The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast

Vacuolar H+-ATPases (V-ATPases) acidify multiple organelles, and subunit isoforms help impart organelle-specific regulation of acidification. The regulator of ATPase of vacuoles and endosomes (RAVE) complex regulates organelle acidification by promoting V-ATPase assembly. This work demonstrates that RAVE is the first identified isoform-specific V-ATPase assembly factor required for control of vacuolar acidification.

• Publication year

  2014

• Venue

  Molecular Biology of the Cell

• Publication date

  2014-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E13-05-0231PMID 24307682PMCID 3907276
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sorting of the Yeast Vacuolar-type, Proton-translocating ATPase Enzyme Complex (V-ATPase)

  2012influential reference
• Subunit Interactions at the V1-Vo Interface in Yeast Vacuolar ATPase*

  2012cited by this paper
• The BioGRID interaction database: 2013 update

  2012cited by this paper
• Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae at 11-Å resolution

  2012cited by this paper
• Rabconnectin3α Promotes Stable Activity of the H+ Pump on Synaptic Vesicles in Hair Cells

  2012influential reference
• The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p in Saccharomyces cerevisiae

  2011cited by this paper
• Consequences of Loss of Vph1 Protein-containing Vacuolar ATPases (V-ATPases) for Overall Cellular pH Homeostasis*

  2011cited by this paper
• Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling*

  2010cited by this paper
• Regulation of Vacuolar Proton-translocating ATPase Activity and Assembly by Extracellular pH*

  2010cited by this paper
• The Genetic Landscape of a Cell

  2010cited by this paper
• The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila.

  2009influential reference
• Subunit Interactions and Requirements for Inhibition of the Yeast V1-ATPase*

  2009cited by this paper
• Cellular physiology of the renal H+ATPase

  2009cited by this paper
• Vacuolar and Plasma Membrane Proton Pumps Collaborate to Achieve Cytosolic pH Homeostasis in Yeast*

  2008cited by this paper
• RAVE Is Essential for the Efficient Assembly of the C Subunit with the Vacuolar H+-ATPase*

  2007cited by this paper
• Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

  2007influential reference
• The long physiological reach of the yeast vacuolar H+-ATPase

  2007cited by this paper
• Knockdown of V-ATPase subunit A (atp6v1a) impairs acid secretion and ion balance in zebrafish (Danio rerio).

  2007cited by this paper
• Cellular Environment Is Important in Controlling V-ATPase Dissociation and Its Dependence on Activity*

  2007cited by this paper
• Skp1p Regulates Soi3p/Rav1p Association with Endosomal Membranes but Is Not Required for Vacuolar ATPase Assembly

  2006cited by this paper
• V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

  2006cited by this paper
• The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H+-ATPase

  2006cited by this paper
• Distinct Expression Patterns of Different Subunit Isoforms of the V-ATPase in the Rat Epididymis1

  2006cited by this paper
• The ESCRT complexes: structure and mechanism of a membrane-trafficking network.

  2006cited by this paper
• The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.

  2005cited by this paper
• Purification and properties of rabconnectin-3.

  2005cited by this paper
• Protein–Protein Interactions of ESCRT Complexes in the Yeast Saccharomyces cerevisiae

  2004cited by this paper
• Global Mapping of the Yeast Genetic Interaction Network

  2004cited by this paper
• Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins.

  2004cited by this paper
• Faculty Opinions recommendation of Subunit rotation of vacuolar-type proton pumping ATPase: relative rotation of the G and C subunits.

  2003cited by this paper
• Subunit Rotation of Vacuolar-type Proton Pumping ATPase

  2003cited by this paper
• From Lysosomes to the Plasma Membrane LOCALIZATION OF VACUOLAR TYPE H -ATPase WITH THE a3 ISOFORM DURING OSTEOCLAST DIFFERENTIATION*

  2003cited by this paper
• From Lysosomes to the Plasma Membrane

  2003cited by this paper
• Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits.

