Mixed chimerism and tolerance without whole body irradiation in a large animal model.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Clinical Investigation

• Publication date

  2000-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI8721PMID 10862793PMCID PMC378506
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Production of monoclonal antibodies reactive with polymorphic and monomorphic determinants of SLA class I gene products

  2005cited by this paper
• Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine.

  2000cited by this paper
• Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine.

  2000cited by this paper
• Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model.

  2000cited by this paper
• Characterization of a monoclonal anti‐porcine CD3 antibody

  1999cited by this paper
• Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate dogs given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantation.

  1999influential reference
• Effect of pig‐specific cytokines on mobilization of hematopoietic progenitor cells in pigs and on pig bone marrow engraftment in baboons

  1999cited by this paper
• An allelic non-histocompatibility antigen with wide tissue distribution as a marker for chimerism in pigs.

  1999cited by this paper
• In vivo T cell depletion in miniature swine using the swine CD3 immunotoxin, pCD3-CRM9.

  1999cited by this paper
• Mixed chimerism as an approach for the induction of transplantation tolerance.

  1999cited by this paper
• Separate regulation of peripheral hematopoietic and thymic engraftment.

  1998cited by this paper
• A phase II study of BTI-322, a monoclonal anti-CD2 antibody, for treatment of steroid-resistant acute graft-versus-host disease.

  1998cited by this paper
• Potent apoptotic signaling and subsequent unresponsiveness induced by a single CD2 mAb (BTI-322) in activated human peripheral T cells.

  1998cited by this paper
• Primate renal transplants using immunotoxin.

  1998cited by this paper
• Current and Future Preparative Regimens for Bone Marrow Transplantation in Thalassemia a

  1998cited by this paper
• Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control.

  1998cited by this paper
• A Phase II Study of BTI-322, a Monoclonal Anti-CD2 Antibody, for Treatment of Steroid-Resistant Acute Graft-Versus-Host Disease

  1998cited by this paper
• Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation.

  1997cited by this paper
• Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts.

  1997cited by this paper
• Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning

  1997cited by this paper
• Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.

  1996cited by this paper
• Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.

  1996cited by this paper
• Bone marrow transplantation for sickle cell disease.

  1996cited by this paper
• In vivo gene transfer of insulin gene into neonatal rats by the HVJ-liposome method resulted in sustained transgene expression.

  1996cited by this paper
• Immunotoxins: an update.

  1996cited by this paper
• Barriers to bone marrow transplantation for sickle cell anemia.

  1996cited by this paper
• A new reagent for the induction of T-cell depletion, anti-CD3-CRM9.

  1996cited by this paper
• The Second International Swine CD Workshop.

  1996cited by this paper
• Mixed Allogeneic Chimerism And Renal Allograft Tolerance In Cynomolgus Monkeys

  1995cited by this paper
• Induction of tolerance to renal allografts across single-haplotype MHC disparities in miniature swine.

  1995cited by this paper
• Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice

  1995cited by this paper
• Characterization of a monoclonal antibody (6G12) recognizing the cynomolgus monkey CD3 antigen.

  1994cited by this paper
• Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum.

  1994cited by this paper
• Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow.

  1994cited by this paper
• Bone marrow transplantation for sickle cell disease.

  1993cited by this paper
• Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice.

  1993influential reference
• Selective breeding of miniature swine leads to an increased rate of acceptance of MHC-identical, but not of class I-disparate, renal allografts.

  1992cited by this paper
• Induction of kidney transplantation tolerance across major histocompatibility complex barriers by bone marrow transplantation in miniature swine.

  1991cited by this paper
• IN VIVO TREATMENT WITH ANTIPORCINE T CELL ANTIBODIES

  1990cited by this paper
• Reconstruction of the haemopoietic and immune systems after marrow transplantation.

  1990cited by this paper
• Mechanism of tolerance following class I--disparate renal allografts in miniature swine. Cellular responses of tolerant animals.

  1990cited by this paper
• Canine models of bone marrow transplantation.

  1990cited by this paper
• Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen

  1989cited by this paper
• BONE MARROW TRANSPLATATION IN MINIATURE SWINE: I. Development of the Model

  1988cited by this paper
• Mixed allogeneic chimerism as an approach to transplantation tolerance.

