Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Biochimica et Biophysica Acta - Molecular Basis of Disease

• Publication date

  2017-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbadis.2017.01.020PMID 28130200PMCID PMC5466897
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
• Cardiorenal syndrome—current understanding and future perspectives

  2014influential reference
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  2013influential reference
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• The Cardiorenal Syndrome

  2011influential reference
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• Global atlas on cardiovascular disease prevention and control.

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• Forecasting the Future of Cardiovascular Disease in the United States: A Policy Statement From the American Heart Association

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  2009cited by this paper
• G protein–coupled receptor kinase 2 (GRK2) modulation and cell cycle progression

  2009cited by this paper
• Mouse surgical models in cardiovascular research.

  2009cited by this paper
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• Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation.

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• Tackling heart failure in the twenty-first century

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• Cardiorenal syndrome.

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