Role of matrix metalloproteinases in invasion, and metastasis: biology, diagnosis and inhibitors

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Cytotechnology (Dordrecht)

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF00744674PMID 7764458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of metalloproteinase genes in human prostate cancer

  2005cited by this paper
• Matrix degrading metalloproteinases

  2005cited by this paper
• Cysteine proteinases and metastasis

  2004cited by this paper
• Mutation in the nm23 gene is associated with metastasis in colorectal cancer.

  1993cited by this paper
• Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle.

  1993cited by this paper
• Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites.

  1993cited by this paper
• M(r) 92,000 type IV collagenase is increased in plasma of patients with colon cancer and breast cancer.

  1993cited by this paper
• Identification and characterization of a novel matrix-degrading protease from hormone-dependent human breast cancer cells.

  1993cited by this paper
• Mr 92,000 Type IV Collagenase Is Increased in Plasma of Patients with Colon Cancer and Breast Cancer

  1993cited by this paper
• Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice.

  1993cited by this paper
• The multistep nature of cancer.

  1993cited by this paper
• Mutation in the nm23 gene is associated with metastasis in colorectal cancer.

  1993cited by this paper
• How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

  1993cited by this paper
• Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential.

  1992cited by this paper
• Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity

  1992cited by this paper
• Digoxigenin as an alternative probe labeling for in situ hybridization.

  1992cited by this paper
• Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.

  1992cited by this paper
• Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma. A clinicopathologic study.

  1992cited by this paper
• Interstitial collagenase gene expression in oral squamous cell carcinoma.

  1992cited by this paper
• A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 3 (stromelysin-1) using monoclonal antibodies.

  1992cited by this paper
• Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas.

  1992cited by this paper
• The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes.

  1992cited by this paper
• Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

  1992cited by this paper
• G proteins.

  1992cited by this paper
• Shaking the tree. Will statistical analysis of DNA pinpoint human origins?

  1992cited by this paper
• Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

  1992cited by this paper
• The role of the C-terminal domain in collagenase and stromelysin specificity.

  1992cited by this paper
• Secreted inhibitors of metalloproteinases (IMPs) that are distinct from TIMP.

  1992cited by this paper
• The c‐Ets oncoprotein activates the stromelysin promoter through the same elements as several non‐nuclear oncoproteins.

  1991cited by this paper
• Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.

  1991cited by this paper
• Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2.

  1991cited by this paper
• Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene.

  1991cited by this paper
• Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis.

  1991cited by this paper
• Tumor cell invasion inhibited by TIMP-2.

  1991cited by this paper
• Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2.

  1991cited by this paper
• Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the "cysteine switch".

  1991cited by this paper
• Expression and localization of the matrix metalloproteinase pump‐1 (MMP‐7) in human gastric and colon carcinomas

  1991influential reference
• Metastasis suppressor genes.

  1991cited by this paper
• Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).

  1991cited by this paper
• Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.

  1991cited by this paper
• Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma.

  1991cited by this paper
• Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.

  1991cited by this paper
• The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor.

  1991cited by this paper
• Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

  1991cited by this paper
• Expression of collagenase‐related metalloproteinase genes in human lung or head and neck tumours

  1991cited by this paper
• The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts.

  1991cited by this paper
• The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.

  1991cited by this paper
• Dictyostelium Nucleoside Diphospate Kinase Highly Homologous to Nm23 and Awd Proteins Involved in Mammalian Tumor Metastasis and Drosphila Development

  1990cited by this paper
• Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases.

  1990cited by this paper
• Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

  1990cited by this paper
• Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone.

  1990cited by this paper
• A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

  1990cited by this paper
• The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

  1990cited by this paper
• Dictyostelium nucleoside diphosphate kinase highly homologous to Nm23 and Awd proteins involved in mammalian tumor metastasis and Drosophila development.

  1990cited by this paper
• Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.

  1990cited by this paper
• Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

  1990cited by this paper
• Metalloproteinases and their inhibitors in matrix remodeling.

  1990cited by this paper
• TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence.

  1990cited by this paper
• cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

  1990cited by this paper
• A genetic model for colorectal tumorigenesis.

  1990cited by this paper
• Stromelysin in tumor progression and metastasis

  1990cited by this paper
• Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

  1990cited by this paper
• Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate.