  1988cited by this paper
• BONE MARROW TRANSPLANTATION IN MINIATURE SWINE: II Effect of Selective Genetic Differences on Engraftment and Recipient Survival

  1988cited by this paper
• Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia. Identification of host-derived antidonor allocytotoxic T lymphocytes.

  1987cited by this paper
• Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

  1986cited by this paper
• Administration of F(ab')2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells.

  1986cited by this paper
• A correlation between conditioning and engraftment in recipients of MHC-mismatched T cell-depleted murine bone marrow transplants.

  1985cited by this paper
• Preparation and characterization of monoclonal antibodies reactive with porcine PBL.

  1984cited by this paper
• Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

  1984cited by this paper
• TRANSPLANTATION IN MINIATURE SWINE: VIII. RECOMBINATION WITHIN THE MAJOR HISTOCOMPATIBILITY COMPLEX OF MINIATURE SWINE

  1981cited by this paper
• BONE MARROW TRANSPLANTATION ACROSS MAJOR HISTOCOMPATIBILITY BARRIERS IN MICE EFFECT OF ELIMINATION OF T CELLS FROM DONOR GRAFTS BY TREATMENT WITH MONOCLONAL THY‐1.2 PLUS COMPLEMENT OR ANTIBODY ALONE

  1981cited by this paper
• TRANSPLANTATION IN MINIATURE SWINE: VII. EVIDENCE FOR CELLULAR IMMUNE MECHANISMS IN HYPERACUTE REJECTION OF RENAL ALLOGRAFTS

  1979cited by this paper
• Transplantation in miniature swine. III: effects of MSLA and A-O blood group matching on skin allograft survival.

  1978cited by this paper
• TRANSPLANTATION IN MINIATURE SWINE: I. Fixation of the Major Histocompatibility Complex

  1976cited by this paper
• Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen

  1974cited by this paper
• Tolerance of Sk-incompatible skin grafts.

  1973cited by this paper
• Rejection of Skin Allografts by Radiation Chimaeras: Selective Gene Action in the Specification of Cell Surface Structure

  1970cited by this paper
• Rejection of skin allografts by radiation chimaeras: selective gene action in the specification of cell surface structure.

  1970cited by this paper

• Chimerism and a framework for clinical practice: A report from the Cellular Therapies Section Coordinating Committee (CTSCC) of Association for Advancement of Blood and Biotherapies (AABB).

  2026cites this paper
• Chimerism and immunological tolerance in solid organ transplantation

  2025cites this paper
• Durable Mixed Chimerism May Permit Subsequent Immunosuppression-Free Intestinal Transplantation - a Proof-of-Principle Study.

  2024cites this paper
• Advanced biomaterials for regenerative medicine and their possible therapeutic significance in treating COVID-19: a critical overview

  2024cites this paper
• Tolerance in intestinal transplantation.

  2024cites this paper
• Leveraging the lymphohematopoietic graft-versus-host reaction (LGVHR) to achieve allograft tolerance and restore self tolerance with minimal toxicity

  2023cites this paper
• CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

  2022cites this paper
• The MHC-characterized Miniature Swine: Lessons Learned From a 40-Year Experience in Transplantation

  2021cites this paper
• Biomarkers of immune tolerance in kidney transplantation: an overview

  2021cites this paper
• The importance of MHC class II in allogeneic bone marrow transplantation and chimerism-based solid organ tolerance in a rat model

  2020cites this paper
• The immune system in infants: Relevance to xenotransplantation

  2020cites this paper
• Cellular Immunotherapies in Pre-Clinical Large Animal Models of Transplantation.

  2020cites this paper
• Impact of combined heart and lung transplantation on bronchiolitis obliterans syndrome, cardiac allograft vasculopathy, and long-term survival.

  2019cites this paper
• Hematopoietic Stem Cell Properties, Markers, and Therapeutics

  2019cites this paper
• Biosafety Barrier to Xenotransplantation

  2019cites this paper
• Transplantation tolerance through mixed chimerism: From allo to xeno

  2018cites this paper
• Induction of Tolerance Towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Models.

  2018cites this paper
• Immune Tolerance, Xenografts, and Large‐Animal Studies in Transplantation

  2017cites this paper
• Mechanisms of Mixed Chimerism-Based Transplant Tolerance.

