  2011cites this paper
• Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity

  2010cites this paper
• A better immune reaction to Erbb-2 tumors is elicited in mice by DNA vaccines encoding rat/human chimeric proteins.

  2010cites this paper
• The idiotype connection: linking infection and multiple sclerosis.

  2010cites this paper
• Review: To What Extent are T Cells Tolerant to Immunoglobulin Variable Regions?

  2009cites this paper
• Tracking early autoimmune disease by bioluminescent imaging of NF-kappaB activation reveals pathology in multiple organ systems.

  2009cites this paper
• Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3

  2009cites this paper
• PATHOGENIC AND THERAPEUTIC ASPECTS OF INTRATHECAL IMMUNE RESPONSES IN MULTIPLE SCLEROSIS

  2009cites this paper
• Resposta imune a peptídeos derivados da imunoglobulina: da tolerância à auto-imunidade

  2008cites this paper
• T Cells from Multiple Sclerosis Patients Recognize Multiple Epitopes on Self‐IgG

  2007cites this paper
• Gangliosides, Ab1 and Ab2 antibodies I. Towards a molecular dissection of an idiotype-anti-idiotype system.

  2007cites this paper
• Immunogenicity of autologous immunoglobulins: principles and practices.

  2007cites this paper
• Gangliosides, Ab1 and Ab2 antibodies III. The idiotype of anti-ganglioside mAb P3 is immunogenic in a T cell-dependent manner.

  2007cites this paper
• B Cells and Dendritic Cells from Vκ8 Light Chain Transgenic Mice Activate MRL-lpr/gld CD4+ T Cells1

  2006influential citation
• Regulatory T Cells in Lupus

  2006cites this paper
• Chain Transgenic Mice Activate MRL-8 Light κ B Cells and Dendritic Cells from V

  2006influential citation
• B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells.

  2006cites this paper
• T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens

  2005cites this paper
• Ioannides Sequence of Antiidiotypic Antibodies ? H-terminal V 2 T-Cell Epitopes Nested in Unique NH + CD 8 Directed Expression of − Functional Idiotopes : Tumor Antigen

  2005influential citation
• Systemic Autoimmune Disease Caused by Autoreactive B Cells That Receive Chronic Help from Ig V Region-Specific T Cells1

  2005cites this paper
• Functional idiotopes: tumor antigen-directed expression of CD8+ T-cell epitopes nested in unique NH2-terminal VH sequence of antiidiotypic antibodies?

  2005influential citation
• Cerebrospinal fluid T cell clones from patients with multiple sclerosis: recognition of idiotopes on monoclonal IgG secreted by autologous cerebrospinal fluid B cells

  2005cites this paper
• T Cell Tolerance to Germline-Encoded Antibody Sequences in a Lupus-Prone Mouse1

  2005cites this paper
• Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity

  2005cites this paper
• ligation facilitates switch to IgG production lymphocyte collaboration: B cell Receptor MHC-restricted Ig V region-driven T-B

  2004cites this paper
• Antinucleosome Autoantibodies Bind Directly to Cell Lines In Vitro and via the FcγRIIB Receptor to B Lymphocytes In Vivo: A Role for Immune Complexes in Interactions between Antinucleosome IgG2a and B cells of BXSB Lupus Mice

  2004cites this paper
• Experimental use of murine lupus models.

  2004cites this paper
• Differences between CD8+ T cells in lupus‐prone (NZB × NZW) F1 mice and healthy (BALB/c × NZW) F1 mice may influence autoimmunity in the lupus model

  2004cites this paper
• Activation and Tolerance in CD4+ T Cells Reactive to an Immunoglobulin Variable Region

  2004cites this paper
• Prevention and control of reciprocal T-B cell diversification: implications for lupus-like autoimmunity.

  2004cites this paper
• MHC-Restricted Ig V Region-Driven T-B Lymphocyte Collaboration: B Cell Receptor Ligation Facilitates Switch to IgG Production

  2004cites this paper
• The scope of receptor editing and its association with autoimmunity.

  2004cites this paper
• Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance.

  2003cites this paper
• Chromatin Specificity of Anti-Double-Stranded DNA Antibodies and a Role for Arg Residues in the Third Complementarity-Determining Region of the Heavy Chain 1

  2003influential citation
• Generalization of single immunological experiences by idiotypically mediated clonal connections.

  2002cites this paper
• Naturally Processed Chromatin Peptides Reveal a Major Autoepitope That Primes Pathogenic T and B Cells of Lupus1

  2002cites this paper
• Pathogenic T and B Cells of Lupus Reveal a Major Autoepitope That Primes Naturally Processed Chromatin Peptides

  2002cites this paper
• Induction of Autoantibody Production Is Limited in Nonautoimmune Mice1

  2002cites this paper
• Rheumatoid factors in health and disease: structure, function, induction and regulation.

  2002cites this paper
• Induction of Autoantibody Production Is Limited in Nonautoimmune Mice1

  2002cites this paper
• Vaccination with Minigenes Encoding VH-derived Major Histocompatibility Complex Class I–binding Epitopes Activates Cytotoxic T Cells that Ablate Autoantibody-producing B Cells and Inhibit Lupus

  2002influential citation
• Heavy Chain Complementarity-determining Region of the Role for Arg Residues in the Third a Anti-double-stranded Dna Antibodies and Chromatin Specificity Of

  year unknowncites this paper