Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Experimental Cell Research

• Publication date

  2016-04-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.yexcr.2015.10.025PMID 26515553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells

  2015cited by this paper
• Isolation of Integrin‐Based Adhesion Complexes

  2015cited by this paper
• Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

  2015cited by this paper
• Mechanoreception at the cell membrane: More than the integrins.

  2015cited by this paper
• Proteomic analysis of integrin‐associated complexes from mesenchymal stem cells

  2015cited by this paper
• Emerging properties of adhesion complexes: what are they and what do they do?

  2015cited by this paper
• The integrin expression profile modulates orientation and dynamics of force transmission at cell–matrix adhesions

  2015cited by this paper
• Anchors and signals: the diverse roles of integrins in development.

  2015cited by this paper
• Phosphorylation and turnover of paxillin in focal contacts is controlled by force and defines the dynamic state of the adhesion site

  2015cited by this paper
• The contractome – a systems view of actomyosin contractility in non-muscle cells

  2015cited by this paper
• Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

  2015influential reference
• A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

  2015cited by this paper
• FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis

  2014cited by this paper
• Microtubules regulate focal adhesion dynamics through MAP4K4.

  2014cited by this paper
• The extracellular matrix modulates the hallmarks of cancer

  2014cited by this paper
• Microtubule-Dependent Modulation of Adhesion Complex Composition

  2014cited by this paper
• Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function

  2014cited by this paper
• Paxillin mediates stretch‐induced Rho signaling and endothelial permeability via assembly of paxillin‐p42/44MAPK‐GEF‐H1 complex

  2014cited by this paper
• The integrin adhesome: from genes and proteins to human disease

  2014influential reference
• GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

  2014cited by this paper
• GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

  2014cited by this paper
• LIM proteins in actin cytoskeleton mechanoresponse.

  2014cited by this paper
• A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

  2014cited by this paper
• Concise Review: Bone Marrow‐Derived Mesenchymal Stem Cells Change Phenotype Following In Vitro Culture: Implications for Basic Research and the Clinic

  2014cited by this paper
• Mechanosensors in integrin signaling: the emerging role of p130Cas.

  2014cited by this paper
• The InterPro protein families database: the classification resource after 15 years

  2014cited by this paper
• Loss of Keratinocyte Focal Adhesion Kinase Stimulates Dermal Proteolysis Through Upregulation of MMP9 in Wound Healing

  2014cited by this paper
• PDMS Elastic Micropost Arrays for Studying Vascular Smooth Muscle Cells.

  2013cited by this paper
• LIM Domains Target Actin Regulators Paxillin and Zyxin to Sites of Stress Fiber Strain

  2013influential reference
• Requirement of LIM domains for the transient accumulation of paxillin at damaged stress fibres

  2013influential reference
• β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

  2013influential reference
• Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

  2013cited by this paper
• Mechanobiology and developmental control.

  2013cited by this paper
• Mechanosensitivity and compositional dynamics of cell–matrix adhesions

  2013influential reference
• Cyclic mechanical reinforcement of integrin-ligand interactions.

  2013cited by this paper
• The tension mounts: Stress fibers as force-generating mechanotransducers

  2013cited by this paper
• Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

  2013cited by this paper
• Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation

  2013cited by this paper
• Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

  2013cited by this paper
• From tissue mechanics to transcription factors.

  2013cited by this paper
• Integrins in mechanotransduction.

  2013cited by this paper
• Focal adhesion kinase regulation of mechanotransduction and its impact on endothelial cell functions.

  2012cited by this paper
• Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

  2012cited by this paper
• Extracellular-matrix tethering regulates stem-cell fate.

  2012cited by this paper
• Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration.

  2012cited by this paper
• Isolation of focal adhesion proteins for biochemical and proteomic analysis.

  2012cited by this paper
• Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators

  2012cited by this paper
• Zyxin is involved in regulation of mechanotransduction in arteriole smooth muscle cells

  2012cited by this paper
• Opening the floodgates: proteomics and the integrin adhesome.

  2012cited by this paper
• Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment.

  2012cited by this paper
• The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration.

  2011cited by this paper
• Quantitative proteomics of the integrin adhesome show a myosin II‐dependent recruitment of LIM domain proteins

  2011influential reference
• Molecular architecture and function of matrix adhesions.

  2011cited by this paper
• PINCH Proteins Regulate Cardiac Contractility by Modulating Integrin-Linked Kinase-Protein Kinase B Signaling

  2011cited by this paper
• Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

  2011influential reference
• Cell-matrix adhesions in 3D.

  2011cited by this paper
• ILK mediates the effects of strain on intestinal epithelial wound closure.

  2011cited by this paper
• Role of YAP/TAZ in mechanotransduction

  2011cited by this paper
• Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

  2011influential reference
• Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

  2010cited by this paper
• Zyxin Mediation of Stretch-Induced Gene Expression in Human Endothelial Cells

  2010cited by this paper
• Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

  2010cited by this paper
• The switchable integrin adhesome

  2010cited by this paper
• A zyxin-mediated mechanism for actin stress fiber maintenance and repair.