  2017cites this paper
• HSCT-Based Approaches for Tolerance Induction in Renal Transplant.

  2017cites this paper
• Vascularized Thymosternal Composite Tissue Allo- and Xenotransplantation in Nonhuman Primates: Initial Experience

  2017cites this paper
• Tolerance of Vascularized Islet‐Kidney Transplants in Rhesus Monkeys

  2017cites this paper
• Clonal Deletion Established via Invariant NKT Cell Activation and Costimulatory Blockade Requires In Vivo Expansion of Regulatory T Cells

  2016cites this paper
• Bone marrow chimerism as a strategy to produce tolerance in solid organ allotransplantation

  2016cites this paper
• Use of hematopoietic cell transplants to achieve tolerance in patients with solid organ transplants.

  2016cites this paper
• Induction of Donor-Specific Tolerance with Vascularized Bone Marrow Transplantation

  2016cites this paper
• Lymphodepletive effects of rabbit anti-pig thymocyte globulin in neonatal swines.

  2016cites this paper
• Transplant Tolerance Induction in Newborn Infants: Mechanisms, Advantages, and Potential Strategies

  2016cites this paper
• Donor Lymphocyte Infusion-Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation.

  2016cites this paper
• Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

  2016cites this paper
• Effects of Transient Donor Chimerism on Rejection of MHC-Mismatched Vascularized Composite Allografts in Swine

  2015cites this paper
• Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease.

  2015cites this paper
• Preclinical Models in Vascularized Composite Allotransplantation

  2015cites this paper
• High Incidence of Xenogenic Bone Marrow Engraftment in Pig‐to‐Baboon Intra‐Bone Bone Marrow Transplantation

  2015cites this paper
• Mixed Chimerism for Tolerance Induction of Vascularized Composite Allografts

  2015cites this paper
• Xenotransplantation: immunological hurdles and progress toward tolerance

  2014cites this paper
• Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation.

  2014cites this paper
• Long‐Term Results in Recipients of Combined HLA‐Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression

  2014cites this paper
• Preparatory Studies to Introduce Regulatory T Cells in Clinical Transplantation

  2014cites this paper
• Overcoming immunological barriers in regenerative medicine

  2014cites this paper
• Induction of tolerance through mixed chimerism.

  2014cites this paper
• Large Animal Models of Transplantation

  2014cites this paper
• Large Animal Models for Vascularized Composite Allotransplantation

  2014cites this paper
• Mechanisms of Allograft Tolerance

  2014cites this paper
• Stable mixed hematopoietic chimerism permits tolerance of vascularized composite allografts across a full major histocompatibility mismatch in swine

  2014cites this paper
• Der Einfluss einer Thymektomie auf die hämatopoetische Rekonstitution und die Effektivität der Induktion spender-spezifischer Transplantationstoleranz in einem Mausmodell der Knochenmarktransplantation

  2013cites this paper
• Optimizing chimerism level through bone marrow transplantation and irradiation to induce long-term tolerance to composite tissue allotransplantation.

  2013cites this paper
• Tolerance induction: hematopoietic chimerism

  2013cites this paper
• Synchimeric Model System of Tolerance Skin Allograft Maintenance in a New

  2013cites this paper
• Ischemia-Reperfusion Injury in Vascularized Composite Allotransplantation

  2013cites this paper
• Induction of Tolerance of Vascularized Composite Allografts

  2013cites this paper
• Stem Cell-based Tolerance Induction in Transplantation

  2013cites this paper
• donor lymphocyte infusion strategy of in utero hematopoietic stem cell transplantation and postnatal Complete allogeneic hematopoietic chimerism achieved by a combined

  2013cites this paper
• Renal allografts in plasma cell myeloma hematopoietic cell graft recipients: on the verge of an explosion?

  2013cites this paper
• Tolerance-Inducing Immunosuppressive Strategies in Clinical Transplantation

  2012cites this paper
• Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation

  2012cites this paper
• Análise do perfil de reatividade do repertório de anticorpos de indivíduos transplantados

  2012cites this paper
• Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning.

  2012cites this paper
• Expression and purification of non-N-glycosylated porcine interleukin 3 in yeast Pichia pastoris.

