ILK mediates the effects of strain on intestinal epithelial wound closure.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2011-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpcell.00273.2010PMID 21084641PMCID PMC3043633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism

  2010influential reference
• The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

  2010cited by this paper
• Strain-induced Proliferation Requires the Phosphatidylinositol 3-Kinase/AKT/Glycogen Synthase Kinase Pathway*

  2009cited by this paper
• Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

  2009cited by this paper
• Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation

  2009cited by this paper
• Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment

  2009cited by this paper
• Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration.

  2009cited by this paper
• Quantification of Focal Adhesion Kinase Activation Loop Phosphorylation as a Biomarker of Src Activity

  2009cited by this paper
• Integrin-linked kinase is an adaptor with essential functions during mouse development

  2009cited by this paper
• Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin.

  2009influential reference
• Role of Fyn and PI3K in H2O2-induced inhibition of apical Cl-/OH- exchange activity in human intestinal epithelial cells.

  2008cited by this paper
• Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis

  2008cited by this paper
• Focal Adhesion Kinase as a RhoA-activable Signaling Scaffold Mediating Akt Activation and Cardiomyocyte Protection*

  2008cited by this paper
• Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis.

  2008cited by this paper
• Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease.

  2008cited by this paper
• Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

  2008cited by this paper
• Integrin-linked kinase – essential roles in physiology and cancer biology

  2008cited by this paper
• Potential Molecular Mechanism for c-Src Kinase-mediated Regulation of Intestinal Cell Migration*

  2008cited by this paper
• Specific signaling cascades involved in cell spreading during healing of micro‐wounded gastric epithelial monolayers

  2008cited by this paper
• Cell Adhesion-dependent Cofilin Serine 3 Phosphorylation by the Integrin-linked Kinase·c-Src Complex*

  2008cited by this paper
• Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells.

  2008influential reference
• Integrin-linked kinase in the vascular smooth muscle cell response to injury.

  2008cited by this paper
• FAK association with multiple signal proteins mediates pressure‐induced colon cancer cell adhesion via a Src‐dependent PI3K/Akt pathway

  2007cited by this paper
• Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells.

  2007cited by this paper
• Integrin-linked kinase is required for epidermal and hair follicle morphogenesis

  2007cited by this paper
• Repetitive Deformation Activates Focal Adhesion Kinase and ERK Mitogenic Signals in Human Caco-2 Intestinal Epithelial Cells through Src and Rac1*

  2007cited by this paper
• Integrin‐linked kinase is an essential mediator for T‐cadherin‐dependent signaling via Akt and GSK3β in endothelial cells

  2007cited by this paper
• Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3beta in endothelial cells.

  2007cited by this paper
• Osteopontin stimulates vascular smooth muscle cell migration by inducing FAK phosphorylation and ILK dephosphorylation.

  2007cited by this paper
• The motogenic effects of cyclic mechanical strain on intestinal epithelial monolayer wound closure are matrix dependent.

  2006influential reference
• Integrin-Linked Kinase Expression Is Elevated in Human Cardiac Hypertrophy and Induces Hypertrophy in Transgenic Mice

  2006cited by this paper
• Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway.

  2006cited by this paper
• Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells.

  2006cited by this paper
• ILK, PINCH and parvin: the tIPP of integrin signalling

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• Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure.

  2006cited by this paper
• Cellular and Molecular Mechanisms of Gastrointestinal Ulcer Healing

  2005cited by this paper
• Integrin-linked kinase: a cancer therapeutic target unique among its ILK

  2005cited by this paper
• Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

  2005cited by this paper
• ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling

  2005cited by this paper
• Epithelia under metabolic stress perceive commensal bacteria as a threat.

  2004cited by this paper
• Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation.

  2003cited by this paper
• Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.

  2003cited by this paper
• Involvement of site‐specific FAK phosphorylation in sphingosine‐1 phosphate‐ and thrombin‐induced focal adhesion remodeling: role of Src and GIT

  2003cited by this paper
• Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation*

  2003cited by this paper
• Integrin‐linked kinase regulates chondrocyte shape and proliferation

  2003cited by this paper
• Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA

  2002cited by this paper
• The structural basis of localization and signaling by the focal adhesion targeting domain.

  2002cited by this paper
• C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes.

  2002cited by this paper
• Molecular Dissection of Actopaxin-Integrin-linked Kinase-Paxillin Interactions and Their Role in Subcellular Localization*

  2002cited by this paper
• Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase.

  2002cited by this paper
• Ca-independent Smooth Muscle Contraction A NOVEL FUNCTION FOR INTEGRIN-LINKED KINASE*

  2001cited by this paper
• Phosphoinositide 3-kinase signalling pathways.

  2001cited by this paper
• Drosophila Integrin-Linked Kinase Is Required at Sites of Integrin Adhesion to Link the Cytoskeleton to the Plasma Membrane

  2001cited by this paper
• A Novel Integrin-Linked Kinase–Binding Protein, Affixin, Is Involved in the Early Stage of Cell–Substrate Interaction

  2001cited by this paper
• Ca2+-independent Smooth Muscle Contraction

  2001cited by this paper
• Review of postoperative ileus.

  2001cited by this paper
• Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase

  2001cited by this paper
• Human caco-2 motility redistributes FAK and paxillin and activates p38 MAPK in a matrix-dependent manner.

  2000cited by this paper
• Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.

  2000cited by this paper
• Increased gut permeability and bacterial translocation in Pseudomonas pneumonia-induced sepsis

  2000cited by this paper
• Matrix‐specific FAK and MAPK reorganization during Caco‐2 cell motility

  2000cited by this paper
• Quantitative analysis of peristalsis in the guinea‐pig small intestine using spatio‐temporal maps

  1999cited by this paper
• Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats.

  1999cited by this paper
• Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

  1998cited by this paper
• Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

  1996cited by this paper
• Amplitude-dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco-2 monolayers.

  1996cited by this paper
• In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells.

  1995cited by this paper
• Normal physiology of small intestinal motility.

  1993cited by this paper
• Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor.

  1992cited by this paper
• Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2.

  1992cited by this paper
• Colonic motility in humans--a growing understanding.

  1991cited by this paper
• Caco‐2 cells cultured in serum‐free medium as a model for the study of enterocytic differentiation in vitro

  1991cited by this paper
• Striated brush border of intestinal absorptive epithelial cells: stereological studies on microvillous morphology in different adaptive states.

  1990cited by this paper
• Altered small bowel motility in irritable bowel syndrome is correlated with symptoms.

  1987cited by this paper
• Quantitative assessment of villous motility.

  1987cited by this paper
• One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

  1977cited by this paper

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  2024cites this paper
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• Selenium yeast modulated ileal transcriptome and microbiota to ameliorate egg production in aged laying hens

  2020cites this paper
• ILK supports RhoA/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process

  2020cites this paper
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  2019cites this paper
• Electrical Stimulation and Recovery of Gastrointestinal Function Following Surgery: A Systematic Review

  2018cites this paper
• Integrin linked kinase regulates syncytialization of BeWo trophoblast cells†

  2017cites this paper
• Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome.

  2016cites this paper
• A novel role for integrin‐linked kinase in periodic mechanical stress‐mediated ERK1/2 mitogenic signaling in rat chondrocytes

  2016influential citation
• Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion.

  2015cites this paper
• Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism.

  2014cites this paper
• Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration

  2012cites this paper
• Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction

  2012cites this paper
• Intestinal mucosal atrophy and adaptation.

  2012cites this paper
• Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells.

  2011cites this paper