  1990cited by this paper
• Structure of the human type IV collagenase gene.

  1990cited by this paper
• Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue.

  1990cited by this paper
• Mechanisms of trophoblast invasiveness and their control: the role of proteases and protease inhibitors

  1990cited by this paper
• The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis.

  1990cited by this paper
• Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C

  1990cited by this paper
• Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells.

  1989cited by this paper
• Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bovine aortic endothelial cells.

  1989cited by this paper
• SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.

  1989influential reference
• Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.

  1989cited by this paper
• Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 (‘gelatinase’) by human neutrophil elastase and cathepsin G

  1989cited by this paper
• Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.

  1989cited by this paper
• The activation of human type IV collagenase proenzyme. Sequence identification of the major conversion product following organomercurial activation.

  1989cited by this paper
• Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

  1989cited by this paper
• Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta.

  1989cited by this paper
• Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

  1989cited by this paper
• NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells.

  1989cited by this paper
• Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

  1989cited by this paper
• Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice

  1989cited by this paper
• Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family.

  1989cited by this paper
• Fragments of human fibroblast collagenase. Purification and characterization.

  1989cited by this paper
• Evidence for a novel gene associated with low tumor metastatic potential.

  1988cited by this paper
• The collagenase gene family in humans consists of at least four members.

  1988cited by this paper
• Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

  1988cited by this paper
• Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction

  1988cited by this paper
• H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

  1988cited by this paper
• Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways.

  1988cited by this paper
• Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters.

  1988cited by this paper
• Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos.

  1988cited by this paper
• A simple quantitative assay for studying the invasive potential of high and low human metastatic variants.

  1987cited by this paper
• Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

  1987influential reference
• Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.

  1987cited by this paper
• A domain structure common to hemopexin, vitronectin, interstitial collagenase, and a collagenase homolog.

  1987cited by this paper
• Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.

  1987cited by this paper
• The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.

  1987cited by this paper
• Primary structure and cDNA cloning of human fibroblast collagenase inhibitor.

  1986cited by this paper
• Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

  1986cited by this paper
• The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

  1986cited by this paper

• The most likely but largely ignored triggering factor for breast (or all) cancer invasion

  2023cites this paper
• The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics.

  2015cites this paper
• Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3)

  2006cites this paper
• The influence of HIV infection to the periodontium; a clinical, microbiological, and enzymological study

  2006cites this paper
• Differential Expression and Activity Status of MMP-1, MMP-2 and MMP-9 in Tumor and Stromal Cells of Squamous Cell Carcinomas of the Lung

  2002cites this paper
• Molecular Analysis of Surgical Margins in Head and Neck Squamous Cell Carcinoma Patients

  2002cites this paper
• Calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human breast cancer cell lines

  2001cites this paper
• The expression and regulation of matrilysin (MMP-7) in human colon cancer and leukaemia cell lines

  2001cites this paper
• Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Laryngeal and Pharyngeal Squamous Cell Carcinoma: A Quantitative Analysis

  2000cites this paper
• Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in Chinese human pancreatic cancer

  2000cites this paper
• Interstitial Collagenase Gene Expression Correlates With In Vitro Invasion in Human Chondrosarcoma

  2000cites this paper
• Investigation of multidrug resistance and invasion in human cancer cell lines

  1999cites this paper
• Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor

  1999cites this paper
• Metastatic and non-metastatic colorectal cancer (CRC) cells induce host metalloproteinase production in vivo

  1999cites this paper
• Expression of metalloproteinases and their inhibitors in human trophoblast continuous cell lines.

  1998cites this paper
• mRNA Levels of Membrane-type 1 Matrix Metalloproteinase (MT1-MMP), MMP-2, and MMP-9 and of their Inhibitors TIMP-2 and TIMP-3 in Normal Thyrocytes and Thyroid Carcinoma Cell Lines

  1998cites this paper
• [Innovative therapy with metalloprotease inhibitors].

  1997cites this paper
• Cloning, expression and activation of a truncated 92-kDa gelatinase minienzyme.

  1997cites this paper
• Regulation of proteolytic activity in tissues.

  1994cites this paper
• AD Award Number : DAMD 17-001-0425 TITLE : Molecular Mechanisms of Calcium Hydroxyapatite Crystal Induced Mitrogenesis in Breast Cancer

  year unknowncites this paper