  2012cites this paper
• Lack of antidonor alloantibody does not indicate lack of immune sensitization: studies of graft loss in a haploidentical hematopoietic cell transplantation swine model.

  2012cites this paper
• Regenerative Therapies for Hematopoietic and Cardiovascular Tissues

  2012cites this paper
• Pathophysiological Aspects of Transplantation-Related Complications:: Following Busulphan/Cyclophosphamide Conditioning Regimen in Mouse Model

  2012cites this paper
• Expression and characterization of recombinant soluble porcine CD3 ectodomain molecules: mapping the epitope of an anti-porcine CD3 monoclonal antibody 898H2-6-15.

  2012cites this paper
• Stem cell mobilization and collection for induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys.

  2011cites this paper
• Immuno-intervention for the induction of transplantation tolerance through mixed chimerism.

  2011cites this paper
• Preclinical and clinical studies on the induction of renal allograft tolerance through transient mixed chimerism

  2011cites this paper
• Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts

  2011cites this paper
• Transplant Tolerance Bench to Bedside 26 th Annual

  2011cites this paper
• Challenges in the pursuit of immune tolerance

  2011cites this paper
• Immunological Considerations for Inducing Skin Graft Tolerance

  2011cites this paper
• Development of a diphtheria toxin based antiporcine CD3 recombinant immunotoxin.

  2011cites this paper
• Transplantation tolerance: Clinical potential of regulatory T cells.

  2011cites this paper
• Organ Transplant: Strategies for Prevention of Antibody-Mediated Allograft Rejection

  2011cites this paper
• Transplant tolerance: bench to bedside--26th annual Samuel Jason Mixter Lecture.

  2011cites this paper
• Hematopoietic Chimerism and Transplantation Tolerance: A Role for Regulatory T Cells

  2011influential citation
• Characterization of microsatellite loci in the SLA class I region.

  2011cites this paper
• Distinct Requirements for Achievement of Allotolerance Versus Reversal of Autoimmunity via Nonmyeloablative Mixed Chimerism Induction in NOD Mice

  2010cites this paper
• Tolerance and Long-Lasting Peripheral Chimerism After Allogeneic Intestinal Transplantation in MGH Miniature Swine

  2010cites this paper
• What Have We Learnt from Experimental Renal Transplantation?

  2010cites this paper
• A potential tolerogeneic role of skin grafts in previously tolerant animals

  2010cites this paper
• Transplantation tolerance through mixed chimerism

  2010cites this paper
• The challenge of immunogenicity in the quest for induced pluripotency

  2010cites this paper
• Immune profiling of operational tolerance in liver transplantation

  2009cites this paper
• Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials.

  2009cites this paper
• Transplantation Tolerance: From Bench to Bedside

  2008cites this paper
• Murine Mobilized Peripheral Blood Stem Cells Have a Lower Capacity than Bone Marrow to Induce Mixed Chimerism and Tolerance

  2008cites this paper
• Tolerance-inducing immunosuppressive strategies in clinical transplantation: an overview.

  2008cites this paper
• HLA-mismatched renal transplantation without maintenance immunosuppression.

  2008cites this paper
• Overcoming skin rejection in composite tissue allotransplantation.

  2008cites this paper
• Manipulating the immune system for anti‐tumor responses and transplant tolerance via mixed hematopoietic chimerism

  2008cites this paper
• Transplant Biology at a Crossroads

  2008cites this paper
• Mixed chimerism achieved by a nonlethal conditioning regimen induces donor-specific tolerance to lung allografts.

  2008cites this paper
• REVIEW ARTICLE Immunologic Approaches to Composite Tissue Allograft

  2007cites this paper
• Perspectives en immunothérapie des allogreffes de tissus composites

  2007cites this paper
• Management of Infections in Living-Donor Transplant Recipients

  2007cites this paper
• [The future of immunotherapy for composite tissues allotransplantation].

  2007cites this paper
• Immune tolerance: mechanisms and application in clinical transplantation

  2007cites this paper
• Immunologic approaches to composite tissue allograft.

  2007cites this paper
• Tolerance in xenotransplantation

  2007cites this paper
• Progress and potential for regenerative medicine.

  2007cites this paper