  2003cited by this paper
• Vps27 recruits ESCRT machinery to endosomes during MVB sorting

  2003cited by this paper
• FunSpec: a web-based cluster interpreter for yeast

  2002cited by this paper
• The RAVE Complex Is Essential for Stable Assembly of the Yeast V-ATPase*

  2002cited by this paper
• Rabconnectin-3, a Novel Protein That Binds Both GDP/GTP Exchange Protein and GTPase-activating Protein for Rab3 Small G Protein Family*

  2002cited by this paper
• The Amino-terminal Domain of the Vacuolar Proton-translocating ATPase a Subunit Controls Targeting and in Vivo Dissociation, and the Carboxyl-terminal Domain Affects Coupling of Proton Transport and ATP Hydrolysis*

  2001influential reference
• Yeast V-ATPase Complexes Containing Different Isoforms of the 100-kDa a-subunit Differ in Coupling Efficiency and in VivoDissociation*

  2001influential reference
• Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

  2001cited by this paper
• Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly

  2001influential reference
• Regulation of V‐ATPases by reversible disassembly

  2000cited by this paper
• Three Subunit a Isoforms of Mouse Vacuolar H+-ATPase

  2000cited by this paper
• The new gene DmX from Drosophila melanogaster encodes a novel WD-repeat protein.

  1998cited by this paper
• Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.

  1996cited by this paper
• VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae

  1995cited by this paper
• STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p.

  1994influential reference
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• An MBoC Favorite: Morphological classification of the yeast vacuolar protein-sorting mutants: evidence for a prevacuolar compartment in class E vps mutants

  1992influential reference
• Assembly and targeting of peripheral and integral membrane subunits of the yeast vacuolar H(+)-ATPase.

  1992cited by this paper
• The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase.

  1992cited by this paper
• Monitoring meiosis and sporulation in Saccharomyces cerevisiae.

  1991cited by this paper
• Three Subunit a Isoforms of Mouse Vacuolar H 1 -ATPase PREFERENTIAL EXPRESSION OF THE a 3 ISOFORM DURING OSTEOCLAST DIFFERENTIATION*

  year unknowncited by this paper

• The ROGDI protein mutated in Kohlschutter–Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly

  2025cites this paper
• V‐ATPase Disassembly at the Yeast Lysosome‐Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging

  2025cites this paper
• Monoclonal nanobodies alter the activity and assembly of the yeast vacuolar H+-ATPase

  2025cites this paper
• Dmxl1 Is an Essential Mammalian Gene that Is Required for V-ATPase Assembly and Function In Vivo

  2024cites this paper
• Vacuolar H+‐ATPase in Diabetes, Hypertension, and Atherosclerosis

  2024cites this paper
• Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase

  2024cites this paper
• V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging

  2024cites this paper
• Structure of yeast RAVE bound to a partial V1 complex

  2024cites this paper
• The cytosolic N-terminal domain of V-ATPase a-subunits is a regulatory hub targeted by multiple signals

  2023influential citation
• Tender love and disassembly: How a TLDc domain protein breaks the V‐ATPase

  2023cites this paper
• The hybrid RAVE complex plays V-ATPase-dependent and -independent pathobiological roles in Cryptococcus neoformans

  2023cites this paper
• Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo

  2022cites this paper
• Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae

  2022cites this paper
• The Plant V-ATPase

  2022cites this paper
• RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification

  2021cites this paper
• A capsule-associated gene of Cryptococcus neoformans, CAP64, is involved in pH homeostasis

  2021cites this paper
• Defining steps in RAVE-catalyzed V-ATPase assembly using purified RAVE and V-ATPase subcomplexes

  2021cites this paper
• Ion Channels and Pumps in Autophagy: A Reciprocal Relationship

  2021cites this paper
• Purification of active human vacuolar H+-ATPase in native lipid-containing nanodiscs

  2021cites this paper
• Regulation and function of V-ATPases in physiology and disease.

