Distinct Requirements for Achievement of Allotolerance Versus Reversal of Autoimmunity via Nonmyeloablative Mixed Chimerism Induction in NOD Mice

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Transplantation

• Publication date

  2010-01-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/TP.0b013e3181c4692ePMID 20061915PMCID PMC3043373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  1999cited by this paper
• NOD mice have a generalized defect in their response to transplantation tolerance induction.

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  1999cited by this paper
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  1997cited by this paper
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  1989cited by this paper
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  1985cited by this paper
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  1983cited by this paper
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