Genetic pleiotropy in complex traits and diseases: implications for genomic medicine

Editorial summary Several recent papers have used summary results from genome-wide association studies to characterize genetic overlap between human complex traits and common diseases. The emerging evidence is that individual DNA variants frequently influence multiple phenotypes, often in unexpected ways. This has important implications for genomic medicine and for the application of genome editing.

• Publication year

  2016

• Venue

  Genome Medicine

• Publication date

  2016-07-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/s13073-016-0332-xPMID 27435222PMCID 4952057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Abundant pleiotropy in human complex diseases and traits.

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• Should biology put complexity first?

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• Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis

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• ASSOCIATIONS BETWEEN EPILEPSY-RELATED POLYGENIC RISK AND BRAIN MORPHOLOGY IN CHILDHOOD

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• Association Between Immune-Related Disease and Allergic Rhinitis: A Two-Sample Mendelian Randomization Study

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• GCPBayes pipeline: a tool for exploring pleiotropy at the gene level

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• Towards understanding the link between gut microbiota and heart failure in the heart-gut axis.

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• Uncovering the Heritable Components of Multimorbidities and Disease Trajectories: A Nationwide Cohort Study

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• Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations

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• Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

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