  2010cited by this paper
• A tense situation: forcing tumour progression

  2009cited by this paper
• Demonstration of catch bonds between an integrin and its ligand

  2009cited by this paper
• Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization

  2009cited by this paper
• Invadosomes at a glance

  2009cited by this paper
• Stretching Single Talin Rod Molecules Activates Vinculin Binding

  2009cited by this paper
• Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

  2009cited by this paper
• Pressure-Induced Vascular Oxidative Stress Is Mediated Through Activation of Integrin-Linked Kinase 1/&bgr;PIX/Rac-1 Pathway

  2009cited by this paper
• Integrins during evolution: evolutionary trees and model organisms.

  2009cited by this paper
• Mechanically Activated Integrin Switch Controls α5β1 Function

  2009cited by this paper
• Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening.

  2009influential reference
• Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

  2008cited by this paper
• Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner

  2008cited by this paper
• Functional atlas of the integrin adhesome

  2007cited by this paper
• Forces and Bond Dynamics in Cell Adhesion

  2007cited by this paper
• Mechanical Stretch Inhibits Oxidized Low Density Lipoprotein-induced Apoptosis in Vascular Smooth Muscle Cells by Up-regulating Integrin αVβ3 and Stablization of PINCH-1*

  2007cited by this paper
• Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells

  2006cited by this paper
• Matrix elasticity directs stem cell lineage specification.

  2006cited by this paper
• Force sensing by mechanical extension of the Src family kinase substrate p130Cas.

  2006cited by this paper
• Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure.

  2006cited by this paper
• Integrin ligands at a glance

  2006cited by this paper
• Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart.

  2006cited by this paper
• Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement

  2005cited by this paper
• Hierarchical assembly of cell-matrix adhesion complexes.

  2004cited by this paper
• Focal Adhesion Protein Zyxin Is a Mechanosensitive Modulator of Gene Expression in Vascular Smooth Muscle Cells

  2004cited by this paper
• The integrin–actin connection, an eternal love affair

  2003cited by this paper
• Cell interactions with three-dimensional matrices.

  2002cited by this paper
• Integrins: bidirectional, allosteric signaling machines.

  2002cited by this paper
• Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.

  2001cited by this paper
• Molecular complexity and dynamics of cell-matrix adhesions.

  2001cited by this paper
• Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

  2001cited by this paper

• Syndecan-4 interacts directly with β-parvin and regulates the ILK-PINCH-β-parvin complex, the β-parvin-β-PIX-Rac1 axis, and cardiomyocyte geometry in a sex-dependent manner

  2025cites this paper
• The ILK–PINCH–parvin complex: a conserved primary adhesome regulating biological processes

  2025cites this paper
• Focal adhesions, reticular adhesions, flat clathrin lattices: What divides them, what unites them?

  2024cites this paper
• Apical integrins as a switchable target to regulate the epithelial barrier

  2024cites this paper
• ECM-dependent regulation of septin 7 in focal adhesions promotes mechanosensing and functional response in fibroblasts

  2024cites this paper
• Highly oriented hydrogels for tissue regeneration: design strategies, cellular mechanisms, and biomedical applications

  2024cites this paper
• The formin FMNL2 plays a role in the response of melanoma cells to substrate stiffness

  2024cites this paper
• A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events.

  2023cites this paper
• PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

  2023cites this paper
• Integrins and their potential roles in mammalian pregnancy

  2023cites this paper
• Protein kinase A is a functional component of focal adhesions

  2023cites this paper
• Two Transient Receptor Potential Channels at Focal Adhesions

  2023cites this paper
• Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

  2023cites this paper
• Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression

  2023cites this paper
• Talin regulates steady-state tensional homeostasis to drive vascular morphodynamics and cancer

  2022cites this paper
• The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

  2022cites this paper
• Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction

  2022cites this paper
• Functional Bioinformatics Analyses of the Matrisome and Integrin Adhesome.

  2021cites this paper
• The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – A review

  2021cites this paper
• Role of the extracellular matrix and YAP/TAZ in cell reprogramming.

  2021cites this paper
• Vinculin is required for neuronal mechanosensing but not for axon outgrowth.

  2021cites this paper
• Mena regulates the LINC complex to control actin–nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression

  2021cites this paper
• Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage

  2021cites this paper
• Involvement of actin cytoskeletal modifications in the inhibition of triple-negative breast cancer growth and metastasis by nimbolide

  2021cites this paper
• Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

  2021cites this paper
• Molecular mechanisms of voiding dysfunction in a novel mouse model of acute urinary retention

  2021cites this paper
• Identification of phenotype-specific networks from paired gene expression–cell shape imaging data

  2021cites this paper
• The Adhesome Network: Key Components Shaping the Tumour Stroma

  2021cites this paper
• The Integrin Interactome: Methods and Protocols

  2021cites this paper
• Global Phosphotyrosinylated Protein Profile of Cell-Matrix Adhesion Complexes of Trabecular Meshwork Cells.