  2020cites this paper
• The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

  2020cites this paper
• Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer’s Disease

  2020cites this paper
• Interaction between the yeast RAVE complex and Vph1-containing Vo sectors is a central glucose-sensitive interaction required for V-ATPase reassembly

  2020cites this paper
• Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor

  2020cites this paper
• Reciprocal Regulation of V-ATPase and Glycolytic Pathway Elements in Health and Disease

  2019cites this paper
• The priming factor CAPS1 regulates dense-core vesicle acidification by interacting with rabconnectin3β/WDR7 in neuroendocrine cells

  2019cites this paper
• Functional reconstitution of vacuolar H+-ATPase from Vo proton channel and mutant V1-ATPase provides insight into the mechanism of reversible disassembly

  2019cites this paper
• 73-deoxychondropsin A : a novel inhibitor of bone resorption sourced from a Great Barrier Reef sponge

  2018cites this paper
• PI(3,5)P2 controls vacuole potassium transport to support cellular osmoregulation

  2018cites this paper
• FcRav2, a gene with a ROGDI domain involved in Fusarium head blight and crown rot on durum wheat caused by Fusarium culmorum.

  2018cites this paper
• Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis

  2018cites this paper
• Asymmetric Segregation of Aged Spindle Pole Bodies During Cell Division: Mechanisms and Relevance Beyond Budding Yeast?

  2018cites this paper
• The Endosomal Network: Mediators and Regulators of Endosome Maturation.

  2018cites this paper
• V-ATPase regulation of Hypoxia Inducible transcription Factors

  2018cites this paper
• H+ and Pi Byproducts of Glycosylation Affect Ca2+ Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1

  2017cites this paper
• Characterization of candidate genes governing complex multicellularity in Neurospora crassa

  2017cites this paper
• Breaking up and making up: The secret life of the vacuolar H+‐ATPase

  2017influential citation
• Compensatory Internalization of Pma1 in V-ATPase Mutants in Saccharomyces cerevisiae Requires Calcium- and Glucose-Sensitive Phosphatases

  2017cites this paper
• The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

  2017cites this paper
• Regulation of V-ATPase activity.

  2017influential citation
• APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes.

  2017cites this paper
• Vacuolar ATPase in Physiology and Pathology: Roles in Neurobiology, Infectious Disease, and Cancer

  2016cites this paper
• Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.

  2016cites this paper
• Vacuolar H+-ATPase Signaling in Cancer

  2016cites this paper
• Eukaryotic V-ATPase and Its Super-complexes: From Structure and Function to Disease and Drug Targeting

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• Study of the Yeast Vacuolar-type ATPase by Electron Cryomicroscopy

  2016cites this paper
• The Vacuolar Proton ATPase (V-ATPase): Regulation and Therapeutic Targeting

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• Binding interactions of the peripheral stalk subunit isoforms from human V-ATPase

  2016cites this paper
• The membrane domain of vacuolar H+ATPase: a crucial player in neurotransmitter exocytotic release

  2015cites this paper
• Recent Insights into the Structure, Regulation, and Function of the V-ATPases.

  2015cites this paper
• Molecular Interactions and Cellular Itinerary of the Yeast RAVE (Regulator of the H+-ATPase of Vacuolar and Endosomal Membranes) Complex*

  2015influential citation
• Elucidating Vacuolar H+-ATPase Subunit Interactions: A Systematic Structural Analysis

  2015cites this paper
• Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

  2014cites this paper
• Yeast Phosphofructokinase-1 Subunit Pfk2p Is Necessary for pH Homeostasis and Glucose-dependent Vacuolar ATPase Reassembly*

  2014influential citation
• Saccharomyces cerevisiae Vacuolar H+-ATPase Regulation by Disassembly and Reassembly: One Structure and Multiple Signals

  2014cites this paper
• Reassembly Glucose-dependent Vacuolar ATPase andPfk 2 p Is Necessary for pH Homeostasis Yeast Phosphofructokinase-1 Subunit Bioenergetics :

  2014influential citation
• The study of vacuolar-type ATPases by single particle electron microscopy.

  2014cites this paper
• Loss of Vacuolar H+-ATPase Activity in Organelles Signals Ubiquitination and Endocytosis of the Yeast Plasma Membrane Proton pump Pma1p*

  2014cites this paper
• Eukaryotic V-ATPase: novel structural findings and functional insights.

  2014cites this paper