  2020cites this paper
• Definition of the fibroblast adhesome using multiplexed proximity biotinylation

  2020cites this paper
• The dynamics of cell–extracellular matrix interactions, with implications for tissue engineering

  2020cites this paper
• The extracellular matrix in development

  2020cites this paper
• Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation

  2020cites this paper
• The Role of Lamina Cribrosa Tissue Stiffness and Fibrosis as Fundamental Biomechanical Drivers of Pathological Glaucomatous Cupping.

  2020cites this paper
• Gone Caving: Roles of the Transcriptional Regulators YAP and TAZ in Skeletal Development

  2020cites this paper
• Recent Advances and Prospects in the Research of Nascent Adhesions

  2020cites this paper
• An Overview of the Cytoskeleton-Associated Role of PDLIM5

  2020cites this paper
• Mechanosensing dysregulation in the fibroblast: a hallmark of the aging heart.

  2020cites this paper
• Dexamethasone and Glucocorticoid-Induced Matrix Temporally Modulate Key Integrins, Caveolins, Contractility, and Stiffness in Human Trabecular Meshwork Cells

  2020cites this paper
• Differential integrin adhesome expression defines human natural killer cell residency and developmental stage

  2020cites this paper
• Extracellular Matrix Omics

  2020influential citation
• Extracellular Matrix Networks: From Connections to Functions

  2020cites this paper
• Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

  2019cites this paper
• Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration.

  2019cites this paper
• Editorial: Metastasis: From Cell Adhesion and Beyond

  2019cites this paper
• Are Integrins Still Practicable Targets for Anti-Cancer Therapy?

  2019cites this paper
• The extracellular matrix in tumor progression and metastasis

  2019cites this paper
• A PINCH-1–Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation

  2019cites this paper
• Signal transduction via integrin adhesion complexes.

  2019cites this paper
• The Fibrillin-1 RGD Integrin Binding Site Regulates Gene Expression and Cell Function through microRNAs.

  2019cites this paper
• The interplay between cardiac progenitor cells and their microenvironment

  2018cites this paper
• Osteoblasts preferentially adhere to peaks on micro-structured titanium.

  2018cites this paper
• Integrin diversity brings specificity in mechanotransduction

  2018cites this paper
• Photoresponsive Hydrogels with Photoswitchable Stiffness: Emerging Platforms to Study Temporal Aspects of Mesenchymal Stem Cell Responses to Extracellular Stiffness Regulation.

  2018cites this paper
• Substrate deformations induce directed keratinocyte migration

  2018cites this paper
• Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

  2018cites this paper
• Protein kinase A activity is regulated by actomyosin contractility during cell migration and is required for durotaxis

  2018cites this paper
• Extracellular matrix-based materials for regenerative medicine

  2018cites this paper
• Exploring integrin and growth factor receptor crosstalk mechanisms

  2018influential citation
• Cardiac shock wave therapy promotes arteriogenesis of coronary micrangium, and ILK is involved in the biomechanical effects by proteomic analysis

  2018cites this paper
• AMPK negatively regulates tensin-dependent integrin activity

  2017cites this paper
• A proteomics view on integrin‐mediated adhesions

  2017cites this paper
• Dual functions of Discoidin domain receptor coordinate cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

  2017cites this paper
• The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans.

  2017cites this paper
• The role of integrins in glaucoma

  2017cites this paper
• Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1

  2017cites this paper
• Mechanochemical coupling and developmental pattern formation

  2017cites this paper
• Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads.

  2017cites this paper
• Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics.

  2017cites this paper
• Conformational states during vinculin unlocking differentially regulate focal adhesion properties

  2017influential citation
• Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD

  2017cites this paper
• The Ras suppressor-1 (RSU-1) in cancer

  2017cites this paper
• AMPK negatively regulates tensin-dependent integrin activity

  2017cites this paper
• The role of focal adhesion kinases and adaptor proteins in integrin-dependent signaling

  2016cites this paper
• Title : The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

  2016cites this paper
• Multiscale View of Cytoskeletal Mechanoregulation of Cell and Tissue Polarity.

  2016cites this paper
• Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis

  2016cites this paper
• Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

  2016cites this paper
• Biology and structure of leukocyte β 2 integrins and their role in inflammation

  2016cites this paper
• Mouse fibroblasts null for the long isoform of β1,4-galactosyltransferase-I show defective cell-matrix interactions.

  2016cites this paper
• YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage

  2016cites this paper
• Role of integrin adhesions in cellular mechanotransduction

  2016cites this paper
• Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

  2016cites this paper
• Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition

  2016influential citation
• The integrin adhesome network at a glance

  2016cites this paper
• Insights into the Utility of the Focal Adhesion Scaffolding Proteins in the Anaerobic Fungus Orpinomyces sp. C1A

  2016cites this paper